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Pathoplastic effect of attachment characteristics on behavioural and psychological symptoms of beginning cognitive disorders in the elderly

English title Pathoplastic effect of attachment characteristics on behavioural and psychological symptoms of beginning cognitive disorders in the elderly
Applicant von Gunten Armin
Number 153378
Funding scheme Project funding (Div. I-III)
Research institution Service Universitaire de Psycho- gériatrie de Lausanne Hôpital de Prilly
Institution of higher education University of Lausanne - LA
Main discipline Neurology, Psychiatry
Start/End 01.04.2015 - 31.03.2020
Approved amount 474'000.00
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Keywords (6)

attachment ; affect; oxytocine; aging; cognitive impairment; Alzheimer

Lay Summary (French)

Lead
Lead.L’humain est une espèce profondément sociale et passe un temps considérable à interagir avec d’autres personnes. Les liens sociaux et l’attachement aux autres sont d’une importance capitale tout au long de la vie de chacun. L’influence de l’attachement sur les comportements et l’état affectif des personnes âgées avec des troubles cognitifs comme par ex. ceux dus à la maladie d’Alzheimer est inconnue.
Lay summary

Contenu et objectifs du projet de recherche.

L’expression clinique des maladies cognitives est en général considérée comme étant due à l’atteinte du cerveau. L’approche plus récente considère cependant que le psychisme forgé durant toute une vie joue un rôle non-négligeable et influence les manifestations cliniques de ces maladies.

Cette étude porte sur les malades âgées (presque 20% de la population suisse) ayant un trouble cognitif débutant. On estime qu’environ 110'000 personnes âgées ont un syndrome démentiel léger à avancé et peut-être le double a un trouble cognitif léger. L’observation récente que les traits de personnalité influencent l’expression clinique des maladies cognitives suggère une première partie de cette étude qui consistera à déterminer s’il y a un lien entre les types d’attachements et les manifestations affectives des pathologies cognitives débutantes. Une deuxième partie consiste à évaluer si les types d’attachement d’une part et les manifestations affectives d’autre part sont en lien avec la génétique et le dosage de neuropeptides spécifiques (oxytocine et vasopressine) dont on sait qu’elles jouent un rôle dans l’attachement chez la personne normale.

 

Contexte scientifique et social du projet de recherche.

Le projet relève de la recherche clinique. Cette étude aidera à mieux comprendre les origines et les mécanismes des troubles affectifs chez des malades souffrant d’un trouble cognitif tel une maladie d’Alzheimer et, par conséquent, de mieux aider et conseiller les personnes touchées par ces maladies et leurs proches dont le nombre toujours croissant représente un sérieux enjeu en terme de santé publique mondiale. 

 

