Telley L., Agirman G., Prados J., Amberg N., Fièvre S., Oberst P., Bartolini G., Vitali I., Cadilhac C., Hippenmeyer S., Nguyen L., Dayer A., Jabaudon D. (2019), Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex, in Science
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Vitali Ilaria, Fièvre Sabine, Telley Ludovic, Oberst Polina, Bariselli Sebastiano, Frangeul Laura, Baumann Natalia, McMahon John J., Klingler Esther, Bocchi Riccardo, Kiss Jozsef Z., Bellone Camilla, Silver Debra L., Jabaudon Denis (2018), Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex, in Cell
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Telley L., Govindan S., Prados J., Stevant I., Nef S., Dermitzakis E., Dayer A., Jabaudon D. (2016), Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex, in Science
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The cerebral cortex is composed of distinct neuronal cell types, which assemble into specific intracortical circuits during development. Understanding the molecular and cellular mechanisms of this assembly is essential, because these circuits underlie most of our sensory, motor, and cognitive abilities, and are disrupted in neurodegenerative diseases, stroke, brain injury, and neurodevelopmental disorders. The current research program proposes to investigate the developmental genetic programs that control the generation of these neurons from progenitors (Work Package 1) and their early postmitotic specification (Work Package 2), their in vivo input-dependent assembly into circuits (Work Package 3), and finally, the self-organizing properties of the circuits they form (Work Package 4). Together, these experiments aim at characterizing the cell-intrinsic (i.e. genetic) and cell-extrinsic (i.e. input-dependent) processes controlling cortical circuit formation, with the long-term aim of providing new cell-based strategies for circuit repair.