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Evolution of host preferences and mechanisms of parasite resistance in birds and mosquitoes infected with avian malaria

Titel Englisch Evolution of host preferences and mechanisms of parasite resistance in birds and mosquitoes infected with avian malaria
Gesuchsteller/in Christe Philippe
Nummer 159600
Förderungsinstrument Projektförderung (Abt. I-III)
Forschungseinrichtung Département d'Ecologie et d'Evolution Faculté de Biologie et de Médecine Université de Lausanne
Hochschule Universität Lausanne - LA
Hauptdisziplin Oekologie
Beginn/Ende 01.04.2015 - 31.10.2018
Bewilligter Betrag 525'000.00
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Keywords (7)

Culex pipiens; host selection; Metabolic rate; Sex-biased parasitism; Oxidative stress; Parus major; Plasmodium

Lay Summary (Französisch)

Lead
A l’exception de l’Antarctique, la malaria aviaire est présente sur tous les continents et infecte sans doute des milliers d’espèces d’oiseaux. Alors qu’elle provoque une mortalité importante lorsqu’elle rencontre une espèce hôte pour la première fois, ses effets sur le succès reproducteur de ses hôtes et sur leurs fonctions physiologiques restent relativement peu connus. Ce projet vise à mieux comprendre les interactions entre oiseaux, moustiques et malaria.
Lay summary

Contenu et objectifs du travail de recherche

 Ce projet s’inscrit dans la continuité de nos recherches menées sur différentes populations nicheuses de mésanges charbonnières. Ces oiseaux sont infectés par plusieurs espèces de Plasmodium, le parasite responsable de la malaria aviaire dont le vecteur principal est le moustique Culex pipiens. Dans une première partie du projet, nous allons évaluer les effets de l’infection sur le succès reproducteur et la longévité des oiseaux  selon qu’ils soient infectés par telle ou telle espèce de Plasmodium. Nous allons également étudier les effets de la qualité de la nourriture, et plus particulièrement la teneur en antioxidant des aliments, sur la capacité à résister à l’infection. Un autre volet du projet est consacré aux vecteurs et à l’étude des critères sur lesquels les moustiques basent leur choix pour choisir leur hôte afin de comprendre le fort parasitisme biaisé selon les sexes que nous observons dans les populations naturelles. Finalement, les effets de l’infection et de l’exposition au parasite sur l’expression de différents gènes impliqués dans la résistance à la malaria seront mesurés chez les moustiques.

Contexte scientifique et social du projet de recherche

La malaria est une maladie qui touche l’homme, mais également les animaux. L’étude des mécanismes de résistance mis en place par les animaux sauvages pour lutter contre cette maladie est importante pour comprendre l’évolution de ce parasite, des mécanismes de résistance et du rôle joué par les vecteurs lors de sa transmission.

 

Direktlink auf Lay Summary Letzte Aktualisierung: 27.03.2015

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Publikationen

Publikation
Haemosporidian infection and co-infection affect host survival and reproduction in wild populations of great tits
Pigeault R., Cozzarolo C.-S., Choquet R., Strehler M., Jenkins T., Delhaye J., Bovet L., Wassef J., Glaizot O., Christe P. (2018), Haemosporidian infection and co-infection affect host survival and reproduction in wild populations of great tits, in International Journal for Parasitology, 48(14), 1079-1087.
Prevalence and diversity of haemosporidian parasites in the yellow-rumped warbler hybrid zone
Cozzarolo Camille-Sophie, Jenkins Tania, Toews David P. L., Brelsford Alan, Christe Philippe (2018), Prevalence and diversity of haemosporidian parasites in the yellow-rumped warbler hybrid zone, in Ecology and Evolution, 8(19), 9834-9847.
The effect of dietary antioxidant supplementation in a vertebrate host on the infection dynamics and transmission of avian malaria to the vector
Delhaye Jessica, Glaizot Olivier, Christe Philippe (2018), The effect of dietary antioxidant supplementation in a vertebrate host on the infection dynamics and transmission of avian malaria to the vector, in Parasitology Research, 117(7), 2043-2052.
Avian malaria and bird humoral immune response
Delhaye Jesica, Jenkins Tania, Glaizot Olivier, Christe Philippe (2018), Avian malaria and bird humoral immune response, in Malaria Journal, 17, 77.
Host shift and cospeciation rate estimation from co-phylogenies
Alcala Nicolas, Jenkins Tania, Christe Philippe, Vuilleumier Séverine (2017), Host shift and cospeciation rate estimation from co-phylogenies, in Ecology Letters, 20(8), 1014-1024.
Diet Induced Modifications of Fatty-Acid Composition in Mealworm Larvae (Tenebrio molitor)
Fasel Nicolas Jean, Mene-Saffrane Laurent, Ruczynski Ireneusz, Komar Ewa, Christe Philippe (2017), Diet Induced Modifications of Fatty-Acid Composition in Mealworm Larvae (Tenebrio molitor), in Journal of Food Research, 6(5), 22-22.
Exposure of the mosquito vector Culex pipiens to the malaria parasite Plasmodium relictum: effect of infected blood intake on immune and antioxidant defences, fecundity and survival
Delhaye Jessica, Aletti Consolée, Glaizot Olivier, Christe Philippe (2016), Exposure of the mosquito vector Culex pipiens to the malaria parasite Plasmodium relictum: effect of infected blood intake on immune and antioxidant defences, fecundity and survival, in Parasites & Vectors, 9(1), 616-616.
Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds
Delhaye Jessica, Salamin Nicolas, Roulin Alexandre, Criscuolo François, Bize Pierre, Christe Philippe (2016), Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds, in AGE, 38(5-6), 433-443.
Plasmodium infection and oxidative status in breeding great tits, Parus major
Delhaye Jessica, Jenkins Tania, Christe Philippe (2016), Plasmodium infection and oxidative status in breeding great tits, Parus major, in Malaria Journal, 15(1), 531-531.

