Brain network; MRI; molecular imaging; connectomics; multimodal imaging
Klauser Antoine, Courvoisier Sebastien, Kasten Jeffrey, Kocher Michel, Guerquin-Kern Matthieu, Van De Ville Dimitri, Lazeyras Francois (2018), Fast high-resolution brain metabolite mapping on a clinical 3T MRI by accelerated 1 H-FID-MRSI and low-rank constrained reconstruction Magnetic Resonance in Medicine, in Magnetic Resonance in Medicine
Lorton Orane, Hyacinthe Jean-Noël, Desgranges Stéphane, Gui Laura, Klauser Antoine, Celicanin Zarko, Crowe Lindsey A., Lazeyras François, Allémann Eric, Taulier Nicolas, Contino-Pépin Christiane, Salomir Rares (2018), Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ 19F MRI mapping of oxygen partial pressure, in Journal of Magnetic Resonance
, 295, 27-37.
Celicanin Zarko, Manasseh Gibran, Petrusca Lorena, Scheffler Klaus, Auboiroux Vincent, Crowe Lindsey A., Hyacinthe Jean-Noel, Natsuaki Yutaka, Santini Francesco, Becker Christoph D., Terraz Sylvain, Bieri Oliver, Salomir Rares (2018), Hybrid ultrasound-MR guided HIFU treatment method with 3D motion compensationHybrid Ultrasound-MR Guided HIFU Method, in Magnetic Resonance in Medicine
, 79(5), 2511-2523.
Crowe Lindsey Alexandra, Manasseh Gibran, Chmielewski Aneta, Hachulla Anne-Lise, Speicher Daniel, Greiser Andreas, Muller Hajo, de Perrot Thomas, Vallee Jean-Paul, Salomir Rares (2018), Spatially Resolved MR-Compatible Doppler Ultrasound: Proof of Concept for Triggering of Diagnostic Quality Cardiovascular MRI for Function and Flow Quantification at 3T, in IEEE Transactions on Biomedical Engineering
, 65(2), 294-306.
Crowe Lindsey A., Montecucco Fabrizio, Carbone Federico, Friedli Iris, Hachulla Anne-Lise, Braunersreuther Vincent, Mach François, Vallée Jean-Paul (2017), 4D cardiac imaging at clinical 3.0 T provides accurate assessment of murine myocardial function and viability, in Magnetic Resonance Imaging
, 44, 46-54.
Orci Lorenzo A., Oldani Graziano, Lacotte Stephanie, Slits Florence, Friedli Iris, Wirth Wolfgang, Toso Christian, Vallée Jean-Paul, Crowe Lindsey A. (2016), Dynamic Volume Assessment of Hepatocellular Carcinoma in Rat Livers Using a Clinical 3T MRI and Novel Segmentation, in Journal of Investigative Surgery
, 31(1), 44-53.
Grouiller Frédéric, Jorge João, Pittau Francesca, van der Zwaag Wietske, Iannotti Giannina Rita, Michel Christoph Martin, Vulliémoz Serge, Vargas Maria Isabel, Lazeyras François (2016), Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results, in Magnetic Resonance Materials in Physics, Biology and Medicine
, 29(3), 605-616.
This request aims at renewing the existing 3T MRI system of the Center for Biomedical Imaging (CIBM) with the latest MRI technology (Siemens Prisma), in order to keep state-of-the-art infrastructure for the lemanic research and teaching activities in MRI.The new 3T scanner will provide significant breakthroughs (stronger gradients, new RF technology) , which will improve advanced MRI applications with better resolutaion and sensitivity.In particular, the new gradients will drastically improve diffusion imaging. This will open new perspectives in the study of cerebral microstructure and cortico-cortical connectivity. In addition, the advent of multi-channel transmit RF technology, which will bring higher sensitivity and better image homogeneity especially for cardiac and body imagingResearch conducted at the CIBM will in general benefit from these advances. More specifically, we strongly believe that the new 3T MRI will improve the research in the 3 following promising fields :i) MR-based molecular imaging and spectroscopy, providing unique means to probe slow bio-logical process in vivo with high sensitivity and specificity.ii) Large-scale cerebral network dynamics with combined EEG and fast fMRI together with functional-structural coupling derived from diffusion-based cerebral connectomics.iii) MR-guided ultra-sound therapy of cancer, thermometry and targeted drug delivery.