Project

Back to overview

Nanostructured metal-oxide gas sensors for non-invasive disease detection by breath analysis

English title Nanostructured metal-oxide gas sensors for non-invasive disease detection by breath analysis
Applicant Pratsinis Sotiris E.
Number 159763
Funding scheme Project funding (Div. I-III)
Research institution Institut für Verfahrenstechnik ETH Zürich
Institution of higher education ETH Zurich - ETHZ
Main discipline Mechanical Engineering
Start/End 01.04.2015 - 31.03.2018
Approved amount 400'000.00
Show all

All Disciplines (4)

Discipline
Mechanical Engineering
Material Sciences
Microelectronics. Optoelectronics
Chemical Engineering

Keywords (7)

Nanostructured materials; Sensor arrays; Flame synthesis; Microsensors; Metal-oxides; Breath Analysis; Gas sensors

Lay Summary (German)

Lead
Die Atemluftanalyse ist eine vielversprechende nicht-invasive Diagnostikmethode zur Erkennung von Krankheiten bereits in einem frühen Stadium sowie deren Überwachung. Dabei dienen veränderte Konzentrationen bestimmter Atemgase als Indikator für bestimmte Krankheiten, wie beispielsweise erhöhte Ammoniakwerte für Nieren- oder Leberversagen oder erhöhte Konzentrationen an Formaldehyd für Lungenkrebs. Der ideale Sensortyp für die Atemluftanalyse sind chemo-resistive Gassensoren, da diese ein hohes Mass an Miniaturisierung, ausreichend Sensitivität, tiefe Herstellungskosten und eine einfache Bedienung bieten.
Lay summary

Das Ziel dieses Projekts ist die Entwicklung tragbarer Gassensoren für die Atemgasanalyse basierend auf neuen, nanostrukturierten Metalloxiden (z.B. α-MoO3). Diese Materialien werden durch Flammensynthese hergestellt, wobei die Eigenschaften (Phase, Kristall- und Korngrösse, Morphologie und Filmdicke) kontrolliert und gezielt optimiert werden. Zur Charakterisierung werden modernste Analyseverfahren (BET, XRD, Raman, FTIR, UV/vis, TEM und SEM) verwendet. Die Sensoreigenschaften werden durch Widerstands- und Impedanzmessung ermittelt und systematisch bezüglich ausreichender Sensitivität atemluftrelevanter Gaskonzentrationen, Selektivität gegenüber anderen Gasen, geringer Einfluss von Luftfeuchtigkeit sowie schnelle Reaktions- und Regenerationszeit optimiert. Ausserdem wird das Sensordesign durch moderne Mikrotechnologie miniaturisiert. Dies verringert den Leistungsverbrauch und erleichtert die Integration in tragbare Geräte, wie z.B. Mobilfunktelefone. Ein weiterer Schwerpunkt dieses Projekts ist die Kombination verschiedener Sensoren in sogenannten Arrays um Selektivitätseinschränkungen einzelner Sensoren (z.B. für Formaldehyd) zu überwinden oder um mehrere Atemgase gleichzeitig detektieren zu können. Dies kann dabei helfen den gesamtphysiologischen Gesundheitszustand eines Patienten zu bewerten. Schlussendlich werden die entwickelten System auf Atemluft getestet, optimiert und zur Detektion wichtiger Atemluftgase eingesetzt.

