Séparation de patron d'activités neuronales; codage sensoriel; olfaction; inhibition
Gschwend Olivier, Beroud Jonathan, Vincis Roberto, Rodriguez Ivan, Carleton Alan (2016), Dense encoding of natural odorants by ensembles of sparsely activated neurons in the olfactory bulb, in Scientific Reports
, 6(1), 36514-36514.
Assens Alexis, Dal Col Julien A., Njoku Anthony, Dietschi Quentin, Kan Chenda, Feinstein Paul, Carleton Alan, Rodriguez Ivan (2016), Alteration of Nrp1 signaling at different stages of olfactory neuron maturation promotes glomerular shifts along distinct axes in the olfactory bulb, in Development
, 143(20), 3817-3825.
Godde Kathrin, Gschwend Olivier, Puchkov Dmytro, Pfeffer Carsten K., Carleton Alan, Jentsch Thomas J. (2016), Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination, in Nature Communications
, 7, 12043-12043.
von der Weid Beno?t, Rossier Daniel, Lindup Matti, Tuberosa Jo?l, Widmer Alexandre, Col Julien Dal, Kan Chenda, Carleton Alan, Rodriguez Ivan (2015), Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo, in Nature Neuroscience
, 18(10), 1455-1463.
Gschwend Olivier, Abraham Nixon M, Lagier Samuel, Begnaud Frédéric, Rodriguez Ivan, Carleton Alan (2015), Neuronal pattern separation in the olfactory bulb improves odor discrimination learning, in Nature Neuroscience
, 18(10), 1474-1482.
Vincis Roberto, Lagier Samuel, Van?De?Ville Dimitri, Rodriguez Ivan, Carleton Alan (2015), Sensory-Evoked Intrinsic Imaging Signals in the Olfactory Bulb Are Independent of Neurovascular Coupling, in Cell Reports
, 12(2), 313-325.
Boillat Madlaina, Challet Ludivine, Rossier Daniel, Kan Chenda, Carleton Alan, Rodriguez Ivan (2015), The Vomeronasal System Mediates Sick Conspecific Avoidance, in Current Biology
, 25(2), 251-255.
Gambino Frederic, Pages Stephane, Kehayas Vassilis, Baptista Daniela, Tatti Roberta, Carleton Alan, Holtmaat Anthony (2014), Sensory-evoked LTP driven by dendritic plateau potentials in vivo, in Nature
, 515(7525), 116-119.
Sensory environments force mammalian brain to adopt the best strategies to separate sensory objects for meaningful perception. The olfactory system is tuned to process complex inputs resulting from a large variety of odorant molecules. Odorants are known to recruit a combination of glomeruli in the olfactory bulb, further evoking complex firing patterns evolving in time in the population of bulbar output neurons, mitral/tufted (M/T) cells. Similar activity patterns evoked by related odorants may be separated over time, a mechanism called pattern decorrelation or separation. Although experimental evidences support slow pattern decorrelation in lower vertebrates such as fish, the existence of such mechanism and its behavioral relevance remain unexplored in mammals. Here we propose to investigate whether pattern decorrelation occurs in the olfactory bulb and if such separation is linked to discrimination behavior. We will use tetrode recordings in awake head-restrained mice, and odor discrimination behavior. We will test if ensemble decorrelation predicts the ability of the mouse to discriminate odorants. Finally, using channelrhodopsin stimulation, we will test if bulbar GABAergic neurons can enhance pattern decorrelation and further improve odor discrimination.