Nanostructured materials; Sensor arrays; Flame synthesis; Microsensors; Metal-oxides; Breath Analysis; Gas sensors
van den Broek Jan, Klein Cerrejon David, Pratsinis Sotiris E., Güntner Andreas T. (2020), Selective formaldehyde detection at ppb in indoor air with a portable sensor, in Journal of Hazardous Materials
, 399, 123052-123052.
Abegg Sebastian, Klein Cerrejon David, Güntner Andreas T., Pratsinis Sotiris E. (2020), Thickness Optimization of Highly Porous Flame-Aerosol Deposited WO3 Films for NO2 Sensing at ppb, in Nanomaterials
, 10(6), 1170-1170.
Abegg Sebastian, Magro Leandro, van den Broek Jan, Pratsinis Sotiris E., Güntner Andreas T. (2020), A pocket-sized device enables detection of methanol adulteration in alcoholic beverages, in Nature Food
, 1(6), 351-354.
van den Broek Jan, Güntner Andreas (2020), Methanol erschnüffeln, in Nachrichten aus der Chemie
, 68(5), 38-40.
Krumeich Frank, Abegg Sebastian, Güntner Andreas T. (2020), Thickness-controlled Growth of Silicalite Membranes on Cerium Oxide SupportsThickness-controlled Growth of Silicalite Membranes on Cerium Oxide Supports, in Zeitschrift für anorganische und allgemeine Chemie
, 646(8), 412-418.
van den Broek J., Abegg S., Pratsinis S. E., Güntner A. T. (2019), Highly selective detection of methanol over ethanol by a handheld gas sensor, in Nature Communications
, 10(1), 4220-4220.
Yoo Ran, Güntner Andreas T., Park Yunji, Rim Hyun Jun, Lee Hyun-Sook, Lee Wooyoung (2019), Sensing of acetone by Al-doped ZnO, in Sensors and Actuators B: Chemical
, 283, 107-115.
Güntner Andreas T., Abegg Sebastian, Königstein Karsten, Gerber Philipp A., Schmidt-Trucksäss Arno, Pratsinis Sotiris E. (2019), Breath Sensors for Health Monitoring, in ACS Sensors
, 4(2), 268-280.
Pineau Nicolay J., Kompalla Julia F., Güntner Andreas T., Pratsinis Sotiris E. (2018), Orthogonal gas sensor arrays by chemoresistive material design, in Microchimica Acta
, 185(12), 563-563.
Güntner Andreas T., Kompalla Julia F., Landis Henning, Theodore S., Geidl Bettina, Sievi Noriane, Kohler Malcolm, Pratsinis Sotiris, Gerber Philipp (2018), Guiding Ketogenic Diet with Breath Acetone Sensors, in Sensors
, 18(11), 3655-3655.
Schon Stéphanie, Theodore S. Jonathan, Güntner Andreas T. (2018), Versatile breath sampler for online gas sensor analysis, in Sensors and Actuators B: Chemical
, 273, 1780-1785.
van den Broek Jan, Güntner Andreas T. (2018), Analyzing Breath with Chemical Sensors, in CHIMIA International Journal for Chemistry
, 72(6), 425-425.
Güntner Andreas T., Pineau NIcolay J., Mochalski Pawel, Wiesenhofer Helmut, Agapiou Agapios, Mayhew Chris A., Pratsinis Sotiris E. (2018), Sniffing Entrapped Humans from their Chemical Signatur, in Analytical Chemistry
, (8), 4940-4945.
van den Broek Jan, Güntner Andreas T., Pratsinis Sotiris E. (2018), Highly Selective and Rapid Breath Isoprene Sensing Enabled by Activated Alumina Filter, in ACS Sensors
, (3), 677-683.
Mochalski Paweł, Wiesenhofer Helmut, Allers Maria, Zimmermann Stefan, Güntner Andreas T., Pineau Nicolay J., Lederer Wolfgang, Agapiou Agapios, Mayhew Christopher A., Ruzsanyi Veronika (2018), Monitoring of selected skin- and breath-borne volatile organic compounds emitted from the human body using gas chromatography ion mobility spectrometry (GC-IMS), in Journal of Chromatography B
Güntner Andreas T., Abegg Sebastian, Wegner Karsten, Pratsinis Sotiris E. (2017), Zeolite membranes for highly selective formaldehyde sensors, in Sensors and Actuators B: Chemical
Güntner A. T., Sievi N. A., Theodore S. J., Gulich T., Kohler M., Pratsinis S. E. (2017), Noninvasive Body Fat Burn Monitoring from Exhaled Acetone with Si-doped WO3-sensing Nanoparticles, in Analytical Chemistry
, 89, 10578-10584.