Direct link to Lay Summary Last update: 31.03.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Selective formaldehyde detection at ppb in indoor air with a portable sensor
van den Broek Jan, Klein Cerrejon David, Pratsinis Sotiris E., Güntner Andreas T. (2020), Selective formaldehyde detection at ppb in indoor air with a portable sensor, in Journal of Hazardous Materials, 399, 123052-123052.
Thickness Optimization of Highly Porous Flame-Aerosol Deposited WO3 Films for NO2 Sensing at ppb
Abegg Sebastian, Klein Cerrejon David, Güntner Andreas T., Pratsinis Sotiris E. (2020), Thickness Optimization of Highly Porous Flame-Aerosol Deposited WO3 Films for NO2 Sensing at ppb, in Nanomaterials, 10(6), 1170-1170.
A pocket-sized device enables detection of methanol adulteration in alcoholic beverages
Abegg Sebastian, Magro Leandro, van den Broek Jan, Pratsinis Sotiris E., Güntner Andreas T. (2020), A pocket-sized device enables detection of methanol adulteration in alcoholic beverages, in Nature Food, 1(6), 351-354.
Methanol erschnüffeln
van den Broek Jan, Güntner Andreas (2020), Methanol erschnüffeln, in Nachrichten aus der Chemie, 68(5), 38-40.
Thickness-controlled Growth of Silicalite Membranes on Cerium Oxide SupportsThickness-controlled Growth of Silicalite Membranes on Cerium Oxide Supports
Krumeich Frank, Abegg Sebastian, Güntner Andreas T. (2020), Thickness-controlled Growth of Silicalite Membranes on Cerium Oxide SupportsThickness-controlled Growth of Silicalite Membranes on Cerium Oxide Supports, in Zeitschrift für anorganische und allgemeine Chemie, 646(8), 412-418.
Highly selective detection of methanol over ethanol by a handheld gas sensor
van den Broek J., Abegg S., Pratsinis S. E., Güntner A. T. (2019), Highly selective detection of methanol over ethanol by a handheld gas sensor, in Nature Communications, 10(1), 4220-4220.
Sensing of acetone by Al-doped ZnO
Yoo Ran, Güntner Andreas T., Park Yunji, Rim Hyun Jun, Lee Hyun-Sook, Lee Wooyoung (2019), Sensing of acetone by Al-doped ZnO, in Sensors and Actuators B: Chemical, 283, 107-115.
Breath Sensors for Health Monitoring
Güntner Andreas T., Abegg Sebastian, Königstein Karsten, Gerber Philipp A., Schmidt-Trucksäss Arno, Pratsinis Sotiris E. (2019), Breath Sensors for Health Monitoring, in ACS Sensors, 4(2), 268-280.
Orthogonal gas sensor arrays by chemoresistive material design
Pineau Nicolay J., Kompalla Julia F., Güntner Andreas T., Pratsinis Sotiris E. (2018), Orthogonal gas sensor arrays by chemoresistive material design, in Microchimica Acta, 185(12), 563-563.
Guiding Ketogenic Diet with Breath Acetone Sensors
Güntner Andreas T., Kompalla Julia F., Landis Henning, Theodore S., Geidl Bettina, Sievi Noriane, Kohler Malcolm, Pratsinis Sotiris, Gerber Philipp (2018), Guiding Ketogenic Diet with Breath Acetone Sensors, in Sensors, 18(11), 3655-3655.
Versatile breath sampler for online gas sensor analysis
Schon Stéphanie, Theodore S. Jonathan, Güntner Andreas T. (2018), Versatile breath sampler for online gas sensor analysis, in Sensors and Actuators B: Chemical, 273, 1780-1785.
