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The vicious-cycle of acute exacerbation in chronic obstructive pulmonary disease: orchestration of infection, systemic inflammatory response and airway remodelling

English title The vicious-cycle of acute exacerbation in chronic obstructive pulmonary disease: orchestration of infection, systemic inflammatory response and airway remodelling
Applicant Stolz Daiana
Number 157530
Funding scheme SNSF Professorships
Research institution
Klinik für Pneumologie Medizinische Universitätsklinik Universitätsspital Basel
Labor Pneumologie, Zentrum für Lehre und Forschung
Institution of higher education University of Basel - BS
Main discipline Internal Medicine
Start/End 01.02.2015 - 30.11.2016
Approved amount 398'077.00
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All Disciplines (2)

Discipline
Internal Medicine
Respiratory Diseases

Keywords (6)

PCR; extracellular matrix; bacteria; endothelial dysfunction; exacerbation; systemic inflammation

Lay Summary (German)

Lead
COPD-Exazerbationen beeinflussen die Lebensqualität von COPD Patienten. Mit dieser Studie wollen wir die Vorhersagen über Krankheitsverlauf und Fortschreiten der Krankheit verbessern und Ansätze für die pharmakologische Intervention liefern.
Lay summary

Ziele

Das primäre Ziel ist es, den schädlichen Kreislauf ausgelöst durch das Zusammenspiel von viraler Infektion und Entzündung mit ihren Auswirkungen auf den Körper und den Umbau der Atemwege zu untersuchen. Die Annahme ist, dass dieser Kreislauf zu wiederholten Exazerbationen und zur klinischen Verschlechterung der COPD führt. Die Studie zielt darauf hin, den pathologischen Prozesses der Exazerbation zu untersuchen im Hinblick auf bakterielle Infektion, systemische Entzündungsreaktion und Umbau der Atemwege. Dafür soll die Keimbelastung in den Atemwegen von COPD Patienten während einer akuten Exazerbation und im stabilen Zustand mithilfe von sowohl konventionellen als auch neu entwickelten molekularen Methoden analysiert werden. Ebenso sollen systemische kardiovaskuläre Risiken durch peripher arterielle Tonometrie bei der COPD im stabilen Zustand und während einer Exazerbation aufgezeigt werden. Als drittes soll der Umbau der Atemwege charakterisiert werden durch Veränderungen in der extrazellularen Matrix während Exazerbationen genauso wie im stabilen Zustand. Diese Veränderungen sollen in einer translationalen Annäherung in Zusammenhang gebracht werden mit klinischen Beschreibungen. Die Studie baut auf Anwendungsbeobachtungen, Längsschnittstudien und verschachtelte Kohortenstudien innerhalb der randomisierten, vom Untersucher initiierten PREVENT-Studie auf.  Zusätzlich evaluiert ein ergänzendes Projekt epidemiologische Lungenfunktionsaspekte der COPD in der Schweiz. Die untersuchten Patienten sind bereits eingeschlossen in der PREVENT-Studie. Die Studie wird am Universitätsspital Basel durchgeführt.

 

