cortical circuits; cortical development; neuronal identity
Vitali Ilaria, Fièvre Sabine, Telley Ludovic, Oberst Polina, Bariselli Sebastiano, Frangeul Laura, Baumann Natalia, McMahon John J., Klingler Esther, Bocchi Riccardo, Kiss Jozsef Z., Bellone Camilla, Silver Debra L., Jabaudon Denis (2018), Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex, in Cell
, 174(5), 1264-1276.e15.
A hallmark of the cerebral cortex is its diversity of neuron subtypes, whose assembly into local and long-distance circuits underlies a broad repertoire of mammalian behaviours. For these behaviours to emerge, inputs from the distinct sense organs reach primary sensory cortical areas, where they are processed locally before they are forwarded to secondary areas and motor cortex to generate appropriate sensorimotor responses. These experiments build on previous work from our laboratory characterizing core genetic programs that control the identity of cortical neurons and their corresponding connectivity. By focusing on the development, organization and function of the neurons which bridge sensory input to motor action, the current proposal aims to understand how sensorimotor control emerges and is refined in the developing mammalian brain.