Analyzing Breath with Chemical Sensors
van den Broek Jan, Güntner Andreas T. (2018), Analyzing Breath with Chemical Sensors, in CHIMIA International Journal for Chemistry, 72(6), 425-425.
Sniffing Entrapped Humans from their Chemical Signatur
Güntner Andreas T., Pineau NIcolay J., Mochalski Pawel, Wiesenhofer Helmut, Agapiou Agapios, Mayhew Chris A., Pratsinis Sotiris E. (2018), Sniffing Entrapped Humans from their Chemical Signatur, in Analytical Chemistry, (8), 4940-4945.
Highly Selective and Rapid Breath Isoprene Sensing Enabled by Activated Alumina Filter
van den Broek Jan, Güntner Andreas T., Pratsinis Sotiris E. (2018), Highly Selective and Rapid Breath Isoprene Sensing Enabled by Activated Alumina Filter, in ACS Sensors, (3), 677-683.
Monitoring of selected skin- and breath-borne volatile organic compounds emitted from the human body using gas chromatography ion mobility spectrometry (GC-IMS)
Mochalski Paweł, Wiesenhofer Helmut, Allers Maria, Zimmermann Stefan, Güntner Andreas T., Pineau Nicolay J., Lederer Wolfgang, Agapiou Agapios, Mayhew Christopher A., Ruzsanyi Veronika (2018), Monitoring of selected skin- and breath-borne volatile organic compounds emitted from the human body using gas chromatography ion mobility spectrometry (GC-IMS), in Journal of Chromatography B, 29-34.
Zeolite membranes for highly selective formaldehyde sensors
Güntner Andreas T., Abegg Sebastian, Wegner Karsten, Pratsinis Sotiris E. (2017), Zeolite membranes for highly selective formaldehyde sensors, in Sensors and Actuators B: Chemical, 916-923.
Noninvasive Body Fat Burn Monitoring from Exhaled Acetone with Si-doped WO3-sensing Nanoparticles
Güntner A. T., Sievi N. A., Theodore S. J., Gulich T., Kohler M., Pratsinis S. E. (2017), Noninvasive Body Fat Burn Monitoring from Exhaled Acetone with Si-doped WO3-sensing Nanoparticles, in Analytical Chemistry, 89, 10578-10584.
In Situ Monitoring of the Deposition of Flame-Made Chemoresistive Gas-Sensing Films
Blattmann Christoph O., Güntner Andreas T., Pratsinis Sotiris E. (2017), In Situ Monitoring of the Deposition of Flame-Made Chemoresistive Gas-Sensing Films, in ACS Applied Materials & Interfaces, 23926-23933.
Selective sensing of isoprene by Ti-doped ZnO for breath diagnostics
Güntner A. T., Pineau N. J., Chie D., Krumeich F., Pratsinis S. E. (2016), Selective sensing of isoprene by Ti-doped ZnO for breath diagnostics, in Journal of Materials Chemistry B, 4, 5358-5366.
E-Nose Sensing of Low-ppb Formaldehyde in Gas Mixtures at High Relative Humidity for Breath Screening of Lung Cancer?
Güntner A. T., Koren V., Chikkadi K., Righettoni M., Pratsinis S. E. (2016), E-Nose Sensing of Low-ppb Formaldehyde in Gas Mixtures at High Relative Humidity for Breath Screening of Lung Cancer?, in ACS Sensors, 528-535.
Selective sensing of NH3 by Si-doped α-MoO3 for breath analysis
Güntner A. T., Righettoni M., Pratsinis S. E. (2015), Selective sensing of NH3 by Si-doped α-MoO3 for breath analysis, in Sensors and Actuators B: Chemical, 266-273.

