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Does ensemble decorrelation in the olfactory bulb predict odor discrimination behavior?

English title Does ensemble decorrelation in the olfactory bulb predict odor discrimination behavior?
Applicant Carleton Alan
Number 153410
Funding scheme Project funding (Div. I-III)
Research institution Dépt des Neurosciences Fondamentales Faculté de Médecine Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Neurophysiology and Brain Research
Start/End 01.04.2014 - 31.03.2017
Approved amount 600'000.00
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Keywords (4)

Séparation de patron d'activités neuronales; codage sensoriel; olfaction; inhibition

Lay Summary (French)

Lead
Est-ce que le bulbe olfactif est un réseau séparant les patrons d'activités induit par des odeurs pour améliorer l’apprentissage olfactif ?
Lay summary

Le cerveau des mammifères doit détecter et reconnaître les informations sensorielles présentes dans l’environnement afin de permettre à l’individu d’avoir des réponses comportementales adaptées. Le système olfactif est organisé de telle manière que le cerveau peut reconnaître des milliards de molécules différentes. Les odeurs sont détectées par les cellules réceptrices de l’épithélium olfactif se trouvant dans la cavité nasale. Ces cellules projettent leurs axones vers le premier relai cérébral de la voie sensorielle appelé le bulbe olfactif. A ce niveau les cellules mitrales reçoivent l’information sensorielle périphérique mais aussi des activités synaptiques venant de neurones inhibiteurs du bulbe olfactif. Les cellules mitrales intègrent l’ensemble de ces informations et véhiculent des patrons d’activité spécifiques des odeurs vers le cortex olfactif.

Des données de la littérature montrent que des odeurs discriminables mais perceptuellement très proches induisent des patrons d’activité des cellules sensorielles très semblables. Dans ce projet de recherche, nous voulons tester l’hypothèse que le réseau du bulbe olfactif est important pour convertir des représentations sensorielles périphériques similaires en des représentations sensorielles transmises vers le cortex plus différentes. En résumé, notre hypothèse est que le bulbe olfactif serait un réseau permettant la séparation d’odeurs similaires afin de le rendre plus facilement reconnaissable par le cortex, permettant ainsi un meilleur apprentissage. Nous testerons ces hypothèses en combinant imagerie cérébrale, électrophysiologie et comportement sur des souris de laboratoire.

Direct link to Lay Summary Last update: 03.04.2014

Responsible applicant and co-applicants

Employees

Publications

Publication
Dense encoding of natural odorants by ensembles of sparsely activated neurons in the olfactory bulb
Gschwend Olivier, Beroud Jonathan, Vincis Roberto, Rodriguez Ivan, Carleton Alan (2016), Dense encoding of natural odorants by ensembles of sparsely activated neurons in the olfactory bulb, in Scientific Reports, 6(1), 36514-36514.
Alteration of Nrp1 signaling at different stages of olfactory neuron maturation promotes glomerular shifts along distinct axes in the olfactory bulb
Assens Alexis, Dal Col Julien A., Njoku Anthony, Dietschi Quentin, Kan Chenda, Feinstein Paul, Carleton Alan, Rodriguez Ivan (2016), Alteration of Nrp1 signaling at different stages of olfactory neuron maturation promotes glomerular shifts along distinct axes in the olfactory bulb, in Development, 143(20), 3817-3825.
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
Godde Kathrin, Gschwend Olivier, Puchkov Dmytro, Pfeffer Carsten K., Carleton Alan, Jentsch Thomas J. (2016), Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination, in Nature Communications, 7, 12043-12043.
Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo
von der Weid Beno?t, Rossier Daniel, Lindup Matti, Tuberosa Jo?l, Widmer Alexandre, Col Julien Dal, Kan Chenda, Carleton Alan, Rodriguez Ivan (2015), Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo, in Nature Neuroscience, 18(10), 1455-1463.
Neuronal pattern separation in the olfactory bulb improves odor discrimination learning
Gschwend Olivier, Abraham Nixon M, Lagier Samuel, Begnaud Frédéric, Rodriguez Ivan, Carleton Alan (2015), Neuronal pattern separation in the olfactory bulb improves odor discrimination learning, in Nature Neuroscience, 18(10), 1474-1482.
Sensory-Evoked Intrinsic Imaging Signals in the Olfactory Bulb Are Independent of Neurovascular Coupling
Vincis Roberto, Lagier Samuel, Van?De?Ville Dimitri, Rodriguez Ivan, Carleton Alan (2015), Sensory-Evoked Intrinsic Imaging Signals in the Olfactory Bulb Are Independent of Neurovascular Coupling, in Cell Reports, 12(2), 313-325.
The Vomeronasal System Mediates Sick Conspecific Avoidance
Boillat Madlaina, Challet Ludivine, Rossier Daniel, Kan Chenda, Carleton Alan, Rodriguez Ivan (2015), The Vomeronasal System Mediates Sick Conspecific Avoidance, in Current Biology, 25(2), 251-255.
Sensory-evoked LTP driven by dendritic plateau potentials in vivo
Gambino Frederic, Pages Stephane, Kehayas Vassilis, Baptista Daniela, Tatti Roberta, Carleton Alan, Holtmaat Anthony (2014), Sensory-evoked LTP driven by dendritic plateau potentials in vivo, in Nature, 515(7525), 116-119.

