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PARED - Parental Responsibility, Epigenetics and DOHaD: Emerging sociotechnical imaginaries of reproduction in the age of epigenetics

English title PARED - Parental Responsibility, Epigenetics and DOHaD: Emerging sociotechnical imaginaries of reproduction in the age of epigenetics
Applicant Panese Francesco
Number 162873
Funding scheme Project funding (Div. I-III)
Research institution Faculté des Sciences Sociales et Politiques - ISS Université de Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Sociology
Start/End 01.01.2016 - 31.12.2018
Approved amount 308'289.00
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All Disciplines (5)

Discipline
Sociology
Genetics
Paediatrics
Congenital Disorders
Embryology, Developmental Biology

Keywords (6)

Developmental Origins of Health and Disease: DOHaD; Science and technology studies; Moral issues in reproduction; Reproductive medicine; Sociotechnical imaginary; Epigenetics

Lay Summary (German)

Lead
PaRED - Elterliche Verantwortung, Epigenetik und DOHaD. Entstehende soziotechnische Vorstellungswelten der Fortpflanzung im Zeitalter der Epigenetik.
Lay summary

Dieses Projekt untersucht wie die Epigenetik, unter der Schirmherrschaft der sogenannten Developmental Origins of Health and Disease (DOHaD) Hypothese, an öffentlichen Diskursen teilhat, die Verantwortlichkeiten über die Gesundheit künftiger Generationen neu verteilt. Indem es sich auf jüngste Fortschritte in den Bereichen der Entwicklungsplanung und der epigenetischen Erbschaft stützt, hinterfragt PaRED die potenzielle, von dieser Forschung veranlasste Umgestaltung von Diskursen und Praktiken der Kindererziehung, und beleuchtet den Zusammenhang dieser Entwicklungen mit jenen, die durch den Aufstieg genetischer Biotechnologien in der Fortpflanzungsmedizin eingeleitet wurden.

PaRED benutzt eine Methodologie am Kreuzweg der Science and Technology Studies (STS) und der Bioethik, und stützt sich insbesondere auf das konzeptionelle Gerüst der ‚Koproduktion’ (Jasanoff 2004) und der soziotechnischen Vorstellungswelten (Jasanoff und Kim 2009; 2013). Es analysiert aufkommende und umstrittene Auffassungen ‚epigenetischer elterlicher Verantwortung’ auf drei sich gegenseitig ergänzenden Stufen: epistemisch (Praktiken und Standards der Wissensbildung in der Epigenetik), normativ (Normen und Verpflichtung künftiger Eltern), und soziopolitisch (Entwicklungen in der gesellschaftlichen und behördlichen Handhabung der Fortpflanzungs- und pädiatrischen Medizin).

Direct link to Lay Summary Last update: 09.10.2015

Lay Summary (French)

Lead
PaRED - Responsabilité parentale, épigénétique et DOHaD. Les imaginaires sociotechniques liés à la reproduction humaine à l’époque de l’épigénétique.
Lay summary

Ce projet analyse l’influence des développements récents dans les domaines de l’épigénétique et des Developmental Origins of Health and Disease (DOHaD) sur les discours publics relatifs à la responsabilité de protéger la santé des générations futures. A partir d’une analyse des recherches et des débats scientifiques sur les origines développementales de la santé au stade fœtal et sur l’hérédité epigénétique, PaRED étudie plus spécifiquement les recompositions des discours et des pratiques en matière de parentalité et de reproduction humaine qui font suite au développement des biotechnologies génétiques dans le domaine de la médecine reproductive.

PaRED se situe à la croisée des Science and Technology Studies (STS) et de la bioéthique, et plus spécifiquement dans le cadre conceptuel de la ‘co-production’ (Jasanoff 2004) et des imaginaires sociotechniques (Jasanoff et Kim 2009; 2013). Son objectif général est d’analyser les différentes acceptions et conceptions de la ‘responsabilité parentale épigénétique’ à trois niveaux complémentaires: épistémique (pratiques et standards de production de la connaissance épigénétique), normatif (normes et obligations morales pour les parents potentiels), et sociopolitique (développements dans la gouvernance de la médecine pédiatrique et de la reproduction).

Direct link to Lay Summary Last update: 09.10.2015

Lay Summary (Italian)

Lead
PaRED - Responsabilità genitoriale, epigenetica e DOHaD. Immaginari socio-tecnici e riproduzione umana al tempo dell'epigenetica.
Lay summary

Il progetto PaIRED analizza il contributo dei recenti sviluppi nel campo dell’epigenetica e dei Developmental Origins of Health and Disease (DOHaD) alla costruzione di discorsi pubblici di responsabilità per il benessere delle generazioni future. A partire da un’analisi del dibattito scientifico sulla programmazione della salute nell’ambiente fetale e sull’eredità epigenetica, PaRED si occupa di investigare il ruolo di queste scoperte nell’elaborazione di discorsi e pratiche di genitorialità, enfatizzando le diverse sfide che esse ci pongono rispetto all’avvento delle biotecnologie genetiche riproduttive.