Collaboration

Group / person Country
Types of collaboration
Prof. Dr. med. Arno Schmidt-Trucksäss, Exercise Physiology, Basel University Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Dr. S. Zimmermann, Inst. of Electrical Eng. and Meas. Technol., Leibniz University Hannover Germany (Europe)
- Publication
Prof. Dr. med. M. Kohler, Dept. of Pulmonology, University Hospital Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Scot Martin, Department of Earth and Planetary Sciences,Harvard University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
- Exchange of personnel
Prof. Dr. C. A. Mayhew, Breath Research Institute, Medizinische Universität Innsbruck Austria (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Dr. Agapios Agapiou, Dept. of Chemistry, Cyprus University Cyprus (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Dr. Nicolae Barsan, Institute of Physical and Theoretical Chemistry, University of Tuebingen Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Dr. Ch. Hierold, Group of Micro- and Nanosystems, Dept. of Mech. and Proc. Engin., ETH Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Dr. Ingo Mayer, Kompetenzbereich Materialemissionen und Extraktstoffe, Berner Fachhochschule Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof. Dr. R. Zenobi, Dept. of Chem. and Appl. Biosciences, ETH Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Fassbind AG Switzerland (Europe)
- Industry/business/other use-inspired collaboration
Prof. Dr. med. Felix Beuschlein, Endocrinology, University Hospital Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
International Meeting on Chemical Sensors Poster Fabrication of microporous membranes for highly selective gas sensors 15.07.2018 Vienna, Austria Abegg Sebastian; Güntner Andreas; Pratsinis Sotiris E.;
International Meeting on Chemical Sensors Talk given at a conference Selective Formaldehyde Detection at low ppb Level with Microporous Membranes and SnO2 Sensors 15.07.2018 Vienna, Austria Güntner Andreas; Pratsinis Sotiris E.; Abegg Sebastian;
Detecting breath and skin emitted tracers of humans with flame-made sensor arrays Talk given at a conference International Meeting on Chemical Sensors 15.07.2018 Vienna, Austria Güntner Andreas; Pineau Nicolay Joakim Tony; Pratsinis Sotiris E.;
International Meeting on Chemical Sensors Poster Isoprene detection with Ti-doped ZnO nanoparticles 15.07.2018 Vienna, Austria Pineau Nicolay Joakim Tony; Güntner Andreas; Pratsinis Sotiris E.;
International Meeting on Chemical Sensors Poster In situ resistance monitoring during deposition of flame-made chemoresistive gas sensing films 15.07.2018 Vienna, Austria Pratsinis Sotiris E.; Güntner Andreas;
International Meeting on Chemical Sensors Poster Orthogonal sensor arrays by material design 15.07.2018 Vienna, Austria Pineau Nicolay Joakim Tony; Güntner Andreas; Pratsinis Sotiris E.;
International Meeting on Chemical Sensors Talk given at a conference Isoprene Selective Gas Sensing by Adsorption Filter 15.07.2018 Vienna, Austria Pratsinis Sotiris E.; Güntner Andreas; van den Broek Jan;
International Meeting on Chemical Sensors Poster Versatile breath sampler for gas sensor anaysis 15.07.2018 Vienna, Austria Pratsinis Sotiris E.; Güntner Andreas;
International Association of Breath Research Summit Poster Sniffing entrapped humans with sensor arrays 17.06.2018 Maastricht, Netherlands Güntner Andreas; Pratsinis Sotiris E.; Pineau Nicolay Joakim Tony;
International Association of Breath Research Summit Poster Highly selective and rapid breath isoprene sensing enabled by activated alumina filter 17.06.2018 Maastricht, Netherlands van den Broek Jan; Güntner Andreas; Pratsinis Sotiris E.;
International Association of Breath Research Summit Poster Highly selective breath marker detection by microporous membrane-gas sensor systems 17.06.2018 Maastricht, Netherlands Abegg Sebastian; Güntner Andreas; Pratsinis Sotiris E.;
European Aerosol Conference Poster Flame-made Si-doped MoO3 for selective breath NH3 sensing to detect kidney failure 27.08.2017 Zürich, Switzerland Güntner Andreas;
European Aerosol Conference Poster Easy cholesterol monitoring from breath by isoprene-selective and flame-made Ti-doped ZnO nanoparticles 27.08.2017 Zürich, Switzerland Güntner Andreas;
European Aerosol Conference Poster Highly selective formaldehyde detection with microporous membranes for indoor air quality monitoring 27.08.2017 Zürich, Switzerland Abegg Sebastian;
European Aerosol Conference Poster Rapid disease screening and monitoring from exhaled breath 27.08.2017 Zürich, Switzerland Pineau Nicolay Joakim Tony;
European Aerosol Conference Poster Aerosol-made E-nose for selective formaldehyde detection 27.08.2017 Zürich, Switzerland Güntner Andreas;
Fall Meeting of the Material Research Society (MRS) Poster Morphology-controlled flame patterning of thermally sensitive films on Si wafers 27.11.2016 Boston, United States of America Güntner Andreas;
