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Novel Imaging and Therapeutic Tools in Systemic Sclerosis

English title Novel Imaging and Therapeutic Tools in Systemic Sclerosis
Applicant Distler Oliver
Number 154490
Funding scheme Sinergia
Research institution Klinik für Rheumatologie Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Internal Medicine
Start/End 01.01.2015 - 31.12.2018
Approved amount 1'783'184.00
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Keywords (6)

Systemic Sclerosis; Radiotracer; Positron Emission Tomography (PET); Radiopharmacy; Vaccination therapy; Molecular Imaging

Lay Summary (German)

Lead
LeadDie systemische Sklerose (SSc) ist eine chronische Autoimmunerkrankung mit deutlich erniedrigter Überlebensrate und hoher Einschränkung der Lebensqualität. Es besteht ein hoher Bedarf an effektiven Therapien und diagnostischen Verfahren, die Organbeteiligungen in einem frühen Stadium, vor dem Auftreten irreversibler Schäden an den Organen, aufdecken können. Dieses Projekt untersucht hierfür neue innovative Verfahren.
Lay summary

Inhalt und Ziele des Forschungsprojekts

Primäres Ziel des Projektes ist die Validierung ein neues, sehr sensitives Bildgebungs-Verfahren (PET&SPECT/CT), das unter Verwendung spezieller Antikörper (Radiotracern) die Krankheitsentstehung bereits auf Molekül-Ebene detektieren kann. Darüber hinaus testet die Studie mit der Immunisierung gegen Schlüsselmoleküle der Krankheitsentstehung ein neues therapeutisches Prinzip, das zu einer spezifischen und andauernden Hemmung dieser Moleküle führt. Ein weiteres Ziel ist es, durch engen Austausch zwischen den verschiedenen beteiligten Disziplinen und durch die Einführung eines strukturierten und detaillierten Mentoring Programms eine optimale Plattform für die Aus- und Weiterbildung junger Nachwuchswissenschaftler zu etablieren.

Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojekts

Sollte sich unser Forschungsansatz als erfolgreich erweisen, planen wir für die Zukunft die Übertragung der Erkenntnisse in klinische Studien bei Patienten mit SSc. Dadurch könnte eine Verhinderung schwerer Organbeteiligungen durch frühe therapeutische Intervention erzielt werden. Unser diagnostischer und therapeutischer Ansatz könnte auch als Vorlage für andere (multisystemische) Autoimmunerkrankungen dienen.

