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Towards motion compensated direct 4D parametric whole-body PET imaging

English title Towards motion compensated direct 4D parametric whole-body PET imaging
Applicant Zaidi Habib
Number 149957
Funding scheme Project funding (Div. I-III)
Research institution Service de Médecine Nucléaire Hôpitaux Universitaires de Genève
Institution of higher education University of Geneva - GE
Main discipline Biomedical Engineering
Start/End 01.10.2013 - 31.03.2016
Approved amount 359'180.00
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All Disciplines (2)

Discipline
Biomedical Engineering
Experimental Cancer Research

Keywords (8)

simulation; parametric imaging; PET-MR; Multimodality imaging; motion compensation; 4D image reconstruction; dynamic whole-body PET imaging; PET-CT

Lay Summary (French)

Lead
Habib ZaidiHôpitaux Universitaires de Genève
Lay summary

L’imagerie hybride corporelle (TEP-TDM et TEP-IRM), faisant usage du « standardized uptake value »  (SUV), sont bien établis en milieu clinique pour le diagnostic et le staging, la surveillance de la réponse au traitement et la planification des traitements de radiothérapie pour un large éventail d’indications oncologiques. Cependant, le SUV dérivé à partir des données de TEP statique ne tient pas compte de la dynamique de la biodistribution du traceur dans le corps. Alternativement, l'imagerie par TEP dynamique, actuellement utilisé principalement en recherche, est capable de suivre la cinétique des traceurs permettant ainsi une quantification plus précise. Ce mode d'acquisition permet de renforcer, dans certaines situations, la caractérisation des tissus normaux et anormaux (tumeur), l'évaluation de la réponse au traitement ou à la planification de la radiothérapie. Toutefois, étant donné les longs temps d'acquisition, la complexité de l'analyse des données et la nécessité de traiter des données énormes, des protocoles d'acquisition de données dynamiques ont été confinés à un champ de vue axial réduit. En tant que tel, l'imagerie paramétrique basée sur l'analyse cinétique complète à l'aide de reconstruction d'images spatio-temporelles est rarement utilisé en raison du bruit statistique, le biais et la variance des paramètres cinétiques. Ainsi l'analyse se limite généralement aux indices semi-quantitatifs (SUV).

Ce projet consiste à développer et valider en milieu clinique une méthode pour l’imagerie 4D paramétrique avec compensation de mouvement applicable en routine clinique pour l'évaluation et la caractérisation de pathologies cancéreuses et leur récurrence.

Direct link to Lay Summary Last update: 25.09.2013

Lay Summary (English)

Lead
Habib ZaidiGeneva University HospitalDivision of Nuclear Medicine and Molecular ImagingGeneva, Switzerland
Lay summary

Whole body hybrid (PET-CT and PET-MR) imaging, making use of the standardized uptake value (SUV) indice, are well established in clinical setting for diagnosis and staging, treatment response monitoring and radiation therapy treatment planning of a wide range of oncologic malignancies. However, the SUV metric derived from static PET data does not capture the dynamics of the PET probe biodistribution in the body. Alternatively, dynamic PET imaging, presently employed mostly in research setting, is capable of tracing tracer kinetics thus allowing for more accurate quantification of tracer uptake. This acquisition mode enables to enhance, in certain situations, normal and abnormal (tumour) tissue characterization, assessment of treatment response or radiation therapy planning. However, given the long acquisition times, complexity of data analysis and the need to handle large data sets, dynamic data acquisition protocols have been confined to limited axial field-of-view (single-bed) coverage. As such, parametric imaging based on full kinetic analysis using spatiotemporal image reconstruction is rarely used due to noise induced bias and variance in kinetic parameters and analysis is usually restricted to semi-quantitative (SUV) indices.