Collaboration

Group / person Country
Types of collaboration
Prof. Holtmaat/ université de Genève Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Rodriguez/ université de Genève Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
invitation Max Planck institute Individual talk Ensemble coding and plasticity in the mammalian olfactory system. 02.12.2015 Jena, Germany Carleton Alan;
45th meeting of the society for neuroscience Talk given at a conference Neuronal pattern separation in the olfactory bulb improves odor discrimination learning 17.10.2015 chicago, United States of America Carleton Alan;
invitation Friedrich Miescher Institute Individual talk Ensemble coding and plasticity in the mammalian olfactory system 10.09.2015 Basel, Switzerland Carleton Alan;
invitation université de Antwerp Individual talk Neural coding in the mouse olfactory system 27.12.2014 Antwerp, Belgium Carleton Alan;
FENS meeting symposium: “Spotlight on olfaction: from odorant receptor to behavior” Individual talk Neuronal pattern separation in the olfactory bulb improves odor discrimination learning 05.07.2014 milan, Italy Carleton Alan;
Workshop: “Olfaction beyond boundaries: towards general principals of olfaction” Talk given at a conference Neuronal pattern separation in the olfactory bulb improves odor discrimination learning 27.05.2014 Cold Spring Harbor, United States of America Carleton Alan;
10th Giessbach Meeting “Cellular and Molecular Neurobiology of Mental Disease” Talk given at a conference Neuronal pattern separation in the olfactory bulb improves odor discrimination learning 15.05.2014 Giessbach , Switzerland Carleton Alan;


Communication with the public

Communication Title Media Place Year
Media relations: radio, television émission CQFD: Comment distingue-t-on les odeurs? RTS la première Western Switzerland 2015
Media relations: radio, television émission CQFD: Du nouveau dans l'IRM fonctionnelle RTS la première Western Switzerland 2015
Media relations: radio, television REPORTAGES VACARME sur MANGER :UN ACTE ENGAGE La première Western Switzerland 2015
Media relations: radio, television Des neurones qui influencent nos sens RSR Western Switzerland 2014
New media (web, blogs, podcasts, news feeds etc.) Discovery of a neuronal population that filters sensory information International 2014
Media relations: radio, television Téléjournal RTS1 Western Switzerland 2014
Media relations: print media, online media Tra naso e cervello i neuroni imparano ad annusare corriere della sera International 2014

Awards

Title Year
Prix Pfizer pour la recherche scientifique 2017

Associated projects

Number Title Start Funding scheme
139189 mechanisms underlying sensory coding and plasticity in olfaction 01.04.2012 SNSF Professorships
164091 Identifying environmental controls over the transcriptional activity of single cells across organs and systems 01.12.2015 R'EQUIP

Abstract

Sensory environments force mammalian brain to adopt the best strategies to separate sensory objects for meaningful perception. The olfactory system is tuned to process complex inputs resulting from a large variety of odorant molecules. Odorants are known to recruit a combination of glomeruli in the olfactory bulb, further evoking complex firing patterns evolving in time in the population of bulbar output neurons, mitral/tufted (M/T) cells. Similar activity patterns evoked by related odorants may be separated over time, a mechanism called pattern decorrelation or separation. Although experimental evidences support slow pattern decorrelation in lower vertebrates such as fish, the existence of such mechanism and its behavioral relevance remain unexplored in mammals. Here we propose to investigate whether pattern decorrelation occurs in the olfactory bulb and if such separation is linked to discrimination behavior. We will use tetrode recordings in awake head-restrained mice, and odor discrimination behavior. We will test if ensemble decorrelation predicts the ability of the mouse to discriminate odorants. Finally, using channelrhodopsin stimulation, we will test if bulbar GABAergic neurons can enhance pattern decorrelation and further improve odor discrimination.
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