Project

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Linking retinal and cortical visual processing

English title Cortical circuit modules
Applicant Roska Botond
Number 163457
Funding scheme Project funding (Div. I-III)
Research institution Friedrich Miescher Institute for Biomedical Research
Institution of higher education Institute Friedrich Miescher - FMI
Main discipline Neurophysiology and Brain Research
Start/End 01.10.2015 - 30.09.2018
Approved amount 930'706.00
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All Disciplines (2)

Discipline
Neurophysiology and Brain Research
Molecular Biology

Keywords (6)

calcium imaging; vision; virus; retina; microcircuits; cortex

Lay Summary (German)

Lead
Wir wollen verstehen, wie der visuelle Kortex Informationen repräsentiert und wollen Erkenntnisse über Struktur und Funktion der neuronalen Netzwerke gewinnen, welche die Retina und den visuellen Kortex miteinander verbinden.
Lay summary

 Das Hauptziel des Projektes ist es zu verstehen, auf welche Weise der Kortex die parallelen Informationskanäle, die in der Retina geformt werden, kombiniert um Representationen von spezifischen, visuellen Merkmalen zu generieren. Dabei untersuchen wir zwei spezifische Fragestellungen: Erstens wollen herausfinden, inwiefern die zwei unterschiedlichen Netzwerk-Architekturen im visuellen Kortex der Maus, die wir kürzlich beschrieben haben, funktionell relevant sind. Zweitens wollen wir untersuchen, wie die Informationskanäle der Retina, die verschiedene visuelle Informationen weiterleiten, im Kortex miteinander verglichen werden, da wir kürzlich Hinweise darauf fanden, dass ein solches Vergleichs-Netzwerk im Kortex existiert. Nun ist es unser Ziel, genauer zu verstehen wie ein solches Vergleichs-Netzwerk auf mechanistischer Ebene funktioniert.

Direct link to Lay Summary Last update: 06.10.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Virus stamping for targeted single-cell infection in vitro and in vivo
Schubert Rajib, Trenholm Stuart, Balint Kamill, Kosche Georg, Cowan Cameron S, Mohr Manuel A, Munz Martin, Martinez-Martin David, Fläschner Gotthold, Newton Richard, Krol Jacek, Scherf Brigitte Gross, Yonehara Keisuke, Wertz Adrian, Ponti Aaron, Ghanem Alexander, Hillier Daniel, Conzelmann Karl-Klaus, Müller Daniel J, Roska Botond (2017), Virus stamping for targeted single-cell infection in vitro and in vivo, in Nature Biotechnology, 36(1), 81-88.
Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex
Hillier Daniel, Fiscella Michele, Drinnenberg Antonia, Trenholm Stuart, Rompani Santiago B, Raics Zoltan, Katona Gergely, Juettner Josephine, Hierlemann Andreas, Rozsa Balazs, Roska Botond (2017), Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex, in Nature Neuroscience, 20(7), 960-968.
Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic Tracing
Rompani Santiago B., Müllner Fiona E., Wanner Adrian, Zhang Chi, Roth Chiara N., Yonehara Keisuke, Roska Botond (2017), Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic Tracing, in Neuron, 93(4), 767-776.e6.
Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity
Yonehara Keisuke, Fiscella Michele, Drinnenberg Antonia, Esposti Federico, Trenholm Stuart, Krol Jacek, Franke Felix, Scherf Brigitte Gross, Kusnyerik Akos, Müller Jan, Szabo Arnold, Jüttner Josephine, Cordoba Francisco, Reddy Ashrithpal Police, Németh János, Nagy Zoltán Zsolt, Munier Francis, Hierlemann Andreas, Roska Botond (2016), Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity, in Neuron, 89(1), 177-193.
Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules
Wertz A., Trenholm S., Yonehara K., Hillier D., Raics Z., Leinweber M., Szalay G., Ghanem A., Keller G., Rozsa B., Conzelmann K.-K., Roska B. (2015), Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules, in Science, 349(6243), 70-74.

Awards

Title Year
Alden W. Spencer Award for Neuroscience, US 2018
Bressler Prize in Vision Science, New York 2018
Cogan Award of ARVO, US 2016
ERC Advanced grant 2015

Associated projects

Number Title Start Funding scheme
182523 Connecting visual and cognitive brain circuits 01.01.2019 Project funding (Div. I-III)
173728 Visual processing in foveated retinæ in the presence of self-motion 01.01.2018 Sinergia
143838 Linking retinal and cortical visual processing 01.10.2012 Project funding (Div. I-III)

Abstract

The proposed project is a continuation of “Linking retinal and cortical visual processing” and builds on two key findings from the project. First, our results revealed the existence of feature-locked and feature-variant cortical networks. In the current proposal we will investigate the functional role of feature variant and feature-locked presynaptic networks. Second, we found a causal link between retinal and cortical direction selectivity. In the current proposal we seek mechanistic insights in the cortical circuits that link retinal direction selective cells to cortical direction selectivity.
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