We request funding to develop and validate in clinical setting a methodology to translate dynamic PET acquisition for 4D parametric imaging with motion compensation to routine clinical practice of whole-body PET-CT and PET-MR imaging for the assessment and characterization of disease spread and recurrence. This work will push forward the development and widespread adoption of dynamic whole body PET-CT and PET-MRI, the latter being an embryonic technology that has excellent potential to become a powerful tool for clinical research and diagnosis.
Direct link to Lay Summary Last update: 25.09.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Accelerated time-of-flight (TOF) PET image reconstruction using TOF bin subsetization and TOF weighting matrix pre-computation.
Mehranian Abolfazl, Kotasidis Fotis, Zaidi Habib (2016), Accelerated time-of-flight (TOF) PET image reconstruction using TOF bin subsetization and TOF weighting matrix pre-computation., in Physics in medicine and biology, 61(3), 1309-31.
Assessment of metal artifact reduction methods in pelvic CT.
Abdoli Mehrsima, Mehranian Abolfazl, Ailianou Angeliki, Becker Minerva, Zaidi Habib (2016), Assessment of metal artifact reduction methods in pelvic CT., in Medical physics, 43(4), 1588-1588.
Atlas-guided generation of pseudoCT images for MR-only and hybrid PET-MRI guided radiation therapy treatment planning
Arabi H, Koutsouvelis N, Rouzaud M, Miralbell R, Zaidi H (2016), Atlas-guided generation of pseudoCT images for MR-only and hybrid PET-MRI guided radiation therapy treatment planning, in Phys Med Biol, 61(17), 6531-6552.
Development of computational small animal models and their applications in preclinical imaging and therapy research.
Xie Tianwu, Zaidi Habib (2016), Development of computational small animal models and their applications in preclinical imaging and therapy research., in Medical physics, 43(1), 111-111.
Generic and robust method for automatic segmentation of PET images using an active contour model.
Zhuang M, Dierckx R, Zaidi H (2016), Generic and robust method for automatic segmentation of PET images using an active contour model., in Med Phys, 43(3), 1130-1155.
Impact of time-of-flight on indirect 3D and direct 4D parametric image reconstruction in the presence of inconsistent dynamic PET data.
Kotasidis F A, Mehranian A, Zaidi H (2016), Impact of time-of-flight on indirect 3D and direct 4D parametric image reconstruction in the presence of inconsistent dynamic PET data., in Physics in medicine and biology, 61(9), 3443-71.
Magnetic resonance imaging-guided attenuation correction in whole-body PET/MRI using a sorted atlas approach.
Arabi Hossein, Zaidi Habib (2016), Magnetic resonance imaging-guided attenuation correction in whole-body PET/MRI using a sorted atlas approach., in Medical image analysis, 31, 1-15.
PET/MR Imaging: Advances in Instrumentation and Quantitative Procedures.
Zaidi Habib (2016), PET/MR Imaging: Advances in Instrumentation and Quantitative Procedures., Elsevier, Philadelphia.
Quantitative analysis of MRI-guided attenuation correction techniques in time-of-flight brain PET/MRI.
Mehranian Abolfazl, Arabi Hossein, Zaidi Habib (2016), Quantitative analysis of MRI-guided attenuation correction techniques in time-of-flight brain PET/MRI., in NeuroImage, 130, 123-33.
The promise of hybrid PET-MRI: Technical advances and clinical applications
Zaidi H, Becker M (2016), The promise of hybrid PET-MRI: Technical advances and clinical applications, in IEEE Signal Process Mag, 33(3), 67-85.
Vision 20/20: Magnetic resonance imaging-guided attenuation correction in PET/MRI: Challenges, solutions, and opportunities.
Mehranian Abolfazl, Arabi Hossein, Zaidi Habib (2016), Vision 20/20: Magnetic resonance imaging-guided attenuation correction in PET/MRI: Challenges, solutions, and opportunities., in Medical physics, 43(3), 1130-1130.
Whole-body direct 4D parametric PET imaging employing nested generalized Patlak expectation-maximization reconstruction.