Direct link to Lay Summary Last update: 09.09.2014

Responsible applicant and co-applicants

Employees

Publications

Publication
Vascular Mechanisms in Systemic Sclerosis
Schniering Janine, Maurer Britta, Distler Oliver (2019), Vascular Mechanisms in Systemic Sclerosis, Springer International Publishing, Cham, 27-37.
Visualisation of interstitial lung disease by molecular imaging of integrin αvβ3 and somatostatin receptor 2
Schniering Janine, Benešová Martina, Brunner Matthias, Haller Stephanie, Cohrs Susan, Frauenfelder Thomas, Vrugt Bart, Feghali-Bostwick Carol A, Schibli Roger, Distler Oliver, Mueller Cristina, Maurer Britta (2019), Visualisation of interstitial lung disease by molecular imaging of integrin αvβ3 and somatostatin receptor 2, in Annals of the Rheumatic Diseases, 78(2), 218-227.
Evaluation of 99mTc-rhAnnexin V-128 SPECT/CT as a diagnostic tool for early stages of interstitial lung disease associated with systemic sclerosis
Schniering Janine, Guo Li, Brunner Matthias, Schibli Roger, Ye Shuang, Distler Oliver, Béhé Martin, Maurer Britta (2018), Evaluation of 99mTc-rhAnnexin V-128 SPECT/CT as a diagnostic tool for early stages of interstitial lung disease associated with systemic sclerosis, in Arthritis Research & Therapy, 20(1), 183-183.
Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horses
Fettelschoss-Gabriel Antonia, Fettelschoss Victoria, Olomski Florian, Birkmann Katharina, Thoms Franziska, Bühler Maya, Kummer Martin, Zeltins Andris, Kündig Thomas M., Bachmann Martin F. (2018), Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horses, in Allergy.
Treating insect-bite hypersensitivity in horses with active vaccination against IL-5
Fettelschoss-Gabriel Antonia, Fettelschoss Victoria, Thoms Franziska, Giese Christoph, Daniel Michelle, Olomski Florian, Kamarachev Jivko, Birkmann Katharina, Bühler Maya, Kummer Martin, Zeltins Andris, Marti Eliane, Kündig Thomas M., Bachmann Martin F. (2018), Treating insect-bite hypersensitivity in horses with active vaccination against IL-5, in Journal of Allergy and Clinical Immunology, 142(4), 1194-1205.e3.
In Vivo Labeling of Plasma Proteins for Imaging of Enhanced Vascular Permeability in the Lungs
Schniering Janine, Borgna Francesca, Siwowska Klaudia, Benešová Martina, Cohrs Susan, Hasler Roger, van der Meulen Nicholas P., Maurer Britta, Schibli Roger, Müller Cristina (2018), In Vivo Labeling of Plasma Proteins for Imaging of Enhanced Vascular Permeability in the Lungs, in Molecular Pharmaceutics, 15(11), 4995-5004.
Vaccination against IL-31 for the treatment of atopic dermatitis in dogs
Bachmann Martin F., Zeltins Andris, Kalnins Gints, Balke Ina, Fischer Nina, Rostaher Ana, Tars Kaspars, Favrot Claude (2018), Vaccination against IL-31 for the treatment of atopic dermatitis in dogs, in Journal of Allergy and Clinical Immunology, 142(1), 279-281.e1.
Reduced 18 F-Folate Conjugates as a New Class of PET Tracers for Folate Receptor Imaging
Boss Silvan D., Müller Cristina, Siwowska Klaudia, Büchel Josephine I., Schmid Raffaella M., Groehn Viola, Schibli Roger, Ametamey Simon M. (2018), Reduced 18 F-Folate Conjugates as a New Class of PET Tracers for Folate Receptor Imaging, in Bioconjugate Chemistry, 29(4), 1119-1130.
PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer
Spalinger Marianne R., Manzini Roberto, Hering Larissa, Riggs Julianne B., Gottier Claudia, Lang Silvia, Atrott Kirstin, Fettelschoss Antonia, Olomski Florian, Kündig Thomas M., Fried Michael, McCole Declan F., Rogler Gerhard, Scharl Michael (2018), PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer, in Cell Reports, 22(7), 1835-1848.
Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
Arnoldini Simon, Moscaroli Alessandra, Chabria Mamta, Hilbert Manuel, Hertig Samuel, Schibli Roger, Béhé Martin, Vogel Viola (2017), Novel peptide probes to assess the tensional state of fibronectin fibers in cancer, in Nature Communications, 8(1), 1793-1793.
Synthesis, Radiolabeling, and Characterization of Plasma Protein-Binding Ligands: Potential Tools for Modulation of the Pharmacokinetic Properties of (Radio)Pharmaceuticals
Müller Cristina, Farkas Renáta, Borgna Francesca, Schmid Raffaella M., Benešová Martina, Schibli Roger (2017), Synthesis, Radiolabeling, and Characterization of Plasma Protein-Binding Ligands: Potential Tools for Modulation of the Pharmacokinetic Properties of (Radio)Pharmaceuticals, in Bioconjugate Chemistry, 28(9), 2372-2383.
Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells
Rauber Simon, Luber Markus, Weber Stefanie, Maul Lisa, Soare Alina, Wohlfahrt Thomas, Lin Neng-Yu, Dietel Katharina, Bozec Aline, Herrmann Martin, Kaplan Mark H, Weigmann Benno, Zaiss Mario M, Fearon Ursula, Veale Douglas J, Cañete Juan D, Distler Oliver, Rivellese Felice, Pitzalis Costantino, Neurath Markus F, McKenzie Andrew N J, Wirtz Stefan, Schett Georg, Distler Jörg H W, et al. (2017), Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells, in Nature Medicine, 938-944.
Preclinical Comparison of Albumin-Binding Radiofolates: Impact of Linker Entities on the in Vitro and in Vivo Properties
Siwowska Klaudia, Haller Stephanie, Bortoli Francesca, Benešová Martina, Groehn Viola, Bernhardt Peter, Schibli Roger, Müller Cristina (2017), Preclinical Comparison of Albumin-Binding Radiofolates: Impact of Linker Entities on the in Vitro and in Vivo Properties, in Molecular Pharmaceutics, 14(2), 523-532.

