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Building cortical sensorimotor circuits: Molecular controls over local and long-distance connectivity

English title Building cortical sensorimotor circuits: Molecular controls over local and long-distance connectivity
Applicant Jabaudon Denis
Number 160164
Funding scheme Project funding (Div. I-III)
Research institution Dépt des Neurosciences Fondamentales Faculté de Médecine Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Neurophysiology and Brain Research
Start/End 01.08.2015 - 31.07.2018
Approved amount 826'990.00
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Keywords (3)

cortical circuits; cortical development; neuronal identity

Lay Summary (French)

Lead
Comprendre la diversité des neurones du cortex cérébrale est importante pour comprendre la diversité de ses fonctions. Ce projet s'intéresse à identifier les gènes qui contrôlent la connectivité cérébrale au cours du développement.
Lay summary

Comprendre la diversité des neurones du cortex cérébrale est importante pour comprendre la diversité de ses fonctions. Ce projet s'intéresse à identifier les gènes qui contrôlent la connectivité cérébrale au cours du développement. Pour ce faire nous utilisons une combinaison de techniques qui nous permettent de manipuler les gènes dans certains sous-types de neurones au cours du développement, et d'examiner leur connectivité. L'ensemble de ces approches nous permet d'étudier les circuits du cerveau dans des conditions normales et pathologiques.

 

Direct link to Lay Summary Last update: 01.06.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex
Vitali Ilaria, Fièvre Sabine, Telley Ludovic, Oberst Polina, Bariselli Sebastiano, Frangeul Laura, Baumann Natalia, McMahon John J., Klingler Esther, Bocchi Riccardo, Kiss Jozsef Z., Bellone Camilla, Silver Debra L., Jabaudon Denis (2018), Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex, in Cell, 174(5), 1264-1276.e15.

Collaboration

Group / person Country
Types of collaboration
Frontiers in Genetics Genomic Plateform Switzerland (Europe)
- Research Infrastructure
Debby Silver, Duke University, USA United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results

Associated projects

Number Title Start Funding scheme
146337 Molecular Identity and Development of Layer 4 Thalamorecipient Neurons of the Neocortex 01.08.2013 SNSF Professorships
157846 Self-Organizing Properties of Neocortical Circuits 01.04.2015 Temporary Backup Schemes
146337 Molecular Identity and Development of Layer 4 Thalamorecipient Neurons of the Neocortex 01.08.2013 SNSF Professorships

Abstract

A hallmark of the cerebral cortex is its diversity of neuron subtypes, whose assembly into local and long-distance circuits underlies a broad repertoire of mammalian behaviours. For these behaviours to emerge, inputs from the distinct sense organs reach primary sensory cortical areas, where they are processed locally before they are forwarded to secondary areas and motor cortex to generate appropriate sensorimotor responses. These experiments build on previous work from our laboratory characterizing core genetic programs that control the identity of cortical neurons and their corresponding connectivity. By focusing on the development, organization and function of the neurons which bridge sensory input to motor action, the current proposal aims to understand how sensorimotor control emerges and is refined in the developing mammalian brain.
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