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The two faces of neuroplasticity - In vivo study of brain plasticity induced by epileptic seizures and electroconvulsive therapy

English title The two faces of neuroplasticity - In vivo study of brain plasticity induced by epileptic seizures and electroconvulsive therapy
Applicant Draganski Bogdan
Number 159780
Funding scheme Project funding (Div. I-III)
Research institution Laboratoire de Recherche en Neuroimagerie Departement de Neuroscience Cliniques CHUV
Institution of higher education University of Lausanne - LA
Main discipline Neurophysiology and Brain Research
Start/End 01.04.2016 - 31.03.2019
Approved amount 372'000.00
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All Disciplines (3)

Discipline
Neurophysiology and Brain Research
Neurology, Psychiatry
Pathophysiology

Keywords (7)

Brain; Computational anatomy; functional MRI; MRI; Neuroplasticity; Electroconvulsive therapy; Seizures

Lay Summary (German)

Lead
Modulation der Neurogenese im menschlichen Hippocampus - neurobiologische Folgen und Auswirkungen auf das Verhalten.
Lay summary

Hauptziel unseres Projektes ist die in vivo Untersuchung der Folgen einer Stimulation der Produktion neuer Hirnzellen (Neurogenese) auf die Funktion des menschlichen Gehirns und Verhaltens. Aufbauend auf unsere frühere Arbeiten zum Thema der Training-induzierten Hirnplastizität und anatomischen Veränderungen vom Hippocampus nach elektro-konvulsiven Therapie, wollen wir unseren Verständnis über die Regelmechanismen der Neurogenese im Erwachsenengehirn vertiefen und diese mit individuellem Lernverhalten in Zusammenhang bringen. Die Hypothese hier ist dass die lebenslange Produktion von neuen Hirnzellen dient nicht nur der Ersetzung alter Neuronen, hat aber hauptsächlich eine wichtige Rolle für das Gedächtnis und im weiteren Sinne für das menschliche Verhalten.

Unser Projekt ist auf Beispiele vom klinischen Alltag basiert - die Experimente sind auf die Modulation der Neurogenese durch endogene (gelegentlicher epileptische Anfall bei Temporallappenepilepsie Patienten) oder exogene (induziert durch geplante therapeutische electro-konvulsive Therapie) epileptische Aktivität fokussiert. Darüber hinaus untersuchen wir die Effekte von repetitiver transkraniellen Magnetstimulation unter der Anfallsschwelle in gesunden Probanden.  

Die akkurate in vivo Erfassung der Dynamik der Neurogenese wird uns verhelfen Grundprinzipien der exogenen und endogenen Modulation vom Verhalten zu verstehen und wird damit neue Perspektiven in der Behandlung von kognitiven Defizite bei Hirnerkrankungen öffnen.