Datasets

Avian malaria and bird humoral immune response

Autor/in Delhaye, Jessica; Jenkins, Tania; Glaizot, Olivier; Christe, Philippe
Publikationsdatum 09.12.2018
Persistent Identifier (PID) 10.5061/dryad.8ft948b
Repository DRYAD


Prevalence and diversity of haemosporidian parasites in the yellow-rumped warbler hybrid zone

Autor/in Cozzarolo, Camille-Sophie; Jenkins, Tania; Toews, David P. L.; Brelsford, Alan; Christe, Philippe
Publikationsdatum 12.10.2018
Persistent Identifier (PID) 10.1002/ece3.4469
Repository DRYAD


Haemosporidian infection and co-infection affect host survival and reproduction in wild populations of great tits

Autor/in Pigeault, R.; Cozzarolo, C.-S.; Choquet, R.; Strehler, M.; Jenkins, T.; Delhaye, J.; Bovet, L.; Wassef, J.; Glaizot, O.; Christe, P.
Publikationsdatum 01.12.2018
Persistent Identifier (PID) 10.1016/j.ijpara.2018.06.007
Repository DRYAD


Zusammenarbeit

Gruppe / Person Land
Formen der Zusammenarbeit
Department of Biology, University of Fribourg, Chemin du musée 10, Fribourg Schweiz (Europa)
- Publikation
Institute of Biological and Environmental Sciences, University of Aberdeen, AB24 2TZ Aberdeen Grossbritannien und Nordirland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Department of Evolution, Ecology and Organismal Biology, University of California, Riverside, Rivers Vereinigte Staaten von Amerika (Nordamerika)
- Publikation
1Leibniz Institute for Zoo and Wildlife Research, Berlin Deutschland (Europa)
- Publikation
Mammal Research Institute Polish Academy of Science, Bialowieza Polen (Europa)
- Publikation
Swiss Institute of Bioinformatics, Quartier Sorge, 1015 Lausanne Schweiz (Europa)
- Publikation
Dpt of Ecology and Evolution, University of Lausanne Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Musée cantonal de Zoologie, Lausanne Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
Centre d’Ecologie Fonctionnelle et Evolutive, UMR 5175, Montpellier Frankreich (Europa)
- Publikation
IPHC, UNISTRA, CNRS, 23 rue du Loess, 67200 Strasbourg Frankreich (Europa)
- Publikation
2Fuller Evolutionary Biology Program, Cornell Lab of Ornithology, Cornell University, Ithaca, New Yo Vereinigte Staaten von Amerika (Nordamerika)
- Publikation

