Project

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In vivo cell dynamics in cancer, immunity and infection

English title In vivo cell dynamics in cancer, immunity and infection
Applicant Petrova Tatiana V.
Number 164119
Funding scheme R'EQUIP
Research institution Centre Pluridiciplinaire d'Oncologie CHUV et Université de Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Experimental Cancer Research
Start/End 01.07.2016 - 31.10.2018
Approved amount 362'227.00
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All Disciplines (3)

Discipline
Experimental Cancer Research
Immunology, Immunopathology
Pathophysiology

Keywords (4)

tumor microenvironment; lymphangiogenesis; angiogenesis; immunology

Lay Summary (French)

Lead
Développement d'imagerie intravitale
Lay summary

La recherche biomédicale nécessite de plus en plus le traçage et l'analyse de populations cellulaires hétérogènes in vivo et en temps réel.

La microscopie deux photons offre des avantages uniques et s’impose comme un outil de premier plan dans la surveillance du comportement dynamique de différents types de cellules ainsi que la détection et l'analyse quantitative d’interactions cellulaires transitoires  inaccessibles par d'autres méthodes.

Ce projet vise le développement d’une plateforme d’imagerie cellulaire biphotonique intravitale de pointe au sein de la communauté bio-médicale lausannoise CHUV-UNIL,  comprenant le Centre d’Oncologie Translationnelle ainsi que le Centre d’Immunité et Infection (CIIL).  Dans ce contexte, l’instrumentation sera mise à la disposition de plus d’une vingtaine de groupes appartenant au Département de Biochimie (UNIL), à la branche lausannoise du Centre Ludwig pour la recherche sur le Cancer de même qu’au Département d’Oncologie (CHUV-UNIL).

Direct link to Lay Summary Last update: 15.09.2016

Responsible applicant and co-applicants

Collaboration

Group / person Country
Types of collaboration
Dr Aldina Barral, Fiocruz, Bahia. Brazil Brazil (South America)
- in-depth/constructive exchanges on approaches, methods or results
Carl June, U Pennsylvania United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Steve Baylin, Johns Hopkins University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
M.De Palma, EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Victor Neel, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Friedemann Kiefer, Max Planck Institute for Biomedicine Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Dr Pascale Kropf, London School of Hygiene and Tropical Medicine, London, Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Melody Swartz, University of Chicago United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
F. Radtke, EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Steve Rosenberg, National Cancer Institute. United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Tayyaba Hasan, Welman Laboratories of Photobiology, Massachusetts General Hospital and Harvard Medic United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Dr James Alexander, University of Strathclyde, Glasgow Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Associated projects

Number Title Start Funding scheme
160674 Therapeutic approaches for treatment of hereditary lymphedema 01.05.2015 ERA-NET
156191 Cancer stromal cell genetic control 01.10.2014 Project funding (Div. I-III)
156266 Signaling pathways controlling intestinal lymphatic vascular homeostasis and function 01.02.2015 Project funding (Div. I-III)
146187 The development of Leishmania-specific immune response 01.04.2013 Project funding (Div. I-III)

Abstract

Progress in biomedical research is increasingly dependent on the analyses of heterogeneous cell populations in vivo. Multiphoton microscopy enables monitoring of dynamic behavior of differ-ent cells types in living tissues as well as detection and quantitative analyses of even transient cellular interactions, inaccessible by other methods. The aim of this application is the development of high-resolution live imaging platform for providing state-of-the-art, advanced technology to the recently established center in translational oncology, immunology and infection of the University of Lausanne and CHUV. The projects, which will benefit directly from such equipment, range from studies of tumor microenvironment to characterization of dynamics interactions of stromal and immune cells in the gut and during host-pathogen interactions. Furthermore, it will open up novel scientific avenues to over 20 groups from Department of Biochemistry, Ludwig Cancer Research Centre, Department of Oncology and CHUV. Therefore the entire cancer and immunology research community will profit from such microscope through the enhanced ability to lead cutting edge innovative research.
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