Collaboration

Group / person Country
Types of collaboration
Merck Cie Schaffhausen Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Industry/business/other use-inspired collaboration
Innate Pharma SA France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Exchange of personnel
- Industry/business/other use-inspired collaboration
Prof. Dr. Burkhard Becher, Institute of Experimental Immunology, University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Vetsuisse Faculty of the University Bern, Clinical Immunology Group, Experimental Clinical Immunolog Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
- Industry/business/other use-inspired collaboration
Prof. Dr. Max Gassmann, Institute of Veterinary Physiology and Full, University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof Dr. J. Distler, Department of Rheumatology, University Hospital Erlangen Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. P. Kaufmann – USZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Dr. Yannick Allanore, Service de Rheumatologie A, Hôpital Cochin, Paris France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Matthias Guckenberger, Department of Radiation Oncology, University Hospital Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Boehringer Ingelheim Pharma GmbH & Co. KG Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Industry/business/other use-inspired collaboration
Debiopharma Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Exchange of personnel
- Industry/business/other use-inspired collaboration
Prof. Holger Moch, Department of Pathology, University Hospital Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof. Simon Ametamey - ETH Z Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
PD Dr. N. Schäfer – USZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Professor Paul PUMPENS, Latvian Biomedical Research and Study Centre, Riga, LV 1067, Latvia Lithuania (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Dr. Carol Feghali-Bostwick, Division of Rheumatology & Immunology, MUSC, Charleston, SC United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Advanced Accelerator Applications SA Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Industry/business/other use-inspired collaboration
InterAx Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Exchange of personnel
- Industry/business/other use-inspired collaboration
Prof. Thomas Frauenfelder, Department of Radiology, University Hospital Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof. Dr. Viola Vogel, D-HEST, ETH Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof. Phil Low - Purude University USA United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
5th Systemic Sclerosis World Congress of Rheumatology Poster Nuclear Imaging Biomarkers for Targeted Visualization of Interstitial Lung Disease in Systemic Sclerosis 16.02.2018 Bordeaux, France Brunner Matthias; Schibli Roger; Distler Oliver; Schniering Janine; Benesova Martina;
Sinergia Symposium: “Medical Imaging and Precision Medicine” Individual talk Nuclear Imaging for Targeted Visualization of Interstitial Lung Disease in Systemic Sclerosis 01.02.2018 Zurich, Switzerland Schibli Roger; Distler Oliver; Schniering Janine; Benesova Martina;
Sinergia Symposium:“Medical Imaging and Precision Medicine” Individual talk Vaccination strategies for the management of fibrotic diseases 01.02.2018 Zurich, Switzerland Brunner Matthias; Olomski Florian; Fettelschoss Antonia; Schniering Janine; Distler Oliver; Kündig Thomas;