PaRED utilizza le risorse teoriche dei Science and Technology Studies (STS) e della bioetica e si inscrive in un quadro concettuale ‘co-produzionista’ (Jasanoff 2004), avvalendosi del concetto di immaginari sociotecnici (Jasanoff and Kim 2009, 2013). Il suo obiettivo generale è di analizzare le controversie legate a diverse nozioni emergenti di ‘responsabilità genitoriale epigenetica’. Nel fare ciò, il progetto si sviluppa su tre livelli complementari: epistemico (pratiche e standard di produzione della conoscenza nel campo dell’epigenetica), normativo (norme comportamentali e obblighi di genitori potenziali) e socio-politico (sviluppi di governance della medicina riproduttiva e pediatrica).

Direct link to Lay Summary Last update: 09.10.2015

Lay Summary (English)

Lead
PaRED - Parental Responsibility, epigenetics and DOHaD. Emerging sociotechnical imaginaries of reproduction in the age of epigenetics.
Lay summary

This project investigates how developments in epigenetics, under the aegis of the so-called Developmental Origins of Health and Disease (DOHaD) hypothesis, partake to a public discourse renegotiating responsibilities to protect the wellbeing of future generations. Drawing from cutting-edge discoveries on developmental programming of health as well as epigenetic inheritance, PaRED scrutinizes the potential reconfiguration of discourses and practices of parenting operated by these discoveries, and maps such developments onto those initiated by the rise of genetic biotechnologies in reproductive medicine.

PaRED resorts to methodologies at the crossroad of Science and Technology Studies (STS) and Bioethics. In particular, the project builds upon the conceptual framework of ‘co-production’ (Jasanoff 2004), and the theoretical notion of sociotechnical imaginaries (Jasanoff and Kim 2009, 2013). PaRED aims at mapping emerging and disputed notions of ‘epigenetic parental responsibility’ at three complementary levels: epistemic (practices and standards of knowledge-production in epigenetics), normative (norms and obligations of prospective parents), and socio-political (developments in the governance of reproductive and paediatric medicine).

Direct link to Lay Summary Last update: 09.10.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Epigenetics: ethics, politics, biosociality
Chiapperino Luca (2018), Epigenetics: ethics, politics, biosociality, in British Medical Bulletin, 128(1), 49-60.
Gendered imaginaries: situating knowledge of epigenetic programming of health
ChiapperinoLuca, PaneseFrancesco (2018), Gendered imaginaries: situating knowledge of epigenetic programming of health, in Sociology of Health & Illness, 40(7), 1233-1249.
The biosocial genome?Interdisciplinary perspectives on environmental epigenetics, health and society
Müller Ruth, Hanson Clare, Hanson Mark, Penkler Michael, Samaras Georgia, Chiapperino Luca, Dupré John, Kenney Martha, Kuzawa Christopher, Latimer Joanna, Lloyd Stephanie, Lunkes Astrid, Macdonald Molly, Meloni Maurizio, Nerlich Brigitte, Panese Francesco, Pickersgill Martyn, Richardson Sarah, Rüegg Joëlle, Schmitz Sigrid, Stelmach Aleksandra, Villa Paula‐Irene (2017), The biosocial genome?Interdisciplinary perspectives on environmental epigenetics, health and society, in EMBO reports, 18(10), 1677-1682.
L’épigénétique et le concept DOHaD. Vers de nouvelles temporalitésde la médecine « personnalisée » ?
Chiapperino Luca, PaneseFrancesco, SimeoniUmberto (2017), L’épigénétique et le concept DOHaD. Vers de nouvelles temporalitésde la médecine « personnalisée » ?, in Revue Médicale Suisse , 13(548), 334-336.
La metafora assoluta della “plasticità” tra i secoli XIX e XX: un’indagine sulle tracce del biosociale in epigenetica
ChiapperinoLuca, PaneseFrancesco (2017), La metafora assoluta della “plasticità” tra i secoli XIX e XX: un’indagine sulle tracce del biosociale in epigenetica, in Mefisto. Rivista di Medicina, Filosofia e Storia, 1(2), 10-27.

