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CIBM human advanced MR imaging platform

Applicant Lazeyras François
Number 150816
Funding scheme R'EQUIP
Research institution Service de Radiologie Hôpitaux Universitaires de Genève
Institution of higher education University of Geneva - GE
Main discipline Biomedical Engineering
Start/End 01.04.2014 - 31.03.2015
Approved amount 375'000.00
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All Disciplines (5)

Discipline
Biomedical Engineering
Clinical Cancer Research
Neurology, Psychiatry
Surgery
Paediatrics

Keywords (5)

Brain network; MRI; molecular imaging; connectomics; multimodal imaging

Lay Summary (French)

Lead
L'imagerie biomédicale, et en particulier l'Imagerie par Résonance Magnétique (IRM), connait un essor considérable grâce a des progrès techniques constants depuis ses premières applications chez l'homme dans les années 80. Ce projet a pour but de mettre à disposition des chercheurs de l'Arc Lémanique une plateforme IRM de dernière technologie.
Lay summary

Contenu et objectifs du travail de recherche

Le centre d'imagerie biomédicale (CIBM) regroupe les chercheurs des hautes écoles lémaniques, telles que l'Université de Genève, l'Université de Lausanne et l'EPFL, ainsi que les 2 hôpitaux universitaires de Lausanne (CHUV) et Genève (HUG). La recherche menée au CIBM va globalement bénéficier de cette nouvelle plateforme. Les axes de recherches cliniques sont nombreux, les plus saillants étant l'étude du développement cérébral, sain et pathologique, la détection du foyer épileptique dans les épilepsies pharmaco-résistantes, l'identification de marqueurs du déclin cognitif chez les personnes âgées. Sur un plan méthodologique, la nouvelle plateforme IRM permettra de développer la recherche dans trois domaines prometteurs: i) la dynamique des réseaux cérébraux par IRM fonctionnelle couplée à l'électroencéphalographie et leur connectivité structurelle, ii) l'imagerie moléculaire de processus biologiques lents basée sur l'IRM et la spectroscopie et iii) traitement local du cancer par ultra-son focalisé guidé par IRM et largage ciblé d'agent anti-tumoraux.

Contexte scientifique et social du projet de recherche

Ce projet s'inscrit dans un contexte unique qui réunit 5 institutions qui réuni ingénieurs, physiciens et médecins afin de développer des nouvelles méthodes d'imagerie et d'analyse novatrices grâce à des équipements et un savoir-faire remarquables.
Direct link to Lay Summary Last update: 24.02.2014

Responsible applicant and co-applicants

Publications

Publication
Fast high-resolution brain metabolite mapping on a clinical 3T MRI by accelerated 1 H-FID-MRSI and low-rank constrained reconstruction Magnetic Resonance in Medicine
Klauser Antoine, Courvoisier Sebastien, Kasten Jeffrey, Kocher Michel, Guerquin-Kern Matthieu, Van De Ville Dimitri, Lazeyras Francois (2018), Fast high-resolution brain metabolite mapping on a clinical 3T MRI by accelerated 1 H-FID-MRSI and low-rank constrained reconstruction Magnetic Resonance in Medicine, in Magnetic Resonance in Medicine, 1-17.
Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ 19F MRI mapping of oxygen partial pressure
Lorton Orane, Hyacinthe Jean-Noël, Desgranges Stéphane, Gui Laura, Klauser Antoine, Celicanin Zarko, Crowe Lindsey A., Lazeyras François, Allémann Eric, Taulier Nicolas, Contino-Pépin Christiane, Salomir Rares (2018), Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ 19F MRI mapping of oxygen partial pressure, in Journal of Magnetic Resonance, 295, 27-37.
Hybrid ultrasound-MR guided HIFU treatment method with 3D motion compensationHybrid Ultrasound-MR Guided HIFU Method
Celicanin Zarko, Manasseh Gibran, Petrusca Lorena, Scheffler Klaus, Auboiroux Vincent, Crowe Lindsey A., Hyacinthe Jean-Noel, Natsuaki Yutaka, Santini Francesco, Becker Christoph D., Terraz Sylvain, Bieri Oliver, Salomir Rares (2018), Hybrid ultrasound-MR guided HIFU treatment method with 3D motion compensationHybrid Ultrasound-MR Guided HIFU Method, in Magnetic Resonance in Medicine, 79(5), 2511-2523.
Spatially Resolved MR-Compatible Doppler Ultrasound: Proof of Concept for Triggering of Diagnostic Quality Cardiovascular MRI for Function and Flow Quantification at 3T
Crowe Lindsey Alexandra, Manasseh Gibran, Chmielewski Aneta, Hachulla Anne-Lise, Speicher Daniel, Greiser Andreas, Muller Hajo, de Perrot Thomas, Vallee Jean-Paul, Salomir Rares (2018), Spatially Resolved MR-Compatible Doppler Ultrasound: Proof of Concept for Triggering of Diagnostic Quality Cardiovascular MRI for Function and Flow Quantification at 3T, in IEEE Transactions on Biomedical Engineering, 65(2), 294-306.
4D cardiac imaging at clinical 3.0 T provides accurate assessment of murine myocardial function and viability
Crowe Lindsey A., Montecucco Fabrizio, Carbone Federico, Friedli Iris, Hachulla Anne-Lise, Braunersreuther Vincent, Mach François, Vallée Jean-Paul (2017), 4D cardiac imaging at clinical 3.0 T provides accurate assessment of murine myocardial function and viability, in Magnetic Resonance Imaging, 44, 46-54.
Dynamic Volume Assessment of Hepatocellular Carcinoma in Rat Livers Using a Clinical 3T MRI and Novel Segmentation
Orci Lorenzo A., Oldani Graziano, Lacotte Stephanie, Slits Florence, Friedli Iris, Wirth Wolfgang, Toso Christian, Vallée Jean-Paul, Crowe Lindsey A. (2016), Dynamic Volume Assessment of Hepatocellular Carcinoma in Rat Livers Using a Clinical 3T MRI and Novel Segmentation, in Journal of Investigative Surgery, 31(1), 44-53.
Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results
Grouiller Frédéric, Jorge João, Pittau Francesca, van der Zwaag Wietske, Iannotti Giannina Rita, Michel Christoph Martin, Vulliémoz Serge, Vargas Maria Isabel, Lazeyras François (2016), Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results, in Magnetic Resonance Materials in Physics, Biology and Medicine, 29(3), 605-616.

