innate lymphoid cell; lymphoid tissue inducer cell; stem cell; development; cytokines; lineage commitment; innate response; immune system; transcription factor; TSLP
Brasseit J Althaus-Steiner E Faderl M Dickgreber N Saurer L Genitsch V Dolowschiak T Li H Fi (2016), CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis., in Mucosal Immunol
, 9(3), 689-701.
Bank U Deiser K Finke D Hämmerling GJ Arnold B Schüler T. (2016), Cutting Edge: Innate Lymphoid Cells Suppress Homeostatic T Cell Expansion in Neonatal Mice., in J Immunol
, 196(9), 3532-3536.
Baerenwaldt A von Burg N Kreuzaler M Sitte S Horvath E Peter A Voehringer D Rolink AG Finke (2016), Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice., in J Immunol
, 196(6), 2561-2571.
von Muenchow L Alberti-Servera L Klein F Capoferri G Finke D Ceredig R Rolink A Tsapogas P. (2016), Permissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment., in Proc Natl Acad Sci U S A
, 113(50), E8122-E8130.
Schmaler M Broggi MA Lagarde N Stöcklin BF King CG Finke D Rossi SW. (2015), IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice., in Proc Natl Acad Sci U S A.
, 112(43), 133350-133355.
von Burg N Turchinovich G Finke D. (2015), Maintenance of Immune Homeostasis through ILC/T Cell Interactions., in Front Immunol.
, 6, 416.
von Burg N Chappaz S Baerenwaldt A Horvath E Bose Dasgupta S Ashok D Pieters J Tacchini-Cotti (2014), Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses., in Proc Natl Acad Sci U S A
, 111(35), 12835-12840.
In the last decade, we have gained substantial knowledge on the control of the fate of innate lymphoid cells (ILCs), a group of lymphocytes including natural killer (NK) cells, which lack, in contrast to T and B cells, somatically rearranged antigen receptors. ILCs are characterized by producing cytokines analogous to Th1, Th2 and Th17 cell subsets and hence divide into 3 major families: 1) INFã-producing ILC1, 2) IL-4, -5, and-13-producing ILC2, and 3) IL-22 and -17-producing ILC3; the latter depend on the nuclear orphan receptor RORãt. Our previous research has shed light on how a subset of ILC3 named lymphoid tissue inducer (LTi) cells is regulated by cytokines. Less is known about their roles in early response to inflammation and in tissue remodelling. In addition various subsets of ILCs with immunogenic or tolerogenic function have been described that may depend on environmental cues. The identification of molecular pathways that regulate ILC differentiation and function is essential for a better understanding of how ILCs may contribute to protective or pathological responses.A main focus of this proposal is to discriminate immune functions of ILCs under steady-state and activating conditions in various organs and to identify pathways that regulate the differentiation of the cells. Using genetically modified mouse models as well as in vitro assays we will investigate whether ILCs can stimulate dendritic cells(DC), T cells and non-hematopoietic cells under steady-state or activating conditions. Finally we will study the transcriptional program regulating ILC development from hematopoietic precursor cells and their functional maturation.