Project

Back to overview

Development of New Quantitative Steady State Magnetic Resonance Imaging Concepts for Fast High-Resolution Relaxometry of Living Tissue

English title Development of New Quantitative Steady State Magnetic Resonance Imaging Concepts for Fast High-Resolution Relaxometry of Living Tissue
Applicant Bieri Oliver
Number 153332
Funding scheme Project funding (Div. I-III)
Research institution Radiologische Physik Departement Radiologie Universitätsspital Basel
Institution of higher education University of Basel - BS
Main discipline Biophysics
Start/End 01.07.2014 - 30.06.2018
Approved amount 371'026.00
Show all

All Disciplines (2)

Discipline
Biophysics
Other disciplines of Physics

Keywords (7)

steady state free precession; MRI; quantification; SSFP; relaxomentry; magnetic resonance imaging; Ultra-High Field MRI

Lay Summary (German)

Lead
Die Entwicklung neuer - und insbesondere schneller - quantitativer bildgebender Magnet-Resonanz-Tomographie (MRT) Verfahren bildet einen der herausforderndsten und zukunftsträchtigsten Aspekte der modernen MRT. Dieses Projekt leistet dazu einen Beitrag.
Lay summary

Die Messung biochemischer und biophysikalischer Eigenschaften nimmt eine zentrale Stellung in den meisten naturwissenschaftlichen Disziplinen und auch der medizinischen Diagnostik ein. Die konventionelle MRT in der klinischen Radiologie ist jedoch eher qualitativer Natur, d.h., sie beschränkt sich meist auf eine „Hell-Dunkel-Interpretation von Bildpunkten“. Eine quantitative Erfassung von Veränderungen, z.B. in pathologischem Gewebe oder als Folge  einer medizinischen Behandlung, zeigt jedoch den entscheidenden Vorteil, dass der Interpretationsspielraum klein, die Daten objektiv (und damit vorurteilsfrei) und im Allgemeinen gut reproduzierbar sind. Grundsätzlich benötigen quantitative, verglichen mit qualitativen, MRT Verfahren aber deutlich längere Aufnahmezeiten, weshalb im klinischen Umfeld schnelle Aufnahmeverfahren von besonderer Bedeutung sind. Ziel dieses Forschungsprojektes ist die Entwicklung neuer und insbesondere schneller MRT Verfahren zur Bestimmung der Relaxationseigenschaften, resp. der Relaxationszeiten T1 und T2, von Gewebe. Beide quantitative Parameter gehören zu den bedeutendsten und sensitivsten Kenngrössen der MRT für pathologische Veränderungen, da sie direkt die Interaktion der Wassermoleküle mit ihrer lokalen Umgebung widerspiegeln.

Direct link to Lay Summary Last update: 02.07.2014

Responsible applicant and co-applicants

Employees

Publications

Collaboration

Group / person Country
Types of collaboration
Klaus Scheffler, Ph.D., Magentic-Resonance-Center, Max-Planck-Institut für biologische Kybernetik Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Proceedings of the International Society of Megnetic Resonance in Medicine (ISMRM) Talk given at a conference Simultaneous B1 and T1 Mapping Using Spiral Variable-Flip-Angle Acquisitions for Whole-Brain Coverage in Less Than One Minute 16.06.2018 Paris, France Bieri Oliver; Heule Rahel;
Proceedings of the International Society of Megnetic Resonance in Medicine (ISMRM) Poster On the decay of SSFP configurations 22.04.2017 Hawaii, United States of America Nguyen Damien; Bieri Oliver;
Proceedings of the International Society of Megnetic Resonance in Medicine (ISMRM) Poster Simultaneous multi-slice triple-echo steady-state (SMS-TESS) T1, T2, PD, and B0 mapping in the human brain 22.04.2017 Hawaii, United States of America Bieri Oliver; Heule Rahel;
Proceedings of the International Society of Megnetic Resonance in Medicine (ISMRM) Poster Snapshot whole-brain T1 mapping using 2D multi-slice variable flip angle spiral imaging with steady-state preparation 22.04.2017 Hawaii, United States of America Heule Rahel; Bieri Oliver;


Awards

Title Year
ISMRM Magna Cum Laude Merit Award 2018
ISMRM Summa Cum Laude Merit Award 2017
Gorter Award of the German Chapter of the ISMRM for the best dissertation of a young scientist in the field of medicine or science 2015

Associated projects

Number Title Start Funding scheme
182008 Development and Application of Rapid Conventional and Unconventional Quantitative Magnetic Resonance Imaging 01.05.2019 Project funding (Div. I-III)

Abstract

There is a common scientific consensus that the acquisition of quantitative rather than qualitative magnetic resonance (MR) images has the unique and unmet potential to fundamentally advance the diagnostic power of MRI. Although considerable effort has been undertaken in the development of fast quantitative methods, all of them either suffer from limited resolution (being traded against acquisition time), problems relating to RF power deposition (an issue that becomes especially critical at high to ultra-high field strength), or numerous other factors, such as flow or motion, heterogeneities in the main magnetic field (B0), as well as variations in the transmit field (B1), affecting the overall reliability of the quantitative measures. It is therefore of outmost interest to develop new methods that not only provide high-resolution quantitative MR images within short acquisition times but also mitigate the aforementioned critical issues that currently flaw a reliable and therefore accurate and reproducible detection of quantitative tissue changes in vivo.This research proposal focuses on the development, exploration and application of new and innovative rapid imaging concepts for in-vivo tissue relaxometry in the clinical setting. Besides our main focus on the basic theoretical and technical progression of these ideas, an important direction of research will focus on high-resolution relaxometry at ultra-high field strengths (up to 9.4T), with a special focus on neurodegenerative diseases in the brain and on cartilage defects and repair in the musculoskeletal system.
-