Karakatsanis N, Casey ME, Lodge MA, Rahmim A, Zaidi H (2016), Whole-body direct 4D parametric PET imaging employing nested generalized Patlak expectation-maximization reconstruction., in Phys Med Biol Vol. 61, No 15, pp , 61(15), 5456-5485.
90Yttrium PET/MR-based dosimetry after liver radioembolization (SIRT).
Wissmeyer Michael, Delattre Bénédicte M A, Zaidi Habib, Terraz Sylvain, Ratib Osman (2015), 90Yttrium PET/MR-based dosimetry after liver radioembolization (SIRT)., in Clinical nuclear medicine, 40(4), 355-7.
An update on novel quantitative techniques in the context of evolving whole-body PET imaging.
Houshmand Sina, Salavati Ali, Hess Søren, Werner Thomas J, Alavi Abass, Zaidi Habib (2015), An update on novel quantitative techniques in the context of evolving whole-body PET imaging., in PET clinics, 10(1), 45-58.
Application of partial volume effect correction and 4D PET in the quantification of FDG avid lung lesions.
Salavati Ali, Borofsky Samuel, Boon-Keng Teo K, Houshmand Sina, Khiewvan Benjapa, Saboury Babak, Codreanu Ion, Torigian Drew A, Zaidi Habib, Alavi Abass (2015), Application of partial volume effect correction and 4D PET in the quantification of FDG avid lung lesions., in Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(1), 140-8.
Assessment of radiation dose in nuclear cardiovascular imaging using realistic computational models.
Xie Tianwu, Lee Choonsik, Bolch Wesley E, Zaidi Habib (2015), Assessment of radiation dose in nuclear cardiovascular imaging using realistic computational models., in Medical physics, 42(6), 2955-66.
Clinical assessment of MR-guided 3-class and 4-class attenuation correction in PET/MR.
Arabi Hossein, Rager Olivier, Alem Asma, Varoquaux Arthur, Becker Minerva, Zaidi Habib (2015), Clinical assessment of MR-guided 3-class and 4-class attenuation correction in PET/MR., in Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(2), 264-76.
Development of image reconstruction and correction techniques in PET/CT and PET/MR imaging
Mehranian Abolfazl (2015), Development of image reconstruction and correction techniques in PET/CT and PET/MR imaging, Université de Genève, Genève.
Emission-based estimation of lung attenuation coefficients for attenuation correction in time-of-flight PET/MR
Mehranian Abolfazl, Zaidi Habib, Zaidi Habib, Zaidi Habib (2015), Emission-based estimation of lung attenuation coefficients for attenuation correction in time-of-flight PET/MR, in Physics in Medicine and Biology, 60(12), 4813-4833.
Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET.
Karakatsanis Nicolas A, Zhou Yun, Lodge Martin A, Casey Michael E, Wahl Richard L, Zaidi Habib, Rahmim Arman (2015), Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET., in Physics in medicine and biology, 60(22), 8643-73.
Joint Estimation of Activity and Attenuation in Whole-Body TOF PET/MRI Using Constrained Gaussian Mixture Models
Mehranian Abolfazl, Zaidi Habib, Zaidi Habib, Zaidi Habib (2015), Joint Estimation of Activity and Attenuation in Whole-Body TOF PET/MRI Using Constrained Gaussian Mixture Models, in IEEE Transactions on Medical Imaging, 34(9), 1808-1821.
Qualitative and Quantitative Evaluation of Blob-Based Time-of-Flight PET Image Reconstruction in Hybrid Brain PET/MR Imaging
Leemans Eva L., Leemans Eva L., Kotasidis Fotis, Wissmeyer Michael, Garibotto Valentina, Zaidi Habib, Zaidi Habib, Zaidi Habib (2015), Qualitative and Quantitative Evaluation of Blob-Based Time-of-Flight PET Image Reconstruction in Hybrid Brain PET/MR Imaging, in Molecular Imaging and Biology, 17(5), 704-713.
Qualitative and Quantitative Evaluation of Blob-Based Time-of-Flight PET Image Reconstruction in Hybrid Brain PET/MR Imaging.
Leemans Eva L, Kotasidis Fotis, Wissmeyer Michael, Garibotto Valentina, Zaidi Habib (2015), Qualitative and Quantitative Evaluation of Blob-Based Time-of-Flight PET Image Reconstruction in Hybrid Brain PET/MR Imaging., in Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(5), 704-13.
Quantifying [18F]fluorodeoxyglucose uptake in the arterial wall: the effects of dual time-point imaging and partial volume effect correction
