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Local and global brain connectivity alterations in focal epilepsy: Effects of disease, surgery and neuromodulation

English title Local and global brain connectivity alterations in focal epilepsy: Effects of disease, surgery and neuromodulation
Applicant Vulliémoz Serge
Number 169198
Funding scheme Project funding (Div. I-III)
Research institution Unité d'EEG et d'exploration de l'épilepsie Service de Neurologie Hôpitaux Universitaires de Genève
Institution of higher education University of Geneva - GE
Main discipline Neurology, Psychiatry
Start/End 01.02.2017 - 31.07.2020
Approved amount 525'000.00
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All Disciplines (2)

Discipline
Neurology, Psychiatry
Neurophysiology and Brain Research

Keywords (5)

High density EEG; Connectivity; Epilepsy; EEG-fMRI; Neuromodulation

Lay Summary (French)

Lead
Etude des connections cérébrales dans l'épilepsie focale et effet du traitement chirurgical et de la stimulation électrique cérébrale
Lay summary

L’épilepsie est l’une des maladies neurologiques chroniques les plus fréquentes qui touche 0.7% de la population. Elle est le plus souvent causée par des crises qui débutent dans une région localisée du cerveau. Notre cerveau est organisé en réseau de régions connectées et nous savons que dans l’épilepsie, de nombreuses régions sont impliquées dans l’activité épileptiques et peuvent influencer les régions localisées d’où partent les crises. Ces régions constituent un réseau épileptique.

Un tiers des patients souffrent de crises résistantes aux médicaments anti-épileptiques. Chez certains de ces patients, il est possible d’identifier une régions d’où partent les crises et la résection de cette région par neurochirurgie peut permettre de contrôler les crises. D’autres patients peuvent être traités par stimulation électrique cérébrale.

 

Le but de ce projet est d’étudier comment les réseaux cérébraux sont modifiés chez les patients souffrant d’épilepsie focale et comment ces altérations sont influencées par les différents traitements. Nous utiliserons des techniques non-invasive pour mesurer l’activité cérébrale et les connections entre les régions: l’électroencéphalogramme (EEG) à haute densité et les enregistrement simultanés d’EEG et Imagerie par Résonance Magnétique (IRM) fonctionnelle.

 

Ce projet a notamment comme but d’améliorer le traitement des patients et nous étudierons comment la connaissance des connections anormales peut être utilisée pour améliorer le diagnostic et prédire l’efficacité du traitement. 

