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Oscillatory mechanisms underlying memory retention and reactivation during sleep

English title Oscillatory mechanisms underlying memory retention and reactivation during sleep
Applicant Rasch Björn
Number 162388
Funding scheme Project funding (Div. I-III)
Research institution Département de Psychologie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Psychology
Start/End 01.10.2015 - 30.09.2018
Approved amount 405'052.00
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All Disciplines (2)

Discipline
Psychology
Neurophysiology and Brain Research

Keywords (7)

Sleep; Memory; Brain-Computer Interface (BCI); Human; Reactivation; Oscillations; High-density EEG

Lay Summary (German)

Lead
Schlaf ist förderlich für die Speicherung und Festigung von Erinnerungen. Auch das Erlernen von Fremdsprachen scheint vom Schlaf zu profitieren, allerdings sind die genauen Mechanismen dieser Prozesse noch nicht vollständig bekannt.
Lay summary

Inhalt und Ziel des Forschungsprojektes

Das Forschungsprojekt untersucht die oszillatorischen Mechanismen der Gedächtnisbildung im Schlaf. Im Schlaf werden neu gelernten Inhalte spontan und wiederholt reaktiviert und somit gefestigt. Wir konnten bereits in vorangegangenen Studien zeigen, dass das erneute Abspielen von zuvor gelernten holländischen Vokabeln im Schlaf diese Reaktivierung verstärkt und die Gedächtnisleistung fördert. Dieses Forschungsprojekt hat nun zum Ziel, die exakten neuronalen Marker einer erfolgreichen Reaktivierung von Gedächtnisinhalten im Schlaf zu identifizieren. Die Hirnaktivität während des Lernens, des Schlafens und des Gedächtnisabrufs wird zu diesem Zweck mittels hochauflösender Elektroenzephalographie (EEG) gemessen. Im Fokus des Projektes stehen die für den Tiefschlaf charakteristischen langsamen Oszillationen (< 1 Hz), die Aktivität im Spindelbereich (11-15 Hz) und die für Gedächtnisprozesse im Wachzustand relevante Aktivität im Thetabereich (4-8 Hz).  Einerseits wird in dem Projekt die Relevanz des bestehenden oszillatorischen Hirnzustands für die erfolgreiche Reaktivierung im Schlaf untersucht (d.h. Tiefschlaf vs. leichter Schlaf vs. REM-Schlaf, Phase der langsamen Oszillationen etc.). Anderseits soll auch  die funktionale Relevanz der ereigniskorrelierten Hirnantworten auf den präsentierten Stimulus im Schlaf experimentell identifiziert werden

 

Wissenschaftlicher Kontext und Relevanz des Forschungsprojekts

Die Ergebnisse des Forschungsprojektes werden dazu beitragen, die neuronalen Mechanismen der erfolgreichen Reaktivierung von Gedächtnisinhalten im Schlaf besser zu verstehen. Zusätzlich werden die Ergebnisse des Projektes eine wichtige Grundlage für die theoriegeleitete Entwicklung von Technologien bilden, die z.B. das Speichern von neu gelernten Information im pädagogischen Kontext und im Alltag unterstützen. 

 