Blomberg Björn A., Blomberg Björn A., Bashyam Arjun, Ramachandran Abhinay, Gholami Saeid, Houshmand Sina, Salavati Ali, Werner Tom, Zaidi Habib, Zaidi Habib, Alavi Abass (2015), Quantifying [18F]fluorodeoxyglucose uptake in the arterial wall: the effects of dual time-point imaging and partial volume effect correction, in European Journal of Nuclear Medicine and Molecular Imaging, 42(9), 1414-1422.
A 5D computational phantom for pharmacokinetic simulation studies in dynamic emission tomography.
Kotasidis Fotis A, Tsoumpas Charalampos, Polycarpou Irene, Zaidi Habib (2014), A 5D computational phantom for pharmacokinetic simulation studies in dynamic emission tomography., in Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging, 38(8), 764-73.
Application of adaptive kinetic modelling for bias propagation reduction in direct 4D image reconstruction.
Kotasidis F A, Matthews J C, Reader A J, Angelis G I, Zaidi H (2014), Application of adaptive kinetic modelling for bias propagation reduction in direct 4D image reconstruction., in Physics in medicine and biology, 59(20), 6061-84.
Derivation of attenuation map for attenuation correction of PET data in the presence of nanoparticulate contrast agents using spectral CT imaging.
Ghadiri Hossein, Shiran Mohammad Bagher, Soltanian-Zadeh Hamid, Rahmim Arman, Zaidi Habib, Ay Mohammad Reza (2014), Derivation of attenuation map for attenuation correction of PET data in the presence of nanoparticulate contrast agents using spectral CT imaging., in Annals of nuclear medicine, 28(6), 559-70.
Detection and quantification of focal uptake in head and neck tumours: (18)F-FDG PET/MR versus PET/CT.
Varoquaux Arthur, Rager Olivier, Poncet Antoine, Delattre Bénédicte M A, Ratib Osman, Becker Christoph D, Dulguerov Pavel, Dulguerov Nicolas, Zaidi Habib, Becker Minerva (2014), Detection and quantification of focal uptake in head and neck tumours: (18)F-FDG PET/MR versus PET/CT., in European journal of nuclear medicine and molecular imaging, 41(3), 462-75.
Dopaminergic denervation is not necessary to induce gait disorders in atypical parkinsonian syndrome
Allali Gilles, Allali Gilles, Garibotto Valentina, Mainta Ismini C., Armand Stephane, Camicioli Richard, Ratib Osman, Zaidi Habib, Herrmann Francois R., Assal Frederic (2014), Dopaminergic denervation is not necessary to induce gait disorders in atypical parkinsonian syndrome, in Journal of the Neurological Sciences, 351(1-2), 127-132.
Effect of respiratory motion on internal radiation dosimetry.
Xie Tianwu, Zaidi Habib (2014), Effect of respiratory motion on internal radiation dosimetry., in Medical physics, 41(11), 112506-112506.
Evaluation of radiation dose to anthropomorphic paediatric models from positron-emitting labelled tracers.
Xie Tianwu, Zaidi Habib (2014), Evaluation of radiation dose to anthropomorphic paediatric models from positron-emitting labelled tracers., in Physics in medicine and biology, 59(5), 1165-87.
Experimental evaluation and basis function optimization of the spatially variant image-space PSF on the Ingenuity PET/MR scanner.
Kotasidis Fotis A, Zaidi Habib (2014), Experimental evaluation and basis function optimization of the spatially variant image-space PSF on the Ingenuity PET/MR scanner., in Medical physics, 41(6), 062501-062501.
Fetal and maternal absorbed dose estimates for positron-emitting molecular imaging probes
Xie Tianwu, Zaidi Habib, Zaidi Habib, Zaidi Habib (2014), Fetal and maternal absorbed dose estimates for positron-emitting molecular imaging probes, in Journal of Nuclear Medicine, 55(9), 1459-1466.
First imaging results of an intraindividual comparison of (11)C-acetate and (18)F-fluorocholine PET/CT in patients with prostate cancer at early biochemical first or second relapse after prostatectomy or radiotherapy.