Direct link to Lay Summary Last update: 12.12.2014

Responsible applicant and co-applicants

Employees

Publications

Publication
A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes.
Eze I, Imboden M, Kumar A, Adam M, Eckardstein A, Stolz D, Gerbase M, Künzli N, Turk N, Schindler C, Kronenberg F (2016), A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes., in Public, Environmental and occupatinonal health, 15, 39-39.
A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes.
Eze Ikenna C, Imboden Medea, Kumar Ashish, Adam Martin, von Eckardstein Arnold, Stolz Daiana, Gerbase Margaret W, Künzli Nino, Turk Alexander, Schindler Christian, Kronenberg Florian, Probst-Hensch Nicole (2016), A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes., in Environmental health : a global access science source, 15(1), 39-39.
Acute Exacerbations of COPD Are Associated With Increased Expression of Heparan Sulfate and Chondroitin Sulfate in BAL.
Papakonstantinou Eleni, Klagas Ioannis, Roth Michael, Tamm Michael, Stolz Daiana (2016), Acute Exacerbations of COPD Are Associated With Increased Expression of Heparan Sulfate and Chondroitin Sulfate in BAL., in Chest, 149(3), 685-95.
Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score.
Eze IC, Imboden M, Kumar A, von Eckardstein A, Stolz D, Gerbase MW, Künzli N, Pons M, Kronenberg F, Schindler C, Probst-Hensch N (2016), Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score., in Public, Enviromental and occupational health, 94, 263-271.
Associations between domains of physical activity, sitting time, and different measures of overweight and obesity.
Wanner M., Martin BW, Autenrieth CS, Schaffner E., Meier F, Brombach C., Stolz D., Baumann A., Rochat T., Schindler C., Kriemler S., Probst-Hensch N. (2016), Associations between domains of physical activity, sitting time, and different measures of overweight and obesity., in Prev. Med. Rep., 3, 177-184.
Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.
Sun Qingzhu, Liu Li, Wang Hui, Mandal Jyotshna, Khan Petra, Hostettler Katrin E, Stolz Daiana, Tamm Michael, Molino Antonio, Lardinois Didier, Lu Shemin, Roth Michael (2016), Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling., in The Journal of allergy and clinical immunology, in press-in press.
Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis.
Amalakuhan B, Habib SA, Mangat M, Reyes LF, Rodriguez AH, Hinojosa CA, Soni NJ, Gilley RP, Bustamante CA, Anzuento A, Levine SM, Peters JI, Aliberti S, Sibila O, Chalmers JD, Torres A, Waterer GW, Martin-Loeches I, Bordon J, Blanquer J, Sanz F, Marcos PJ, Rello J, Ramirez J, Luna CM (2016), Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis., in Biochemistry & Molecular Biology, 88, 267-273.
Flexible bronchoscopy with moderate sedation in COPD: a case-control study.
Grendelmeier P, Tamm M, Jahn K, Pfimlin E, Stolz D (2016), Flexible bronchoscopy with moderate sedation in COPD: a case-control study., in International Journal of COPD, in press, in press-inpress.
How Do Dual Long-acting Bronchodilators Prevent Exacerbations of Chronic Obstructive Pulmonary Disease?
Beeh KM, Burgel PR, Franssen FM, Lopez-Campos JL, Loukides S, Hurst JR, Flezar M, Ulrik CS, Marco F, Stolz D, Valipour A, Casseryl B, Ställberg B, Kostikas K, Wedzicha JA (2016), How Do Dual Long-acting Bronchodilators Prevent Exacerbations of Chronic Obstructive Pulmonary Disease?, in Resp Crit Care Med, epub-epub.
Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study.
