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Development of Advanced Translational High-Field MRI

English title Development of Advanced Translational High-Field MRI
Applicant Stuber Matthias
Number 150828
Funding scheme R'EQUIP
Research institution Département de radiologie médicale Centre Hospitalier Universitaire Vaudois University of Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Structural Research
Start/End 12.05.2014 - 11.05.2015
Approved amount 413'727.00
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All Disciplines (5)

Discipline
Structural Research
Neurophysiology and Brain Research
Electrical Engineering
Cardiovascular Research
Other disciplines of Engineering Sciences

Keywords (1)

Magnetic Resonance, high field, translation

Lay Summary (German)

Lead
Over the past decade, tremendous progress in the development of magnetic resonance imaging (MRI) hardware and software has been made. With the help of REquip funding, we will be able to re-equip our MRI system that is dedicated for translational and interdisciplinary research. This will provide us with the tools to not only remain competitive on an international level but also to continue playing a leading role in our dedicated areas of research and to educate students on state-of-the-art equipment. REquip funding help advance research and discovery in a highly competitive environment will ultimately also benefit patient care.
Lay summary

At the CHUV, we have the unique opportunity to develop novel MRI methods with the objective to provide better diagnostic tools, to better guide and monitor therapy in patients, and to gain new scientific knowledge in a proven interdisciplinary and translational effort. New hardware and software will critically enable us to further advance the scope, quality and tempo of our dedicated research at CIBM-CHUV, to remain competitive with the leading academic centers worldwide, to guarantee continued success, to educate students and medical professionals on state-of-the-art equipment, and to provide our researchers with better tools to meet their scientific objectives. A team of internationally known basic and clinician scientists with vast experience in translational interdisciplinary MR research has been assembled to advance MRI methodology and meet the above objectives. This REquip funding will critically support our timely and topical research in the domains of neuroimaging, cardiovascular imaging, imaging in nephrology and cancer imaging.

Direct link to Lay Summary Last update: 05.05.2014

Responsible applicant and co-applicants

Collaboration

Group / person Country
Types of collaboration
Johns Hopkins University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Other Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Awards

Title Year
At the ISMRM 2015, we were awarded 2 Summa Cum Laude Awards (Top 3% of all submitted abstracts) and 3 Magna Cum Laude (Top 15% of all submitted abstracts) for work conducted on the Prisma Fit System. One additional award was bestowed in the Cardiac Study Group at that meeting. 2015

Associated projects

Number Title Start Funding scheme
144467 Statistical methods for brain connectivity analysis 01.10.2012 Project funding (Div. I-III)
130090 Imaging the connectome in the early phase of psychosis 01.01.2011 Project funding (Div. I-III)
132913 Prognostic value of renal tissue oxygenation on renal disease progression in patients with hypertension and renal diseases 01.10.2010 Project funding (Div. I-III)
144077 19F-Fluorine MRI as a novel imaging approach for detection and tracking of specific cell populations in-vivo 01.11.2012 Project funding (Div. I-III)
141283 Novel Image Processing Methods for Fetal MR Imaging: 3D Reconstruction and Segmentation with Soft Priors 01.10.2012 Project funding (Div. I-III)
144529 Fast Global Tractography for Sensitive MR Connectomics 01.10.2012 Project funding (Div. I-III)
132695 Development of a coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system 01.10.2010 Project funding (Div. I-III)
140332 Imaging large scale neuronal networks in epilepsy 01.05.2012 SPUM
149309 Determinants and prognostic value of renal tissue oxygenation in patients with renal diseases and/or hypertension 01.11.2013 Project funding (Div. I-III)
147121 Cardiac Magnetic Resonance Imaging with T2 relaxation time for Non-Invasive Detection of Acute Cardiac Allograft Rejection in the Maintenance Phase after Orthotopic Heart Transplantation 01.11.2013 Project funding (Div. I-III)
127507 Effets du cannabis fumé sur des performances liées à la conduite automobile chez des consommateurs occasionnels et réguliers 01.01.2010 Project funding (Div. I-III)
143398 The emotional brain and its goals: Neurocognitive mechanisms underlying the processing of goal-relevance 01.11.2012 Project funding (Div. I-III)
131914 Advanced techniques to investigate the physiopathology of multiple sclerosis using high and ultra-high field MRI 01.09.2011 Ambizione
124114 Impact of qualitative MR perfusion imaging on the management of patients with carotid artery disease 01.10.2009 SPUM
125759 NCCR SYNAPSY: The synaptic bases of mental diseases (phase I) 01.10.2010 National Centres of Competence in Research (NCCRs)
135679 Anatomical and functional segregation within cortico-basal ganglia circuits 01.01.2012 Project funding (Div. I-III)
138311 Advanced signal processing on the sphere for high angular resolution diffusion magnetic resonance imaging 01.04.2012 Project funding (Div. I-III)
138146 Assessing cardiac metabolic pathways in the post-ischemic heart and in progressive heart failure using hyperpolarized 13C MR 01.05.2012 Project funding (Div. I-III)
143923 Non-invasive and Regional 3D Measures of Coronary Vasomotor Function, Delayed Hyperenhancement and Vessel Wall Plaque Characteristics in Early Atherosclerosis Using Advanced High-Field Magnetic Resonance Imaging 01.03.2013 Project funding (Div. I-III)
141177 Interaction within and between specialised cortical networks 01.04.2012 Project funding (Div. I-III)
140334 From Cortex to Classroom: Enhancing Brain Development for Premature Infants 01.10.2012 SPUM

Abstract

At the CHUV, a state-of-the art 3T human high field magnetic resonance imaging (MRI) system was installed in 2005. Fifty per cent of the time on that system is used clinically and 50% is dedicated to research and development of the CIBM and its partner network. The CIBM-CHUV MR team provides a platform that guarantees access to the MR equipment for a large number of researchers in the region. As a testimony of this, some 40 scientific studies from more than 30 grant-funded projects proposed by 26 different principal investigators and 4 regional institutions are actively collecting research data on this platform. While the research activities were originally focused on neuroscience, a new CIBM core director was hired as a Full Professor into the program in 2009, and the investigation of cardiovascular disease, kidney disease, cancer, molecular and fetal imaging have since been added to the research portfolio. While the MR system at the CHUV has been well maintained over the past 8 years, the progress in hardware and software by the vendors during this period has been substantial. To further advance the scope, quality and tempo of the MR research of the CIBM-CHUV and its partner network, to remain competitive with the leading academic centers worldwide and to guarantee continued success, to educate students on state-of-the-art equipment, and to provide our researchers with better tools to meet their objectives, we are planning to acquire new 3T MR hardware (Prisma System). Since the equipment is simultaneously used for both clinical routine and research as detailed above, both CIBM & CHUV will contribute to the planned purchase. To leverage these contributions, a team of internationally known and SNF funded basic and clinician scientists with vast experience in translational interdisciplinary MR research has been assembled as co-applicants and seeks for R’Equip matched funding as outlined in this proposal.
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