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Integrating the impact of genetic and environmental factors on trajectories of respiratory disease from birth to school age

English title Integrating the impact of genetic and environmental factors on trajectories of respiratory disease from birth to school age
Applicant Frey Urs
Number 163311
Funding scheme Project funding (Div. I-III)
Research institution Universitäts-Kinderspital beider Basel UKBB
Institution of higher education University of Basel - BS
Main discipline Paediatrics
Start/End 01.10.2015 - 30.09.2018
Approved amount 751'569.53
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All Disciplines (2)

Discipline
Paediatrics
Environmental Research

Keywords (7)

asthma; lung development; infants; microbioma; genetic; lung function; environmental air pollution

Lay Summary (German)

Lead
In der seit langem bestehenden ‚Basel-Bern Infant lung development‘(BILD) Kohorte erforschen wir die frühen Einflüsse von Luftschadstoffen und anderen Umweltfaktoren auf die Entwicklung der gesunden Lunge des Säuglings und Kleinkindes sowie auf die Entstehung des frühkindlichen Asthma bronchiale.
Lay summary
In der aktuellen Studie „Integrating the impact of genetic and enviromental factors on trajectories of respiratory diseases from birth to school age“ versuchen wir herauszufinden, ob es genetische, immunologische oder lungenfunktionelle Biomarker gibt, die uns schon kurz nach der Geburt voraussagen können, welche Kinder später ein Asthma entwickeln werden und welche Kinder speziell empfindlich für Luftschadstoffe sind. Um frühe vorbeugende oder therapeutische Massnahmen für diese Risikokinder zu entwickeln, sind solche Beobachtungsstudien im frühen Kindesalter wichtig, da immer mehr bekannt ist, dass die Entstehung vieler chronischer Erkrankungen, wie beispielsweise des Asthma bronchiale, durch das komplexe Zusammenspiel von genetischen Voraussetzungen und Umwelteinflüssen schon während der Schwangerschaft und der frühen Säuglingsphase beginnt. Mit neuartigen Methoden der Epidemiologie und der Systembiologie werden z.B. Blutproben aus dem Nabelschnurblut oder Urinproben im ersten kindlichen Urin nach der Geburt mit der gemessenen Luftschadstoffbelastung während der Schwangerschaft verglichen. Die Säuglinge werden dann in regelmässigen Abständen engmaschig im ersten Lebensjahr und weiter bis ins Schulalter nachkontrolliert und die Entstehung von Allergien, Asthma und eingeschränkter Lungenfunktion gemessen. Das bessere Verständnis der Ursachen der Asthmaentwicklung beim Kind ist von grösster gesundheitspolitischen Relevanz,  da der Zusammenhang von Umweltschadstoffen und Asthma auf der ganzen Welt vermehrt beobachtet wird.
Direct link to Lay Summary Last update: 20.10.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Nasal microbiota and symptom persistence in acute respiratory tract infections in infants
Neumann Roland P., Hilty Markus, Xu Binbin, Usemann Jakob, Korten Insa, Mika Moana, Müller Loretta, Latzin Philipp, Frey Urs (2018), Nasal microbiota and symptom persistence in acute respiratory tract infections in infants, in ERJ Open Research, 4(4), 00066-2018-00066-2018.
Dynamics of respiratory symptoms during infancy and associations with wheezing at school age
Usemann Jakob, Xu Binbin, Delgado-Eckert Edgar, Korten Insa, Anagnostopoulou Pinelopi, Gorlanova Olga, Kuehni Claudia, Röösli Martin, Latzin Philipp, Frey Urs (2018), Dynamics of respiratory symptoms during infancy and associations with wheezing at school age, in ERJ Open Research, 4(4), 00037-2018-00037-2018.
Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy: A Cohort Study
Usemann Jakob, Suter Andrea, Zannin Emanuela, Proietti Elena, Fouzas Sotirios, Schulzke Sven, Latzin Philipp, Frey Urs, Fuchs Oliver, Korten Insa, Anagnostopoulou Pinelopi, Gorlanova Olga, Frey Urs, Latzin Philipp, Proietti Elena, Usemann Jakob (2018), Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy: A Cohort Study, in The Journal of Pediatrics, 31414-31418.
Neighbourhood child population density as a proxy measure for exposure to respiratory infections in the first year of life: A validation study