Fall Meeting of the Materials Research Society (MRS) Poster Fat burn monitoring during exercise with flame-made Si:WO3 breath sensors 27.11.2016 Boston, United States of America Güntner Andreas;
Fall Meeting of the Materials Research Society (MRS) Poster Carcinogenic isoprene detection at low-ppb level with nanostructured Ti-doped ZnO sensors 27.11.2016 Boston, United States of America Güntner Andreas;
Fall Meeting of the Materials Research Society (MRS) Talk given at a conference Lung cancer detection from breath? Portable E-nose for selective low-ppb formaldehyde sensing 27.11.2016 Boston, United States of America Güntner Andreas;
International Association of Breath Research Summit Poster Miniaturizing sensors for portable breath analyzers 14.09.2016 Zürich, Switzerland Güntner Andreas;
International Association of Breath Research Summit Poster Selective isoprene detection by portable Ti-doped ZnO sensors 14.09.2016 Zürich, Switzerland Güntner Andreas;
International Association of Breath Research Summit Poster Analyte selective sensor materials by flame aerosol synthesis 14.09.2016 Zürich, Switzerland Güntner Andreas;
International Association of Breath Research Summit Talk given at a conference E-nose for selective formaldehyde detection in breath analysis 14.09.2016 Zürich, Switzerland Güntner Andreas;
International Meeting on Chemical Sensors Poster Novel nano-structured materials from flames: towards analyte-selective sensing 10.07.2016 Jeju Island, Korean Republic (South Korea) Güntner Andreas;
International Meeting on Chemical Sensors Poster Lung cancer detection from breath ? Portable E-nose for selective low-ppb formaldehyde sensing 10.07.2016 Jeju Island, Korean Republic (South Korea) Güntner Andreas;
International Meeting on Chemical Sensors Poster Kidney disease detection and monitoring by breath analysis: selective sensing of NH3 by Si-doped α-MoO3 10.07.2016 Jeju Island, Korean Republic (South Korea) Güntner Andreas;
International Meeting of Chemical Sensors Talk given at a conference Selective isoprene sensing for breath analysis by Ti-doped ZnO chemo-resistive sensors 10.07.2016 Jeju Insland, Korean Republic (South Korea) Güntner Andreas;
ETH Zürich's MaP Graduate Symposium Poster Cancer detection from breath? Portable E-nose for selective low-ppb formaldehyde sensing 09.06.2016 Zürich, Switzerland Güntner Andreas;
ETH Zürich's MaP Graduate Symposium Poster Kidney disease detection and monitoring by breath analysis: selective sensing of NH3 by Si-doped α-MoO3 09.06.2016 Zürich, Switzerland Güntner Andreas;
International Congress on Particle Technology Talk given at a conference Cancer detection from breath? Aldehyde sensing by nanostructured microsensor arrays 19.04.2016 Nuremberg, Germany Güntner Andreas;
International Congress on Particle Technology Poster Kidney disease detection & monitoring via breath ammonia sensing by tailored Si-doped MoO3 19.04.2016 Nuremberg, Germany Güntner Andreas;
International Congress on Particle Technology Poster Cancer detection from breath? Aldehyde sensing by nanostructured microsensor arrays 19.04.2016 Nuremberg, Germany Güntner Andreas;
International Congress on Particle Technolog Poster Flame-made ZnO for Enhanced Acetone Sensing in Breath Analysis 19.04.2016 Nuremberg, Germany Güntner Andreas;
Fall Meeting of the Material Research Society (MRS) Poster Si-Doped MoO3: from nanobelts to –needles improving breath NH3 sensing for end-stage renal disease monitoring 29.11.2015 Boston, United States of America Güntner Andreas;
Fall Meeting of the Material Research Society (MRS) Poster Flame-made ZnO for Enhanced Acetone Sensing in Breath Analysis 29.11.2015 Boston, United States of America Güntner Andreas;
Fall Meeting of the Material Research Society (MRS) Poster Cancer Detection from Breath? Aldehyde Sensing by Microsensor Arrays 29.11.2015 Boston, United States of America Güntner Andreas;
Fall Meeting of the Material Research Society (MRS) Poster Towards portable breath analyzers for disease detection and monitoring: NH3, acetone, ethanol and formaldehyde sensing by nanostructured MOx arrays 29.11.2015 Boston, United States of America Güntner Andreas;
International Association of Breath Research Summit Poster Highly crystalline Si-doped α-MoO3 for NH3 detection at the ppb-level 14.09.2015 Vienna, Austria Güntner Andreas;
International Association of Breath Research Summit Talk given at a conference Selective NH3 detection by portable Si-doped α-MoO3 sensor for breath analysis 14.09.2015 Vienna, Austria Güntner Andreas;
Fall Meeting of the Material Research Society (MRS) Poster Room temperature gas sensor based ε-WO3-polyaniline nanocomposite 29.04.2015 Boston, United States of America Güntner Andreas;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Breath sensor research in Zurich, University Medicine Zurich Annual Meeting Talk 04.11.2019 Zürich, Switzerland Güntner Andreas;
Rettungshund 2.0, Swiss Alpine Museum Talk 03.04.2019 Bern, Switzerland Güntner Andreas;