Wissenschaftliche Veranstaltungen

Aktiver Beitrag

Titel Art des Beitrags Titel des Artikels oder Beitrages Datum Ort Beteiligte Personen
4th International Conference on Malaria and Related Haemosporidian Parasites of Wildlife Vortrag im Rahmen einer Tagung Haemosporidian infection and co-infection affect host survival and reproduction in wild populations of great tits 01.11.2018 Beijing, China Cozzarolo Camille-Sophie; Pigeault Romain;
The 4th International Conference on Malaria and Related Haemosporidian Parasites of Wildlife Vortrag im Rahmen einer Tagung Sex-biased parasitism in vector-borne diseases: vector preference? 01.11.2018 Beijing, China Cozzarolo Camille-Sophie;
The Second Joint Congress on Evolutionary Biology, Montpellier (France) Poster Sex-biased parasitism in vector-borne diseases: vector preference? 19.08.2018 Montpellier, Frankreich Pigeault Romain; Christe Philippe; Cozzarolo Camille-Sophie;
Conference Jacques Monod, Open questions in disease ecology and evolution: from basic research to evolutionary medicine Poster Testing for a role of haemosporidian parasites on speciation in yellow-rumped warblers (Setophaga coronata) 30.10.2017 Roscoff, Frankreich Christe Philippe; Cozzarolo Camille-Sophie; Jenkins Antoinette;
Jacques Monod conference, Open questions in disease ecology and evolution: from basic research to evolutionary medicine Vortrag im Rahmen einer Tagung How to maximize fitness when survival prospects are challenged by haemosporidian infection? 30.10.2017 Roscoff, Frankreich Blatti Elise; Christe Philippe; Jenkins Antoinette; Pigeault Romain; Delhaye Jessica;
Biology16, Lausanne Vortrag im Rahmen einer Tagung Testing for a role of avian malaria in speciation 10.02.2016 Lausanne, Schweiz Cozzarolo Camille-Sophie; Christe Philippe; Jenkins Antoinette;


Verbundene Projekte

Nummer Titel Start Förderungsinstrument
138187 Physiological mechanisms of parasite resistance, local adaptation and host preference by vectors in a natural population of great tits infected with two main lineages of avian malaria 01.01.2012 Projektförderung (Abt. I-III)
120479 Virulence, host preferences and life-history traits in a natural population of great tits infected with malaria 01.09.2008 Projektförderung (Abt. I-III)
179378 Dynamic of haemosporidian parasites: from individual to communities 01.11.2018 Projektförderung (Abt. I-III)

Abstract

Avian malaria parasites are emerging as a model system for understanding the ecology and evolution of malaria parasites in the wild. Their high diversity and spatial variability makes them a versatile system for the study of coevolutionary dynamics and the epidemiology of wildlife diseases. Despite recent advances in the field, large gaps still exist in our knowledge of the interplay among the three players of this bird-mosquito-Plasmodium interaction. For example, the costs of parasite resistance in both vertebrate hosts and vectors, but also the mechanisms by which vectors choose their hosts, have implications on host-vector- parasite coevolution as well as on the epidemiology of the disease. In a current research project funded by the SNF, we have found substantial spatial variation in malaria parasite lineages infecting great tits (Parus major) at our study sites but also temporal variation in lineages infecting the mosquito, Culex pipiens, the main vector for Plasmodium relictum. We have also conducted the first experimental test for coevolution among Plasmodium parasites and their hosts. Our studies also suggest that there may be a link between the ability to resist parasite infection and host oxidative stress and we plan a series of experiments to further test this hypothesis. The present application is a continuation of the research program on avian malaria in the great tit in the wild and in captive canaries (Serinus canaria) and on the role of the vector Culex pipiens on the epidemiology of the parasite. Specifically, we will perform a series of field and lab experiments in order to:a) Evaluate the long-term consequences of infection with Plasmodium lineages on life-history traits in our great tit population.b) Experimentally investigate how antioxidant supplementation affects host oxidative stress level and parasitaemia and how this could affect parasite transmission.c) Test if metabolic rate is modified by malarial infection and how this affects oxidative stress level. Secondly, we will focus on different aspects of the interactions between Plasmodium and mosquitoes. With a series of lab experiments and data collected in the field we will:d) Test how mosquito-feeding preference drives the temporal variation in Plasmodium lineage prevalence.e) Investigate under laboratory conditions if there is vector preference for juvenile male birds which would confirm our previous findings that juvenile male great tits were more prone to infection than females.f) Investigate the cost of resistance in mosquitoes that have fed on infected birds by comparing life history parameters and the level of expression of immune defence genes between individuals that were exposed to Plasmodium and those that were not. Overall, we expect that these experiments will disentangle the complex interactions and constraints affecting the relationship between hosts, vectors and parasites. These future studies therefore will shed light on the coevolutionary interactions and epidemiology of avian malaria parasites.
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