Lupatsch Judith E., Kreis Christian, Korten Insa, Latzin Philipp, Frey Urs, Kuehni Claudia E., Spycher Ben D. (2018), Neighbourhood child population density as a proxy measure for exposure to respiratory infections in the first year of life: A validation study, in PLOS ONE, 13(9), e0203743-e0203743.
Glucocorticoid metabolites in newborns: A marker for traffic noise related stress?
Cantuaria Manuella Lech, Usemann Jakob, Proietti Elena, Blanes-Vidal Victoria, Dick Bernhard, Flück Christa E., Rüedi Simone, Héritier Harris, Wunderli Jean-Marc, Latzin Philipp, Frey Urs, Röösli Martin, Vienneau Danielle (2018), Glucocorticoid metabolites in newborns: A marker for traffic noise related stress?, in Environment International, 117, 319-326.
Response of cord blood cells to environmental, hereditary and perinatal factors: A prospective birth cohort study
Lurà Marco Patrick, Gorlanova Olga, Müller Loretta, Proietti Elena, Vienneau Danielle, Reppucci Diana, Pavlovic Rodoljub, Dahinden Clemens, Röösli Martin, Latzin Philipp, Frey Urs (2018), Response of cord blood cells to environmental, hereditary and perinatal factors: A prospective birth cohort study, in PLOS ONE, 13(7), e0200236-e0200236.
Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth
Korten Insa, Kieninger Elisabeth, Yammine Sophie, Cangiano Giulia, Nyilas Sylvia, Anagnostopoulou Pinelopi, Singer Florian, Kuehni Claudia E., Regamey Nicolas, Frey Urs, Casaulta Carmen, Spycher Ben D., Latzin Philipp (2018), Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth, in Journal of Cystic Fibrosis, 1569-1993.
After asthma: redefining airways diseases
Pavord Ian D, Beasley Richard, Agusti Alvar, Anderson Gary P, Bel Elisabeth, Brusselle Guy, Cullinan Paul, Custovic Adnan, Ducharme Francine M, Fahy John V, Frey Urs, Gibson Peter, Heaney Liam G, Holt Patrick G, Humbert Marc, Lloyd Clare M, Marks Guy, Martinez Fernando D, Sly Peter D, von Mutius Erika, Wenzel Sally, Zar Heather J, Bush Andy (2018), After asthma: redefining airways diseases, in The Lancet, 391(10118), 350-400.
Surface electromyography for analysis of heart rate variability in preterm infants
Jost Kerstin, Scherer Sebastian, De Angelis Chiara, Büchler Marcel, Datta Alexandre N, Cattin Philippe C, Frey Urs, Suki Béla, Schulzke Sven M (2018), Surface electromyography for analysis of heart rate variability in preterm infants, in Physiological Measurement, 39(1), 015004-015004.
A time-varying biased random walk approach to human growth
Suki Béla, Frey Urs (2017), A time-varying biased random walk approach to human growth, in Scientific Reports, 7(1), 7805-7805.
Elevated lung clearance index in infants with cystic fibrosis shortly after birth
Kieninger Elisabeth, Yammine Sophie, Korten Insa, Anagnostopoulou Pinelopi, Singer Florian, Frey Urs, Mornand Anne, Zanolari Maura, Rochat Isabelle, Trachsel Daniel, Mueller-Suter Dominik, Moeller Alexander, Casaulta Carmen, Latzin Philipp (2017), Elevated lung clearance index in infants with cystic fibrosis shortly after birth, in European Respiratory Journal, 50(5), 1700580-1700580.
Interrupter technique in infancy: Higher airway resistance and lower short-term variability in preterm versus term infants
Usemann Jakob, Demann Désirée, Anagnostopoulou Pinelopi, Korten Insa, Gorlanova Olga, Schulzke Sven, Frey Urs, Latzin Philipp (2017), Interrupter technique in infancy: Higher airway resistance and lower short-term variability in preterm versus term infants, in Pediatric Pulmonology, 52(10), 1355-1362.
Breath-to-breath variability of exhaled CO2 as a marker of lung dysmaturity in infancy
Fouzas Sotirios, Theodorakopoulos Ilias, Delgado-Eckert Edgar, Latzin Philipp, Frey Urs (2017), Breath-to-breath variability of exhaled CO2 as a marker of lung dysmaturity in infancy, in Journal of applied physiology , 1-27.
Respiratory viruses in healthy infants and infants with cystic fibrosis: a prospective cohort study
Korten Insa, Kieninger Elisabeth, Klenja Shkipe, Mack Ines, Schlaepfer Njima, Barbani Maria Teresa, Regamey Nicolas, Kuehni Claudia, Hilty Markus, Frey Urs, Gorgievski Meri, Casaulta Carmen, Latzin Philipp (2017), Respiratory viruses in healthy infants and infants with cystic fibrosis: a prospective cohort study, in Thorax, 1-9.