Direct link to Lay Summary Last update: 23.04.2014

Responsible applicant and co-applicants

Employees

Project partner

Publications

Publication
Relationship between childhood maltreatment and geriatric depression: the mediator effect of personality traits
Gomes Jardim Gabriel Behr, von Gunten Armin, da Silva Filho Irenio Gomes, Ziegelmann Patricia Klarmann, Bumaguin Daniela Benzano, Nogueira Eduardo Lopes, Engroff Paula, Neto Alfredo Cataldo (2019), Relationship between childhood maltreatment and geriatric depression: the mediator effect of personality traits, in International Psychogeriatrics, 31(12), 1759-1767.
Phenomenological contribution to understanding of vocally disruptive behaviour: A clinical case study in a patient with dementia
Tible Olivier, Mendez Montserrat, von Gunten Armin (2019), Phenomenological contribution to understanding of vocally disruptive behaviour: A clinical case study in a patient with dementia, in International Journal of Geriatric Psychiatry, 34(9), 1294-1300.
Early Secure Attachment as a Protective Factor Against Later Cognitive Decline and Dementia
Walsh Emilie, Blake Yvonne, Donati Alessia, Stoop Ron, von Gunten Armin (2019), Early Secure Attachment as a Protective Factor Against Later Cognitive Decline and Dementia, in Frontiers in Aging Neuroscience, 11, 161.
Acute and long-lasting effects of oxytocin in cortico-limbic circuits: consequences for fear recall and extinction
Triana-Del Río Rodrigo, van den Burg Erwin, Stoop Ron, Hegoburu Chloé (2019), Acute and long-lasting effects of oxytocin in cortico-limbic circuits: consequences for fear recall and extinction, in Psychopharmacology, 236(1), 339-354.
Neuropeptide signalling in the central nucleus of the amygdala
van den Burg Erwin H, Stoop Ron (2019), Neuropeptide signalling in the central nucleus of the amygdala, in Cell and Tissue Research, 375(1), 93-101.
Oxytocin receptor polymorphisms and attachment style in patients with cognitive impairment and affective symptoms
Tible Olivier, von Gunten Armin (2018), Oxytocin receptor polymorphisms and attachment style in patients with cognitive impairment and affective symptoms, in Journal of behavioral neuroscience, 2(1), 1-6.
The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study
Terburg David, Scheggia Diego, Triana del Rio Rodrigo, Klumpers Floris, Ciobanu Alexandru Cristian, Morgan Barak, Montoya Estrella R., Bos Peter A., Giobellina Gion, van den Burg Erwin H., de Gelder Beatrice, Stein Dan J., Stoop Ron, van Honk Jack (2018), The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study, in Cell, 175(3), 723-735.e16.
Do diurnal cortisol levels mediate the association between sleep disturbances and cognitive impairment?
Haba-Rubio José, Ouanes Sami, Franc Yannick, Marques-Vidal Pedro, Waeber Gerard, Vollenweider Peter, von Gunten Armin, Preisig Martin, Kuehner Christine, Castelao Enrique, Heinzer Raphaël, Popp Julius (2018), Do diurnal cortisol levels mediate the association between sleep disturbances and cognitive impairment?, in Neurobiology of Aging, 69, 65-67.
Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors
Grinevich Valery, Stoop Ron (2018), Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors, in Neuron, 99(5), 887-904.
Influence of childhood abuse and neglect subtypes on late-life suicide risk beyond depression
Behr Gomes Jardim Gabriel, Novelo Marta, Spanemberg Lucas, von Gunten Armin, Engroff Paula, Nogueira Eduardo Lopes, Cataldo Neto Alfredo (2018), Influence of childhood abuse and neglect subtypes on late-life suicide risk beyond depression, in Child Abuse & Neglect, 80, 249-256.
Effects of childhood multiple maltreatment experiences on depression of socioeconomic disadvantaged elderly in Brazil