Direct link to Lay Summary Last update: 23.06.2019

Responsible applicant and co-applicants

Employees

Publications

Publication
A nation-wide initiative for brain imaging and clinical phenotype data federation in Swiss university memory centres
Draganski Bogdan, Kherif Ferath, Damian Daniel, Demonet Jean-Francois (2019), A nation-wide initiative for brain imaging and clinical phenotype data federation in Swiss university memory centres, in Current Opinion in Neurology, 32(4), 557-563.
Example dataset for the hMRI toolbox
Callaghan Martina F., Lutti Antoine, Ashburner John, Balteau Evelyne, Corbin Nadège, Draganski Bogdan, Helms Gunther, Kherif Ferath, Leutritz Tobias, Mohammadi Siawoosh, Phillips Christophe, Reimer Enrico, Ruthotto Lars, Seif Maryam, Tabelow Karsten, Ziegler Gabriel, Weiskopf Nikolaus (2019), Example dataset for the hMRI toolbox, in Data in Brief, 25, 104132-104132.
Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease
Jastrzębowska Maya A., Marquis Renaud, Melie‐García Lester, Lutti Antoine, Kherif Ferath, Herzog Michael H., Draganski Bogdan (2019), Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease, in Human Brain Mapping, hbm.24710-hbm.24710.
hMRI – A toolbox for quantitative MRI in neuroscience and clinical research
Tabelow Karsten, Balteau Evelyne, Ashburner John, Callaghan Martina F., Draganski Bogdan, Helms Gunther, Kherif Ferath, Leutritz Tobias, Lutti Antoine, Phillips Christophe, Reimer Enrico, Ruthotto Lars, Seif Maryam, Weiskopf Nikolaus, Ziegler Gabriel, Mohammadi Siawoosh (2019), hMRI – A toolbox for quantitative MRI in neuroscience and clinical research, in NeuroImage, 194, 191-210.
Spatial Resolution and Imaging Encoding fMRI Settings for Optimal Cortical and Subcortical Motor Somatotopy in the Human Brain
Marquis Renaud, Muller Sandrine, Lorio Sara, Rodriguez-Herreros Borja, Melie-Garcia Lester, Kherif Ferath, Lutti Antoine, Draganski Bogdan (2019), Spatial Resolution and Imaging Encoding fMRI Settings for Optimal Cortical and Subcortical Motor Somatotopy in the Human Brain, in Frontiers in Neuroscience, 13, 571.
The Combination of DAT-SPECT, Structural and Diffusion MRI Predicts Clinical Progression in Parkinson’s Disease
Lorio Sara, Sambataro Fabio, Bertolino Alessandro, Draganski Bogdan, Dukart Juergen (2019), The Combination of DAT-SPECT, Structural and Diffusion MRI Predicts Clinical Progression in Parkinson’s Disease, in Frontiers in Aging Neuroscience, 11, 57.
Controlling motion artefact levels in MR images by suspending data acquisition during periods of head motionCastella et al.
Castella Rémi, Arn Lionel, Dupuis Estelle, Callaghan Martina F., Draganski Bogdan, Lutti Antoine (2018), Controlling motion artefact levels in MR images by suspending data acquisition during periods of head motionCastella et al., in Magnetic Resonance in Medicine, 80(6), 2415-2426.
Change in Emotional and Theory of Mind Processing in Borderline Personality DisorderA Pilot Study
Kramer Ueli, Kolly Stéphane, Maillard Pauline, Pascual-Leone Antonio, Samson Andrea C., Schmitt Ruth, Bernini Adriano, Allenbach Gilles, Charbon Patrick, de Roten Yves, Conus Philippe, Despland Jean-Nicolas, Draganski Bogdan (2018), Change in Emotional and Theory of Mind Processing in Borderline Personality DisorderA Pilot Study, in The Journal of Nervous and Mental Disease, 206(12), 935-943.
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Sønderby Ida E, Gústafsson Ómar, Doan Nhat Trung, Hibar Derrek P, Martin-Brevet Sandra, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Michael, Armstrong Nicola J, Bernard Manon, Blackburn Nicholas, Blangero John, Boomsma Dorret I, Bralten Janita, Brattbak Hans-Richard, Brodaty Henry, Brouwer Rachel M, Bülow Robin, Calhoun Vince, Caspers Svenja, Cavalleri Gianpiero, Chen Chi-Hua, Cichon Sven, et al. (2018), Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia, in Molecular Psychiatry, 132.
Quantifying the Effects of 16p11.2 Copy Number Variants on Brain Structure: A Multisite Genetic-First Study
Martin-Brevet Sandra, Rodríguez-Herreros Borja, Nielsen Jared A., Moreau Clara, Modenato Claudia, Maillard Anne M., Pain Aurélie, Richetin Sonia, Jønch Aia E., Qureshi Abid Y., Zürcher Nicole R., Conus Philippe, Chung Wendy K., Sherr Elliott H., Spiro John E., Kherif Ferath, Beckmann Jacques S., Hadjikhani Nouchine, Reymond Alexandre, Buckner Randy L., Draganski Bogdan, Jacquemont Sébastien, Addor Marie-Claude, Andrieux Joris, et al. (2018), Quantifying the Effects of 16p11.2 Copy Number Variants on Brain Structure: A Multisite Genetic-First Study, in Biological Psychiatry, 84(4), 253-264.
Simultaneous estimation of population receptive field and hemodynamic parameters from single point BOLD responses using Metropolis-Hastings sampling
Adaszewski Stanisław, Slater David, Melie-Garcia Lester, Draganski Bogdan, Bogorodzki Piotr (2018), Simultaneous estimation of population receptive field and hemodynamic parameters from single point BOLD responses using Metropolis-Hastings sampling, in NeuroImage, 172, 175-193.
Networks of myelin covariance
Melie‐Garcia Lester, Slater David, Ruef Anne, Sanabria‐Diaz Gretel, Preisig Martin, Kherif Ferath, Draganski Bogdan, Lutti Antoine (2018), Networks of myelin covariance, in Human Brain Mapping, 39(4), 1532-1554.
Evolution of white matter tract microstructure across the life span
Slater David A., Melie‐Garcia Lester, Preisig Martin, Kherif Ferath, Lutti Antoine, Draganski Bogdan (2017), Evolution of white matter tract microstructure across the life span, in Human Brain Mapping, 40(7), 2252-2268.
Regional volumetric change in Parkinson's disease with cognitive decline
Gee Myrlene, Dukart Juergen, Draganski Bogdan, Wayne Martin WR, Emery Derek, Camicioli Richard (2017), Regional volumetric change in Parkinson's disease with cognitive decline, in Journal of the Neurological Sciences, 373, 88-94.
The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy
Oltedal Leif, Bartsch Hauke, Sørhaug Ole Johan Evjenth, Kessler Ute, Abbott Christopher, Dols Annemieke, Stek Max L, Ersland Lars, Emsell Louise, van Eijndhoven Philip, Argyelan Miklos, Tendolkar Indira, Nordanskog Pia, Hamilton Paul, Jorgensen Martin Balslev, Sommer Iris E, Heringa Sophie M, Draganski Bogdan, Redlich Ronny, Dannlowski Udo, Kugel Harald, Bouckaert Filip, Sienaert Pascal, Anand Amit, et al. (2017), The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy, in NeuroImage: Clinical, 14, 422-432.
Brain networks modulated by subthalamic nucleus deep brain stimulation
Accolla Ettore A., Herrojo Ruiz Maria, Horn Andreas, Schneider Gerd-Helge, Schmitz-Hübsch Tanja, Draganski Bogdan, Kühn Andrea A. (2016), Brain networks modulated by subthalamic nucleus deep brain stimulation, in Brain, 139(9), 2503-2515.