Influence of the pneumococcal conjugate vaccines on the temporal variation of pneumococcal carriage and the nasal microbiota in healthy infants: a longitudinal analysis of a case-control study
Mika Moana, Maurer Josua, Korten Insa, Allemann Aurelie, Aebi Suzanne, Brugger Silvio D., Qi Weihong, Frey Urs, Latzin Philipp, Hilty Markus (2017), Influence of the pneumococcal conjugate vaccines on the temporal variation of pneumococcal carriage and the nasal microbiota in healthy infants: a longitudinal analysis of a case-control study, in MICROBIOME, 5, 1-19.
Reply: Complexity Analysis of Respiratory Dynamics
Thamrin Cindy, Frey Urs, Kaminsky David A., Reddel Helen K., Seely Andrew J. E., Suki Béla, Sterk Peter J. (2017), Reply: Complexity Analysis of Respiratory Dynamics, in American Journal of Respiratory and Critical Care Medicine, 196(2), 248-249.
Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls
Korten Insa, Liechti Margot, Singer Florian, Hafen Gaundez, Rochat Isabelle, Anagnostopoulou Pinelopi, Mueller-Suter Dominik, Usemann Jakob, Moeller Alexander, Frey Urs, Latzin Philipp, Casaulta Carmen (2017), Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls, in Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society, 1-4.
Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls
Korten Insa, Liechti Margot, Singer Florian, Hafen Gaudenz, Rochat Isabelle, Anagnostopoulou Pinelopi, Müller-Suter Dominik, Usemann Jakob, Moeller Alexander, Frey Urs, Latzin Philipp, Casaulta Carmen (2017), Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls, in Journal of Cystic Fibrosis, XX-XX.
Dynamics and complexity of body temperature in preterm infants nursed in incubators
Jost Kerstin, Pramana Isabelle, Delgado-Eckert Edgar, Kumar Nitin, Datta Alexandre N., Frey Urs, Schulzke Sven M. (2017), Dynamics and complexity of body temperature in preterm infants nursed in incubators, in PLOS ONE, 12(4), 1-15.
Changes in minute ventilation after exposure to 4% sulfur hexafluoride (SF6) in infants
Jost Kerstin, Egger Barbara, Kieninger Elisabeth, Singer Florian, Frey Urs, Latzin Philipp (2017), Changes in minute ventilation after exposure to 4% sulfur hexafluoride (SF6) in infants, in PEDIATRIC PULMONOLOGY, 52(2), 151-153.
6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms
Fuchs Oliver, Gorlanova Olga, Latzin Philipp, Schmidt Anne, Schieck Maximilian, Toncheva Antionetta, Michel Sven, Gaertner Vincent, Kabesch Michael, Frey Urs (2017), 6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms, in Journal of Allergy and Clinical Immunology, 1-9.
Interactions of Respiratory Viruses and the Nasal Microbiota during the First Year of Life in Healthy Infants
Korten Insa, Mika Moana, Klenja Shkipe, Kieninger Elisabeth, Mack Ines, Barbani Maria Teresa, Gorgievski Meri, Frey Urs, Hilty Markus, Latzin Philipp (2016), Interactions of Respiratory Viruses and the Nasal Microbiota during the First Year of Life in Healthy Infants, in MSPHERE, 1(6), 1-13.
Lung clearance index and moment ratios at different cut-off values in infant multiple-breath washout measurements
Egger Barbara, Jost Kerstin, Anagnostopoulou Pinelopi, Yammine Sophie, Singer Florian, Casaulta Carmen, Frey Urs, Latzin Philipp (2016), Lung clearance index and moment ratios at different cut-off values in infant multiple-breath washout measurements, in PEDIATRIC PULMONOLOGY, 51(12), 1373-1381.
Air pollution modelling for birth cohorts: a time-space regression model
Proietti Elena, Delgado-Eckert Edgar, Vienneau Danielle, Stern Georgette, Tsai Ming-Yi, Latzin Philipp, Frey Urs, Röösli Martin (2016), Air pollution modelling for birth cohorts: a time-space regression model, in Environmental Health, 15(1), 61-61.
Lung clearance index and moment ratios at different cut-off values in infant multiple-breath washout measurementsMoment Ratios at Different Cut-Off Values
Egger Barbara, Jost Kerstin, Anagnostopoulou Pinelopi, Yammine Sophie, Singer Florian, Casaulta Carmen, Frey Urs, Latzin Philipp (2016), Lung clearance index and moment ratios at different cut-off values in infant multiple-breath washout measurementsMoment Ratios at Different Cut-Off Values, in Pediatric Pulmonology, 51(12), 1373-1381.
CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
Usemann Jakob, Frey Urs, Mack Ines, Schmidt Anne, Gorlanova Olga, Röösli Martin, Hartl Dominik, Latzin Philipp (2016), CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development, in BMC Pulmonary Medicine, 16(1), 81-81.
Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet
Thamrin Cindy, Frey Urs, Kaminsky David A., Reddel Helen K., Seely Andrew J. E., Suki Béla, Sterk Peter J. (2016), Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet, in American Journal of Respiratory and Critical Care Medicine, 194(9), 1053-1061.
Immediate effects of phototherapy on sleep in very preterm neonates: an observational study
Cremer Martin, Jost Kerstin, Gensmer Anna, Pramana Isabelle, Delgado-Eckert Edgar, Frey Urs, Schulzke Sven M., Datta Alexandre N. (2016), Immediate effects of phototherapy on sleep in very preterm neonates: an observational study, in JOURNAL OF SLEEP RESEARCH, 25(5), 517-523.
Rhinovirus Infections and Associated Respiratory Morbidity in Infants A Prospective Cohort Study
Mack Ines, Kieninger Elisabeth, Cangiano Giulia, Tapparel Caroline, Kuehni Claudia, Spycher Ben, Kaiser Laurent, Frey Urs, Regamey Nicolas, Latzin Philipp (2016), Rhinovirus Infections and Associated Respiratory Morbidity in Infants A Prospective Cohort Study, in PEDIATRIC INFECTIOUS DISEASE JOURNAL, 35(10), 1069-1074.
Patterns of respiratory pathogen nasal colonization in the first year of life in healthy infants and infants with cystic fibrosis
Korten Insa, Kieninger Elisabeth, Schlapfer Njima, Ginocchio Christine C., Janis Carole, Klenja Shkipe, Barbani Maria Teresa, Frey Urs, Regamey Nicolas, Kuehni Claudia, Hilty Markus, Casaulta Carmen, Latzin Philipp, Gorgievski Meri (2016), Patterns of respiratory pathogen nasal colonization in the first year of life in healthy infants and infants with cystic fibrosis, in JOURNAL OF CLINICAL VIROLOGY, 82, 118-119.
Predictive value of exhaled nitric oxide in healthy infants for asthma at school age
Usemann Jakob, Fuchs Oliver, Anagnostopoulou Pinelopi, Korten Insa, Gorlanova Olga, Roosli Martin, Latzin Philipp, Frey Urs (2016), Predictive value of exhaled nitric oxide in healthy infants for asthma at school age, in EUROPEAN RESPIRATORY JOURNAL, 48(3), 925-928.
Predictive value of exhaled nitric oxide in healthy infants for asthma at school age
Usemann Jakob, Fuchs Oliver, Anagnostopoulou Pinelopi, Korten Insa, Gorlanova Olga, Röösli Martin, Latzin Philipp, Frey Urs (2016), Predictive value of exhaled nitric oxide in healthy infants for asthma at school age, in European Respiratory Journal, 48(3), 925-928.
The nasal microbiota in infants with cystic fibrosis in the first year of life: a prospective cohort study
Mika Moana, Korten Insa, Qi Weihong, Regamey Nicolas, Frey Urs, Casaulta Carmen, Latzin Philipp, Hilty Markus (2016), The nasal microbiota in infants with cystic fibrosis in the first year of life: a prospective cohort study, in The Lancet Respiratory Medicine, 4(8), 627-635.
Physiological phenotyping of pediatric chronic obstructive airway diseases
Nyilas Sylvia, Singer Florian, Kumar Nitin, Yammine Sophie, Meier-Girard Delphine, Koerner-Rettberg Cordula, Casaulta Carmen, Frey Urs, Latzin Philipp (2016), Physiological phenotyping of pediatric chronic obstructive airway diseases, in Journal of Applied Physiology, 121(1), 324-332.
Changes in breathing pattern upon 100% oxygen in children at early school age
Jost K., Lenherr N., Singer F., Schulzke S.M., Frey U., Latzin P., Yammine S. (2016), Changes in breathing pattern upon 100% oxygen in children at early school age, in Respiratory Physiology & Neurobiology, 228, 9-15.
Effects of Breastfeeding on Respiratory Symptoms in Infancy
Gorlanova Olga, Thalmann Simone, Proietti Elena, Stern Georgette, Latzin Philipp, Kühni Claudia, Röösli Martin, Frey Urs (2016), Effects of Breastfeeding on Respiratory Symptoms in Infancy, in The Journal of Pediatrics, 174, 111-117.e5.
Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children
