Cardiovascular disease; Leukemia; Inflammation; Inflammasome; Mucosal immunology; Bacterial pathogenesis; Metabolism; Cancer
Jaeger-Ruckstuhl Carla A., Hinterbrandner Magdalena, Höpner Sabine, Correnti Colin E., Lüthi Ursina, Friedli Olivier, Freigang Stefan, Al Sayed Mohamad F., Bührer Elias D., Amrein Michael A., Schürch Christian M., Radpour Ramin, Riether Carsten, Ochsenbein Adrian F. (2020), TNIK signaling imprints CD8+ T cell memory formation early after priming, in Nature Communications
, 11(1), 1632-1632.
Freigang Stefan (2016), The regulation of inflammation by oxidized phospholipids., in European Journal of Immunology
, 46(8), 1818-1825.
Zysset Daniel, Weber Benjamin, Rihs Silvia, Brasseit Jennifer, Freigang Stefan, Riether Carsten, Banz Yara, Cerwenka Adelheid, Simillion Cedric, Marques-Vidal Pedro, Ochsenbein Adrian F, Saurer Leslie, Mueller Christoph (2016), TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis, in Nature Communications
, 7, 13151.
Bretscher Peter, Egger Julian, Shamshiev Abdijapar, Trötzmüller Martin, Köfeler Harald, Carreira Erick, Kopf Manfred, Freigang Stefan (2015), Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2., in EMBO Molecular Medicine
, 7(5), 593-607.
Matsushita Mai, Freigang Stefan, Schneider Christoph, Conrad Marcus, Bornkamm Georg, Kopf Manfred (2015), T cell lipid peroxidation induces ferroptosis and prevents immunity to infection., in Journal of Experimental Medicine
, 212(4), 555-568.
Egger Julian, Fischer Stefan, Bretscher Peter, Freigang Stefan, Kopf Manfred, Carreira Erick (2015), Total Synthesis of Prostaglandin 15d-PGJ(2) and Investigation of its Effect on the Secretion of IL-6 and IL-12., in Organic Letters
, 17(17), 4340-4343.
Egger Julian, Bretscher Peter, Freigang Stefan, Kopf Manfred, Carreira Eric (2014), Discovery of a highly potent anti-inflammatory epoxyisoprostane-derived lactone., in J Am Chem Soc
, 136(50), 17382-17385.
It is increasingly recognized that the metabolic system and the immune system are not only essential for maintaining and defending a constant internal milieu against environmental challenges, but also that they are directly linked at multiple levels and critically depend on each other’s function. For example, innate and adaptive immune mechanisms regulate metabolic homeostasis, whereas distinct metabolic programs guarantee the maintenance and effector functions of different immune cell subsets. Furthermore, metabolic dysfunction and chronic inflammation reciprocally interact in the pathogenesis of metabolic disorders, including obesity, diabetes or cardio-vascular disease, and of cancer. To understand the role of cellular metabolic programs in the determination of cell fate and function during homeostasis, inflammation or malignant transformation it is thus essential to directly correlate parameters of cellular metabolism, such as mitochondrial respiration and glycolysis, with the characterization of cellular function in vitro and in vivo. Here, we apply for subsidiary funding for the purchase of an Extracellular Flux Analyzer in combination with a hypoxia chamber in order to obtain this key technology for our research. In particular, we aim to investigate the mutual crosstalk between metabolism and vascular inflammation (Group Freigang), malignant transformation (Group Tschan) and anti-microbial immunity (Group Hapfelmeier). The apparatus will be established as a technology platform in the Division of Experimental Pathology and will be made accessible to the scientific community at the University of Bern. Given that several groups working in the fields of immunology, experimental medicine and cell biology have already expressed their strong interest in applying this technology to their own research, we anticipate that the apparatus will be frequently used and will foster scientific collaborations in the future.