PhD Committee Meeting Individual talk Novel imaging and therapeutic tools in systemic sclerosis 08.12.2017 Zurich, Switzerland Schniering Janine; Distler Oliver; Schibli Roger;
American College of Rheumatology Annual Meeting 2017 Poster Molecular Imaging Biomarkers for Personalized Medicine Strategies in Systemic Sclerosis-Related Interstitial Lung Disease 06.11.2017 San Diego, CA, United States of America Schibli Roger; Distler Oliver; Brunner Matthias; Schniering Janine; Benesova Martina;
Doktorandentag at the Department of Chemistry and Applied Biosciences ETH Zurich Individual talk Nuclear Imaging for Targeted Visualization of Interstitial Lung Disease in Systemic Sclerosis 13.09.2017 Zurich, Switzerland Distler Oliver; Schibli Roger; Schniering Janine; Benesova Martina; Brunner Matthias;
79th Annual Meeting of SSAHE Poster Molecular Targeted Imaging Biomarkers for Personalized Medicine Strategies in Systemic Sclerosis-Related Interstitial Lung Disease 08.09.2017 Zurich, Switzerland Schniering Janine; Benesova Martina; Schibli Roger; Brunner Matthias; Distler Oliver;
Swiss Congress of Rheumatology 2017 Poster Molecular Targeted Imaging Biomarkers for Personalized Medicine Strategies in Systemic Sclerosis-Related Interstitial Lung Disease 07.09.2017 Interlaken, Switzerland Schibli Roger; Brunner Matthias; Distler Oliver; Benesova Martina; Schniering Janine;
Annual European Congress of Rheumatology 2017 Talk given at a conference Molecular targeted imaging biomarkers for personalized medicine strategies in systemic sclerosis-related interstitial lung disease 14.06.2017 Madrid, Spain Benesova Martina; Schibli Roger; Distler Oliver; Brunner Matthias; Schniering Janine;
International Symposium on Radiopharmaceutical Sciences (ISRS) Talk given at a conference Evaluation of Various Radiolabeled Tracers for Early Detection of Lung Inflammation and Incipient Fibrosis 14.05.2017 Dresden, Germany Benesova Martina; Schibli Roger; Schniering Janine; Brunner Matthias; Distler Oliver;
16th Day of Clinical Research Talk given at a conference Targeted Nuclear Imaging for the Early Detection of Lung Involvement in Systemic Sclerosis 09.02.2017 Zurich, Switzerland Brunner Matthias; Schibli Roger; Benesova Martina; Distler Oliver; Schniering Janine;
Invited Talk at Novartis Individual talk New avenues in Systemic Sclerosis Research 09.01.2017 Basel, Switzerland Distler Oliver;
11th Central European Congress of Rheumatology Talk given at a conference Advances in treatment of scleroderma – from bench to bedside 08.12.2016 Prag, Czech Republic Distler Oliver;
Wagi Lunch Seminar Individual talk Targeted Nuclear Imaging for the Early Detection of Lung Involvement in Systemic Sclerosis 07.12.2016 Schlieren, Switzerland Benesova Martina; Schibli Roger; Jüngel Astrid; Schniering Janine; Distler Oliver;
Invited Talk at the Johns Hopkins Hospital Individual talk Molecular Targeted Imaging Biomarkers in Systemic Sclerosis 18.11.2016 Baltimore, United States of America Distler Oliver; Schniering Janine;
American College of Rheumatology Annual Meeting 2016 Talk given at a conference Targeted Nuclear Imaging for the Early Detection of Lung Involvement in Systemic Sclerosis 16.11.2016 Washington D.C., United States of America Schibli Roger; Haller Stephanie; Benesova Martina; Schniering Janine; Distler Oliver;
Lab Meeting Center of Experimental Rheumatology Individual talk Novel Imaging and Therapeutic Tools in Systemic Sclerosis - Progress Report 14.10.2016 Schlieren, Switzerland Schniering Janine; Jüngel Astrid; Distler Oliver;
