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Multifunctional nanoparticles for targeted theranostics

Applicant Pratsinis Sotiris E.
Number 163243
Funding scheme Project funding (Div. I-III)
Research institution Institut für Verfahrenstechnik ETH Zürich
Institution of higher education ETH Zurich - ETHZ
Main discipline Mechanical Engineering
Start/End 01.01.2016 - 31.12.2018
Approved amount 300'000.00
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Keywords (4)

biomedical materials; flame aerosol technology; nanoparticles; theranostics

Lay Summary (German)

Lead
Nanotechnologie findet heute stark steigende Anwendung im biomedizinischen Bereich. Dies kann auf neu entstehende Eigenschaften von Materialien mit Grössen kleiner als 1µm zurückgeführt werden. Besonders Systeme, die zur Diagnose aber auch zur Therapie von verschiedensten Krankheiten dienen sollen, werden intensiv erforscht.
Lay summary
Inhalt und Ziele des Forschungsprojekts

In diesem Projekt werden neuartige Nanomaterialien hergestellt, die der Diagnose und Therapie von Krebs dienen. Solche multifunktionalen Nanostrukturen gelten als besonders vielversprechend, da sie mehrere Anwendungen in einem System kombinieren und somit die zu injizierende Fremdstoffmenge drastisch verringert werden kann. Trotz einiger vielversprechender Resultate stellte sich in den letzten Jahren insbesondere die Synthese derartiger Materialien als problematisch dar. Die Skalierbarkeit des verwendeten Herstellungsverfahrens ist diktierend für eine erfolgreiche klinische Anwendung und ist in den meisten Fällen nicht gegeben. Die in diesem Projekt zur Materialherstellung angewandte Flammensynthese erfüllt diese Anforderung und besticht ausserdem durch Vielfältigkeit besonders in der Wahl und Kombination der zu produzierenden Systeme.

 

 Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojekts

Im Detail werden in dieser Arbeit verschiedenste neuartige und innovative Nanomaterialien hergestellt und mit modernsten Techniken analysiert. Besonderes Augenmerk wird auf die biomedizinische Anwendung der Systeme gelegt. Hierfür werden in enger Zusammenarbeit mit dem Universitätsspital Zürich kund diversen Forschungsgruppen innerhalb der ETH Zürich Untersuchungen durchgeführt,  um Toxizität und Anwendbarkeit dieser vielversprechenden Materialien zu evaluieren und optimieren.

Direct link to Lay Summary Last update: 06.10.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Engineering the Bioactivity of Flame-Made Ceria and Ceria/Bioglass Hybrid Nanoparticles
Matter Martin T., Furer Lea A., Starsich Fabian H. L., Fortunato Giuseppino, Pratsinis Sotiris E., Herrmann Inge K. (2018), Engineering the Bioactivity of Flame-Made Ceria and Ceria/Bioglass Hybrid Nanoparticles, in ACS Applied Materials & Interfaces, 11(3), 2830-2839.
Lanthanide-Doped Hafnia Nanoparticles for Multimodal Theranostics: Tailoring the Physicochemical Properties and Interactions with Biological Entities
Gerken Lukas R. H., Keevend Kerda, Zhang Yucheng, Starsich Fabian H. L., Eberhardt Christian, Panzarasa Guido, Matter Martin T., Wichser Adrian, Boss Andreas, Neels Antonia, Herrmann Inge K. (2018), Lanthanide-Doped Hafnia Nanoparticles for Multimodal Theranostics: Tailoring the Physicochemical Properties and Interactions with Biological Entities, in ACS Applied Materials & Interfaces, 11(1), 437-448.
Reduced Magnetic Coupling in Ultrasmall Iron Oxide T 1 MRI Contrast Agents
Starsich Fabian H.L., Eberhardt Christian, Keevend Kerda, Boss Andreas, Hirt Ann. M., Herrmann Inge K., Pratsinis Sotiris E. (2018), Reduced Magnetic Coupling in Ultrasmall Iron Oxide T 1 MRI Contrast Agents, in ACS Applied Bio Materials, 1(3), 783-791.