Direct link to Lay Summary Last update: 18.10.2016

Responsible applicant and co-applicants

Employees

Publications

Publication
High-density Electric Source Imaging of interictal epileptic discharges: How many electrodes and which time point?
Vorderwülbecke Bernd J., Carboni Margherita, Tourbier Sebastien, Brunet Denis, Seeber Martin, Spinelli Laurent, Seeck Margitta, Vulliemoz Serge (2020), High-density Electric Source Imaging of interictal epileptic discharges: How many electrodes and which time point?, in Clinical Neurophysiology, 131(12), 2795-2803.
Ictal EEG source localization in focal epilepsy: Review and future perspectives
van Mierlo Pieter, Vorderwülbecke Bernd J., Staljanssens Willeke, Seeck Margitta, Vulliémoz Serge (2020), Ictal EEG source localization in focal epilepsy: Review and future perspectives, in Clinical Neurophysiology, 131(11), 2600-2616.
Brain networks involved in generalized periodic discharges (GPD) in post-anoxic-ischemic encephalopathy
De Stefano Pia, Carboni Margherita, Pugin Deborah, Seeck Margitta, Vulliémoz Serge (2020), Brain networks involved in generalized periodic discharges (GPD) in post-anoxic-ischemic encephalopathy, in Resuscitation, 155, 143-151.
Lateralized Rhythmic Delta Activity Synchronous with Hippocampal Epileptiform Discharges on Intracranial EEG
De Stefano Pia, Vulliémoz Serge, Seeck Margitta, Mégevand Pierre (2020), Lateralized Rhythmic Delta Activity Synchronous with Hippocampal Epileptiform Discharges on Intracranial EEG, in European Neurology, 83(2), 225-227.
Detection of epileptic activity in presumably normal EEG
Baldini Sara, Pittau Francesca, Birot Gwenael, Rochas Vincent, Tomescu Miralena I, Vulliémoz Serge, Seeck Margitta (2020), Detection of epileptic activity in presumably normal EEG, in Brain Communications, 2(2).
Resting-State Brain Activity for Early Prediction Outcome in Postanoxic Patients in a Coma with Indeterminate Clinical Prognosis
Pugin D., Hofmeister J., Gasche Y., Vulliemoz S., Lövblad K.-O., Ville D. Van De, Haller S. (2020), Resting-State Brain Activity for Early Prediction Outcome in Postanoxic Patients in a Coma with Indeterminate Clinical Prognosis, in American Journal of Neuroradiology, 41(6), 1022-1030.
Abnormal directed connectivity of resting state networks in focal epilepsy
Carboni Margherita, De Stefano Pia, Vorderwülbecke Bernd J., Tourbier Sebastien, Mullier Emeline, Rubega Maria, Momjian Shahan, Schaller Karl, Hagmann Patric, Seeck Margitta, Michel Christoph M., van Mierlo Pieter, Vulliemoz Serge (2020), Abnormal directed connectivity of resting state networks in focal epilepsy, in NeuroImage: Clinical, 27, 102336-102336.
Localizing non-epileptiform abnormal brain function in children using high density EEG: Electric Source Imaging of focal slowing
Baldini Sara, Coito Ana, Korff Christian M., Garibotto Valentina, Ndenghera Martin, Spinelli Laurent, Bartoli Andrea, Momjian Shahan, Schaller Karl, Seeck Margittta, Pittau Francesca, Vulliemoz Serge (2020), Localizing non-epileptiform abnormal brain function in children using high density EEG: Electric Source Imaging of focal slowing, in Epilepsy Research, 159, 106245-106245.
Using structural connectivity to augment community structure in EEG functional connectivity
Glomb Katharina, Mullier Emeline, Carboni Margherita, Rubega Maria, Iannotti Giannarita, Tourbier Sebastien, Seeber Martin, Vulliemoz Serge, Hagmann Patric (2020), Using structural connectivity to augment community structure in EEG functional connectivity, in Network Neuroscience, 4(3), 761-787.
Visual analysis of high density EEG: As good as electrical source imaging?
Toscano Gianpaolo, Carboni Margherita, Rubega Maria, Spinelli Laurent, Pittau Francesca, Bartoli Andrea, Momjian Shahan, Manni Raffaele, Terzaghi Michele, Vulliemoz Serge, Seeck Margitta (2020), Visual analysis of high density EEG: As good as electrical source imaging?, in Clinical Neurophysiology Practice, 5, 16-22.
The network integration of epileptic activity in relation to surgical outcome