den Dekker Herman T., Sonnenschein-van der Voort Agnes M.M., de Jongste Johan C., Anessi-Maesano Isabella, Arshad S. Hasan, Barros Henrique, Beardsmore Caroline S., Bisgaard Hans, Phar Sofia Correia, Craig Leone, Devereux Graham, van der Ent C. Kors, Esplugues Ana, Fantini Maria P., Flexeder Claudia, Frey Urs, Forastiere Francesco, Gehring Ulrike, Gori Davide, van der Gugten Anne C., Henderson A. John, Heude Barbara, Ibarluzea Jesús, Inskip Hazel M., et al. (2016), Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children, in Journal of Allergy and Clinical Immunology, 137(4), 1026-1035.
Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children
den Dekker Herman T., Sonnenschein-van der Voort Agnes M.M., de Jongste Johan C., Anessi-Maesano Isabella, Arshad S. Hasan, Barros Henrique, Beardsmore Caroline S., Bisgaard Hans, Phar Sofia Correia, Craig Leone, Devereux Graham, van der Ent C. Kors, Esplugues Ana, Fantini Maria P., Flexeder Claudia, Frey Urs, Forastiere Francesco, Gehring Ulrike, Gori Davide, van der Gugten Anne C., Henderson A. John, Heude Barbara, Ibarluzea Jesús, Inskip Hazel M., et al. (2016), Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children, in Journal of Allergy and Clinical Immunology, 137(4), 1026-1035.
Influence of respiratory dead space on lung clearance index in preterm infants
Neumann Roland P., Pillow J. Jane, Thamrin Cindy, Frey Urs, Schulzke Sven M. (2016), Influence of respiratory dead space on lung clearance index in preterm infants, in Respiratory Physiology & Neurobiology, 223, 43-48.
Multiple breath washout analysis in infants: quality assessment and recommendations for improvement
Anagnostopoulou Pinelopi, Egger Barbara, Lurà Marco, Usemann Jakob, Schmidt Anne, Gorlanova Olga, Korten Insa, Roos Markus, Frey Urs, Latzin Philipp (2016), Multiple breath washout analysis in infants: quality assessment and recommendations for improvement, in Physiological Measurement, 37(3), L1-L15.
Functional evidence for continued alveolarisation in former preterms at school age?
Yammine Sophie, Schmidt Anne, Sutter Oliver, Fouzas Sotirios, Singer Florian, Frey Urs, Latzin Philipp (2015), Functional evidence for continued alveolarisation in former preterms at school age?, in European Respiratory Journal, 47(1), 147-155.
Sigh-induced changes of breathing pattern in preterm infants
Jost K., Latzin P., Fouzas S., Proietti E., Delgado-Eckert E. W., Frey U., Schulzke S. M. (2015), Sigh-induced changes of breathing pattern in preterm infants, in Physiological Reports, 3(11), e12613-e12613.
Human Rhinovirus Types and Association with Respiratory Symptoms During the First Year of Life
Müller Loretta, Mack Ines, Tapparel Caroline, Kaiser Laurent, Alves Marco P., Kieninger Elisabeth, Frey Urs, Regamey Nicolas, Latzin Philipp (2015), Human Rhinovirus Types and Association with Respiratory Symptoms During the First Year of Life, in The Pediatric Infectious Disease Journal, 34(8), 907-909.
Validation of multiple-breath washout equipment for infants and young childrenValidation of Pediatric MBW Equipment
Schmidt Anne, Yammine Sophie, Proietti Elena, Frey Urs, Latzin Philipp, Riedel Thomas, Singer Florian (2015), Validation of multiple-breath washout equipment for infants and young childrenValidation of Pediatric MBW Equipment, in Pediatric Pulmonology, 50(6), 607-614.
Accuracy of tidal breathing measurement of floright compared to an ultrasonic flowmeter in infantsValidation of FloRight-System in Infants
Petrus Nicole C.M., Thamrin Cindy, Fuchs Oliver, Frey Urs (2015), Accuracy of tidal breathing measurement of floright compared to an ultrasonic flowmeter in infantsValidation of FloRight-System in Infants, in Pediatric Pulmonology, 50(4), 380-388.
Dynamics of the nasal microbiota in infancy: A prospective cohort study
Mika Moana, Mack Ines, Korten Insa, Qi Weihong, Aebi Suzanne, Frey Urs, Latzin Philipp, Hilty Markus (2015), Dynamics of the nasal microbiota in infancy: A prospective cohort study, in Journal of Allergy and Clinical Immunology, 135(4), 905-912.e11.
Nasal Microbiota and Respiratory Tract Infections: The Role of Viral Detection
Korten I, Ramsey K, Mika M, Usemann J, Hilty M, Latzin P, Nasal Microbiota and Respiratory Tract Infections: The Role of Viral Detection, in Am J Respir Crit Care Med.