Endes Simon, Schaffner Emmanuel, Caviezel Seraina, Dratva Julia, Autenrieth Christine S, Wanner Miriam, Martin Brian, Stolz Daiana, Pons Marco, Turk Alexander, Bettschart Robert, Schindler Christian, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2016), Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study., in Age and ageing, 45(1), 110-5.
Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study.
Endes S, Schaffner E, Caviezel S, Dratva J, Autenrieht C, Wanner M, Martin B, Stolz D, Pons M, Turk A, Bettschart R, Schindler C, Kunzli N, Probst-Hensch N, Schmid (2016), Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study., in Geriatrics & Gerontology, 45, 110-110.
Mortality risk prediction in COPD by a prognostic biomarker panel.
Stolz Daiana, Meyer Anja, Rakic Janko, Boeck Lucas, Scherr Andreas, Tamm Michael (2016), Mortality risk prediction in COPD by a prognostic biomarker panel., in The European respiratory journal, 44(6), 1557-70.
PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts.
Sun Q, Mandal J, Molino A, Stolz D, Tamm M, Lu S, Roth M (2016), PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts., in Cell Biology, epub-epub.
Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study.
Endes Simon, Schaffner Emmanuel, Caviezel Seraina, Dratva Julia, Autenrieth Christine Sonja, Wanner Miriam, Martin Brian, Stolz Daiana, Pons Marco, Turk Alexander, Bettschart Robert, Schindler Christian, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2016), Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study., in European journal of epidemiology, 31(3), 275-85.
Prognostic assessment in COPD without lung function: the B-AE-D indices.
Boeck L, Soriano J, Busse-Keizer M, Blasi F, Kostikas K, Boersma W, Milenkovic B, Louis R, Lacoma A, Djamin R, Aerts J, Torres A, Rohde G, Welte T, Martinez-Camblor P, Rakic J, Scherr A, Koller M, van der Palen J, Marin JM, Alfageme I, Almagro P, Casanova C, Esteban C, Soler-Cataluna J (2016), Prognostic assessment in COPD without lung function: the B-AE-D indices., in European Respiratory Journal, 47, 1635-1644.
Prognostic value of procalcitonin in respiratory tract infections across clinical settings.
Kutz Alexander, Briel Matthias, Christ-Crain Mirjam, Stolz Daiana, Bouadma Lila, Wolff Michel, Kristoffersen Kristina B, Wei Long, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Tamm Michael, Bhatnagar Neera, Bucher Heiner C, Luyt Charles-Edouard, Chastre Jean, Tubach Florence, Mueller Beat, Schuetz Philipp (2016), Prognostic value of procalcitonin in respiratory tract infections across clinical settings., in Critical care (London, England), 19, 74-74.
Propofol versus midazolam in medical thoracoscopy: a randomized, noninferiority trial.
Grendelmeier Peter, Tamm Michael, Jahn Kathleen, Pflimlin Eric, Stolz Daiana (2016), Propofol versus midazolam in medical thoracoscopy: a randomized, noninferiority trial., in Respiration; international review of thoracic diseases, 88(2), 126-36.
Single-Breath Washout Tests to Assess Small Airway Disease in COPD.
Boeck L, Gensmer A, Nyilas S, Stieltjes B, Re TJ, Tamm M, Latzin P, Stolz D (2016), Single-Breath Washout Tests to Assess Small Airway Disease in COPD., in Chest, epub-epub.
Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD.
Stolz D, Leeming DJ, Kristensen J, Kardal M, Boersma W, Louis R, Milenkovic B, Kostikas K, Blasi F, Aerts J, Sand J, Wouters E, Rohde G, Part C, Torres A, Welte T, Roth M, Papakonstantinou E, Tamm M (2016), Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD., in Chest, 26, epub-epub.
Therapy with proton-pump inhibitors for gastroesophageal reflux disease does not reduce the risk for severe exacerbations in COPD.