Carboni M., Rubega M., Iannotti G.R., De Stefano P., Toscano G., Tourbier S., Pittau F., Hagmann P., Momjian S., Schaller K., Seeck M., Michel C.M., van Mierlo P., Vulliemoz S. (2019), The network integration of epileptic activity in relation to surgical outcome, in Clinical Neurophysiology, 130(12), 2193-2202.
The Role of EEG-fMRI in Studying Cognitive Network Alterations in Epilepsy
Shamshiri Elhum A., Sheybani Laurent, Vulliemoz Serge (2019), The Role of EEG-fMRI in Studying Cognitive Network Alterations in Epilepsy, in Frontiers in Neurology, 10, 1033.
Postoperative memory prognosis in temporal lobe epilepsy surgery: The contribution of postictal memory
Sveikata Lukas, Kavan Nicole, Pegna Alan J., Seeck Margitta, Assal Frederic, Momjian Shahan, Schaller Karl, Vulliemoz Serge (2019), Postoperative memory prognosis in temporal lobe epilepsy surgery: The contribution of postictal memory, in Epilepsia, 60(8), 1639-1649.
Network Perspectives on Epilepsy Using EEG/MEG Source Connectivity
van Mierlo Pieter, Höller Yvonne, Focke Niels K., Vulliemoz Serge (2019), Network Perspectives on Epilepsy Using EEG/MEG Source Connectivity, in Frontiers in Neurology, 10, 721.
Estimating EEG Source Dipole Orientation Based on Singular-value Decomposition for Connectivity Analysis
Rubega M., Carboni M., Seeber M., Pascucci D., Tourbier S., Toscano G., Van Mierlo P., Hagmann P., Plomp G., Vulliemoz S., Michel C. M. (2019), Estimating EEG Source Dipole Orientation Based on Singular-value Decomposition for Connectivity Analysis, in Brain Topography, 32(4), 704-719.
Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low‐density EEG
Coito Ana, Biethahn Silke, Tepperberg Janina, Carboni Margherita, Roelcke Ulrich, SeeckMargitta, van MierloPieter, GschwindMarkus, VulliemozSerge (2019), Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low‐density EEG, in Epilepsia Open, 4(2), 281-292.
Directed functional connections underlying spontaneous brain activity
Coito Ana, Michel Christoph M., Vulliemoz Serge, Plomp Gijs (2018), Directed functional connections underlying spontaneous brain activity, in Human Brain Mapping, 40(3), 879-888.
Influence of Time-Series Normalization, Number of Nodes, Connectivity and Graph Measure Selection on Seizure-Onset Zone Localization from Intracranial EEG
van Mierlo Pieter, Lie Octavian, Staljanssens Willeke, Coito Ana, Vulliémoz Serge (2018), Influence of Time-Series Normalization, Number of Nodes, Connectivity and Graph Measure Selection on Seizure-Onset Zone Localization from Intracranial EEG, in Brain Topography, 31(5), 753-766.
Clinical Neuroimaging Using 7 T MRI: Challenges and ProspectsClinical Use of 7 T MR in Neuroradiology
Vargas Maria Isabel, Martelli Pascal, Xin Lijing, Ipek Ozlem, Grouiller Frederic, Pittau Francesca, Trampel Robert, Gruetter Rolf, Vulliemoz Serge, Lazeyras Francois (2018), Clinical Neuroimaging Using 7 T MRI: Challenges and ProspectsClinical Use of 7 T MR in Neuroradiology, in Journal of Neuroimaging, 28(1), 5-13.
Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes
Verhoeven Thibault, Coito Ana, Plomp Gijs, Thomschewski Aljoscha, Pittau Francesca, Trinka Eugen, Wiest Roland, Schaller Karl, Michel Christoph, Seeck Margitta, Dambre Joni, Vulliemoz Serge, van Mierlo Pieter (2018), Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes, in NeuroImage: Clinical, 17, 10-15.
Seizure Onset Zone Localization from Ictal High-Density EEG in Refractory Focal Epilepsy
Staljanssens Willeke, Strobbe Gregor, Holen Roel Van, Birot Gwénaël, Gschwind Markus, Seeck Margitta, Vandenberghe Stefaan, Vulliémoz Serge, van Mierlo Pieter (2017), Seizure Onset Zone Localization from Ictal High-Density EEG in Refractory Focal Epilepsy, in Brain Topography, 30(2), 257-271.
EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy
Staljanssens Willeke, Strobbe Gregor, Van Holen Roel, Keereman Vincent, Gadeyne Stefanie, Carrette Evelien, Meurs Alfred, Pittau Francesca, Momjian Shahan, Seeck Margitta, Boon Paul, Vandenberghe Stefaan, Vulliemoz Serge, Vonck Kristl, van Mierlo Pieter (2017), EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy, in NeuroImage: Clinical, 16, 689-698.

