attachment ; affect; oxytocine; aging; cognitive impairment; Alzheimer
Gomes Jardim Gabriel Behr, von Gunten Armin, da Silva Filho Irenio Gomes, Ziegelmann Patricia Klarmann, Bumaguin Daniela Benzano, Nogueira Eduardo Lopes, Engroff Paula, Neto Alfredo Cataldo (2019), Relationship between childhood maltreatment and geriatric depression: the mediator effect of personality traits, in International Psychogeriatrics
, 31(12), 1759-1767.
Tible Olivier, Mendez Montserrat, von Gunten Armin (2019), Phenomenological contribution to understanding of vocally disruptive behaviour: A clinical case study in a patient with dementia, in International Journal of Geriatric Psychiatry
, 34(9), 1294-1300.
Walsh Emilie, Blake Yvonne, Donati Alessia, Stoop Ron, von Gunten Armin (2019), Early Secure Attachment as a Protective Factor Against Later Cognitive Decline and Dementia, in Frontiers in Aging Neuroscience
, 11, 161.
Triana-Del Río Rodrigo, van den Burg Erwin, Stoop Ron, Hegoburu Chloé (2019), Acute and long-lasting effects of oxytocin in cortico-limbic circuits: consequences for fear recall and extinction, in Psychopharmacology
, 236(1), 339-354.
van den Burg Erwin H, Stoop Ron (2019), Neuropeptide signalling in the central nucleus of the amygdala, in Cell and Tissue Research
, 375(1), 93-101.
Tible Olivier, von Gunten Armin (2018), Oxytocin receptor polymorphisms and attachment style in patients with cognitive impairment and affective symptoms, in Journal of behavioral neuroscience
, 2(1), 1-6.
Terburg David, Scheggia Diego, Triana del Rio Rodrigo, Klumpers Floris, Ciobanu Alexandru Cristian, Morgan Barak, Montoya Estrella R., Bos Peter A., Giobellina Gion, van den Burg Erwin H., de Gelder Beatrice, Stein Dan J., Stoop Ron, van Honk Jack (2018), The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study, in Cell
, 175(3), 723-735.e16.
Haba-Rubio José, Ouanes Sami, Franc Yannick, Marques-Vidal Pedro, Waeber Gerard, Vollenweider Peter, von Gunten Armin, Preisig Martin, Kuehner Christine, Castelao Enrique, Heinzer Raphaël, Popp Julius (2018), Do diurnal cortisol levels mediate the association between sleep disturbances and cognitive impairment?, in Neurobiology of Aging
, 69, 65-67.
Grinevich Valery, Stoop Ron (2018), Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors, in Neuron
, 99(5), 887-904.
Behr Gomes Jardim Gabriel, Novelo Marta, Spanemberg Lucas, von Gunten Armin, Engroff Paula, Nogueira Eduardo Lopes, Cataldo Neto Alfredo (2018), Influence of childhood abuse and neglect subtypes on late-life suicide risk beyond depression, in Child Abuse & Neglect
, 80, 249-256.
Novelo Marta, von Gunten Armin, Gomes Jardim Gabriel Behr, Spanemberg Lucas, Argimon Irani Iracema de Lima, Nogueira Eduardo L. (2018), Effects of childhood multiple maltreatment experiences on depression of socioeconomic disadvantaged elderly in Brazil, in Child Abuse & Neglect
, 79, 350-357.
von GuntenArmin, WalshEmilie, DonatiAlessia (2018), Influence des relations primaires et manifestations des symptômes comportementaux et psychologiques., in La Gazette médicale
Tautvydaitė D., Antonietti J.P., Henry H., von Gunten A., Popp J. (2017), Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology, in Journal of Psychiatric Research
, 90, 12-20.
Tible Olivier Pierre, Riese Florian, Savaskan Egemen, von Gunten Armin (2017), Best practice in the management of behavioural and psychological symptoms of dementia, in Therapeutic Advances in Neurological Disorders
, 10(8), 297-309.
Ouanes Sami, Castelao Enrique, von Gunten Armin, Vidal Pedro M., Preisig Martin, Popp Julius (2017), Personality, Cortisol, and Cognition in Non-demented Elderly Subjects: Results from a Population-Based Study, in Frontiers in Aging Neuroscience
, 9, 63.
Ouanes Sami, Castelao Enrique, Gebreab Sirak, von Gunten Armin, Preisig Martin, Popp Julius (2017), Life events, salivary cortisol, and cognitive performance in nondemented subjects: a population-based study, in Neurobiology of Aging
, 51, 1-8.
