PCR; extracellular matrix; bacteria; endothelial dysfunction; exacerbation; systemic inflammation
Eze I, Imboden M, Kumar A, Adam M, Eckardstein A, Stolz D, Gerbase M, Künzli N, Turk N, Schindler C, Kronenberg F (2016), A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes., in Public, Environmental and occupatinonal health
, 15, 39-39.
Eze Ikenna C, Imboden Medea, Kumar Ashish, Adam Martin, von Eckardstein Arnold, Stolz Daiana, Gerbase Margaret W, Künzli Nino, Turk Alexander, Schindler Christian, Kronenberg Florian, Probst-Hensch Nicole (2016), A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes., in Environmental health : a global access science source
, 15(1), 39-39.
Papakonstantinou Eleni, Klagas Ioannis, Roth Michael, Tamm Michael, Stolz Daiana (2016), Acute Exacerbations of COPD Are Associated With Increased Expression of Heparan Sulfate and Chondroitin Sulfate in BAL., in Chest
, 149(3), 685-95.
Eze IC, Imboden M, Kumar A, von Eckardstein A, Stolz D, Gerbase MW, Künzli N, Pons M, Kronenberg F, Schindler C, Probst-Hensch N (2016), Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score., in Public, Enviromental and occupational health
, 94, 263-271.
Wanner M., Martin BW, Autenrieth CS, Schaffner E., Meier F, Brombach C., Stolz D., Baumann A., Rochat T., Schindler C., Kriemler S., Probst-Hensch N. (2016), Associations between domains of physical activity, sitting time, and different measures of overweight and obesity., in Prev. Med. Rep.
, 3, 177-184.
Sun Qingzhu, Liu Li, Wang Hui, Mandal Jyotshna, Khan Petra, Hostettler Katrin E, Stolz Daiana, Tamm Michael, Molino Antonio, Lardinois Didier, Lu Shemin, Roth Michael (2016), Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling., in The Journal of allergy and clinical immunology
, in press-in press.
Amalakuhan B, Habib SA, Mangat M, Reyes LF, Rodriguez AH, Hinojosa CA, Soni NJ, Gilley RP, Bustamante CA, Anzuento A, Levine SM, Peters JI, Aliberti S, Sibila O, Chalmers JD, Torres A, Waterer GW, Martin-Loeches I, Bordon J, Blanquer J, Sanz F, Marcos PJ, Rello J, Ramirez J, Luna CM (2016), Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis., in Biochemistry & Molecular Biology
, 88, 267-273.
Grendelmeier P, Tamm M, Jahn K, Pfimlin E, Stolz D (2016), Flexible bronchoscopy with moderate sedation in COPD: a case-control study., in International Journal of COPD
, in press, in press-inpress.
Beeh KM, Burgel PR, Franssen FM, Lopez-Campos JL, Loukides S, Hurst JR, Flezar M, Ulrik CS, Marco F, Stolz D, Valipour A, Casseryl B, Ställberg B, Kostikas K, Wedzicha JA (2016), How Do Dual Long-acting Bronchodilators Prevent Exacerbations of Chronic Obstructive Pulmonary Disease?, in Resp Crit Care Med
Endes Simon, Schaffner Emmanuel, Caviezel Seraina, Dratva Julia, Autenrieth Christine S, Wanner Miriam, Martin Brian, Stolz Daiana, Pons Marco, Turk Alexander, Bettschart Robert, Schindler Christian, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2016), Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study., in Age and ageing
, 45(1), 110-5.
Endes S, Schaffner E, Caviezel S, Dratva J, Autenrieht C, Wanner M, Martin B, Stolz D, Pons M, Turk A, Bettschart R, Schindler C, Kunzli N, Probst-Hensch N, Schmid (2016), Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study., in Geriatrics & Gerontology
, 45, 110-110.
Stolz Daiana, Meyer Anja, Rakic Janko, Boeck Lucas, Scherr Andreas, Tamm Michael (2016), Mortality risk prediction in COPD by a prognostic biomarker panel., in The European respiratory journal
, 44(6), 1557-70.