Novelo Marta, von Gunten Armin, Gomes Jardim Gabriel Behr, Spanemberg Lucas, Argimon Irani Iracema de Lima, Nogueira Eduardo L. (2018), Effects of childhood multiple maltreatment experiences on depression of socioeconomic disadvantaged elderly in Brazil, in Child Abuse & Neglect, 79, 350-357.
Influence des relations primaires et manifestations des symptômes comportementaux et psychologiques.
von GuntenArmin, WalshEmilie, DonatiAlessia (2018), Influence des relations primaires et manifestations des symptômes comportementaux et psychologiques., in La Gazette médicale, 3.
Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology
Tautvydaitė D., Antonietti J.P., Henry H., von Gunten A., Popp J. (2017), Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology, in Journal of Psychiatric Research, 90, 12-20.
Best practice in the management of behavioural and psychological symptoms of dementia
Tible Olivier Pierre, Riese Florian, Savaskan Egemen, von Gunten Armin (2017), Best practice in the management of behavioural and psychological symptoms of dementia, in Therapeutic Advances in Neurological Disorders, 10(8), 297-309.
Personality, Cortisol, and Cognition in Non-demented Elderly Subjects: Results from a Population-Based Study
Ouanes Sami, Castelao Enrique, von Gunten Armin, Vidal Pedro M., Preisig Martin, Popp Julius (2017), Personality, Cortisol, and Cognition in Non-demented Elderly Subjects: Results from a Population-Based Study, in Frontiers in Aging Neuroscience, 9, 63.
Life events, salivary cortisol, and cognitive performance in nondemented subjects: a population-based study
Ouanes Sami, Castelao Enrique, Gebreab Sirak, von Gunten Armin, Preisig Martin, Popp Julius (2017), Life events, salivary cortisol, and cognitive performance in nondemented subjects: a population-based study, in Neurobiology of Aging, 51, 1-8.
Special issue on: “Oxytocin in development and plasticity”Oxytocin
Stoop Ron, Yu Xiang (2017), Special issue on: “Oxytocin in development and plasticity”Oxytocin, in Developmental Neurobiology, 77(2), 125-127.
Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease
Zufferey Valérie, Donati Alessia, Popp Julius, Meuli Reto, Rossier Jérôme, Frackowiak Richard, Draganski Bogdan, Gunten Armin, Kherif Ferath (2017), Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease, in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 7(1), 107-114.
Translational neuroscience of basolateral amygdala lesions: Studies of urbach-wiethe diseaseBLA Lesions and Urbach-Wiethe Disease
Koen N., Fourie J., Terburg D., Stoop R., Morgan B., Stein D.J., van Honk J. (2016), Translational neuroscience of basolateral amygdala lesions: Studies of urbach-wiethe diseaseBLA Lesions and Urbach-Wiethe Disease, in Journal of Neuroscience Research, 94(6), 504-512.
Sniffing and Oxytocin: Effects on Olfactory Memories
Stoop Ron (2016), Sniffing and Oxytocin: Effects on Olfactory Memories, in Neuron, 90(3), 431-433.
A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing
Eliava Marina, Melchior Meggane, Knobloch-Bollmann H. Sophie, Wahis Jérôme, da Silva Gouveia Miriam, Tang Yan, Ciobanu Alexandru Cristian, Triana del Rio Rodrigo, Roth Lena C., Althammer Ferdinand, Chavant Virginie, Goumon Yannick, Gruber Tim, Petit-Demoulière Nathalie, Busnelli Marta, Chini Bice, Tan Linette L., Mitre Mariela, Froemke Robert C., Chao Moses V., Giese Günter, Sprengel Rolf, Kuner Rohini, Poisbeau Pierrick, et al. (2016), A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing, in Neuron, 89(6), 1291-1304.
New Opportunities in Vasopressin and Oxytocin Research: A Perspective from the Amygdala
Stoop Ron, Hegoburu Chloé, van den Burg Erwin (2015), New Opportunities in Vasopressin and Oxytocin Research: A Perspective from the Amygdala, in Annual Review of Neuroscience, 38(1), 369-388.