Direct link to Lay Summary Last update: 29.09.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Increased neuronal signatures of targeted memory reactivation during slow-wave up states
Göldi Maurice, van Poppel Eva Anna Maria, Rasch Björn, Schreiner Thomas (2019), Increased neuronal signatures of targeted memory reactivation during slow-wave up states, in Scientific Reports, 9(1), 2715-2715.
Effects of targeted memory reactivation during sleep at home depend on sleep disturbances and habituation
Göldi Maurice, Rasch Björn (2019), Effects of targeted memory reactivation during sleep at home depend on sleep disturbances and habituation, in npj Science of Learning, 4(1), 5-5.
Psychosocial Stress Before a Nap Increases Sleep Latency and Decreases Early Slow-Wave Activity
Ackermann Sandra, Cordi Maren, La Marca Roberto, Seifritz Erich, Rasch Björn (2019), Psychosocial Stress Before a Nap Increases Sleep Latency and Decreases Early Slow-Wave Activity, in Frontiers in Psychology, 10, 1.
No effect of vocabulary reactivation in older adults
Cordi Maren Jasmin, Schreiner Thomas, Rasch Björn (2018), No effect of vocabulary reactivation in older adults, in Neuropsychologia, 119, 253-261.
Theta Phase-Coordinated Memory Reactivation Reoccurs in a Slow-Oscillatory Rhythm during NREM Sleep
Schreiner Thomas, Doeller Christian F., Jensen Ole, Rasch Björn, Staudigl Tobias (2018), Theta Phase-Coordinated Memory Reactivation Reoccurs in a Slow-Oscillatory Rhythm during NREM Sleep, in Cell Reports, 25(2), 296-301.
The effect of dream report collection and dream incorporation on memory consolidation during sleep
Schoch Sarah F., Cordi Maren J., Schredl Michael, Rasch Björn (2018), The effect of dream report collection and dream incorporation on memory consolidation during sleep, in Journal of Sleep Research, e12754-e12754.
To gain or not to gain – The complex role of sleep for memory
Schreiner Thomas, Rasch Björn (2018), To gain or not to gain – The complex role of sleep for memory, in Cortex, 101, 282-287.
Modulating influences of memory strength and sensitivity of the retrieval test on the detectability of the sleep consolidation effect
Schoch Sarah F., Cordi Maren J., Rasch Björn (2017), Modulating influences of memory strength and sensitivity of the retrieval test on the detectability of the sleep consolidation effect, in Neurobiology of Learning and Memory, 145, 181-189.
Neural correlates of experimental trauma memory retrievalTrauma Memory and fMRI
Gvozdanovic Geraldine A., Stämpfli Philipp, Seifritz Erich, Rasch Björn (2017), Neural correlates of experimental trauma memory retrievalTrauma Memory and fMRI, in Human Brain Mapping, 38(7), 3592-3602.
Sleep and language learning
Rasch Björn (ed.) (2017), Sleep and language learning, Elsevier, Amsterdam.
The beneficial role of memory reactivation for language learning during sleep: A review
Schreiner Thomas, Rasch Björn (2017), The beneficial role of memory reactivation for language learning during sleep: A review, in Brain and Language, 167, 94-105.
Clicking the brain into deep sleep. Commentary on Weigenand et al . ()
Göldi Maurice, Schreiner Thomas (2017), Clicking the brain into deep sleep. Commentary on Weigenand et al . (), in European Journal of Neuroscience, 45(5), 629-630.
Cognitive Neuroscience of Memory Consolidation
AxmacherNikolai, RaschBjörn (2017), Cognitive Neuroscience of Memory Consolidation, Springer International Publishing, Cham.
Reinforcing language learning during sleep
SchreinerThomas, LehmannMick, RaschBjörn (2017), Reinforcing language learning during sleep, in Axmacher Nikolai, Rasch Björn (ed.), Elsevier International Publishing, Cham, 347-366.
Emotional arousal modulates oscillatory correlates of targeted memory reactivation during NREM, but not REM sleep
Lehmann Mick, Schreiner Thomas, Seifritz Erich, Rasch Björn (2016), Emotional arousal modulates oscillatory correlates of targeted memory reactivation during NREM, but not REM sleep, in Scientific Reports, 6(1), 39229-39229.
Re-presentation of Olfactory Exposure Therapy Success Cues during Non-Rapid Eye Movement Sleep did not Increase Therapy Outcome but Increased Sleep Spindles
Rihm Julia S., Sollberger Silja B., Soravia Leila M., Rasch Björn (2016), Re-presentation of Olfactory Exposure Therapy Success Cues during Non-Rapid Eye Movement Sleep did not Increase Therapy Outcome but Increased Sleep Spindles, in Frontiers in Human Neuroscience, 10, 340.
Sleep benefits emotional and neutral associative memories equally
Lehmann Mick, Seifritz Erich, Rasch Björn (2016), Sleep benefits emotional and neutral associative memories equally, in Somnologie, 20(1), 47-53.
No Evidence for Memory Decontextualization across One Night of Sleep
Jurewicz Katarzyna, Cordi Maren Jasmin, Staudigl Tobias, Rasch Björn (2016), No Evidence for Memory Decontextualization across One Night of Sleep, in Frontiers in Human Neuroscience, 10, 7.
Auditory feedback blocks memory benefits of cueing during sleep
Schreiner Thomas, Lehmann Mick, Rasch Björn (2015), Auditory feedback blocks memory benefits of cueing during sleep, in Nature Communications, 6(1), 8729-8729.