Sun Q, Mandal J, Molino A, Stolz D, Tamm M, Lu S, Roth M (2016), PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts., in Cell Biology
Endes Simon, Schaffner Emmanuel, Caviezel Seraina, Dratva Julia, Autenrieth Christine Sonja, Wanner Miriam, Martin Brian, Stolz Daiana, Pons Marco, Turk Alexander, Bettschart Robert, Schindler Christian, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2016), Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study., in European journal of epidemiology
, 31(3), 275-85.
Boeck L, Soriano J, Busse-Keizer M, Blasi F, Kostikas K, Boersma W, Milenkovic B, Louis R, Lacoma A, Djamin R, Aerts J, Torres A, Rohde G, Welte T, Martinez-Camblor P, Rakic J, Scherr A, Koller M, van der Palen J, Marin JM, Alfageme I, Almagro P, Casanova C, Esteban C, Soler-Cataluna J (2016), Prognostic assessment in COPD without lung function: the B-AE-D indices., in European Respiratory Journal
, 47, 1635-1644.
Kutz Alexander, Briel Matthias, Christ-Crain Mirjam, Stolz Daiana, Bouadma Lila, Wolff Michel, Kristoffersen Kristina B, Wei Long, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Tamm Michael, Bhatnagar Neera, Bucher Heiner C, Luyt Charles-Edouard, Chastre Jean, Tubach Florence, Mueller Beat, Schuetz Philipp (2016), Prognostic value of procalcitonin in respiratory tract infections across clinical settings., in Critical care (London, England)
, 19, 74-74.
Grendelmeier Peter, Tamm Michael, Jahn Kathleen, Pflimlin Eric, Stolz Daiana (2016), Propofol versus midazolam in medical thoracoscopy: a randomized, noninferiority trial., in Respiration; international review of thoracic diseases
, 88(2), 126-36.
Boeck L, Gensmer A, Nyilas S, Stieltjes B, Re TJ, Tamm M, Latzin P, Stolz D (2016), Single-Breath Washout Tests to Assess Small Airway Disease in COPD., in Chest
Stolz D, Leeming DJ, Kristensen J, Kardal M, Boersma W, Louis R, Milenkovic B, Kostikas K, Blasi F, Aerts J, Sand J, Wouters E, Rohde G, Part C, Torres A, Welte T, Roth M, Papakonstantinou E, Tamm M (2016), Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD., in Chest
, 26, epub-epub.
Baumeler Luzia, Papakonstantinou Eleni, Milenkovic Branislava, Lacoma Alicia, Louis Renaud, Aerts Joachim G, Welte Tobias, Kostikas Konstantinos, Blasi Francesco, Boersma Wim, Torres Antoni, Rohde Gernot G U, Boeck Lucas, Rakic Janko, Scherr Andreas, Tamm Michael, Stolz Daiana (2016), Therapy with proton-pump inhibitors for gastroesophageal reflux disease does not reduce the risk for severe exacerbations in COPD., in Respirology (Carlton, Vic.)
Papakonstantinou Eleni, Karakiulakis George, Batzios Spyros, Savic Spasenija, Roth Michael, Tamm Michael, Stolz Daiana (2015), Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection., in Respiratory research
, 16, 78-78.
Brusse-Keizer Marjolein, Zuur-Telgen Maaike, van der Palen Job, VanderValk Paul, Kerstjens Huib, Boersma Wim, Blasi Francesco, Kostikas Konstantinos, Milenkovic Branislava, Tamm Michael, Stolz Daiana (2015), Adrenomedullin optimises mortality prediction in COPD patients., in Respiratory medicine
, 109(6), 734-42.
Grendelmeier Peter, Tamm Michael, Jahn Kathleen, Pflimlin Eric, Stolz Daiana (2015), Authors' reply., in Respiration; international review of thoracic diseases
, 89(5), 437-437.
Jahn Kathleen, Papakonstantinou Eleni, Stolz Daiana (2015), Cardiac biomarkers in the identification of future risk in chronic obstructive pulmonary disease., in Current topics in medicinal chemistry
Papaioannou Andriana I, Bartziokas Konstantinos, Loukides Stelios, Tsikrika Stamatoula, Karakontaki Foteini, Haniotou Aikaterini, Papiris Spyros, Stolz Daiana, Kostikas Konstantinos (2015), Cardiovascular comorbidities in hospitalised COPD patients: a determinant of future risk?, in The European respiratory journal
, 46(3), 846-9.
