Gender; Chronic kidney disease; Acute kidney injury; Contrast-enhanced Ultrasound; Renal sodium handling; MRI
Bane Octavia, Mendichovszky Iosif A., Milani Bastien, Dekkers Ilona A., Deux Jean-Francois, Eckerbom Per, Grenier Nicolas, Hall Michael E., Inoue Tsutomu, Laustsen Christoffer, Lerman Lilach O., Liu Chunlei, Morrell Glen, Pedersen Michael, Pruijm Menno, Sadowski Elizabeth A., Seeliger Erdmann, Sharma Kanishka, Thoeny Harriet, Vermathen Peter, Wang Zhen J., Serafin Zbigniew, Zhang Jeff L., Francis Susan T., et al. (2019), Consensus-based technical recommendations for clinical translation of renal BOLD MRI, in Magnetic Resonance Materials in Physics, Biology and Medicine
Braconnier Philippe, Milani Bastien, Loncle Nicolas, Lourenco Joao M., Brito Wendy, Delacoste Jean, Maillard Marc, Stuber Matthias, Burnier Michel, Pruijm Menno (2019), Short-term changes in dietary sodium intake influence sweat sodium concentration and muscle sodium content in healthy individuals, in Journal of Hypertension
Milani Bastien, Delacoste Jean, Burnier Michel, Pruijm Menno (2019), Exploring a new method for quantitative sodium MRI in the human upper leg with a surface coil and symmetrically arranged reference phantoms, in Quantitative Imaging in Medicine and Surgery
, 9(6), 985-999.
Damianaki Katerina, Lourenco Joao Miguel, Braconnier Philippe, Ghobril Jean-Pierre, Devuyst Olivier, Burnier Michel, Lenglet Sebastien, Augsburger Marc, Thomas Aurelien, Pruijm Menno (2019), Renal handling of zinc in chronic kidney disease patients and the role of circulating zinc levels in renal function decline, in Nephrology Dialysis Transplantation
, 21(April), 1-8.
Vakilzadeh Nima, Zanchi Anne, Milani Bastien, Ledoux Jean-Baptiste, Braconnier Philippe, Burnier Michel, Pruijm Menno (2019), Acute hyperglycemia increases renal tissue oxygenation as measured by BOLD-MRI in healthy overweight volunteers, in Diabetes Research and Clinical Practice
, 150, 138-143.
Wurzner-GhajarzadehArlene, BraconnierPhilippe, BurnierMichel, Pruijm Menno (2019), The skin as third kidney, in Revue Medicale Suisse
, 15(639), 418-421.
Maarten Koeners, Fredrik Palm (2018), Hypoxia in Kidney Disease
, Frontiers Media SA, Frontiers in Physiology.
Caroli Anna, Pruijm Menno, Burnier Michel, Selby Nicholas M (2018), Functional magnetic resonance imaging of the kidneys: where do we stand? The perspective of the European COST Action PARENCHIMA, in Nephrology Dialysis Transplantation
, 33(suppl_2), ii1-ii3.
Pruijm Menno, Mendichovszky Iosif A, Liss Per, Van der Niepen Patricia, Textor Stephen C, Lerman Lilach O, Krediet C T Paul, Caroli Anna, Burnier Michel, Prasad Pottumarthi Vara (2018), Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review, in Nephrology Dialysis Transplantation
, 33(suppl_2), ii22-ii28.
Pruijm Menno, Milani Bastien, Pivin Edward, Podhajska Agata, Vogt Bruno, Stuber Matthias, Burnier Michel (2018), Reduced cortical oxygenation predicts a progressive decline of renal function in patients with chronic kidney disease, in Kidney International
, 93(4), 932-940.
Pruijm Menno, Lu Yimin, Megdiche Fatma, Piskunowicz Maciej, Milani Bastien, Stuber Matthias, Bachtler Matthias, Vogt Bruno, Burnier Michel, Pasch Andreas (2017), Serum calcification propensity is associated with renal tissue oxygenation and resistive index in patients with arterial hypertension or chronic kidney disease., in Journal of hypertension
, 35(10), 2044-2052.
Mehier Patricia, Burnier Michel, Pruijm Menno (2017), [Gender differences in chronic kidney diseases : myth or reality ?], in Revue medicale suisse
, 13(551), 473-476.
Pruijm Menno, Milani Bastien, Burnier Michel (2016), Blood Oxygenation Level-Dependent MRI to Assess Renal Oxygenation in Renal Diseases: Progresses and Challenges., in Frontiers in physiology
, 7, 667-667.
Piskunowicz Maciej, Swieton Dominik, Rybczynska Dorota, Szarmach Arkadiusz, Szurowska Edyta, Pruijm Menno (2016), Premature Destruction of Microbubbles during Voiding Urosonography in Children and Possible Underlying Mechanisms: Post Hoc Analysis from the Prospective Study, in BIOMED RESEARCH INTERNATIONAL
Chehade Hassib, Milani Bastien, Ansaloni Annalisa, Anex Christiane, Bassi Isabelle, Piskunowicz Maciej, Stuber Matthias, Cachat Francois, Burnier Michel, Pruijm Menno (2016), Renal tissue oxygenation in children with chronic kidney disease due to vesicoureteral reflux, in PEDIATRIC NEPHROLOGY
, 31(11), 2103-2111.
Chronic kidney disease (CKD) is a fast growing global health problem with an estimated prevalence in Switzerland of ~10%. Despite important research efforts, the available preventive and therapeutic strategies are not very successful in halting the CKD epidemic. Of interest, women are less prone to the development of CKD, suffer less often from hypertension, and progress less rapidly to end stage renal disease. This protection seems lost when entering menopause. Why women are protected remains so far incompletely understood. In experimental models, chronic renal tissue hypoxia is a common and final pathway of CKD, irrespective of its cause. Using blood oxygenation level-dependent MRI (BOLD-MRI), we have recently demonstrated that CKD patients have indeed lower cortical oxygenation than controls. Of importance for this project, in both groups cortical oxygenation was higher in women than men. Renal tissue oxygenation depends of anatomical (renal size, renal arteries, glomeruli number, degree of fibrosis), dietary (fluid and sodium intake), and functional parameters (renal blood flow, renal sodium handling, glomerular filtration rate, tubular active transport). The impact of sex hormones on renal oxygenation in humans is, so far, unknown. We hypothesize that the higher cortical oxygenation in women is due to sex differences in relative cortical perfusion, renal and skin sodium handling, different responses to external factors, and differences in renal anatomy (size) and histology (number of glomeruli). We also hypothesize that fluctuations in renal oxygenation take place during the menstrual cycle, menopause and under the influence of oral anticonceptives. New radiological and histological techniques offer unique opportunities to study the above mentioned factors and will be used in this project, yet some techniques have to be further developed, or used in new ways. In this context, the main aims of this project are:1/ To assess the influence of menstrual cycle and menopause on renal oxygenation, hemodynamics and sodium handling using BOLD MRI, diffusion weighted MRI, Na23 MRI and CEUS.2/ To assess whether sex differences exist in renal perfusion in response to external stimuli (L-arginine) in normal and stressful (acute kidney injury) conditions using contrast-enhanced ultrasound (CEUS).3/ To develop a new analysis technique of CEUS to acquire detailed, layer by layer, information on renal perfusion.4/ To assess whether renal structural and histological differences exist between men and women using autopsy data and histological techniques that will be further developed in the light of this project(automatic counting of glomeruli)