Communication with the public

Communication Title Media Place Year
Media relations: radio, television 10vor10 SRF Western Switzerland 2020
Media relations: radio, television Das Display anhauchen? Auf Umwegen zum Handy mit Geruchssinn SRF Western Switzerland 2020
Media relations: radio, television Breath Methanol Detektor SKAI International 2019
Media relations: print media, online media Measuring ethanol’s deadly twin ETH News International 2019
Media relations: print media, online media Technology: A pocket-sized device that can help prevent methanol poisoning Nature Press International 2019
Media relations: radio, television Tendance jeûne, 36.9° RTS Western Switzerland 2019
Media relations: print media, online media An electronic rescue dog ETH News International 2018
New media (web, blogs, podcasts, news feeds etc.) Cheap, portable gadget could save disaster victims' lives New Atlas International 2018
Media relations: print media, online media Die Fettverbrennung im Atem messen Sonntagszeitung International 2018
Media relations: print media, online media Elektronische Spürnase findet Verschüttete über Ausdünstung Blick German-speaking Switzerland 2018
Media relations: print media, online media Elektronische Spürnase soll Verschüttete über Ausdünstung finden NZZ International 2018
Media relations: print media, online media Krankheiten in der Atemluft diagnostizieren Tagesanzeiger International 2018
New media (web, blogs, podcasts, news feeds etc.) New Portable Sensor Could Aid First Responders in Search and Rescue Operations AZO Sensors International 2018
Media relations: print media, online media Novel portable device can sniff out' trapped humans Business Standard International 2018
New media (web, blogs, podcasts, news feeds etc.) Novel portable device can sniff out trapped humans: Here's how DNA International 2018
Media relations: print media, online media Optimal leaps in optimizing fat burn Yale Scientific Magazine International 2018
Media relations: print media, online media Portable device can ‘sniff out’ humans trapped after quakes The Hindu International 2018
New media (web, blogs, podcasts, news feeds etc.) Portable Device Can Save Lives After Natural Disasters ECN International 2018
New media (web, blogs, podcasts, news feeds etc.) Portable device to sniff out trapped humans Homeland Security News Wire International 2018
New media (web, blogs, podcasts, news feeds etc.) Portable Device to Sniff Out Trapped Humans Science Newsline International 2018
New media (web, blogs, podcasts, news feeds etc.) Portable Device to Sniff Out Trapped People Technology Networks International 2018
New media (web, blogs, podcasts, news feeds etc.) Portable sensor array to detect trapped humans after a calamity News Medical International 2018
Media relations: print media, online media Robotic noses could be the future of disaster rescue—if they can outsniff search dogs Popular Science International 2018
New media (web, blogs, podcasts, news feeds etc.) Scientists develop electronic rescue dog Greater Zurich Area International 2018
New media (web, blogs, podcasts, news feeds etc.) Sniffing Entrapped Humans With Sensor Arrays Product Design & Development International 2018
New media (web, blogs, podcasts, news feeds etc.) Sniffing Sensors to Save Entrapped Humans ChemBites International 2018
Media relations: print media, online media Working Like a Dog The Analytical Scientist International 2018
New media (web, blogs, podcasts, news feeds etc.) Zurich scientists develop device to rival the canine nose swiss.info International 2018
New media (web, blogs, podcasts, news feeds etc.) A breathalyzer for real-time monitoring of lipolysis: how a chip could have a role in diabetes diagn Bioanalysis Zone International 2017
Media relations: radio, television Atemtest für Diabetiker Deutschlandfunk Radio International 2017
New media (web, blogs, podcasts, news feeds etc.) Breath Instead of a Blood Test R&D International 2017
New media (web, blogs, podcasts, news feeds etc.) Breath instead of a blood test EurekaAlert! International 2017
Video/Film Breath instead of Blood Test International 2017
Media relations: print media, online media Breath Instead of Blood Test FARS News International 2017
New media (web, blogs, podcasts, news feeds etc.) Breath sensor tells you when you’re burning fat futurity.org International 2017
New media (web, blogs, podcasts, news feeds etc.) Breath Test Takes the Place of Blood Test Controlled Environments International 2017
Media relations: print media, online media Breath Test To Analyze Fat Breakdown in The Body MedIndia International 2017
Media relations: print media, online media Den Fettabbau über die Atemluft messen NZZ International Western Switzerland 2017
Media relations: print media, online media Dieses Gerät misst in der Atemluft, wie gut jemand Fett verbrennt Luzerner Zeitung German-speaking Switzerland 2017
Media relations: print media, online media ETH entwickelt günstigen Fettweg-Sensor 20min German-speaking Switzerland 2017
Media relations: print media, online media Fettabbau über Atemluft messen Walliser Bote German-speaking Switzerland 2017
Media relations: print media, online media Fürs Training oder die Diät: Sensor misst Fettabbau per Atemluft Heilpraxisnet.de International 2017
Talks/events/exhibitions Infopoint Hochschulgebiet Zürich Zentrum Western Switzerland 2017
Media relations: radio, television Mehr Trainingseffizienz durch Atemkontrolle SWR2 Impuls Radiosendung (Südwestrundfunk, Deutschland) International 2017
Media relations: print media, online media Mit kleinsten Gassensoren dem Atem auf der Spur Hochschulmedizin Zürich News German-speaking Switzerland 2017
Media relations: print media, online media New breath test being developed to help weightwatchers shed kilos The Malaysian Times International 2017
New media (web, blogs, podcasts, news feeds etc.) New Sensor with a Breathalyzer Prevents the Need for a Blood Test AZO NANO International 2017
Media relations: print media, online media Researchers Develop A Sensor To Tell When You’re Burning Fat Huffington Post International 2017
New media (web, blogs, podcasts, news feeds etc.) Scientists develop new method for monitoring lipolysis by testing person's exhaled breath News Medical International 2017
Media relations: print media, online media Sensor misst Atemluft und zeigt an, ob der Körper Fett verbrennt Der Standard International 2017
New media (web, blogs, podcasts, news feeds etc.) Tiny Breath Acetone Sensor to Measure Fat Burning During Exercise, Help Monitor Diabetes medgadget International 2017
Media relations: print media, online media Zürcher ETH-Forscher messen Fettabbau über die Atemluft Blick German-speaking Switzerland 2017
Media relations: radio, television Für Diagnose bitte blasen SRF TV Show Puls German-speaking Switzerland 2016