Datasets

Connectome dataset for the publication: EEG and fMRI connectomes are reliably related: a simultaneous EEG-fMRI study from 1.5 T to 7T.

Author Wirsich, Jonathan
Publication date 08.07.2020
Persistent Identifier (PID) doi: 10.5281/zenodo.3905103
Repository Zenodo
Abstract
EEG and connectivity matrices derived from resting state EEG-fMRI datasets of healthy controlsA related publication is available (Wirsich et al. 2020, BioRxiv, doi: 10.1101/2020.06.16.154625) and in revision in a peer review journal.

Collaboration

Group / person Country
Types of collaboration
Functional Brain Mapping Lab, University of Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Neurology Dpt, Ghent University Hospital Belgium (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Institute of Bioengineering, EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Faculty of Psychology, University of Fribourg Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
EEG and Epilepsy Unit, University Hospital of Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Neuropediatric Unit, University Hospital of Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Center for Biomedical Imaging and Brain Behaviour Lab, University of Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Medical Image and Signal Processing Group, Department of Electronics and Information Systems, Ghent Belgium (Europe)
- in-depth/constructive exchanges on approaches, methods or results
UCL Institute of Child Health, London, UK Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Alpine Brain Imaging Meeting Talk given at a conference Reliability of the bimodal functional connectome using concurrent EEG-fMRI: from 1.5T to 7T 14.01.2020 Champéry, Switzerland Wirsich Jonathan;
Meeting of the Organisation for Human Brain Mapping Talk given at a conference Spatio-Temporal Large-Scale Organization of the Trimodal Connectome Derived from Concurrent EEG-fMRI and Diffusion MRI 13.06.2019 Rome, Italy Wirsich Jonathan;
Meeting of the Organisation for Human Brain Mapping Poster Brain connectivity with or without epileptic spikes: a simultaneous scalp and intracranial EEG study 12.06.2019 Rome, Italy Carboni Margherita;
Meeting of the Organisation for Human Brain Mapping Poster Differences between pre-operative and post-operative connectivity in patients with focal epilepsy 10.06.2019 Rome, Italy Shamshiri Elhum;
3-Laender Tagung Epileptologie. German, Austrian and Swiss League against Epilepsy Talk given at a conference EEG source reconstruction and functional network analysis 08.05.2019 Basel, Switzerland Vulliémoz Serge;
Alpine Brain Imaging Meeting Talk given at a conference HD-EEG source connectivity in focal epilepsy can predict post-operative seizure outcome in the presence and absence of scalp interictal epileptic discharges 10.01.2019 Champery, Switzerland Carboni Margherita;
Alpine Brain Imaging Meeting Poster Differences between pre-operative and post-operative connectivity in patients with focal epilepsy 10.01.2019 Champéry, Switzerland Shamshiri Elhum;
European Epilepsy Congress Talk given at a conference EEG and fMRI connectivity of epileptic activity 29.08.2018 Vienna, Austria Vulliémoz Serge;
Meeting of Swiss Society for Clinical Neurophysiology Poster Differences between pre-operative and post-operative connectivity in patients with epilepsy 31.05.2018 Aarau, Switzerland Shamshiri Elhum;
Alpine Brain Imaging Meeting Poster Increased network segregation as a biomarker in focal epilepsy 11.01.2018 Champéry, Switzerland Carboni Margherita;
American Epilepsy Society Meeting Talk given at a conference Electric Source Imaging and simultaneous EEG-fMRI in brain tumors 03.12.2017 Washington, United States of America Vulliémoz Serge;
American Epilepsy Society Meeting Talk given at a conference Dense array EEG to localise the epileptogenic zone 01.12.2017 Washington, United States of America Vulliémoz Serge;
Alpine Chapter of the Organisation for Human Brain Mapping Talk given at a conference Functional imaging of epileptic activity: from sources to networks 03.11.2017 Bern, Switzerland Vulliémoz Serge;
Alpine Chapter of the Organisation for Human Brain Mapping Talk given at a conference EEG-fMRI in Neurology 03.11.2017 Bern, Switzerland Vulliémoz Serge;
French Epilepsy Society Meeting Individual talk Interictal activity and epileptic networks 16.10.2017 Marseille, France Vulliémoz Serge;
Epilepsy and Genetics Talk given at a conference Case presentation 26.09.2017 Geneva, Switzerland Vulliémoz Serge;
Meeting of Swiss Society for Clinical Neurophysiology Talk given at a conference Connectivity: what the clinician should know 18.05.2017 Fribourg, Switzerland Vulliémoz Serge;
3-Laender Tagung Epileptologie. German, Austrian and Swiss League against Epilepsy Talk given at a conference Electric Source Imaging and simultaneous EEG-fMRI 05.05.2017 Vienna, Austria Vulliémoz Serge;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Neuroclub of medical students, Faculty of Medicine Talk 30.03.2017 Geneva, Switzerland Vulliémoz Serge;


Awards

Title Year
Epilepsia Open Journal Prize, for Publication Coito.... et Vulliemoz (https://doi.org/10.1002/epi4.12318) 2019

Associated projects

Number Title Start Funding scheme
141165 Identifying new markers of interictal epileptic activity in humans 01.10.2012 Project funding (Div. I-III)
140332 Imaging large scale neuronal networks in epilepsy 01.05.2012 SPUM
192749 Network Diagnosis for Epilepsy 01.01.2021 Project funding (Div. I-III)

Abstract

The aim of this research project is to investigate how brain networks are altered in patients suffering from focal epilepsy and how these alterations are affected by different treatment options such as resective surgery of the epileptic focus or chronic neuromodulation using deep brain electrical stimulation or vagal nerve stimulation. In this project, we will use non-invasive brain imaging techniques such as high-density EEG (hd-EEG) and simultaneous EEG and fMRI (EEG-fMRI) to characterize the patterns and strength of connections between brain regions and explore relationships between electrical and hemodynamic connectivity measures. Here, we propose 3 workpackages in patients with focal epilepsy using high-density EEG, simultaneous EEG-fMRI and simultaneous scalp and intracranial EEG. We will apply connectivity measures on patient recordings with and without detectable epileptic activity before and after treatment with resective surgery or neuromodulation, based on our techniques developed to investigate brain connectivity in the human brain using high-density EEG and EEG-fMRI. The role of these connectivity patterns for diagnostic (patient classification) and prognostic purposes (treatment response) will be tested. The better understanding of altered connectivity patterns in focal epilepsies and the way these patterns are influenced by respective surgery or electrical neuromodulation will advance our understanding of the variability of treatment response and post-surgical outcome. From a methodological point of view, the availability of invasive validation offered by clinical invasive recordings and post-operative follow-up is of crucial interest for the neuro-scientists using brain connectivity measures in other applications. New markers of brain dysfunction might help better monitor disease activity and tailor therapy.
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