Collaboration

Group / person Country
Types of collaboration
PsychoLaus Study. Multiple-FNS-funded. M. Preisig Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Biomarker study in the normal and cognitively impaired elderly. FNS grant. J. Popp Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Instituto de Geriatria e Gerontologia da Pontificia Universidade Catolica do Rio Grande do Sul Brazil (South America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Oxytocin as a key factor in behavioral and psychological symptoms ...-Synapsis Foundation - R. Stoop Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Psychologie du développement. Prof. R Miljkovitch France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Exchange of personnel
Prof. Jack van Honk, Stellenbosch University South Africa (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Measuring oxytocin in human blood with novel combination of Darpin... - Spark program FNS - R. Stoop Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Synapsis Foundation / Swiss-South African Joint Research Programme (SSAJRP) du FNS Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Synapsis foundation meeting Poster Humans with Urbach Wiethe Disease: Afrikaners with specific loss of BLA as a human model for Hyper Emotionality in patients with Alzheimer's disease 01.11.2018 Lausanne, Stateless von Gunten Armin; Stoop Ronaldus;
Jeudi de la Vaudoise. Psychiatrie gériatrique. Société Vaudoise de Médecine Talk given at a conference Aspects psychiatriques et comportementaux des démences débutantes à modérées et leur prise en charge 18.01.2018 Lausanne, Switzerland von Gunten Armin;
Journée de recherche du DP-CHUV Talk given at a conference Troubles anxieux et dégénérescence de l’amygdale chez des patients avec un trouble cognitif débutant 17.11.2017 Lausanne, Switzerland Stoop Ronaldus; von Gunten Armin;
Journée de recherche du DP-CHUV Talk given at a conference L’influence des caractéristiques de l’attachement sur les affects des patients âgés avec un trouble cognitif débutant 17.11.2017 Lausanne, Switzerland Walsh Emilie; Donati Alessia; von Gunten Armin; Stoop Ronaldus;
Schwabe symposium “Pushing back frontiers in neuropsychiatric disease therapy”. World Psychiatric Association World Congress of psychiatry Talk given at a conference Behavioural and psychological symptoms associated with dementia (BPSD) : prevalence, clinical importance, and treatment options 08.10.2017 Berlin, Germany von Gunten Armin;
Plénière lors du Congrès de la Société de Psychogériatrie de Langue Française (SPLF) Talk given at a conference Modèle étiopathogénique du traitement des symptômes comportementaux et psychologiques des démences (SCPD) 14.09.2017 Limoges, France von Gunten Armin;
IAC International Attachment Conference Poster Attachment in the elderly: respective roles of primary and/or later relationships on coping with early cognitive disorders 29.06.2017 London - UK, Stateless von Gunten Armin; Donati Alessia; Walsh Emilie;
International Psychogeriatric Association 2016 Asian Regional Meeting Poster Specific personality changes in subjects with MCI and mild dementia are associated with cerebral Alzheimer’s disease pathology 09.12.2016 Taipei, Taiwan Popp Julius; von Gunten Armin;
International Psychogeriatric Association 2016 Asian Regional Meeting Poster Personality, cortisol, and cognition in non-demented subjects: a population-based study 09.12.2016 Taipei, Taiwan Popp Julius; von Gunten Armin;
Symposium “Troubles de la personnalité chez le sujet âgé”. 8ème Congrès Français de Psychiatrie Talk given at a conference Déclin cognitif et personnalité 25.11.2016 Montpellier, France von Gunten Armin;
Congress of the Swiss Society for Psychiatry and Psychotherapy and the Swiss Society for Child and Adolescent Psychiatry and Psychotherapy Poster Specific personality changes in subjects with MCI and mild dementia are associated with cerebral Alzheimer’s pathology 18.08.2016 Bâle, Switzerland Popp Julius; von Gunten Armin;
19ème Journée de recherche des Départements de Psychiatrie de Lausanne et de Genève Talk given at a conference Specific personality changes in subjects with MCI and mild dementia are associated with cerebral Alzheimer’s pathology 09.06.2016 Genève, Switzerland von Gunten Armin; Popp Julius;
19ème Journée de recherche des Départements de Psychiatrie de Lausanne et de Genève Talk given at a conference Cortisol, life events and cognition in non-demented subjects: a population-based study 09.06.2016 Genève, Switzerland Popp Julius; von Gunten Armin;
Schwabe Symposium. Congress of the European Academy of Neurology Talk given at a conference Behavioural and psychological symptoms associated with dementia (BPSD): prevalence, clinical importance and treatment options 28.05.2016 Copenhague, Denmark von Gunten Armin;
24th Congress of the European Psychiatric Association Poster Specific personality changes in subjects with MCI and mild dementia are associated with cerebral Alzheimer’s pathology 12.03.2016 Madrid, Spain Popp Julius; von Gunten Armin;
EMJ (European Medical Journal) Neurology 2016 ; 41:47-48 Poster Schwabe symposium on behavioural and psychological symptoms associated with dementia: prevalence, clinical importance, and treatment options 01.01.2016 EMJ, Stateless von Gunten Armin;
24th European Congress of Psychiatry. Eur Psychiatry Poster Cortisol, life events and cognition in non-demented subjects: a population-based study 01.01.2016 ?, Stateless von Gunten Armin; Popp Julius;
A comparative analysis of Alzheimer's and Urbach Wiethe Disease Swiss Society for Neuroscience meetings Talk given at a conference Neurodegenerative Loss of Amygdala Inhibition and Hyper Emotionality 01.01.2016 Lausanne, Stateless von Gunten Armin; Stoop Ronaldus;
Post-graduate lecture to psychiatrist of the Psychiatrische Dienste Solothurn Individual talk Persönlichkeit und Demenz 25.10.2015 Soleure, Switzerland von Gunten Armin;
A comparative analysis of Alzheimer's and Urbach Wiethe Disease Lemanic Neuroscience Doctoral School meeting Talk given at a conference Neurodegenerative Loss of Amygdala Inhibition and Hyper Emotionality 01.09.2015 Les Diablerets, Switzerland von Gunten Armin; Stoop Ronaldus;


Self-organised

Title Date Place

Knowledge transfer events



Self-organised

Title Date Place
Mystères de l'UNIL 24.05.2019 Lausanne, Switzerland

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Amygdale et attachement Allez Savoir Western Switzerland 2019
Print (books, brochures, leaflets) Les mystères de la peur, interviewé et écrit par Bruno Pellegrino Western Switzerland 2019
Talks/events/exhibitions Mystères de l'UNIL Western Switzerland 2019
Talks/events/exhibitions Portes ouvertes MP16 : A l'occasion de la Journée mondiale Alzheimer Western Switzerland 2019
Talks/events/exhibitions Quoi de neuf, Docteur? Soirée conférence tout public. Association Alzheimer Vaud Western Switzerland 2018
Talks/events/exhibitions Portes ouvertes MP16 : Attachement et maladie d'Alzheimer Western Switzerland 2017
Talks/events/exhibitions World Alzheimer Day : Attachement et maladie d'Alzheimer Western Switzerland 2017
Media relations: radio, television Et guérir de tendresse France 5 International 2016
Media relations: radio, television rsr CQFD Western Switzerland 2015

