Project

Back to overview

Adaptation of the circadian clock to changes in the environment

English title Adaptation of the circadian clock to changes in the environment
Applicant Albrecht Urs Emanuel
Number 166682
Funding scheme Project funding (Div. I-III)
Research institution Division de Biochimie Département de Biologie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Biochemistry
Start/End 01.04.2016 - 31.03.2019
Approved amount 678'000.00
Show all

All Disciplines (3)

Discipline
Biochemistry
Molecular Biology
Genetics

Keywords (5)

metabolism; astrocytes; Circadian clock; Kinase; neurons

Lay Summary (German)

Lead
Lebewesen auf der Erde erfahren Umweltveränderungen wie den Tag-Nacht Wechsel oder die Jahreszeiten. Um sich optimal auf den Tagesablauf einstellen zu können hat sich über Jahrtausende ein Mechanismus entwickelt der es Lebewesen erlaubt täglich wiederkehrende Ereignisse vorauszusagen. Diese sogenannte innere Uhr ist genetisch in jeder Zelle verankert und erlaubt es biochemische und neurobiologische Prozesse im Körper zeitlich zu koordinieren. Sind teile der inneren Uhr defekt oder wird die inneren Uhr durch falsche Signale wie zum Beispiel Stress oder Jet lag verwirrt kann das zu Übergewicht, Herzproblemen und Depressionen führen. Wie das Funktioniert ist nicht verstanden. Das Projekt leistet einen Beitrag dazu.
Lay summary

Über das Jahr verändert sich die Tageslänge und Teile der inneren Uhr können das registrieren und somit die zeitliche Organisation der Körperfunktionen beeinflussen und der Jahreszeit anpassen. Wie dies genau geschieht ist weitgehend unbekannt. Deshalb studieren wir in diesem Projekt den Einfluss von Umweltsignalen auf die innere Uhr und die Körperfunktionen der Maus. Dabei fokussieren wir unsere Studien auf die Uhrenkomponente Per2, da diese nicht nur Teil des Uhrwerkes ist, sondern auch direkt auf Lichtsignale aus der Umwelt reagiert. Wir wollen herausfinden wie Umweltsignale Per2 verändern und damit direkt Einfluss auf das Verhalten nehmen. Dabei interessiert uns im speziellen wie Per2 die Funktion verschiedener Hirnzelltypen koordiniert und dabei das Wohlbefinden und Essverhalten steuert.  

 

Das Projekt befasst sich mit Grundlagenforschung. Um das Verhalten in Bezug auf Veränderungen in der Umwelt zu studieren, ist es nicht nur wichtig Beobachtungen am Menschen anzustellen, sondern auch Mäuse zu studieren welche genetisch verändert werden können um somit kausale und nicht nur parallel ablaufende Zusammenhänge herausfinden zu können.

