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Rheology of Lipid Bilayers

English title Rheology of Lipid Bilayers
Applicant Vermant Jan
Number 165974
Funding scheme Project funding (Div. I-III)
Research institution Departement Materialwissenschaft ETH Zürich
Institution of higher education ETH Zurich - ETHZ
Main discipline Material Sciences
Start/End 01.09.2016 - 31.08.2019
Approved amount 221'008.00
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All Disciplines (2)

Discipline
Material Sciences
Chemical Engineering

Keywords (3)

phospholipid bilayers; rheology; interfaces

Lay Summary (French)

Lead
Rhéologie des double couches, formées par des lipides.
Lay summary
Dans se projet on a comme objectif d'étudier des membranes composés des phospholipides. On veut developper un dispositif pour étudier les proprietes mécaniques, afin de comprendre  le liens entre le composition est la fluidité (ou l'absence de cela) de ces membranes. La rhéologie étudie la relation entre les deformations et les contraintes, donc on espère mesurer la deformabilité, la mobilité et la possibilité d'un comportent viscoélastique dans des membranes minimalistes. 
 
Direct link to Lay Summary Last update: 06.09.2016

Responsible applicant and co-applicants

Employees

Name Institute

Publications

Publication
Designer liquid-liquid interfaces made from transient double emulsions
Dockx Greet, Geisel Steffen, Moore David G., Koos Erin, Studart Andre R., Vermant Jan (2018), Designer liquid-liquid interfaces made from transient double emulsions, in Nature Communications, 9(1), 4763-4763.
Toward Realistic Large-Area Cell Membrane Mimics: Excluding Oil, Controlling Composition, and Including Ion Channels
Beltramo Peter J., Scheidegger Laura, Vermant Jan (2018), Toward Realistic Large-Area Cell Membrane Mimics: Excluding Oil, Controlling Composition, and Including Ion Channels, in Langmuir, 34(20), 5880-5888.
Arresting dissolution by interfacial rheology design
Beltramo Peter J., Gupta Manish, Alicke Alexandra, Liascukiene Irma, Gunes Deniz Z., Baroud Charles N., Vermant Jan (2017), Arresting dissolution by interfacial rheology design, in Proceedings of the National Academy of Sciences, 114(39), 10373-10378.
Characterization and modelling of Langmuir interfaces with finite elasticity
Pepicelli Martina, Verwijlen Tom, Tervoort Theo A., Vermant Jan (2017), Characterization and modelling of Langmuir interfaces with finite elasticity, in Soft Matter, 13(35), 5977-5990.
Simple Optical Imaging of Nanoscale Features in Free-Standing Films
Beltramo Peter Vermant Jan (2016), Simple Optical Imaging of Nanoscale Features in Free-Standing Films, in ACS omega, 1(3), 363-370.
Operating windows for oscillatory interfacial shear rheology"
RenngliDamian, AlickeAlexandra, EwoldtRandy, VermantJan, Operating windows for oscillatory interfacial shear rheology", in Journal of Rheology, 65(1).

Collaboration

Group / person Country
Types of collaboration
Baroud Group, école polytechnique France (Europe)
- Publication
Beltramo group United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Fuller groups United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Nestlé Research. Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Industry/business/other use-inspired collaboration

Scientific events



Self-organised

Title Date Place

Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Bierschaum als Inspirationsquelle German-speaking Switzerland 2019

Awards

Title Year
Weissenberg award of the European Society of Rheology 2019
Onsager professorship and medal (NTNU) 2016

Associated projects

Number Title Start Funding scheme
170745 Coherent Anti-Stokes Raman Scattering (CARS) applied to complex fluid-fluid interfaces. 01.05.2017 R'EQUIP

Abstract

Soft matter interfaces are common to living systems, foods, personal products, and the environment. They occur whenever surface-active moieties or particles find themselves at fluid interfaces and render them non-linear in their response to flow and deformation. In the last decades good progress has been made in the experimental characterization of monolayers of surface-active species or particles. For bilayers, which constitute the membrane of living cells and can be viewed as the ultimate success of self-assembly in materials science, the situation is different and despite the even greater relevance of such systems our current understanding is limited. In this project we propose take on the challenge to measure and characterize the full interfacial rheology-structure relation of bilayers. So far, this was difficult as existing methods to fabricate freestanding model membranes are limited in size and control over composition and thermodynamics and thus the studies that can be performed are limited. We have developed a method to generate freestanding, planar, phospholipid bilayers with millimeter scale areas. The technique relies on an adapted thin-film balance apparatus allowing for the dynamic control of the nucleation and growth of a planar black lipid membrane in the center of an orifice surrounded by microfluidic channels. Success has been demonstrated using several different lipid types, including mixtures that show the same temperature dependent phase separation as existing protocols. An advantage unique to our approach is the dynamic control of the membrane tension. We now propose to use this platform for freestanding, planar, phospholipid bilayers with millimeter scale areas to measure the rheological properties of these systems, trying to obtain well-defined kinematic conditions for shear, dilation and bending. The goal is to come to a complete holistic description of the membrane rheology. This should help us understand these systems, rationalize their mechano-chemical response, and lead to a new paradigm for studying the mechanics, structure, and function of model membranes.
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