Collaboration

Group / person Country
Types of collaboration
Jan Born, University of Tübingen Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Markus Werkle-Bergener, MPI Human Development, Berlin Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Markus Siegel, University of Tübingen Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Michael Tangermann, University of Freiburg Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Nikolai Axmacher, University of Bonn Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Christiane Thiehl, University of Oldenburg Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Annual Meeting of the German Society for Sleep Research and Sleep Medicine Talk given at a conference The role of memory reactivations during sleep 09.11.2017 Münster, Germany Schreiner Thomas;
ICOM-6 6th International Conference on Memory Talk given at a conference Oscillatory mechanisms of memory reactivation during sleep 21.07.2017 Budapest, Hungary Rasch Björn;
Donders Centre for Cognitive Neuroimaging Talk given at a conference Reactivating memories during sleep 09.02.2017 Nijmegen, Netherlands Rasch Björn;
56. Fachtagung für klinische Neurophysiologie und angrenzende Gebiete Talk given at a conference Schlaf & Gedächtnis 27.01.2017 Grindelwald, Switzerland Rasch Björn;
Department of Psychology, University of York Individual talk The impact of replaying memories during sleep on memory formation 25.11.2016 York, Great Britain and Northern Ireland Schreiner Thomas;
School Seminars, Birmingham School of Psychology Talk given at a conference The impact of replaying memories during sleep on memory formation. School Seminars, Birmingham School of Psychology 23.11.2016 Birmingham, Great Britain and Northern Ireland Schreiner Thomas;
Sleep and Cognition Talk given at a conference When less is more: Auditory feedback blocks beneficial effects of cueing during sleep 10.05.2016 Amsterdam, Netherlands Schreiner Thomas;
Milton Erickson Gesellschaft für Klinische Hypnose MEG: Jahrestagung Talk given at a conference Lernen und Schlaf 03.03.2016 Bad Kissingen, Germany Rasch Björn;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Willkommensveranstaltung neue Mitarbeitende, Universität Freiburg Talk 11.05.2018 Fribourg, Switzerland Rasch Björn;
SwissCore (Contact Office for European Research Innivation and Education) and Mission of Switzerland to the European Union Talk 14.09.2016 Brussels, Belgium Rasch Björn;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Cerebral Doping: movie "Limitless" and open discussion Western Switzerland 2018
Talks/events/exhibitions Le sommeil et les fonctions cognitives et affectives Western Switzerland 2018
Talks/events/exhibitions Lernen und Schlaf German-speaking Switzerland 2016
Talks/events/exhibitions Schlaf und was du schon immer darüber wissen wolltest German-speaking Switzerland 2016

Awards

Title Year
Late PostDoc mobility fellowship: Identifying memory reactivations sleep 2018
Early PostDoc mobility fellowship: The role of memory reactivations during wakefulness and sleep 2016

Associated projects

Number Title Start Funding scheme
133685 A brain state-dependent role of reactivation for memory formation 01.04.2011 SNSF Professorships

Abstract

Memory formation crucially depends on oscillatory processes of temporally organized neural firing patterns of neuronal assemblies. In addition, coordinated interactions between low- (~ 4 Hz - 15 Hz) and high-frequency (> 30 Hz, i.e., gamma range) rhythmic neural activity have been proposed as a possible mechanism for the control and representation of mnemonic contents during wakefulness. During sleep, a fine-tuned interaction between hippocampal memory reactivations, thalamic spindle activity (13 - 15 Hz) and cortical slow oscillations (< 1 Hz) is assumed to underlie the beneficial effect of sleep on memory. A causal role of memory reactivations is supported by studies showing that inducing reactivations during sleep by cueing improves memory formation. However, the oscillatory mechanisms of “successful” memory reactivation during sleep underlying the subsequent strengthening of memory traces by reactivation are currently unknown. In this project we aim at identifying the oscillatory underpinnings of successful memory reactivations during sleep. Similar to previous studies on the “subsequent memory effect” (SME) during wakefulness, we will focus on the oscillatory correlates as well as changes in cross-frequency coupling of the “subsequent memory effect of reactivation” (SME-R) during sleep, i.e. by comparing neural signals during reactivation of subsequently remembered vs. forgotten items. In the planned experiments, we will (a) specify and characterize the oscillatory correlates of SME-R depending on different pre-reactivation microstates (up- vs. down-state of slow oscillation as inferred from surface slow waves) during several sleep macro-states (N3 vs. N2 vs. rapid-eye movement (REM) sleep) and (b) experimental induce different oscillatory patterns after the SME-R period to examine a possible causal role for SME-R related oscillatory activity (slow wave activity, spindle activity, theta activity) for later memory improvements. In addition, we will relate the SME-R during sleep to oscillatory correlates of the SME during learning as well as during retrieval testing. The results of this project will greatly enhance our theoretical understanding of the oscillatory mechanisms underlying successful memory reactivation and strengthening during sleep, and will integrate these processes with current accounts on oscillatory processes involved in memory retention during wakefulness. Furthermore, by possibly identifying that combined induction of an oscillatory pattern + reactivation improves memory consolidation during sleep, the results of this project might also have important clinical implications for patients with memory impairments and/or sleep disorders.
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