18. Asia Pacific League of Associations for Rheumatology Congress Talk given at a conference Early detection and novel treatments for CTD-ILD 26.09.2016 Shanghai, China Distler Oliver;
18. Asia Pacific League of Associations for Rheumatology Congress Talk given at a conference Systemic sclerosis- update on diagnosis and therapies 26.09.2016 Shanghai, China Distler Oliver;
Sinergia Data Meeting Individual talk Novel Therapeutic Tools in Systemic Sclerosis- Targeting Cytokines for the Treatment of Systemic Sclerosis 22.09.2016 Zurich, Switzerland Distler Oliver; Schniering Janine; Kündig Thomas; Olomski Florian; Jüngel Astrid; Fettelschoss Antonia;
Deutscher Allergiekongress DAK Talk given at a conference VLP – der Weg zu neuen Adjuvantien 19.09.2016 Berlin, Germany Kündig Thomas;
Swiss Congress of Rheumatology 2016 Poster Early detection of lung involvement in systemic sclerosis using molecular targeted nuclear imaging 25.08.2016 Interlaken, Switzerland Distler Oliver; Schibli Roger; Haller Stephanie; Schniering Janine;
Sinergia Meeting 2016 Individual talk Novel Imaging and Therapeutic Tools in Systemic Sclerosis 24.06.2016 Schlieren, Switzerland Distler Oliver; Fettelschoss Antonia; Kündig Thomas; Schibli Roger; Schniering Janine; Benesova Martina; Olomski Florian; Jüngel Astrid;
4th Havemeryer Workshop on Equine Skin Allergy Talk given at a conference Therapeutic vaccination in IBH-affected horses 24.06.2016 Hvanneyri, Iceland Kündig Thomas; Fettelschoss Antonia;
11th Retreat of the Integrative Molecular Medicine PhD program Individual talk Early Detection of Lung Involvement in Systemic Sclerosis Using Molecular Targeted Imaging 13.06.2016 Magglingen, Switzerland Benesova Martina; Distler Oliver; Schibli Roger; Schniering Janine; Jüngel Astrid;
EAACI, European Academy Allergy Clinical Immunology Talk given at a conference VLP as novel adjuvants 12.06.2016 Vienna , Austria Kündig Thomas;
Annual European Congress of Rheumatology 2016 Talk given at a conference Early detection of lung involvement in systemic sclerosis using molecular targeted imaging 10.06.2016 London, Great Britain and Northern Ireland Schibli Roger; Distler Oliver; Schniering Janine; Haller Stephanie;
CRS Seminar Day 2016 Individual talk Early Detection of Lung Involvement in Systemic Sclerosis 13.05.2016 Zürich, Switzerland Schibli Roger; Schniering Janine;
Immunology Bern Meetings 2016 Individual talk Targeting Cytokines for the Treatment of Systemic Sclerosis - Novel Imaging and Therapeutic Tools 04.04.2016 Bern, Switzerland Fettelschoss Antonia; Olomski Florian; Kündig Thomas;
Lab Meeting Research of Systemic Autoimmune Diseases Individual talk Novel Imaging and Therapeutic Tools in Systemic Sclerosis - Progress Report 09.03.2016 Zürich, Switzerland Jüngel Astrid; Schniering Janine; Distler Oliver;
18th Conference on Advances in Targeted Therapies Talk given at a conference Update on Systemic Sclerosis 01.03.2016 Palma De Mallorca, Spain Distler Oliver;
4th Systemic Sclerosis World Congress Talk given at a conference How to take Skin Biopsies 18.02.2016 Lisbon, Portugal Distler Oliver;
Lab Meetings Dermatology Individual talk Targeting Cytokines for the Treatment of Systemic Sclerosis - Novel Imaging and Therapeutic Tools 27.01.2016 Zurich, Switzerland Fettelschoss Antonia; Olomski Florian; Kündig Thomas;
MIM Intro Course Individual talk Targeting Cytokines for the Treatment of Systemic Sclerosis 13.01.2016 Zurich, Switzerland Kündig Thomas; Olomski Florian;
Abschiedssymposium Leitung Rheumaklinik Universitätsspital Zürich Individual talk Rheumatologie, quo vadis? 03.12.2015 Zurich, Switzerland Distler Oliver;