Blattmann Christoph O., Güntner Andreas T., Pratsinis Sotiris E. (2017), In Situ Monitoring of the Deposition of Flame-Made Chemoresistive Gas-Sensing Films, in ACS Applied Materials & Interfaces
Güntner A. T., Pineau N. J., Chie D., Krumeich F., Pratsinis S. E. (2016), Selective sensing of isoprene by Ti-doped ZnO for breath diagnostics, in Journal of Materials Chemistry B
, 4, 5358-5366.
Güntner A. T., Koren V., Chikkadi K., Righettoni M., Pratsinis S. E. (2016), E-Nose Sensing of Low-ppb Formaldehyde in Gas Mixtures at High Relative Humidity for Breath Screening of Lung Cancer?, in ACS Sensors
Güntner A. T., Righettoni M., Pratsinis S. E. (2015), Selective sensing of NH3 by Si-doped α-MoO3 for breath analysis, in Sensors and Actuators B: Chemical
Fast rising expenses for health care motivate innovation in medical services. Breath analysis represents a promising non-invasive and rapid alternative to well-established diagnostic techniques such as blood analysis, endoscopy, ultrasonic and tomographic monitoring. Especially hand-held breath analysis devices that do not require trained personnel bear the potential to drastically reduce medical diagnostic and monitoring costs. More specifically, the ability to detect diseases already in an early stage and monitor their progress may improve medical treatment to a point-of-care therapy with higher chance for patient recovery and thus better quality of life.So far, more than 3’000 trace volatile organic compounds (VOC) have been identified in human breath. Among these, a few have been related to certain disease (breath markers). For instance, elevated acetone levels were detected in diabetic patients, increased exhaled ammonia was connected to liver and kidney dysfunction or even patterns of certain chemical families (e.g. aldehydes) were observed in lung cancer patients. Despite the huge potential of breath analysis as a novel non-invasive diagnostic tool, development of appropriate sensors tailored for target breath markers is challenging as human breath is a complex gas mixture. Clinically relevant breath markers are present at very low concentrations thus requiring sensors with high sensitivity and selectivity for the analyte. As only few breath tests are currently available (e.g. CO2 capnography), further research and development for new sensors are necessary to promote breath analysis as standard technique for clinical diagnostics.Chemo-resistive gas sensors based on metal-oxide nanostructures are promising candidates as they can detect analytes in the ppb range. Together with high miniaturization potential and low production cost, they represent an attractive detector type for hand-held breath analysis devices. As their sensing characteristics are mainly governed by material and surface properties, precisely tailoring them offers the opportunity to optimize their sensing performance. For instance, reducing grain and crystal size to twice the material’s Debye length dramatically increases the sensitivity. Dopants also enhance the sensitivity or improve the sensor's thermal stability. Major drawbacks of common metal-oxides (e.g. SnO2) are poor selectivity and high cross-sensitivity to humidity which are crucial requirements for breath analysis. Therefore, tailored nanostructured materials for detection of target breath markers need to be explored and optimized to address breath analysis related challenges.The goal of this project is the development of nanostructured metal-oxides with unique sensing characteristics (e.g. a-MoO3) specifically tailored for the detection of promising breath markers (e.g. ammonia). Flame spray pyrolysis (FSP) is a versatile and proven scalable tool for synthesis of metal-oxides with superior control over material characteristics (phase, crystal size, film morphology and thickness). Coupled with state-of-the-art material and surface characterization techniques (BET, XRD, Raman, FTIR, UV/vis, TEM and SEM imaging) and sensor performance evaluation (resistance and impedance), all available at PTL, materials will be systematically prepared and examined with respect to analyte detection at breath relevant concentrations, selectivity against interfering gases, low cross-sensitivity to humidity and fast response/recovery times. Additionally, to reduce power consumption and increase portability, microsensors will be designed and investigated. This could motivate their further integration into other portable electronic devices of daily life, such as cell-phones. FSP allows the direct deposition of sensing films in a single step, thus arrays of multiple sensors can be efficiently fabricated. Furthermore by combining differently selective materials in a microsensor array, selectivity limitations of single-standing sensors towards specific analytes (e.g. aldehydes) could be overcome. Additionally, simultaneous measurement of multiple breath markers for pattern-related disease detection (e.g. cancer) or the monitoring of the overall physiological state from human breath could be enabled. This project will contribute to the education of two PhD students in nanostructured material synthesis, processing and sensor development for medical diagnostics. Participating BSc and MSc students will gain a solid knowledge in experimental and analytical methods, and process design in an emerging engineering field. Results will be presented at international conferences and published in peer-reviewed scientific journals.