Direct link to Lay Summary Last update: 29.03.2016

Responsible applicant and co-applicants

Employees

Publications

Publication
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease
Gerber Hermeto, Mosser Sebastien, Boury-Jamot Benjamin, Stumpe Michael, Piersigilli Alessandra, Goepfert Christine, Dengjel Joern, Albrecht Urs, Magara Fulvio, Fraering Patrick C. (2019), The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease, in Acta Neuropathologica Communications, 7(1), 13-13.
Measuring Food Anticipation in Mice
Martini Tomaz, Ripperger Jürgen, Albrecht Urs (2018), Measuring Food Anticipation in Mice, in Clocks & Sleep, 1(1), 65-74.
Circadian Clocks and Sleep: Impact of Rhythmic Metabolism and Waste Clearance on the Brain
Albrecht Urs, Ripperger Jürgen A. (2018), Circadian Clocks and Sleep: Impact of Rhythmic Metabolism and Waste Clearance on the Brain, in Trends in Neurosciences, 41(10), 677-688.
Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics
Schmitt Karen, Grimm Amandine, Dallmann Robert, Oettinghaus Bjoern, Restelli Lisa Michelle, Witzig Melissa, Ishihara Naotada, Mihara Katsuyoshi, Ripperger Jürgen A., Albrecht Urs, Frank Stephan, Brown Steven A., Eckert Anne (2018), Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics, in Cell Metabolism, 27(3), 657-666.e5.
VGLUT1 Binding to Endophilin or Intersectin1 and Dynamin Phosphorylation in a Diurnal Context
Richter Karin, Schmutz Isabelle, Darna Mahesh, Zander Johannes-F, Chavan Rohit, Albrecht Urs, Ahnert-Hilger Gudrun (2018), VGLUT1 Binding to Endophilin or Intersectin1 and Dynamin Phosphorylation in a Diurnal Context, in Neuroscience, 371, 29-37.
Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice
Stieglitz Marc S., Fenske Stefanie, Hammelmann Verena, Becirovic Elvir, Schöttle Verena, Delorme James E., Schöll-Weidinger Martha, Mader Robert, Deussing Jan, Wolfer David P., Seeliger Mathias W., Albrecht Urs, Wotjak Carsten T., Biel Martin, Michalakis Stylianos, Wahl-Schott Christian (2018), Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice, in Frontiers in Molecular Neuroscience, 10, ---.
KLB , encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism
Xu Cheng, Messina Andrea, Somm Emmanuel, Miraoui Hichem, Kinnunen Tarja, Acierno James, Niederländer Nicolas J, Bouilly Justine, Dwyer Andrew A, Sidis Yisrael, Cassatella Daniele, Sykiotis Gerasimos P, Quinton Richard, De Geyter Christian, Dirlewanger Mirjam, Schwitzgebel Valérie, Cole Trevor R, Toogood Andrew A, Kirk Jeremy MW, Plummer Lacey, Albrecht Urs, Crowley William F, Mohammadi Moosa, Tena‐Sempere Manuel, et al. (2017), KLB , encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism, in EMBO Molecular Medicine, 9(10), 1379-1397.
β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue
Somm Emmanuel, Henry Hugues, Bruce Stephen J., Aeby Sébastien, Rosikiewicz Marta, Sykiotis Gerasimos P., Asrih Mohammed, Jornayvaz François R., Denechaud Pierre Damien, Albrecht Urs, Mohammadi Moosa, Dwyer Andrew, Acierno James S., Schoonjans Kristina, Fajas Lluis, Greub Gilbert, Pitteloud Nelly (2017), β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue, in JCI Insight, 2(8), ---.
Biological Timekeeping: Clocks, Rhythms and Behaviour
Chavan Rohit, Albrecht Urs, Okabe Takashi (2017), Biological Timekeeping: Clocks, Rhythms and Behaviour, Springer India, New Delhi.
Molecular Mechanisms in Mood Regulation Involving the Circadian Clock
Albrecht Urs (2017), Molecular Mechanisms in Mood Regulation Involving the Circadian Clock, in Frontiers in Neurology, 8, 1-6.
The circadian clock, metabolism and obesityClock and obesity
Albrecht U. (2017), The circadian clock, metabolism and obesityClock and obesity, in Obesity Reviews, 18, 25-33.
REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
Chavan Rohit, Preitner Nadia, Okabe Takashi, Strittmatter Laureen Mansencal, Xu Cheng, Ripperger Jürgen A., Pitteloud Nelly, Albrecht Urs (2017), REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6, in Biology Open, 6(1), 1-7.
REV-ERBα influences stability and nuclear localization of the glucocorticoid receptor
Okabe Takashi, Chavan Rohit, Costa Sara S. Fonseca, Brenna Andrea, Ripperger Jürgen A., Albrecht Urs (2016), REV-ERBα influences stability and nuclear localization of the glucocorticoid receptor, in Journal of Cell Science, jcs.190959-jcs.190959.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
LS2 Annual Meeting Poster Sleep characteristics of mice lacking circadian core clock gene Per2 in the CNS 14.02.2019 Zürich, Switzerland Wendrich Katrin Sophie;
