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High frequency, high resolution Ultrasound imaging platform (Vevo2100) for preclinical imaging

English title High frequency, High resolution Ultrasound imaging platform (Vevo2100) for preclinical imaging
Applicant Giraud Marie-Noëlle
Number 157658
Funding scheme R'EQUIP
Research institution Department of Clinical Research, DKF Division of Cardiovascular Surgery University Hospital Bern, Insel
Institution of higher education University of Fribourg - FR
Main discipline Cardiovascular Research
Start/End 01.12.2014 - 30.11.2015
Approved amount 175'000.00
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Keywords (1)

high resolution ultrasound

Lay Summary (French)

Lead
Système d'imagerie à haute résolution
Lay summary

Le système  Vevo3100 de Visualsonics est une plateforme permettant l'acquisition d'image  échographique à haute fréquence avec une résolution de 30 microns. Cet équipement fournit un outil très performant pour la recherche appliquée et le développement de nouvelles thérapies. En particulier, le vevo3100 sera utilisé pour l'étude longitudinale non invasive de la morphologie, la taille et la vascularisation des organes tels que le coeur, les reins ainsi que les tumeurs et le cortex visuel.

Direct link to Lay Summary Last update: 02.12.2014

Responsible applicant and co-applicants

Collaboration

Group / person Country
Types of collaboration
Claire Maufrais/Physiologie Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Exchange of personnel
Zhihong Yang/Physiologie Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Exchange of personnel
Stéphane Cook/ HFR Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events



Self-organised

Title Date Place
workshop : Vevo3100 demo 21.01.2015 Fribourg, Switzerland

Communication with the public

Communication Title Media Place Year
Media relations: radio, television La régénération des cellules du cœur après un infarctus RTS Western Switzerland 2015

Associated projects

Number Title Start Funding scheme
135738 Unraveling mechanisms of brest cancer metastasis 01.03.2012 Project funding (Div. I-III)
125744 NCCR Kidney.CH: Kidney Control of Homeostasis (phase I) 01.08.2010 National Centres of Competence in Research (NCCRs)
150271 Topical delivery of photosensitizers to atherosclerotic plaques and intra-arterial photodynamic therapy: a pre-clinical study 01.12.2013 Interdisciplinary projects
143390 Impact of basal forebrain deep brain stimulation on information processing in the tree shrew visual cortex 01.10.2013 Project funding (Div. I-III)
149986 Reduction Of Left Ventricle Remodeling After Cell-Based Therapy: A Pre-Clinical Study 01.01.2014 Project funding (Div. I-III)
137079 Cell migration in tumorigenesis and metastasis 01.01.2012 ProDoc
141070 S6K1, arginase-II, and vascular endothelial aging 01.04.2012 Project funding (Div. I-III)

Abstract

The VisualSonics Vevo 3100 system is an high frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode.It is the gold standard high-resolution ultrasound based technology for patho-physiological and pre-clinical researches.Vevo 3100 technology provides imaging for translational research and biomarker development in animals with a resolution down to 30 microns. Software and quantification tools are customized for small animal physiology. The high frame rate of acquisition provides the best temporal and spatial resolution specifications compared to other imaging modalities such as MRI or CT. In addition to extensive assessment of organ vascularization, size and function, the advanced high resolution-imaging platform will allow us for the first time to visualize cell injection for cell therapy approach (as presented here with cardiac and brain applications).In particular, the current proposal described the projects intended to use the Vevo 2100 high-resolution system for non-invasive real time evaluation and quantification of•Local Cardiac function and perfusion (Dr Giraud)•Treatment of atherosclerotic vulnerable plaques (Prof Cook)•Aging and heart function (Prof Yang)•Kidney size, morphology and function in a longitudinal study (Prof Montani)•Hemodynamic cerebral blood volume activation in the primary visual cortex (Prof Gregor Rainer)•Tumor angiogenesis (Prof Curzio Ruëgg)
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