Baumeler Luzia, Papakonstantinou Eleni, Milenkovic Branislava, Lacoma Alicia, Louis Renaud, Aerts Joachim G, Welte Tobias, Kostikas Konstantinos, Blasi Francesco, Boersma Wim, Torres Antoni, Rohde Gernot G U, Boeck Lucas, Rakic Janko, Scherr Andreas, Tamm Michael, Stolz Daiana (2016), Therapy with proton-pump inhibitors for gastroesophageal reflux disease does not reduce the risk for severe exacerbations in COPD., in Respirology (Carlton, Vic.), x.
Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection.
Papakonstantinou Eleni, Karakiulakis George, Batzios Spyros, Savic Spasenija, Roth Michael, Tamm Michael, Stolz Daiana (2015), Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection., in Respiratory research, 16, 78-78.
Adrenomedullin optimises mortality prediction in COPD patients.
Brusse-Keizer Marjolein, Zuur-Telgen Maaike, van der Palen Job, VanderValk Paul, Kerstjens Huib, Boersma Wim, Blasi Francesco, Kostikas Konstantinos, Milenkovic Branislava, Tamm Michael, Stolz Daiana (2015), Adrenomedullin optimises mortality prediction in COPD patients., in Respiratory medicine, 109(6), 734-42.
Authors' reply.
Grendelmeier Peter, Tamm Michael, Jahn Kathleen, Pflimlin Eric, Stolz Daiana (2015), Authors' reply., in Respiration; international review of thoracic diseases, 89(5), 437-437.
Cardiac biomarkers in the identification of future risk in chronic obstructive pulmonary disease.
Jahn Kathleen, Papakonstantinou Eleni, Stolz Daiana (2015), Cardiac biomarkers in the identification of future risk in chronic obstructive pulmonary disease., in Current topics in medicinal chemistry, x.
Cardiovascular comorbidities in hospitalised COPD patients: a determinant of future risk?
Papaioannou Andriana I, Bartziokas Konstantinos, Loukides Stelios, Tsikrika Stamatoula, Karakontaki Foteini, Haniotou Aikaterini, Papiris Spyros, Stolz Daiana, Kostikas Konstantinos (2015), Cardiovascular comorbidities in hospitalised COPD patients: a determinant of future risk?, in The European respiratory journal, 46(3), 846-9.
COPD Exacerbations Are Associated With Proinflammatory Degradation of Hyaluronic Acid.
Papakonstantinou Eleni, Roth Michael, Klagas Ioannis, Karakiulakis George, Tamm Michael, Stolz Daiana (2015), COPD Exacerbations Are Associated With Proinflammatory Degradation of Hyaluronic Acid., in Chest, 148(6), 1497-507.
Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective.
Schuetz Philipp, Balk Robert, Briel Matthias, Kutz Alexander, Christ-Crain Mirjam, Stolz Daiana, Bouadma Lila, Wolff Michel, Kristoffersen Kristina B, Wei Long, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Tamm Michael, Bhatnagar Neera, Bucher Heiner C, Luyt Charles-Edouard, Chastre Jean, Tubach Florence, Mueller Beat, Lacey Michael J, Ohsfeldt Robert L, Scheibling Cara M, Schneider John E (2015), Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective., in Clinical chemistry and laboratory medicine, 53(4), 583-92.
Effect of a smoking ban on respiratory health in nonsmoking hospitality workers: a prospective cohort study.
Rajkumar Sarah, Stolz Daiana, Hammer Jürg, Moeller Alexander, Bauer Georg F, Huynh Cong Khanh, Röösli Martin (2015), Effect of a smoking ban on respiratory health in nonsmoking hospitality workers: a prospective cohort study., in Journal of occupational and environmental medicine, 56(10), 86-91.
ERS/EBAP European Accreditation of Training Centres in Adult Respiratory Medicine: how could it benefit your centre?
Sutter Sandy, Stolz Daiana, Rohde Gernot (2015), ERS/EBAP European Accreditation of Training Centres in Adult Respiratory Medicine: how could it benefit your centre?, in Breathe (Sheffield, England), 11(3), 183-5.