Collaboration

Group / person Country
Types of collaboration
Neurologie - Fribourg Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Neuroradiologie Unispital Bern Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Wellcome Trust Centre for Neuroimaging - UCL Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Service Neurologie - HUG Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Longitudinal MRI workshop Talk given at a conference Brain plasticity - the nature of nurture 19.11.2018 Melbourne, Australia Draganski Bogdan;
2nd GEMRIC workshop Talk given at a conference Voxel-Based Morphometry -useful extensions 17.09.2018 Bergen, Norway Draganski Bogdan;
Brain Meeting - Wellcome Trust Centre for Neuroimaging, UCL Talk given at a conference Neural plasticity – the quest for brain’s green matter 23.03.2018 London, Great Britain and Northern Ireland Draganski Bogdan;
OHBM Talk given at a conference In vivo studies of use-dependant brain tissue property changes 17.06.2017 Vancouver, Canada Draganski Bogdan;
Continuity and discontinuity in brain research Talk given at a conference Brain plasticity – past, presence and future of neuroimgaing 11.03.2017 Padua, Italy Draganski Bogdan;
11th winter conference European Society for Molecular Imaging Talk given at a conference In vivo studies of use-dependent changes in brain tissue properties 19.02.2017 Les Houches, France Draganski Bogdan;
Neuroscientific colloque, Psychology Department, University Salzburg Talk given at a conference In vivo study of brain plasticity 22.06.2016 Salzburg, Austria Draganski Bogdan;


Associated projects

Number Title Start Funding scheme
186239 Swiss Centenarian Study (SWISS100): Vulnerability and Resilience at Age 100 01.01.2020 Sinergia
140332 Imaging large scale neuronal networks in epilepsy 01.05.2012 SPUM
156854 Structural and functional brain plasticity in inhibitory control: towards expertise 01.01.2015 Project funding (Div. I-III)
135679 Anatomical and functional segregation within cortico-basal ganglia circuits 01.01.2012 Project funding (Div. I-III)

Abstract

After more than two decades of research into adult neurogenesis the role of newly generated hippocampal neurons remains poorly understood. Motivated by our early work on use-dependent brain plasticity and our recent findings on the impact of electro-convulsive therapy (ECT) on hippocampus anatomy and behaviour, we want to investigate human neurogenesis in detail and to link the findings to memory performance. We propose to use leading-edge technologies we have pioneered and finally to contrast findings in normal subjects with those in diseases associated with aberrant neurogenesis.We will concentrate on the functional relevance of new immature dentate granule cells on memory encoding. We plan to use epileptic seizures and ECT to boost hippocampal neurogenesis at well-defined time-points and to follow the consequences. These clinical perturbations will i) allow us to define in detail the temporal trajectory of neurogenesis-induced structural brain changes locally in hippocampus and on any effects on cortical areas; ii) permit analysis of the impact of changes in local anatomy and connectivity on inter-individual cognitive variability; and iii) facilitate an assessment of the functional relevance of neurogenesis on memory. We will use new magnetic resonance imaging techniques to quantitatively characterise local in vivo anatomical effects produced by seizure- and ECT- induced neurogenesis. To this end we measure local brain tissue properties known to be sensitive to changes in cyto- and myeloarchitecture. Additional technical refinements will capture neurogenesis-related activity changes associated with the anatomical modifications for linkage to memory performance measured behaviourally.
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