Papakonstantinou Eleni, Roth Michael, Klagas Ioannis, Karakiulakis George, Tamm Michael, Stolz Daiana (2015), COPD Exacerbations Are Associated With Proinflammatory Degradation of Hyaluronic Acid., in Chest
, 148(6), 1497-507.
Schuetz Philipp, Balk Robert, Briel Matthias, Kutz Alexander, Christ-Crain Mirjam, Stolz Daiana, Bouadma Lila, Wolff Michel, Kristoffersen Kristina B, Wei Long, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Tamm Michael, Bhatnagar Neera, Bucher Heiner C, Luyt Charles-Edouard, Chastre Jean, Tubach Florence, Mueller Beat, Lacey Michael J, Ohsfeldt Robert L, Scheibling Cara M, Schneider John E (2015), Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective., in Clinical chemistry and laboratory medicine
, 53(4), 583-92.
Rajkumar Sarah, Stolz Daiana, Hammer Jürg, Moeller Alexander, Bauer Georg F, Huynh Cong Khanh, Röösli Martin (2015), Effect of a smoking ban on respiratory health in nonsmoking hospitality workers: a prospective cohort study., in Journal of occupational and environmental medicine
, 56(10), 86-91.
Sutter Sandy, Stolz Daiana, Rohde Gernot (2015), ERS/EBAP European Accreditation of Training Centres in Adult Respiratory Medicine: how could it benefit your centre?, in Breathe (Sheffield, England)
, 11(3), 183-5.
Affolter Kristina, Tamm Michael, Jahn Kathleen, Halter Jörg, Passweg Jakob, Hirsch Hans H, Stolz Daiana (2015), Galactomannan in bronchoalveolar lavage for diagnosing invasive fungal disease., in American journal of respiratory and critical care medicine
, 190(3), 309-17.
Dratva Julia, Caviezel Seraina, Schaffner Emmanuel, Bettschart Robert, Kuenzli Nino, Schindler Christian, Schmidt-Trucksäss Arno, Stolz Daiana, Zemp Elisabeth, Probst-Hensch Nicole (2015), Infectious diseases are associated with carotid intima media thickness in adolescence., in Atherosclerosis
, 243(2), 609-15.
Boeck Lucas, Mandal Jyotshna, Costa Luigi, Roth Michael, Tamm Michael, Stolz Daiana (2015), Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease., in Respiration; international review of thoracic diseases
, 90(2), 97-104.
Mandal Jyotshna, Malla Bijaya, Steffensen Rudi, Costa Luigi, Egli Adrian, Trendelenburg Marten, Blasi Francesco, Kostikas Kostantinos, Welte Tobias, Torres Antoni, Louis Renaud, Boersma Wim, Milenkovic Branislava, Aerts Joachim, Rohde Gernot G U, Lacoma Alicia, Rentsch Katharina, Roth Michael, Tamm Michael, Stolz Daiana (2015), Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study., in Respiratory research
, 16, 150-150.
Jahn Kathleen, Kuisma Marko, Mäki Minna, Grendelmeier Peter, Hirsch Hans H, Tamm Michael, Papakonstantinou Eleni, Stolz Daiana (2015), Molecular diagnostics for bacterial infections in bronchoalveolar lavage--a case-control, pilot study., in Swiss medical weekly
, 145, 14193-14193.
Sun Qingzhu, Liu Li, Mandal Jyotshna, Molino Antonio, Stolz Daiana, Tamm Michael, Lu Shemin, Roth Michael (2015), PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts., in Cellular signalling
, 28(4), 307-15.
Scherr Andreas, Seifert Bruno, Kuster Martin, Meyer Anja, Fagerstroem Karl-Olov, Tamm Michael, Stolz Daiana (2015), Predictors of marked weight gain in a population of health care and industrial workers following smoking cessation, in BMC PUBLIC HEALTH
, 15, 520.