Collaboration

Group / person Country
Types of collaboration
Demokritou, Philip, Assist. Prof., Aerosol Technology Laboratory, D.Envir.Health,Harvard United States of America (North America)
- Publication
- Research Infrastructure
Hirt, Ann, Prof. Dr., Institut für Geophysik, EPM, D-ERDW, ETHZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Leroux, Jean-Christophe, Prof. Dr., Drug Formulation & Delivery, IPW, D-CHAB, ETHZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Materials Research Society Fall Meeting & Exhibit 2018 Poster Thermal Sensing with Luminescent Nanothermometers Operating in the Near-Infrared 25.11.2018 Boston, United States of America Pratsinis Sotiris E.; Starsich Fabian;
Materials Research Society Fall Meeting & Exhibit 2018 Talk given at a conference Ultra-Small Biocompatible Iron Oxide T1 MRI Contrast Agents with Reduced Magnetic Coupling 25.11.2018 Boston, United States of America Starsich Fabian; Eberhardt Christian; Pratsinis Sotiris E.; Boss Andreas;
Materials Research Society Fall Meeting & Exhibit 2017 Talk given at a conference Deep Tissue Imaging with Highly Fluorescent NIR Nanocrystals after Systematic Host Screening 26.11.2017 Boston, United States of America Starsich Fabian;
Materials Research Society Fall Meeting & Exhibit 2017 Poster How material properties dictate magnetic nanoparticle heating 26.11.2017 Boston, United States of America Starsich Fabian; Boss Andreas; Pratsinis Sotiris E.; Eberhardt Christian;
Materials Research Society Fall Meeting & Exhibit 2017 Talk given at a conference Deep tissue imaging with highly fluorescent NIR nanocrystals after systematic host screening 26.11.2017 Boston, United States of America Starsich Fabian; Pratsinis Sotiris E.;
Materials Research Society Fall Meeting & Exhibit 2017 Poster Highly Sensitive Luminescent Ratiometric Nanothermometers for Deep-Tissue Thermal Sensing 26.11.2017 Boston, United States of America Pratsinis Sotiris E.; Starsich Fabian;
Materials Research Society Fall Meeting & Exhibit 2017 Poster Silica-coated non-stoichiometric nano Zn-ferrites for theranostic applications 26.11.2017 Boston, United States of America Pratsinis Sotiris E.; Eberhardt Christian; Sotiriou Georgios A.; Starsich Fabian; Boss Andreas;
European Aerosol Conference 2017 Poster Deep tissue imaging with highly fluorescent NIR nanocrystals after systematic host screening 27.08.2017 Zürich, Switzerland Pratsinis Sotiris E.; Starsich Fabian;
Materials Research Society Fall Meeting & Exhibit 2016 Talk given at a conference One-step synthesis of heterogenous nano-contrast agents for dual T1 / T2 magnetic resonance imaging via scalable flame spray pyrolysis 27.11.2016 Boston, United States of America Boss Andreas; Pratsinis Sotiris E.; Sotiriou Georgios A.; Starsich Fabian; Eberhardt Christian;
Materials Research Society Fall Meeting & Exhibit 2016 Poster Silica-coated non-stoichiometric nano Zn-ferrites for theranostic applications 27.11.2016 Boston, United States of America Starsich Fabian; Pratsinis Sotiris E.; Boss Andreas; Sotiriou Georgios A.; Eberhardt Christian;
International Congress on Particle Technology (PARTEC) 2016 Talk given at a conference Multifunctional nanoparticles for targeted theranostics 19.04.2016 Nürnberg, Germany Boss Andreas; Starsich Fabian; Pratsinis Sotiris E.; Sotiriou Georgios A.;
International Congress on Particle Technology (PARTEC) 2016 Poster One-step synthesis of heterogeneous multifunctional nanoparticles for biomedical applications via scalable flame spray pyrolysis 19.04.2016 Nürnberg, Germany Pratsinis Sotiris E.; Starsich Fabian;


Awards

Title Year
Best Poster Award, European Aerosol Conference "Deep tissue imaging with highly fluorescent NIR nanocrystals after systematic host screening" 2017

Associated projects

Number Title Start Funding scheme
177037 Versatile Characterization system for novel theranostic nanomaterials 01.12.2017 R'EQUIP
146176 Flame-made multifunctional nanoparticles for biomedics 01.04.2013 Project funding (Div. I-III)
126694 Flame synthesis of nanostructured materials for functional nanocomposites 01.01.2010 Project funding (Div. I-III)

Abstract

Multifunctional nanomaterials are sought out in novel theranostic (therapy and diagnostic) applications. For example, plasmonic nanomaterials such as nano-Au or -Ag have the unique property of absorbing light and converting it into heat at high efficiency. This so-called photothermal effect can be used for thermal destruction of diseased cells (e.g. tumors). These plasmonic nanostructures, however, have to be designed in a way that they absorb light effectively within the near infrared window (700-900 nm) where light transmission in human tissue is highest. In addition, for early diagnosis of illnesses, imaging techniques such as magnetic resonance imaging (MRI) require efficient contrast agents. Superparamagnetic materials like nanosized iron oxides exhibit desirable magnetic properties and therefore are promising for such diagnostics, while their localization in specific sites in vivo may be enhanced by the application of an external magnetic field. The combination of such materials with different properties leads to advanced multifunctional systems that are attractive in an array of biomedical applications. In the proposed research, such multifunctional nanomaterials will be made with emphasis on close control of their properties for specific performance. These materials will be produced by flame aerosol technology, a unique asset of our laboratory, that has proven its versatility and scalability in stable synthesis of metastable materials of high purity for heterogeneous catalysts, (bio)sensors and even nutritional materials. The structure and morphology of these nanomaterials will be closely investigated by systematically varying their synthesis conditions. The efficiency of these optically active and superparamagnetic nanostructures will be investigated in detail, targeting superior performance both as diagnostic (e.g. MRI) and therapeutic photothermal agents. A specific goal is the integration of several materials in one system to achieve the desired multifunctionality. To this end the understanding and optimization of flame aerosol synthesis of multicomponent materials will be a key issue. Apart from material optimization, targeting the desired site in vitro with the produced system represents a further goal of the project. Surface functionalization with specific biomolecules (PEG, antibodies) will be employed. In vitro studies with the flame-made multifunctional nanoparticles will be performed, to analyze biocompatibility as well as theranostic efficiency.A goal of this project is to obtain a fundamental understanding of the important properties that dictate the performance of such multifunctional nanosystems with respect to targeted theranostics. This includes detailed synthesis, characterization and optimization of process-unique (e.g. metastable) materials. This may lead to the development of completely novel systems. The close interaction with medical research facilities shall result in an increased relevance and structured orientation of this research to facilitate the development of such biomedically-oriented nanomaterials. Therefore we will capitalize especially on our established collaborations with the Institute for Diagnostic and Interventional Radiology at the University Hospital Zurich (UZH, Dr. Boss) and the Institute of Pharmaceutical Sciences at ETH Zurich (Dr. Sotiriou, Professor Leroux).This project will assist the education of one doctoral student in engineering specializing in nanoparticle processing and partially to a post-doctoral student at UZH while it will allow Bachelor and Master students to gain knowledge in engineering of multifunctional nanomaterials, with special emphasis on their biomedical applications, a rapidly growing and high value industry. Research results will be presented in international conferences and submitted for publication in refereed journals.
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