Collaboration

Group / person Country
Types of collaboration
CIBM signal processing, EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
CIBM MRI core at CHUV Switzerland (Europe)
- Research Infrastructure
CIBM animal core and 7T MRI (AIT) at EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
International Society for Magnetic Resonance in Medicine Poster NODDI Intra-Axonal Volume Fraction Shows Stronger Correlation with Developmental Age Than Fractional Anisotropy in Preterm Human Newborns 01.06.2015 Toronto, Canada Lazeyras François;
International Society for Magnetic Resonance in Medicine Poster Modulation of Resting-State Brain Networks in Newborns by Heel Prick 01.06.2015 Toronto, Canada Lazeyras François;
International Society for Magnetic Resonance in Medicine Poster Brain Network Modular Fingerprint of Premature Born Children 01.06.2015 Toronto, Canada Lazeyras François;
International Society for Magnetic Resonance in Medicine Poster Mapping Epileptic Networks Using Simultaneous EEG-MRI at Ultra-High Field 01.06.2015 Toronto, Canada Lazeyras François;
International Society for Magnetic Resonance in Medicine Talk given at a conference Hybrid MR/US-Guided HIFU for Abdominal Targets: In Vivo Demonstration of 3D Motion Correction and Focal Point Locking on an Absolute Reference Marker 01.06.2015 Toronto, Canada Salomir Rares;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Opening day MRI PRisma Western Switzerland 2014

Associated projects

Number Title Start Funding scheme
125050 Behavioral, neuro-functional and neuro-anatomical correlates of experience dependant music perception 01.10.2009 Project funding (Div. I-III)
135425 Viability assessment of marginal donors’ kidney before transplantation using MRI and 31P-MRS 01.06.2011 Project funding (Div. I-III)
141300 Medical image retrieval in mANY dimensions 2 (MANY2) 01.09.2012 Project funding (Div. I-III)
143477 Emotional functioning in late-life depression: attentional bias, emotion recognition and emotion regulation 01.01.2013 Project funding (Div. I-III)

Abstract

This request aims at renewing the existing 3T MRI system of the Center for Biomedical Imaging (CIBM) with the latest MRI technology (Siemens Prisma), in order to keep state-of-the-art infrastructure for the lemanic research and teaching activities in MRI.The new 3T scanner will provide significant breakthroughs (stronger gradients, new RF technology) , which will improve advanced MRI applications with better resolutaion and sensitivity.In particular, the new gradients will drastically improve diffusion imaging. This will open new perspectives in the study of cerebral microstructure and cortico-cortical connectivity. In addition, the advent of multi-channel transmit RF technology, which will bring higher sensitivity and better image homogeneity especially for cardiac and body imagingResearch conducted at the CIBM will in general benefit from these advances. More specifically, we strongly believe that the new 3T MRI will improve the research in the 3 following promising fields :i) MR-based molecular imaging and spectroscopy, providing unique means to probe slow bio-logical process in vivo with high sensitivity and specificity.ii) Large-scale cerebral network dynamics with combined EEG and fast fMRI together with functional-structural coupling derived from diffusion-based cerebral connectomics.iii) MR-guided ultra-sound therapy of cancer, thermometry and targeted drug delivery.
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