Collaboration

Group / person Country
Types of collaboration
Laboratory of Behavioral Genetics LGC (EPFL) Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Service de biomédecine du CHUV Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Service de pédiatrie, DMCP. Centre Hospitalier Universitaire Vaudois (CHUV) Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Centre Maurice Halbwachs (Paris) France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Institut d'histoire de la médecine et de la santé publique (IUHMSP-UNIL-CHUV) Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Institute of Social and Preventive Medicine (IUMSP-CHUV) Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Laboratory of Neuroepigenetics, Brain Research Institute (UZH), Switzerland Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Unité d'éthique UNIL-CHUV Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
ASA Conference 2018: Sociality, matter, and the imagination: re-creating Anthropology Talk given at a conference The biosocial spatio-temporalities of epigenetics: from labs to politics? 18.09.2018 Oxford, Great Britain and Northern Ireland Chiapperino Luca; Panese Francesco;
EASST Conference 2018: Meetings – Making Science, Technology and Society Together Talk given at a conference “Environmental Enrichment: an experiment in biosocial intervention” 27.07.2018 Lancaster, Great Britain and Northern Ireland Chiapperino Luca; Panese Francesco;
Séminaire commun des Instituts suisses d’histoire de la médecine Talk given at a conference “On the traces of the biosocial. A genealogy of plasticity in epigenetics” 24.05.2018 Bern, Switzerland Panese Francesco; Chiapperino Luca;
Optimiser son quotidien: de l’injonction à l’appropriation Talk given at a conference “L’optimisation biosociale : imaginaire émergent de l’action sur la vie à l’ère de l’épigénétique ? 22.03.2018 Paris, France Chiapperino Luca; Panese Francesco;
The many faces of epigenetics. Multidisciplinary perspectives “over” genetics Talk given at a conference “The biosocial economies of epigenetics” 07.12.2017 Oxford, Great Britain and Northern Ireland Panese Francesco; Chiapperino Luca;
Society for Social Studies of Science (4S) Conference: “STS (In)Sensibilities” Talk given at a conference “On the Traces of Biosocial Plasticity. A Genealogical Approach” 29.08.2017 Boston, United States of America Panese Francesco; Chiapperino Luca;
Le humanities in ambito biomedico. Attualità e futuro Talk given at a conference "Sulle tracce del biosociale. Una genealogia della co-laborazione in STS" 26.01.2017 Pistoia, Italy Panese Francesco; Chiapperino Luca;
Plasticity and its limits: An Interdisciplinary Workshop Talk given at a conference “On the traces of biosocial plasticity. A historical and epistemological perambulation” 19.01.2017 Munich, Germany Chiapperino Luca; Panese Francesco;
3ème congrès de la Société francophone pour la recherche et l'éducation sur les Origines Développementales Environnementales et Epigénétiques de la Santé et des Maladies (SFDOHAD) Talk given at a conference “Epigenetics and DOHaD: the moral economies of parenting and reproduction in the post-genomic age”. 01.12.2016 Paris, France Panese Francesco; Simeoni Umberto; Chiapperino Luca;
4S-EASST Conference: Science and technology by other means: exploring collectives, spaces, futures. Talk given at a conference “Parental responsibilities, epigenetics and DOHaD: emerging imaginaries of reproduction in the post-genomic age”. 01.09.2016 Barcelona, Spain Chiapperino Luca; Simeoni Umberto; Panese Francesco;


Self-organised

Title Date Place

Knowledge transfer events



Self-organised

Title Date Place
Various teaching activities at Bachelor, Master and Doctoral level for UNIL, UNIFR, CUSO and (planned for 2019) EPFL 01.02.2017 Lausanne, Fribourg, Montreux, Switzerland
Master's degree thesis in Social Sciences by David Nicolet: “Mutations d’un champ biomédical : la cancérologie à l’ère post-genomique” 01.01.2017 Lausanne, Switzerland

Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions 6èmes Rencontres du Grand Forum des Tout-Petits International 2018
Talks/events/exhibitions 5èmes Rencontres du Grand Forum des Tout-Petits International 2017
Talks/events/exhibitions 4ème Rencontres du Grand forum des Tout-Petits International 2016

Awards

Title Year
Fellowship of the Brocher Foundation Visiting Program. Proposal Title: "Inheritance. The moral economies of reproduction in the biosocial age" 2018

Associated projects

Number Title Start Funding scheme
185822 Constructing the Biosocial: an engaged inquiry into epigenetics and post-genomic biosciences 01.07.2020 Ambizione
168933 Developmental programming of health and epigenetics: what role in the public arena? 01.11.2016 Scientific Conferences
180350 Development of Personalized Health in Switzerland: Social Sciences Perpectives 01.01.2019 Sinergia

Abstract

This project investigates how developments in epigenetics, under the aegis of the so-called Developmental Origins of Health and Disease (DOHaD) hypothesis, partake to a public discourse renegotiating responsibilities to protect the wellbeing of future generations. Drawing from cutting-edge discoveries on developmental programming of health as well as epigenetic inheritance, PaRED scrutinizes the potential reconfiguration of discourses and practices of parenting operated by these discoveries, and maps such developments onto those initiated by the rise of genetic biotechnologies in reproductive medicine.PaRED resorts to methodologies at the crossroad of Science and Technology Studies (STS) and Bioethics. In particular, the project builds upon the conceptual framework of ‘co-production’ (Jasanoff 2004), and the theoretical notion of sociotechnical imaginaries (Jasanoff and Kim 2009, 2013). PaRED aims at mapping emerging and disputed notions of ‘epigenetic parental responsibility’ at three complementary levels: epistemic (practices and standards of knowledge-production in epigenetics), normative (norms and obligations of prospective parents), and socio-political (developments in the governance of reproductive and paediatric medicine).
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