Awards

Title Year
Plenary Lecture, 715. Heraeus Seminar on Fuels, Processes, and Combustion Physics in the Energy Transformation 2020
Best Poster Award for Exposure Measurement Methods and Techniques, European Aerosol Conference 2019
Excellence Award in Product Design and Engineering, European Federation of Chemical Engineering 2019
Fellow of the Global Young Scientist Summit 2019
Gesellschaft für Aerosolforschung (GAeF) PhD Award 2019
Invited Lecture, 2nd Intl. Conference on Soft Chemical Ionisation Mass Spectrometry 2019
Invited Lecture, 8th Intl. PTR-MS Conference 2019
Invited Lecture, Geneva Health Forum 2019
Invited Lecture, Selective gas sensors from flames for breath analysis, 12th European Congress of Chemical Engineering & 5th European Congress of Applied Biotechnology 2019
Invited Lecture, International Breath Analysis Association Summit 2018
Invited Lecture, International Meeting on Chemical Sensors 2018
Invited Lecture, International Meeting on Chemical Sensors 2018
The Royal Society of Chemistry Poster Prize, European Aerosol Conference 2018
Best Poster Award for Instrumentation of Chemical Aerosol Characterization, European Aerosol Conference 2017
Best Poster Award for Synthesis and Structuring of Functional Nanoparticles, European Aerosol Conference 2017
ETH medal for best PhD thesis 2017
Reuel Shinnar Lecture, The City College of New York. 2017
Diels-Planck-Lecture, Christian-Albrechts-Universität zu Kiel 2016
Invited Lecture, AIST Japan 2016
Invited Lecture, Hiroshima University 2016
Invited Lecture, University Nagoya 2016
Plenary Lecture, 36th International Symposium on Combustion 2016
Invited Lecture, University of Cyprus 2015