Collaboration

Group / person Country
Types of collaboration
Dept. of Social and Preventative Medicine, University of Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Institute for Infectious Diseases of the University of Bern Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
University of Regensburg Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Dept. of Paediatrics, University Hospital of Munich Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Dept. of Social and Preventative Medicine, University of Bern Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Epithelial cell lab, University Children's Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
European Respiratory Society annual congress Poster Respiratory rate in infants with Cystic Fibrosis and healthy controls throughout the first year of life. 11.09.2017 Milan, Italy Korten Insa;
European Respiratory Society annual congress Poster Treatment response of inhalation therapy assessed by single breath washout tests in patients with COPD. 11.09.2017 Milan, Italy Korten Insa;
European Respiratory Society annual congress Poster Temporal behavior of respiratory symptoms during infancy and associations with asthma at school age 10.09.2017 Milan, Italy Usemann Jakob;


Awards

Title Year
Fellow of the European Respiratory Society (FERS) 2016

Associated projects

Number Title Start Funding scheme
173044 Natural history, phenotypes and disease classification in primary ciliary dyskinesia 01.05.2017 Project funding (Div. I-III)
182871 Impact of air pollution on profibrotic and autophagy related mechanisms involved in the development of the respiratory system in infants 01.10.2018 Project funding (Div. I-III)
173330 Novel methods for investigating acute and long term effects of transportation noise on health 01.08.2017 Project funding (special)
68025 Early Environmental and Maternal Determinants of Airway Inflammation in Wheezing Disorders in Infants 01.01.2003 Project funding (Div. I-III)
51974 Alterations in Airway Wall Properties as a Possible Mechanism forWheezing Disorders in Infants. (SCORE B) 01.04.1998 Ambizione
112099 The impact of early environmental and maternal factors on airway development in and wheezing disorders up to preschool age 01.06.2006 Project funding (Div. I-III)
182719 Multiple Breath Washout in Children with Cystic Fibrosis: Transition from a Specialised Tool to Clinical Implementation 01.01.2019 Project funding (Div. I-III)
168173 Impact of Early Lung Physiology, Viral Infections and Microbiome on the Development and Progression of Lung Disease in Children with Cystic Fibrosis 01.08.2017 Ambizione
144280 The prospective Basel-Bern infant lung development birth cohort (BILD): early impact of genetic and environmental factors on lung growth and respiratory morbidity 01.10.2012 Project funding (special)