Galactomannan in bronchoalveolar lavage for diagnosing invasive fungal disease.
Affolter Kristina, Tamm Michael, Jahn Kathleen, Halter Jörg, Passweg Jakob, Hirsch Hans H, Stolz Daiana (2015), Galactomannan in bronchoalveolar lavage for diagnosing invasive fungal disease., in American journal of respiratory and critical care medicine, 190(3), 309-17.
Infectious diseases are associated with carotid intima media thickness in adolescence.
Dratva Julia, Caviezel Seraina, Schaffner Emmanuel, Bettschart Robert, Kuenzli Nino, Schindler Christian, Schmidt-Trucksäss Arno, Stolz Daiana, Zemp Elisabeth, Probst-Hensch Nicole (2015), Infectious diseases are associated with carotid intima media thickness in adolescence., in Atherosclerosis, 243(2), 609-15.
Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease.
Boeck Lucas, Mandal Jyotshna, Costa Luigi, Roth Michael, Tamm Michael, Stolz Daiana (2015), Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease., in Respiration; international review of thoracic diseases, 90(2), 97-104.
Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.
Mandal Jyotshna, Malla Bijaya, Steffensen Rudi, Costa Luigi, Egli Adrian, Trendelenburg Marten, Blasi Francesco, Kostikas Kostantinos, Welte Tobias, Torres Antoni, Louis Renaud, Boersma Wim, Milenkovic Branislava, Aerts Joachim, Rohde Gernot G U, Lacoma Alicia, Rentsch Katharina, Roth Michael, Tamm Michael, Stolz Daiana (2015), Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study., in Respiratory research, 16, 150-150.
Molecular diagnostics for bacterial infections in bronchoalveolar lavage--a case-control, pilot study.
Jahn Kathleen, Kuisma Marko, Mäki Minna, Grendelmeier Peter, Hirsch Hans H, Tamm Michael, Papakonstantinou Eleni, Stolz Daiana (2015), Molecular diagnostics for bacterial infections in bronchoalveolar lavage--a case-control, pilot study., in Swiss medical weekly, 145, 14193-14193.
PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts.
Sun Qingzhu, Liu Li, Mandal Jyotshna, Molino Antonio, Stolz Daiana, Tamm Michael, Lu Shemin, Roth Michael (2015), PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts., in Cellular signalling, 28(4), 307-15.
Predictors of marked weight gain in a population of health care and industrial workers following smoking cessation
Scherr Andreas, Seifert Bruno, Kuster Martin, Meyer Anja, Fagerstroem Karl-Olov, Tamm Michael, Stolz Daiana (2015), Predictors of marked weight gain in a population of health care and industrial workers following smoking cessation, in BMC PUBLIC HEALTH, 15, 520.
Spirometer Replacement and Serial Lung Function Measurements in Population Studies: Results From the SAPALDIA Study.
Bridevaux Pierre-Olivier, Dupuis-Lozeron Elise, Schindler Christian, Keidel Dirk, Gerbase Margaret W, Probst-Hensch Nicole M, Bettschart Robert, Burdet Luc, Pons Marco, Rothe Thomas, Turk Alexander, Stolz Daiana, Tschopp Jean-Marie, Kuenzli Nino, Rochat Thierry (2015), Spirometer Replacement and Serial Lung Function Measurements in Population Studies: Results From the SAPALDIA Study., in American journal of epidemiology, 181(10), 752-61.
Vasoactive Intestinal Peptide for Diagnosing Exacerbation in Chronic Obstructive Pulmonary Disease.
Mandal Jyotshna, Roth Michael, Costa Luigi, Boeck Lucas, Rakic Janko, Scherr Andreas, Tamm Michael, Stolz Daiana (2015), Vasoactive Intestinal Peptide for Diagnosing Exacerbation in Chronic Obstructive Pulmonary Disease., in Respiration; international review of thoracic diseases, 90(5), 357-68.