European Sleep Foundation Sleep Science Winter School Talk given at a conference Circadian rhythms’ 09.02.2019 Wengen, Switzerland Albrecht Urs Emanuel;
Cinchron Kick-off meeting Talk given at a conference Circadian rhythms in mammals 26.11.2018 Valencia, Spain Albrecht Urs Emanuel;
2018 IMB Workshop: Molecular Mechanisms of Circadian Clocks Talk given at a conference CDK5-mediated phosphorylation of PER2 regulates circadian clock 15.11.2018 Mainz, Germany Brenna Andrea;
Congress of the European Sleep Research Society (ESRS) Poster CDK5-mediated phosphorylation of PER2 regulates circadian clock 26.09.2018 Basel, Switzerland Brenna Andrea;
Swiss-Sleep Annual Meeting Talk given at a conference CDK5-mediated phosphorylation of PER2 regulates circadian clock 25.09.2018 Basel, Switzerland Brenna Andrea;
Swiss Chronobiology meeting Talk given at a conference CDK5-mediated phosphorylation of PER2 regulates circadian clock 06.09.2018 Fribourg, Switzerland Brenna Andrea;
Swiss Physiology Meeting Talk given at a conference Involvement of the monocarboxylate transporter 1 (MCT1) in anticipation of recurrent food availability in mice 04.09.2018 Fribourg, Switzerland Martini Tomaz;
BeFri Research Retreat Poster CDK5-mediated phosphorylation of PER2 regulates circadian clock 26.04.2018 Kandersteg, Switzerland Brenna Andrea;
BeFri Research Retreat Poster Physical interaction between CDK5 and PER2 25.04.2018 Kandersteg, Switzerland Brenna Andrea;
Swiss Young Sleep Wake Chronobiology Network (SYSWCN) Talk given at a conference CDK5-mediated phosphorylation of PER2 regulates circadian clock 14.04.2018 Zürich, Switzerland Brenna Andrea;
BeFri Research Retreat Poster Effect of astrocyte Period 2 knockout on animal behaviour 10.04.2018 Kandersteg, Switzerland Martini Tomaz;
1st Sleep Science Winter School Talk given at a conference Circadian rhythms across species 01.03.2018 Wengen, Switzerland Albrecht Urs Emanuel;
BENEFRI Neurobiology workshop Poster Effect of astrocyte Period 2 knockout on animal behaviour 14.02.2018 Fribourg, Switzerland Martini Tomaz;
LS2 Meeting Poster Effect of astrocyte Period 2 knockout on animal behaviour 12.02.2018 Lausanne, Switzerland Martini Tomaz;
World Sleep Congress Talk given at a conference Basic circadian regulation of metabolism 07.10.2017 Prag, Czech Republic Albrecht Urs Emanuel;
Harnack-Haus Max-Planck-Gesellschaft Individual talk A PERsonal view on 20 years in chronobiology research 21.09.2017 Berlin, Germany Albrecht Urs Emanuel;
Neurex Summer School: Basic and Clinical Aspects of Neurobiology of Rhythms Talk given at a conference Circadian Clocks: From Molecular Mechanisms to Cell Function 30.08.2017 Strasbourg, France Albrecht Urs Emanuel;
XV Congress of the European Biological Rhythms Society Talk given at a conference Is the food entrainable oscillator a systemic oscillator ? 30.07.2017 Amsterdam, Netherlands Albrecht Urs Emanuel;
CUSO StarOmics Talk given at a conference Astroclock and mood -- effect of molecular clock gene Per2 knock-out from astrocytes on animal behaviour 08.06.2017 Münchenwiler, Switzerland Martini Tomaz;
BeFri Research Retreat Talk given at a conference Circadian phase regulation via daily CDK5-mediated PER2 phosphorylation 04.05.2017 Kandersteg, Switzerland Brenna Andrea;
Spring Meeting of the Swiss Society of Pharmacology and Toxicology Talk given at a conference The circadian clock in animal models 20.04.2017 Bern, Switzerland Albrecht Urs Emanuel;
BeFri Research Retreat Poster Astroclock and mood -- effect of molecular clock gene Per2 knock-out from astrocytes on animal behaviour 07.04.2017 Kandersteg, Switzerland Martini Tomaz;
Saitama Medical University Individual talk How is feeding time anticipated ? 02.03.2017 Saitama, Japan Albrecht Urs Emanuel;
RIKEN Brain Science Institute Individual talk How is feeding time anticipated ? 28.02.2017 Tokyo, Japan Albrecht Urs Emanuel;
Swiss Chronobiology Meeting Talk given at a conference REV-ERBα influences the stability and nuclear localisation of the glucocorticoid receptor 01.09.2016 Fribourg, Switzerland Brenna Andrea;
28th Annual Meeting of the Society for Light Treatment and Biological Rhythms Talk given at a conference Clock Genes and Mood Related Behavior 29.06.2016 New York, United States of America Albrecht Urs Emanuel;
Seminar at the Department of Pharmacy, LMU Munich Individual talk Food anticipation and the circadian clock 13.06.2016 Munich, Germany Albrecht Urs Emanuel;
Annual Meeting of the Schweizerische Gesellschaft für Schlafforschung, Schlafmedizin und Chronobiologie Talk given at a conference Circadian Metabolism: Implications for night eating syndrome 28.04.2016 Basel, Switzerland Albrecht Urs Emanuel;