Grand Colloque Commun d’Immunologie, Rhumatologie, Dermatologie, HUG Individual talk Novel developments in diagnosis and treatment of systemic sclerosis 01.12.2015 Geneva, Switzerland Distler Oliver;
Berner Immunologie-Tag Individual talk Translation von der Pathogenese zur Therapie 19.11.2015 Bern, Switzerland Distler Oliver;
Sinergia Meeting Individual talk Targeting Cytokines for the Treatment of Systemic Sclerosis 13.11.2015 Zurich/Research Lab of Systemic Autoimmune Diseases/USZ, Switzerland Kündig Thomas; Sun Tao; Haller Stephanie; Schibli Roger; Olomski Florian; Distler Oliver; Jüngel Astrid; Schniering Janine;
PhD committee meeting Individual talk Novel imaging and therapeutic tools in systemic sclerosis 13.11.2015 Zurich/USZ/Dermatology, Switzerland Kündig Thomas; Olomski Florian;
PhD Committee Meeting Individual talk Novel Imaging and Therapeutic Tools in Systemic Sclerosis and Generation of Bispecific Antibodies for the Immunotherapy of Cancer 13.11.2015 Zurich/Research Lab Systemic Autoimmune Diseases/USZ, Switzerland Kündig Thomas; Jüngel Astrid; Distler Oliver; Olomski Florian;
Lab Meeting Research of Systemic Autoimmune Diseases Individual talk Novel imaging and therapeutic tools in systemic sclerosis 21.10.2015 Zurich/Research lab of Systemic Autoimmune Diseases, Switzerland Schniering Janine; Jüngel Astrid; Distler Oliver; Olomski Florian;
Progress Report, Dermatology Seminar Individual talk Targeting Cytokines for the Treatment of Systemic Sclerosis - Novel Imaging and Therapeutic Tools 21.10.2015 Dermatology/USZ, Switzerland Kündig Thomas; Olomski Florian;
Invited Talk at Medical University of Bialystok Individual talk Animal models of fibrosis and vascular injury 10.10.2015 Bialystok, Poland Distler Oliver;
VLP Meeting Talk given at a conference Targeting Cytokines for the Treatment of Systemic Sclerosis 02.10.2015 Bern/Inselspital, Switzerland Olomski Florian; Kündig Thomas;
Masterclass on Digital Ulcers Individual talk Early detection of organ involvement in SSc 02.10.2015 Florence, Italy Distler Oliver;
Seminari di Rheumatologia, University of Florence Individual talk Animals models of SSc-what they are good for 01.10.2015 Florence, Italy Distler Oliver;
European Congress of Immunology Talk given at a conference Distinct T helper cell dependence of memory B cell proliferation versus plasma cell differentiation 09.09.2015 Vienna, Austria Kündig Thomas;
Invited Talk at the UTHealth Medical School, University of Texas Individual talk Translational Science in SSc - From Bench to Bedside 02.08.2015 Housten, United States of America Distler Oliver;
Rheumatology Research Seminar, Stanford University School of Medicine Individual talk Novel approaches to anti-fibrotic therapies in SSc 01.08.2015 Standford, United States of America Distler Oliver;
WSF & EUSTAR Scleroderma Masterclasses, I° Master Course on Ulcers in Systemic Sclerosis Individual talk The pathophysiology of vascular lesions in SSc 01.07.2015 Bucharest, Romania Distler Oliver;
CRS seminar day Talk given at a conference Novel imaging tools and therapy in systemic sclerosis 19.06.2015 Zurich/ETH, Switzerland Schniering Janine; Schibli Roger; Haller Stephanie;
Lab Meeting Research of Systemic Autoimmune Diseases Individual talk Novel imaging and therapeutic tools in systemic sclerosis 22.04.2015 Zurich, Research of Systemic Autoimmune Diseases/USZ, Switzerland Haller Stephanie; Olomski Florian; Jüngel Astrid; Schniering Janine; Distler Oliver;
EUSTAR educational course on systemic sclerosis Individual talk State of the art of SSc pathogenesis 26.02.2015 Katowice, Poland Distler Oliver;