Collaboration

Group / person Country
Types of collaboration
Prof. Hans Hirsch, Head Department of Microbiology, University Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Dr. Christian Schindler, Institute of Social and Preventive Medicine Swiss Tropical Institute Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Michael Tamm, Head Clinic of Pulmonary Medicine, University Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Prof. Michael Roth, Head Respiratory Cell Research, University Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Prof. Michael Zellweger, Clinic of Cardiology, University Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof. Richard Irwin, Head Pulmonary Medicine, University of Massachusetts Memorial Hospital United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Emiel Wouters, Head of the Department of Respiratory Medicine, University Hospital Maastricht Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Dr. Reno Frei, Clinic of Cardiology, University Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Suma Aire Talk given at a conference Impact and prevention of exacerbations. Latest developments 08.02.2016 Granada, Spain Stolz Daiana;
4e Symposium new insights into pulmonary infectious diseases Talk given at a conference State of the art lecture: Biomarkers in exacerbations of COPD 08.02.2016 Rotterdam, Netherlands Stolz Daiana;
ERS Talk given at a conference Nitrogen multiple breath washout for diagnosis of biopsy proven bronchiolitis obliterans in patients after allogeneic stem cell transplantation 08.02.2016 London, Great Britain and Northern Ireland Stolz Daiana;
COPD Day Talk given at a conference Was ist der Stellenwert von Biomarkern in der Behandlung von COPD Patienten 08.02.2016 Zürich, Switzerland Stolz Daiana;
Annual Conference Swiss Society of Pneumology/Swiss Society of Cardiology Talk given at a conference Biomarkers in the differential diagnosis of dyspnea 07.02.2016 Lausanne, Switzerland Stolz Daiana;
National Congress of Pneumology North Portugal Talk given at a conference Biomarkers for ACOS 07.02.2016 Porto, Portugal Stolz Daiana;
15th EPOC Symposium Talk given at a conference Biomarkers in COPD-Are they useful? 07.02.2016 Barcelona, Spain Stolz Daiana;
Barmelweid Talk given at a conference Indication for each exercise testing 10.12.2015 Barmelweid, Switzerland Stolz Daiana;
20. Zürcher Herzkreislauftag Talk given at a conference COPD: Diagnose, Verlauf und Behandlung 03.12.2015 Zürich, Switzerland Stolz Daiana;
Medical Tribune Talk given at a conference Focus on Airway Infection and COPD 19.11.2015 Zürich, Switzerland Stolz Daiana;
ERS Highlights 2015 Talk given at a conference ERS Highlights 2015 16.11.2015 Zürich, Switzerland Stolz Daiana;
Pneumo Update Lausanne Individual talk Bio marqueurs et leur utilité dans le traitement des BPCO 05.11.2015 Lausanne, Switzerland Stolz Daiana;
1. Swiss-German Lung Symposium Talk given at a conference Therapy of asthma and COPD: from pharmacotherapy to bronchial thermoplaty and lung volume reduction 31.10.2015 Lörrach, Germany Stolz Daiana;
European Respiratory Society annual Congress Talk given at a conference Circulating vasoactive intestinal peptide for diagnosis of exacerbation of COPD 26.09.2015 Amsterdam, Netherlands Mandal Jyotshna;
European Respiratory Society annual Congress Talk given at a conference Infection in COPD: different aspects of the host/pathogen balance CHAIR 26.09.2015 Amsterdam, Netherlands Stolz Daiana;
European Respiratory Society annual Congress Poster Molecular diagnostics in the bronchoalveolar lavage in a large cohort of immunocompromised patients 26.09.2015 Amsterdam, Netherlands Stolz Daiana;
European Respiratory Society annual Congress Individual talk Biomarkers and rapid diagnostics in antibiotic stewardship (Postgraduate Course) 26.09.2015 Amsterdam, Netherlands Stolz Daiana;
European Respiratory Society annual Congress Talk given at a conference Late Breaking Abstracts: Biomarkers of ECM turnover and clinical relevant outcomes in COPD: Results of the multicenter PROMISE study 26.09.2015 Amsterdam, Netherlands Stolz Daiana;
European Respiratory Society annual Congress Poster Hyaluronic acid is associated with survival time in stable COPD independently of exacerbation rate, BODE index and adjusted Charlson score 26.09.2015 Amsterdam, Netherlands Papakonstantinou Eleni;
European Respiratory Society annual Congress Talk given at a conference Irisin is associated with severe exacerbations of COPD independently of lung function, comorbidities and exercise capacity 26.09.2015 Amsterdam, Netherlands Stolz Daiana;
European Respiratory Society annual Congress Talk given at a conference Is there something new in biomarkers that might predict differentiate AECOPD from CAP+COPD? 26.09.2015 Amsterdam, Netherlands Stolz Daiana;
Cologne consensus Conference on CME 2015, Talk given at a conference What do providers offer: present and future 11.09.2015 Köln, Germany Stolz Daiana;
Problemi aperti in medicina respiratoria: confronto con gli esperti Talk given at a conference Predictors of mortality risk in COPD 05.06.2015 Catania, Italy Stolz Daiana;
SGP 2015 Individual talk Pro-Contra-Session: Inhalative Steroiden bei COPD (Pro) 16.04.2015 Lugano, Switzerland Stolz Daiana;
Suma Aire meeting, Barcelona, Spain, 2015 Individual talk Are biomarkers useful to better COPD exacerbation management? 13.02.2015 Barcelona, Spain Stolz Daiana;


Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Forschung braucht Zeit Lungenliga Vivo German-speaking Switzerland 2016
Media relations: radio, television Puls, Thermoplastie SRF 1 German-speaking Switzerland 2015