Patents

Title Date Number Inventor Owner
Fat burning analyzer 16.11.2016 US10667722B2

Associated projects

Number Title Start Funding scheme
130582 Tailored nano-detectors for early stage diagnosis of ilnesses from the human breath 01.05.2010 Project funding (Div. I-III)
175754 Flame-made gas sensor arrays: Membrane-enhanced selectivity for breath analysis 01.04.2018 Project funding (Div. I-III)
170729 Integrated system for in operando characterization and development of portable breath analyzers 01.12.2016 R'EQUIP
177037 Versatile Characterization system for novel theranostic nanomaterials 01.12.2017 R'EQUIP

Abstract

Fast rising expenses for health care motivate innovation in medical services. Breath analysis represents a promising non-invasive and rapid alternative to well-established diagnostic techniques such as blood analysis, endoscopy, ultrasonic and tomographic monitoring. Especially hand-held breath analysis devices that do not require trained personnel bear the potential to drastically reduce medical diagnostic and monitoring costs. More specifically, the ability to detect diseases already in an early stage and monitor their progress may improve medical treatment to a point-of-care therapy with higher chance for patient recovery and thus better quality of life.So far, more than 3’000 trace volatile organic compounds (VOC) have been identified in human breath. Among these, a few have been related to certain disease (breath markers). For instance, elevated acetone levels were detected in diabetic patients, increased exhaled ammonia was connected to liver and kidney dysfunction or even patterns of certain chemical families (e.g. aldehydes) were observed in lung cancer patients. Despite the huge potential of breath analysis as a novel non-invasive diagnostic tool, development of appropriate sensors tailored for target breath markers is challenging as human breath is a complex gas mixture. Clinically relevant breath markers are present at very low concentrations thus requiring sensors with high sensitivity and selectivity for the analyte. As only few breath tests are currently available (e.g. CO2 capnography), further research and development for new sensors are necessary to promote breath analysis as standard technique for clinical diagnostics.Chemo-resistive gas sensors based on metal-oxide nanostructures are promising candidates as they can detect analytes in the ppb range. Together with high miniaturization potential and low production cost, they represent an attractive detector type for hand-held breath analysis devices. As their sensing characteristics are mainly governed by material and surface properties, precisely tailoring them offers the opportunity to optimize their sensing performance. For instance, reducing grain and crystal size to twice the material’s Debye length dramatically increases the sensitivity. Dopants also enhance the sensitivity or improve the sensor's thermal stability. Major drawbacks of common metal-oxides (e.g. SnO2) are poor selectivity and high cross-sensitivity to humidity which are crucial requirements for breath analysis. Therefore, tailored nanostructured materials for detection of target breath markers need to be explored and optimized to address breath analysis related challenges.The goal of this project is the development of nanostructured metal-oxides with unique sensing characteristics (e.g. a-MoO3) specifically tailored for the detection of promising breath markers (e.g. ammonia). Flame spray pyrolysis (FSP) is a versatile and proven scalable tool for synthesis of metal-oxides with superior control over material characteristics (phase, crystal size, film morphology and thickness). Coupled with state-of-the-art material and surface characterization techniques (BET, XRD, Raman, FTIR, UV/vis, TEM and SEM imaging) and sensor performance evaluation (resistance and impedance), all available at PTL, materials will be systematically prepared and examined with respect to analyte detection at breath relevant concentrations, selectivity against interfering gases, low cross-sensitivity to humidity and fast response/recovery times. Additionally, to reduce power consumption and increase portability, microsensors will be designed and investigated. This could motivate their further integration into other portable electronic devices of daily life, such as cell-phones. FSP allows the direct deposition of sensing films in a single step, thus arrays of multiple sensors can be efficiently fabricated. Furthermore by combining differently selective materials in a microsensor array, selectivity limitations of single-standing sensors towards specific analytes (e.g. aldehydes) could be overcome. Additionally, simultaneous measurement of multiple breath markers for pattern-related disease detection (e.g. cancer) or the monitoring of the overall physiological state from human breath could be enabled. This project will contribute to the education of two PhD students in nanostructured material synthesis, processing and sensor development for medical diagnostics. Participating BSc and MSc students will gain a solid knowledge in experimental and analytical methods, and process design in an emerging engineering field. Results will be presented at international conferences and published in peer-reviewed scientific journals.
-