Gerber Hermeto, Mosser Sebastien, Boury-Jamot Benjamin, Stumpe Michael, Piersigilli Alessandra, Goepfert Christine, Dengjel Joern, Albrecht Urs, Magara Fulvio, Fraering Patrick C. (2019), The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease, in Acta Neuropathologica Communications
, 7(1), 13-13.
Martini Tomaz, Ripperger Jürgen, Albrecht Urs (2018), Measuring Food Anticipation in Mice, in Clocks & Sleep
, 1(1), 65-74.
Albrecht Urs, Ripperger Jürgen A. (2018), Circadian Clocks and Sleep: Impact of Rhythmic Metabolism and Waste Clearance on the Brain, in Trends in Neurosciences
, 41(10), 677-688.
Schmitt Karen, Grimm Amandine, Dallmann Robert, Oettinghaus Bjoern, Restelli Lisa Michelle, Witzig Melissa, Ishihara Naotada, Mihara Katsuyoshi, Ripperger Jürgen A., Albrecht Urs, Frank Stephan, Brown Steven A., Eckert Anne (2018), Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics, in Cell Metabolism
, 27(3), 657-666.e5.
Richter Karin, Schmutz Isabelle, Darna Mahesh, Zander Johannes-F, Chavan Rohit, Albrecht Urs, Ahnert-Hilger Gudrun (2018), VGLUT1 Binding to Endophilin or Intersectin1 and Dynamin Phosphorylation in a Diurnal Context, in Neuroscience
, 371, 29-37.
Stieglitz Marc S., Fenske Stefanie, Hammelmann Verena, Becirovic Elvir, Schöttle Verena, Delorme James E., Schöll-Weidinger Martha, Mader Robert, Deussing Jan, Wolfer David P., Seeliger Mathias W., Albrecht Urs, Wotjak Carsten T., Biel Martin, Michalakis Stylianos, Wahl-Schott Christian (2018), Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice, in Frontiers in Molecular Neuroscience
, 10, ---.
Xu Cheng, Messina Andrea, Somm Emmanuel, Miraoui Hichem, Kinnunen Tarja, Acierno James, Niederländer Nicolas J, Bouilly Justine, Dwyer Andrew A, Sidis Yisrael, Cassatella Daniele, Sykiotis Gerasimos P, Quinton Richard, De Geyter Christian, Dirlewanger Mirjam, Schwitzgebel Valérie, Cole Trevor R, Toogood Andrew A, Kirk Jeremy MW, Plummer Lacey, Albrecht Urs, Crowley William F, Mohammadi Moosa, Tena‐Sempere Manuel, et al. (2017), KLB , encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism, in EMBO Molecular Medicine
, 9(10), 1379-1397.
Somm Emmanuel, Henry Hugues, Bruce Stephen J., Aeby Sébastien, Rosikiewicz Marta, Sykiotis Gerasimos P., Asrih Mohammed, Jornayvaz François R., Denechaud Pierre Damien, Albrecht Urs, Mohammadi Moosa, Dwyer Andrew, Acierno James S., Schoonjans Kristina, Fajas Lluis, Greub Gilbert, Pitteloud Nelly (2017), β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue, in JCI Insight
, 2(8), ---.
Chavan Rohit, Albrecht Urs, Okabe Takashi (2017), Biological Timekeeping: Clocks, Rhythms and Behaviour
, Springer India, New Delhi.
Albrecht Urs (2017), Molecular Mechanisms in Mood Regulation Involving the Circadian Clock, in Frontiers in Neurology
, 8, 1-6.
Albrecht U. (2017), The circadian clock, metabolism and obesityClock and obesity, in Obesity Reviews
, 18, 25-33.
Chavan Rohit, Preitner Nadia, Okabe Takashi, Strittmatter Laureen Mansencal, Xu Cheng, Ripperger Jürgen A., Pitteloud Nelly, Albrecht Urs (2017), REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6, in Biology Open
, 6(1), 1-7.
Okabe Takashi, Chavan Rohit, Costa Sara S. Fonseca, Brenna Andrea, Ripperger Jürgen A., Albrecht Urs (2016), REV-ERBα influences stability and nuclear localization of the glucocorticoid receptor, in Journal of Cell Science
Mammals experience environmental changes at various time scales, including daily light dark alterations and seasonal variations. In order to optimize the organism’s performance a mechanism developed to predict daily recurring events. This mechanism is termed circadian clock, which is at the cellular level an auto-regulatory feedback loop that cycles in a 24-hour rhythm. However, this mechanism has to be adaptable to changes, because daily light-dark transitions vary over the year. Defects in clock components as well as in clock adaptability to environmental challenges contribute most likely to metabolic and neurological diseases.In this proposal we are investigating how environmental challenges modulate the clock with a focus on the Per2 gene, which is a common component of both the clock input pathways and the core clock mechanism. The first part of the project focuses on the health benefits when day-length matches with clock period in mice. The second part investigates the regulation of phosphorylation of the PER2 protein a target of various protein kinases, which act on the PER2 protein in response to environmental challenges. The third part aims at understanding how neurons and astrocytes, which both express PER2, coordinate their influence to modulate responses to environmental challenges.