Awards

Title Year
Horizon 2020 Marie Skłodowska-Curie Individual Fellowship, project URBACH-ALZ, 01.2017-01.2019, Support for Dr. Diego Scheggia which allowed him (as described above) to develop a very promising animal model for different types of fear responses in UWD patients that we apply to AD patients in the current project. 2017
Bourse octroyée par la Confédération Suisse dans le cadre des Scholarships d'Excellence obtenue par la (entretemps) Dre Y Blake, originaire de l'Afrique du Sud, pour faire une thèse en Suisse au Centre de Neurosciences psychiatriques sur le site de Cery, co-tutoré par Profs. R Stoop, A von Gunten et J van Honk (Stellenbosch University, South Africa). 2015
Bourse par le fonds National Sud Africain, pour faire une thèse co-tutoré par Profs. R Stoop, J van Honk et A von Gunten au Centre de Neurosciences Psychiatriques. La (entretemps) Dre Y Blake, originaire de l'Afrique du Sud, a obtenu cette bourse pour étudier 3 ans pour une thèse doctorale en Suisse 2015
P.S. Titre de la thèse d'Y Blake: Emotional Processing and Anxiety in Patients with Mild Cognitive Impairment and Healthy Older Adults (could not edit the previous entries anymore, system does not seem to allow that !) 2015

Associated projects

Number Title Start Funding scheme
122263 The impact of personality characterisitcs on the clinical expression of MCI 01.03.2009 Project funding (Div. I-III)
186239 Swiss Centenarian Study (SWISS100): Vulnerability and Resilience at Age 100 01.01.2020 Sinergia

Abstract

Background. Human beings are a profoundly social species and spend a great deal of their time interacting with each other. Social bonding or attachment issues remain central stage throughout every person’s life. With advancing age, the elderly are exposed to multiple losses, be they cognitive, physical or relational. These losses may put considerable strain on the elderly and their interpersonal bonds. Premorbid attachment styles may shape the behavioural and psychological response to these losses and, thus, the clinical expression of early cognitive disorders in later life. Behavioural and psychological symptoms and signs of the affective type (aBPS) are tremendously frequent in cognitive disorders and among the most important determinants of patient and caregiver distress. As disease-modifying therapies in most cognitive disorders are by and large lacking, quality-of-life-oriented approaches such as those aiming at improving aBPS are urgently needed. Whether or not premorbid characteristics are associated with aBPS in early cognitive disorders remains a matter of debate. However, increasing evidence suggests that premorbid personality traits play a role in the clinical expression of aBPS. These observations and the association between personality traits and attachment styles suggest that adult attachment styles may also have an impact on the clinical expression in early cognitive disorders. However, currently available data are very scarce. Furthermore, the current state of the art is difficult to interpret because of conceptual and methodological differences. These include not only differences in the assessment of both attachment and aBPS, but also the variability of possible biomarkers associated with attachment characteristics or aBPS. Work stemming from various fields of research on attachment suggests that oxytocin and vasopressin (OT/VP) may both be major determinants of attachment characteristics and possibly be associated with aBPS. Hypothesis. In patients with early cognitive impairment, the appearance of aBPS is associated with the presence of premorbid insecure attachment profiles as a result of underlying differences in OT/VP signalling. Aims. To test our hypothesis, we plan to conduct the following cross-sectional studies: In part A) we will assess whether the presence of aBPS in patients with early cognitive impairment co-segregates with insecure attachment profiles In part B) we will assess whether differences in OT/VP signalling co-segregate, on one hand, with differences in secure versus insecure attachment profiles in both control and cognitively impaired patients and, on the other hand, with the presence of aBPS in cognitively impaired patients. Potential differences in OT/VP signalling will be investigated by measuring OT/VP levels in blood and cerebrospinal fluid as well as by assessing polymorphisms in OT/VP receptor genes. Relevance. In case of confirmation of our hypothesis, such findings could quickly lead to both drug and person-centred psychosocial intervention studies. Ultimately, clinically useful interventions in the cognitively impaired elderly with aBPS may be derived from this study as aBPS may be treatable by changing OT/VP signalling in these patients either through pharmacological intervention or behavioural therapies or both. Of course, a follow-up study will be envisioned depending on the results of this cross-sectional part; it will also include the question as to whether or not specific attachment patterns predict further cognitive decline in patients with early cognitive disorder.
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