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Micro-ultrasound for in vivo imaging of small animals

English title Micro-ultrasound for in vivo imaging of small animals
Applicant Hall Michael
Number 164100
Funding scheme R'EQUIP
Research institution Abteilung Biochemie Biozentrum Universität Basel
Institution of higher education University of Basel - BS
Main discipline Cellular Biology, Cytology
Start/End 01.12.2015 - 30.11.2016
Approved amount 135'000.00
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Keywords (5)

infection biology; ultrasound; neurobiology; cancer; immunology

Lay Summary (German)

Lead
Micro-ultrasound for in vivo imaging of small animals
Lay summary

Wir werden ein Gerät zur Untersuchung von Kleintieren anschaffen, das mittels Mikro-Ultraschall Bilder erzeugt. Diese Form der Bildgebung ermöglicht die Detektion von Weichteilgewebe sowie des Blutflusses in vivo über nicht-invasive Ultraschallwellen. Das Mikro- Ultraschall-Gerät (Fujifilm Visualsonics Vevo 3100 Imaging System) liefert Bilder mit einer hohen zeitlichen (Echtzeit) und räumlichen (30 Mikrometer) Auflösung. Aufgrund dieser hohen Auflösung und der speziellen Konstruktion wird es primär in der präklinischen Forschung an kleinen Modellorganismen wie Ratten, Mäusen, Hühnerembryonen und Zebrafischen eingesetzt. Das Gerät wird in der Tierstation des Biozentrums platziert und steht allen Forschungsgruppen des Biozentrums zur Verfügung.

Direct link to Lay Summary Last update: 26.01.2016

Lay Summary (English)

Lead
Micro-ultrasound for in vivo imaging of small animals
Lay summary

We will purchase an instrument to perform micro-ultrasound imaging on small animals. Ultrasound imaging allows in vivo detection of soft tissue and blood flow via non-invasive transmission and receiving of ultrasound waves. The micro-ultrasound instrument we will purchase (Fujifilm VisualSonics Vevo 3100 Imaging System) provides high temporal (real time) and spatial (30 micron) resolution. Given its high resolution and dedicated design, it is commonly used for pre-clinical research on small model organisms such as rats, mice, chick embryos, and zebra fish. The imaging system will be housed in the animal facility of the Biozentrum of the University of Basel and will be widely available for use by members of the Biozentrum research community. 

Direct link to Lay Summary Last update: 26.01.2016

Responsible applicant and co-applicants

Publications

Publication
mTOR signaling confers resistance to targeted cancer drugs
Guri Yakir, mTOR signaling confers resistance to targeted cancer drugs, in Trends in Cancer.

Collaboration

Group / person Country
Types of collaboration
ETH Zurich/Niko Beerenwinkel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
DBM Basel/Gerhard Christofori Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
UniHospital Basel/Markus Heim Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Associated projects

Number Title Start Funding scheme
163088 Regulation and lineage dynamics of adult neural stem cells 01.03.2017 Project funding (Div. I-III)
156818 Diversity of Salmonella-host encounters in infected tissues 01.03.2015 Project funding (Div. I-III)
146463 Regulation of Cell Surface Signaling by Coronin Proteins 01.07.2013 Project funding (Div. I-III)
166663 Dissection of the coronin 1-mediated signal transduction pathway 01.10.2016 Project funding (Div. I-III)
159492 mTOR signaling in growth and metabolism 01.04.2015 Project funding (Div. I-III)

Abstract

We will purchase an instrument to perform micro-ultrasound imaging on small animals. Ultrasound imaging allows in vivo detection of soft tissue and blood flow via non-invasive transmission and receiving of ultrasound waves. The micro-ultrasound instrument we will purchase (Fujifilm VisualSonics Vevo 3100 Imaging System) provides high temporal (real time) and spatial (30 micron) resolution. Given its high resolution and dedicated design, it is commonly used for pre-clinical research on small model organisms such as rats, mice, chick embryos, and zebra fish. The imaging system will be housed in the animal facility of the Biozentrum of the University of Basel and will be widely available for use by members of the Biozentrum research community.
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