Bridevaux Pierre-Olivier, Dupuis-Lozeron Elise, Schindler Christian, Keidel Dirk, Gerbase Margaret W, Probst-Hensch Nicole M, Bettschart Robert, Burdet Luc, Pons Marco, Rothe Thomas, Turk Alexander, Stolz Daiana, Tschopp Jean-Marie, Kuenzli Nino, Rochat Thierry (2015), Spirometer Replacement and Serial Lung Function Measurements in Population Studies: Results From the SAPALDIA Study., in American journal of epidemiology
, 181(10), 752-61.
Mandal Jyotshna, Roth Michael, Costa Luigi, Boeck Lucas, Rakic Janko, Scherr Andreas, Tamm Michael, Stolz Daiana (2015), Vasoactive Intestinal Peptide for Diagnosing Exacerbation in Chronic Obstructive Pulmonary Disease., in Respiration; international review of thoracic diseases
, 90(5), 357-68.
General background: Frequent exacerbations accelerate lung function decline affecting the quality of life of COPD patients and moreover, remain the major contributors to mortality and morbidity of these patients. Exacerbations of COPD can be triggered by viral or bacterial infection of the lower respiratory tract and stimulate both airway and systemic inflammatory response. The orchestration of viral and infection, inflammation with its systemic repercussions and airway remodelling are thought to represent a vicious cycle leading to repeated exacerbation and to progressive clinical worsening in COPD. The role of intensified combination therapy with inhaled corticosteroid/LABA at the onset of upper respiratory tract infection symptoms in the control of virus-induced inflammatory cytokine production in the upper and lower airways and its effect in reducing exacerbations in patients with COPD receiving low maintenance dose steroids/LABA is being currently analyzed within the PREVENT study. The three subprojects involved in this subsequent study aim to examine the importance of the other constituents of the pathological process of exacerbation: bacterial infection; systemic inflammatory response and airway remodelling. Aims: a) to analyze the bacterial burden in the airways of COPD patients during an acute exacerbation as well as at stable state using both conventional and newly developed molecular methods; b) to determine systemic cardiovascular risk by peripheral arterial tonometry in COPD at stable state and during exacerbation; c) to characterize airway remodeling by changes in extracellular matrix at exacerbation as well as the stable state and to correlate these changes to clinical characteristics in a translational approach.Design: Subprojects 1 and 2 are observational, longitudinal, nested cohort studies within the randomized, investigator-initiated- and driven PREVENT study. Subproject 3 explores translational aspects of this well-characterized COPD cohort. In addition, a subsidiary project evaluates epidemiological lung function aspects of COPD in Switzerland.Setting: University Hospital Basel, Switzerland.Patients: ca. 300 patients with COPD included in the PREVENT study with age = 40 years, smoking history = 10 pack-years and moderate to very severe stable COPD (GOLD II-IV without exacerbation for = 4 weeks), history of severe exacerbation in previous year. Excluded are patients with pulmonary conditions other than COPD as the main respiratory disease; rapid lethal disease, severe immunosuppression; known allergy or intolerance to the study medication; pregnancy.Primary Endpoints: a) Number (%) of patients presenting at least one positive potentially pathogenic bacteria in sputum during exacerbation by conventional microbiology and multiplex bacterial PCR; b) Median reactive hyperemia index across COPD severity as assessed by the GOLD classes and groups (II-IV, A-D); c) Secretion and deposition of glycosaminoglycans as well as theirs synthesizing/degrading enzymes and receptors in COPD and controls.Analyses: A sample size of 300 patients will be able to provide power of 93% to detect a projected 20% absolute difference in the detection of potentially pathogenic bacteria in sputum at exacerbation comparing conventional bacteriology and multiplex bacterial PCR using a two-sided p=.05 level test. Similarly, the same sample size enables 94% power evidence a difference in mean reactive hyperaemia index between patients at exacerbation and stable state (1.7±2.0 vs. 2.5±2.0) using a two-sided p=.05 level test.Subsidiary Project: Predictive value of bodyplethysmography and diffusion capacity indices on long-term mortality in Chronic Obstructive Pulmonary Disease (COPD): the BASCOP (Basel Survival COPD) StudySignificance: Exacerbations of COPD are associated with significant morbidity, mortality and health-care associated costs. By better understanding the vicious cycle of infection, systemic inflammation and airway remodelling in COPD we expect to improve prediction of clinical outcomes including disease progression and to provide targets for pharmacological intervention.