Culex pipiens; host selection; Metabolic rate; Sex-biased parasitism; Oxidative stress; Parus major; Plasmodium
Pigeault R., Cozzarolo C.-S., Choquet R., Strehler M., Jenkins T., Delhaye J., Bovet L., Wassef J., Glaizot O., Christe P. (2018), Haemosporidian infection and co-infection affect host survival and reproduction in wild populations of great tits, in International Journal for Parasitology
, 48(14), 1079-1087.
Cozzarolo Camille-Sophie, Jenkins Tania, Toews David P. L., Brelsford Alan, Christe Philippe (2018), Prevalence and diversity of haemosporidian parasites in the yellow-rumped warbler hybrid zone, in Ecology and Evolution
, 8(19), 9834-9847.
Delhaye Jessica, Glaizot Olivier, Christe Philippe (2018), The effect of dietary antioxidant supplementation in a vertebrate host on the infection dynamics and transmission of avian malaria to the vector, in Parasitology Research
, 117(7), 2043-2052.
Delhaye Jesica, Jenkins Tania, Glaizot Olivier, Christe Philippe (2018), Avian malaria and bird humoral immune response, in Malaria Journal
, 17, 77.
Alcala Nicolas, Jenkins Tania, Christe Philippe, Vuilleumier Séverine (2017), Host shift and cospeciation rate estimation from co-phylogenies, in Ecology Letters
, 20(8), 1014-1024.
Fasel Nicolas Jean, Mene-Saffrane Laurent, Ruczynski Ireneusz, Komar Ewa, Christe Philippe (2017), Diet Induced Modifications of Fatty-Acid Composition in Mealworm Larvae (Tenebrio molitor), in Journal of Food Research
, 6(5), 22-22.
Delhaye Jessica, Aletti Consolée, Glaizot Olivier, Christe Philippe (2016), Exposure of the mosquito vector Culex pipiens to the malaria parasite Plasmodium relictum: effect of infected blood intake on immune and antioxidant defences, fecundity and survival, in Parasites & Vectors
, 9(1), 616-616.
Delhaye Jessica, Salamin Nicolas, Roulin Alexandre, Criscuolo François, Bize Pierre, Christe Philippe (2016), Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds, in AGE
, 38(5-6), 433-443.
Delhaye Jessica, Jenkins Tania, Christe Philippe (2016), Plasmodium infection and oxidative status in breeding great tits, Parus major, in Malaria Journal
, 15(1), 531-531.
Avian malaria parasites are emerging as a model system for understanding the ecology and evolution of malaria parasites in the wild. Their high diversity and spatial variability makes them a versatile system for the study of coevolutionary dynamics and the epidemiology of wildlife diseases. Despite recent advances in the field, large gaps still exist in our knowledge of the interplay among the three players of this bird-mosquito-Plasmodium interaction. For example, the costs of parasite resistance in both vertebrate hosts and vectors, but also the mechanisms by which vectors choose their hosts, have implications on host-vector- parasite coevolution as well as on the epidemiology of the disease. In a current research project funded by the SNF, we have found substantial spatial variation in malaria parasite lineages infecting great tits (Parus major) at our study sites but also temporal variation in lineages infecting the mosquito, Culex pipiens, the main vector for Plasmodium relictum. We have also conducted the first experimental test for coevolution among Plasmodium parasites and their hosts. Our studies also suggest that there may be a link between the ability to resist parasite infection and host oxidative stress and we plan a series of experiments to further test this hypothesis. The present application is a continuation of the research program on avian malaria in the great tit in the wild and in captive canaries (Serinus canaria) and on the role of the vector Culex pipiens on the epidemiology of the parasite. Specifically, we will perform a series of field and lab experiments in order to:a) Evaluate the long-term consequences of infection with Plasmodium lineages on life-history traits in our great tit population.b) Experimentally investigate how antioxidant supplementation affects host oxidative stress level and parasitaemia and how this could affect parasite transmission.c) Test if metabolic rate is modified by malarial infection and how this affects oxidative stress level. Secondly, we will focus on different aspects of the interactions between Plasmodium and mosquitoes. With a series of lab experiments and data collected in the field we will:d) Test how mosquito-feeding preference drives the temporal variation in Plasmodium lineage prevalence.e) Investigate under laboratory conditions if there is vector preference for juvenile male birds which would confirm our previous findings that juvenile male great tits were more prone to infection than females.f) Investigate the cost of resistance in mosquitoes that have fed on infected birds by comparing life history parameters and the level of expression of immune defence genes between individuals that were exposed to Plasmodium and those that were not. Overall, we expect that these experiments will disentangle the complex interactions and constraints affecting the relationship between hosts, vectors and parasites. These future studies therefore will shed light on the coevolutionary interactions and epidemiology of avian malaria parasites.