Self-organised

Title Date Place
7th Swiss Chronobiology Meeting 06.09.2018 Fribourg, Switzerland
6th Swiss Chronobiology Meeting 07.09.2017 Fribourg, Switzerland
5th Swiss Chronobiology Meeting 01.09.2016 Fribourg, Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
SwissCore Science briefing on "Longing for a good night's sleep - solutions at the cross-roads between psychology, biology and neuroscience: how to best support interdisciplinarity Talk 14.09.2016 Brussels, Belgium Albrecht Urs Emanuel;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Cafés scientifiques Western Switzerland 2017
Media relations: print media, online media Eine ethisceh Güterabwägung Freiburger Nachrichten Western Switzerland 2017
Media relations: radio, television Schlaf und Zeitumstellung Radio Fribourg Western Switzerland 2017
Media relations: print media, online media Wie unsere innere Uhr tickt Tages Anzeiger German-speaking Switzerland 2017
Media relations: radio, television Wissenschaftsmagazin SRF German-speaking Switzerland 2017

Awards

Title Year
Poster award 2019

Associated projects

Number Title Start Funding scheme
146265 Clock synchronization: From brain to periphery or periphery to brain? 01.04.2013 Project funding (Div. I-III)
184667 Environmental conditions, clock and sleep 01.04.2019 Project funding (Div. I-III)

Abstract

Mammals experience environmental changes at various time scales, including daily light dark alterations and seasonal variations. In order to optimize the organism’s performance a mechanism developed to predict daily recurring events. This mechanism is termed circadian clock, which is at the cellular level an auto-regulatory feedback loop that cycles in a 24-hour rhythm. However, this mechanism has to be adaptable to changes, because daily light-dark transitions vary over the year. Defects in clock components as well as in clock adaptability to environmental challenges contribute most likely to metabolic and neurological diseases.In this proposal we are investigating how environmental challenges modulate the clock with a focus on the Per2 gene, which is a common component of both the clock input pathways and the core clock mechanism. The first part of the project focuses on the health benefits when day-length matches with clock period in mice. The second part investigates the regulation of phosphorylation of the PER2 protein a target of various protein kinases, which act on the PER2 protein in response to environmental challenges. The third part aims at understanding how neurons and astrocytes, which both express PER2, coordinate their influence to modulate responses to environmental challenges.
-