Stoop Ron, Yu Xiang (2017), Special issue on: “Oxytocin in development and plasticity”Oxytocin, in Developmental Neurobiology
, 77(2), 125-127.
Zufferey Valérie, Donati Alessia, Popp Julius, Meuli Reto, Rossier Jérôme, Frackowiak Richard, Draganski Bogdan, Gunten Armin, Kherif Ferath (2017), Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease, in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
, 7(1), 107-114.
Koen N., Fourie J., Terburg D., Stoop R., Morgan B., Stein D.J., van Honk J. (2016), Translational neuroscience of basolateral amygdala lesions: Studies of urbach-wiethe diseaseBLA Lesions and Urbach-Wiethe Disease, in Journal of Neuroscience Research
, 94(6), 504-512.
Stoop Ron (2016), Sniffing and Oxytocin: Effects on Olfactory Memories, in Neuron
, 90(3), 431-433.
Eliava Marina, Melchior Meggane, Knobloch-Bollmann H. Sophie, Wahis Jérôme, da Silva Gouveia Miriam, Tang Yan, Ciobanu Alexandru Cristian, Triana del Rio Rodrigo, Roth Lena C., Althammer Ferdinand, Chavant Virginie, Goumon Yannick, Gruber Tim, Petit-Demoulière Nathalie, Busnelli Marta, Chini Bice, Tan Linette L., Mitre Mariela, Froemke Robert C., Chao Moses V., Giese Günter, Sprengel Rolf, Kuner Rohini, Poisbeau Pierrick, et al. (2016), A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing, in Neuron
, 89(6), 1291-1304.
Stoop Ron, Hegoburu Chloé, van den Burg Erwin (2015), New Opportunities in Vasopressin and Oxytocin Research: A Perspective from the Amygdala, in Annual Review of Neuroscience
, 38(1), 369-388.
Background. Human beings are a profoundly social species and spend a great deal of their time interacting with each other. Social bonding or attachment issues remain central stage throughout every person’s life. With advancing age, the elderly are exposed to multiple losses, be they cognitive, physical or relational. These losses may put considerable strain on the elderly and their interpersonal bonds. Premorbid attachment styles may shape the behavioural and psychological response to these losses and, thus, the clinical expression of early cognitive disorders in later life. Behavioural and psychological symptoms and signs of the affective type (aBPS) are tremendously frequent in cognitive disorders and among the most important determinants of patient and caregiver distress. As disease-modifying therapies in most cognitive disorders are by and large lacking, quality-of-life-oriented approaches such as those aiming at improving aBPS are urgently needed. Whether or not premorbid characteristics are associated with aBPS in early cognitive disorders remains a matter of debate. However, increasing evidence suggests that premorbid personality traits play a role in the clinical expression of aBPS. These observations and the association between personality traits and attachment styles suggest that adult attachment styles may also have an impact on the clinical expression in early cognitive disorders. However, currently available data are very scarce. Furthermore, the current state of the art is difficult to interpret because of conceptual and methodological differences. These include not only differences in the assessment of both attachment and aBPS, but also the variability of possible biomarkers associated with attachment characteristics or aBPS. Work stemming from various fields of research on attachment suggests that oxytocin and vasopressin (OT/VP) may both be major determinants of attachment characteristics and possibly be associated with aBPS. Hypothesis. In patients with early cognitive impairment, the appearance of aBPS is associated with the presence of premorbid insecure attachment profiles as a result of underlying differences in OT/VP signalling. Aims. To test our hypothesis, we plan to conduct the following cross-sectional studies: In part A) we will assess whether the presence of aBPS in patients with early cognitive impairment co-segregates with insecure attachment profiles In part B) we will assess whether differences in OT/VP signalling co-segregate, on one hand, with differences in secure versus insecure attachment profiles in both control and cognitively impaired patients and, on the other hand, with the presence of aBPS in cognitively impaired patients. Potential differences in OT/VP signalling will be investigated by measuring OT/VP levels in blood and cerebrospinal fluid as well as by assessing polymorphisms in OT/VP receptor genes. Relevance. In case of confirmation of our hypothesis, such findings could quickly lead to both drug and person-centred psychosocial intervention studies. Ultimately, clinically useful interventions in the cognitively impaired elderly with aBPS may be derived from this study as aBPS may be treatable by changing OT/VP signalling in these patients either through pharmacological intervention or behavioural therapies or both. Of course, a follow-up study will be envisioned depending on the results of this cross-sectional part; it will also include the question as to whether or not specific attachment patterns predict further cognitive decline in patients with early cognitive disorder.