Self-organised

Title Date Place
Sinergia Symposium: “Medical Imaging and Precision Medicine” 01.02.2018 Zurich, Switzerland

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Molekulare bildgebende Biomarker für die Diagnose der ILD Rheumanachrichten German-speaking Switzerland 2018
Talks/events/exhibitions Neues aus der Forschung. Patientenabend für Sklerodermie-Betroffene und interessierte Angehörige German-speaking Switzerland 2018
Talks/events/exhibitions Sinergia Symposium: “Medical Imaging and Precision Medicine” German-speaking Switzerland 2018
Talks/events/exhibitions "Nuclear Imaging for SSc-ILD", Tag der offenen Tür für SSc-Betroffene und interessierte Angehörige German-speaking Switzerland 2017
Media relations: print media, online media Biomarker discriminate lung inflammation and fibrosis in SSc-related interstitial lung disease Eular Congress News 2017 International 2017
Media relations: print media, online media Oliver Distler wird neuer Direktor der Klinik für Rheumatologie am UniversitätsSpital Zürich USZ News German-speaking Switzerland 2016
Media relations: print media, online media Radiotracer shows promise for early detection of SSc lung disease Eular Congress News International 2016
Media relations: print media, online media Schweizer Nationalfonds unterstützt Forschung in der Sklerodermie: Molekulare bildgebende Verfahren Schweizerische Vereinigung der Sklerodermie-Betroffenen German-speaking Switzerland 2016
Talks/events/exhibitions Understanding lung problems, Patient Programm, 4th Systemic Sclerosis World Congress International 2016
Media relations: print media, online media IATROS – neue bildgebende Verfahren und therapeutische Massnahmen in systemischer Sklerose (Sinergia website University Hospital German-speaking Switzerland International 2015

Awards

Title Year
Max Cloetta Research Position (awarded to PD. Dr. med Britta Maurer) 2017
Travel Bursary for the Annual European Congress of Rheumatology 2017, Madrid, Spain 2017
Travel Bursary for the Annual European Congress of Rheumatology 2016, London, UK 2016

Associated projects

Number Title Start Funding scheme
166259 Long non-coding RNAs in systemic sclerosis and other fibrotic diseases 01.06.2016 Project funding (Div. I-III)
180953 Self-assembling glycoprotein nanoparticle vaccines 01.01.2019 Bridge - Discovery

Abstract

Systemic sclerosis (SSc) is a multisystem autoimmune disease, in which vasculopathy, inflammation, and fibrosis result in a complex pattern of skin- and organ-based complications. The 10 year survival rate is as poor as 60%. The equally high morbidity does not only substantially decrease quality of life, but also represents a major socioeconomic burden. In the recent past, significant progress has been made in the identification of potential molecular and cellular targets for anti-fibrotic therapies with the help of appropriate animal models of SSc covering different aspects and combinations of disease pathophysiology. However, there is a lack of sensitive, disease-specific imaging tools allowing the detection of organ involvement at earliest, still reversible stages, and there is also a lack of clinically effective, specific antifibrotic therapies. This interdisciplinary Sinergia project aims to overcome the diagnostic and therapeutic shortcomings in SSc by joining scientific excellence in nuclear imaging (partner A), translational SSc research (partner B), and molecular-targeted immunization (partner C). Nuclear PET&SPECT/CT will be validated in different animal models of SSc using both novel as well as existing radiotracers which visualize key pathways of the SSc pathophysiology, i.e. microangiopathy (integrins), inflammation (activated macrophages expressing folate receptor (FR)-ß), inflammation-dependent (cannabinoid receptors) fibrosis, and inflammation-independent (integrins, fibroblast activation protein (FAP)) fibrosis. This sensitive and highly specific diagnostic approach should allow the detection of early preclinical organ involvement and help to monitor therapies. As a novel therapeutic concept, we propose the immunization of SSc mouse models against potential molecular key players in the pathogenesis of SSc including IL-1, IL-6, IL-12/23 (p40), IL-13, IL-17, and VEGF to specifically and sustainably inhibit these targeted molecules. Our approach could serve as a template for many other (multisystem) autoimmune diseases. Therefore, an optimized dissemination of new research results to enhance the scientific impact will be a key aspect of this consortium. Furthermore, the wide array of techniques used in this interdisciplinary proposal ranging from nuclear imaging methodologies, animal experiments, cellular and molecular biology methods to vaccine generation will provide a unique training opportunity for young researchers. The implementation of a structured and detailed mentoring program is also novel in such an interdisciplinary program and could prove efficacy and applicability for career development and education/teaching in this setting. If this project is successful, our approach will be translated from “bench to bedside” in clinical studies with SSc patients in order to optimize and personalize treatment in the future. Molecular imaging and vaccination therapies could thus lead to paradigm shift in the clinical care of SSc patients.
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