Abstract

This is a direct continuation of a series of projects based on the on-going prospective birth cohort, BILD, which investigated the impact of environmental factors on lung growth and development, and subsequent consequences for later respiratory morbidity in early childhood. Motivation for the study came from the fact that the high prevalence of wheezing disorders and asthma in infants and preschool children has become a major health issue. Wheezing disorders can occur as a result of simple viral infections, and are then mostly episodic and transient in nature. However, their recurrence could be an expression of disturbed fetal growth or lung development, or the consequence of early allergic bronchial asthma. While genetic risk factors such as parental atopy (allergy) play an important role, environmental factors, such as tobacco smoke exposure, Western lifestyle, and air pollution, are also known risk factors for wheezing disorders in children 1. The hypothesis - that different mechanisms may be responsible for the impairment of lung growth versus those for the impairment of the immune, allergic or inflammatory systems - has been recently reinforced by several longitudinal studies. Typically, however, the relative contribution of each risk factor is small, and the network-type interactions between genetic, environmental, and developmental aspects are still poorly understood. It becomes increasingly clear, however, that certain constellations of these contributors, at specific time intervals, will increase the risk for later asthmatic disease. Thus, it is important not only to analytically identify the relative risks of each factor by way of a multivariable statistical approach, but to also make use of these multiple risk factors and biomarkers in a novel systems medicine approach in order to identify - on an individualized basis - those infants at risk for later asthma.Aim and Methods: Since the cohort itself is extremely data-rich; consisting of genetic analysis, environmental air pollution measurements, microbial colonization and viral infection data, and highly standardised longitudinal clinical, lung functional and inflammatory biomarker data, the general aims have not changed. However, the current research questions have been adapted to our previous findings from project phase SNF144280 (see 2.2.) and are now grouped into four work packages (WP A-C analytical, D systems-based). WP A) Early effects of air pollution on respiratory symptoms. We identified small effects of air pollution on respiratory symptoms and infectious episodes in early infancy (ref 2). We will investigate whether air pollution exposure - prenatally, in infancy, or in early childhood - are correlated with asthma symptoms, lung function, and atopic sensitisation at early school age, using a multivariable regression approach and adjusting for confounders.WP B) Stability of upper airway bacterial microbioma in early infancy. We found that upper airway bacterial diversity in infancy is more specific to the host than to the population3, and thus may be a marker for the interaction between host and environment. At the epithelial level, the balance between the immune system and the microbioma is potentially important for the later development of asthma. To further evaluate the stability of the host specific microbioma, we will investigate the impact of environmental factors (such as viral infections, tobacco exposure, air pollution, antibiotic use, siblings, and nursery care) in two weekly time series of nasal microbioma. In a cross-sectional dataset we will investigate the change in diversity prior to, and three weeks after the first viral infection.WP C) Genetic risk biomarkers in early infancy. In SNF144280, we identified a novel genetic polymorphism (SNP) related to NO metabolism in infancy (rs208515), a well-known asthma associated marker, and a novel SNPs (rs10076782) related to neonatal lung function. We will investigate whether or not these genetic markers and neonatal lung function are correlated with asthma symptoms, lung function and atopic sensitisation at early school age, using a multivariable regression approach, and thus identify their relative contribution to known clinical risk factors.WP D) Systems medicine approach: clustering based on fluctuation of weekly symptoms in the first year. Pilot data show that fluctuations of weekly symptoms in the first year of life are disease phenotype specific, and can be identified using our newly developed fluctuation based clustering method (FBC) 4 . We investigate whether clusters of infants identified by FBC in infancy are correlated with known early biomarkers and whether these infants are more likely to develop later asthma or allergy at school age.Study design: In this prospective birth cohort of unselected healthy term (n=837) and preterm infants (n=487) we: -estimate indoor and outdoor air pollution exposure for various critical time windows during pregnancy and in early infancy and preschool age; -assess family, obstetric, and birth history; -measure immunological factors and known target genes in cord blood (known polymorphism in target genes of lung growth and asthma as well as GWAS samples); -assess weekly respiratory symptoms by telephone interview; -determine virus infections and microbiome diversity in biweekly samples (subgroup of 100), and at the first lower respiratory tract infection of life. We then follow these children to school age (n=360 healthy, 182 preterm) where we again determine lung functional measures as well as standardised respiratory outcomes (primary outcomes) and immunological factors related to asthma and allergy (secondary outcomes). Significance: The impact of air pollution on fetal neonatal lung and immune-development, and its interaction in response to respiratory viruses and bacterial colonisation is still largely unknown, but is likely highly complex and with interdependent effects. In order to better understand its comprehensive impact on the evolution of respiratory disease, we need longitudinal data to analytically identify the time course and relative contribution of involved mechanisms, and integrate their small contribution into systems based models, which would enable us to better identify infants at risk. This approach would also enable us to develop environmental, preventative, and therapeutic strategies for infants and children.
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