Awards

Title Year
Best Poster Award, Swiss Pneumology Society, 2016 (Senior Author) 2016
Medical Faculty Award, University Basel, 2016 (Senior Author) 2016
Prize Viollier AG 2015 2015
Swiss Addiction Research Award (SARA), 2015 2015

Associated projects

Number Title Start Funding scheme
128412 Preventing viral exacerbation of chronic obstructive pulmonary disease in upper respiratory tract infection - The PREVENT study 01.02.2011 SNSF Professorships

Abstract

General background: Frequent exacerbations accelerate lung function decline affecting the quality of life of COPD patients and moreover, remain the major contributors to mortality and morbidity of these patients. Exacerbations of COPD can be triggered by viral or bacterial infection of the lower respiratory tract and stimulate both airway and systemic inflammatory response. The orchestration of viral and infection, inflammation with its systemic repercussions and airway remodelling are thought to represent a vicious cycle leading to repeated exacerbation and to progressive clinical worsening in COPD. The role of intensified combination therapy with inhaled corticosteroid/LABA at the onset of upper respiratory tract infection symptoms in the control of virus-induced inflammatory cytokine production in the upper and lower airways and its effect in reducing exacerbations in patients with COPD receiving low maintenance dose steroids/LABA is being currently analyzed within the PREVENT study. The three subprojects involved in this subsequent study aim to examine the importance of the other constituents of the pathological process of exacerbation: bacterial infection; systemic inflammatory response and airway remodelling. Aims: a) to analyze the bacterial burden in the airways of COPD patients during an acute exacerbation as well as at stable state using both conventional and newly developed molecular methods; b) to determine systemic cardiovascular risk by peripheral arterial tonometry in COPD at stable state and during exacerbation; c) to characterize airway remodeling by changes in extracellular matrix at exacerbation as well as the stable state and to correlate these changes to clinical characteristics in a translational approach.Design: Subprojects 1 and 2 are observational, longitudinal, nested cohort studies within the randomized, investigator-initiated- and driven PREVENT study. Subproject 3 explores translational aspects of this well-characterized COPD cohort. In addition, a subsidiary project evaluates epidemiological lung function aspects of COPD in Switzerland.Setting: University Hospital Basel, Switzerland.Patients: ca. 300 patients with COPD included in the PREVENT study with age = 40 years, smoking history = 10 pack-years and moderate to very severe stable COPD (GOLD II-IV without exacerbation for = 4 weeks), history of severe exacerbation in previous year. Excluded are patients with pulmonary conditions other than COPD as the main respiratory disease; rapid lethal disease, severe immunosuppression; known allergy or intolerance to the study medication; pregnancy.Primary Endpoints: a) Number (%) of patients presenting at least one positive potentially pathogenic bacteria in sputum during exacerbation by conventional microbiology and multiplex bacterial PCR; b) Median reactive hyperemia index across COPD severity as assessed by the GOLD classes and groups (II-IV, A-D); c) Secretion and deposition of glycosaminoglycans as well as theirs synthesizing/degrading enzymes and receptors in COPD and controls.Analyses: A sample size of 300 patients will be able to provide power of 93% to detect a projected 20% absolute difference in the detection of potentially pathogenic bacteria in sputum at exacerbation comparing conventional bacteriology and multiplex bacterial PCR using a two-sided p=.05 level test. Similarly, the same sample size enables 94% power evidence a difference in mean reactive hyperaemia index between patients at exacerbation and stable state (1.7±2.0 vs. 2.5±2.0) using a two-sided p=.05 level test.Subsidiary Project: Predictive value of bodyplethysmography and diffusion capacity indices on long-term mortality in Chronic Obstructive Pulmonary Disease (COPD): the BASCOP (Basel Survival COPD) StudySignificance: Exacerbations of COPD are associated with significant morbidity, mortality and health-care associated costs. By better understanding the vicious cycle of infection, systemic inflammation and airway remodelling in COPD we expect to improve prediction of clinical outcomes including disease progression and to provide targets for pharmacological intervention.
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