Buchegger Franz, Garibotto Valentina, Zilli Thomas, Allainmat Laurent, Jorcano Sandra, Vees Hansjörg, Rager Olivier, Steiner Charles, Zaidi Habib, Seimbille Yann, Ratib Osman, Miralbell Raymond (2014), First imaging results of an intraindividual comparison of (11)C-acetate and (18)F-fluorocholine PET/CT in patients with prostate cancer at early biochemical first or second relapse after prostatectomy or radiotherapy., in European journal of nuclear medicine and molecular imaging, 41(1), 68-78.
Imaging in head and neck squamous cell carcinoma: The potential role of PET/MRI
Becker Minerva, Zaidi Habib (2014), Imaging in head and neck squamous cell carcinoma: The potential role of PET/MRI, in British Journal of Radiology, 87(1036), 20130677-20130677.
Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI.
Becker Minerva, Zaidi Habib (2014), Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI., in The British journal of radiology, 87(1036), 20130677-20130677.
Impact of time-of-flight PET on quantification errors in MR imaging-based attenuation correction
Mehranian Abolfazl, Zaidi Habib, Zaidi Habib, Zaidi Habib (2014), Impact of time-of-flight PET on quantification errors in MR imaging-based attenuation correction, in Journal of Nuclear Medicine, 56(4), 635-641.
Improved nuclear medicine uniformity assessment with noise texture analysis
Nelson Jeffrey S., Christianson Olav I., Harkness Beth A., Madsen Mark T., Mah Eugene, Thomas Stephen R., Zaidi Habib, Zaidi Habib, Zaidi Habib, Samei Ehsan (2014), Improved nuclear medicine uniformity assessment with noise texture analysis, in Journal of Nuclear Medicine, 55(1), 169-174.
Improved nuclear medicine uniformity assessment with noise texture analysis.
Nelson Jeffrey S, Christianson Olav I, Harkness Beth A, Madsen Mark T, Mah Eugene, Thomas Stephen R, Zaidi Habib, Samei Ehsan (2014), Improved nuclear medicine uniformity assessment with noise texture analysis., in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 169-74.
Improvement of pseudo multispectral classification of brain MR images
Fatnassi C., Fatnassi C., Boucenna R., Zaidi H. (2014), Improvement of pseudo multispectral classification of brain MR images, in IFMBE Proceedings, 51, 111-114.
Isotope specific resolution recovery image reconstruction in high resolution PET imaging
Kotasidis Fotis A., Kotasidis Fotis A., Angelis Georgios I., Anton-Rodriguez Jose, Matthews Julian C., Reader Andrew J., Reader Andrew J., Zaidi Habib, Zaidi Habib, Zaidi Habib (2014), Isotope specific resolution recovery image reconstruction in high resolution PET imaging, in Medical Physics, 41(5), 052503-1-052503-11.
Molecular imaging of small animals: Instrumentation and applications
Zaidi Habib (2014), Molecular imaging of small animals: Instrumentation and applications, in Molecular Imaging of Small Animals: Instrumentation and Applications, 1-760.
Monte Carlo-based assessment of the trade-off between spatial resolution, field-of-view and scattered radiation in the variable resolution X-ray CT scanner
Arabi Hossein, Kamali Asl Ali Reza, Ay Mohammad Reza, Ay Mohammad Reza, Zaidi Habib, Zaidi Habib, Zaidi Habib (2014), Monte Carlo-based assessment of the trade-off between spatial resolution, field-of-view and scattered radiation in the variable resolution X-ray CT scanner, in Physica Medica, 31(5), 510-516.
MR constrained simultaneous reconstruction of activity and attenuation maps in brain TOF-PET/MR imaging.
Mehranian Abolfazl, Zaidi Habib (2014), MR constrained simultaneous reconstruction of activity and attenuation maps in brain TOF-PET/MR imaging., in EJNMMI physics, 1(Suppl 1), 55-55.
Multimodality molecular imaging: A futuristic outlook
Zaidi Habib, Alavi Abass (2014), Multimodality molecular imaging: A futuristic outlook, in Molecular Imaging of Small Animals: Instrumentation and Applications, 753-760.
Numerical simpson’s rule for real time and accurate T2* Maps generation using 3D quantitative GRE
Fatnassi C., Fatnassi C., Boucenna R., Zaidi H. (2014), Numerical simpson’s rule for real time and accurate T2* Maps generation using 3D quantitative GRE, in IFMBE Proceedings, 51, 107-110.
Quantification of small-animal imaging data
Zaidi Habib (2014), Quantification of small-animal imaging data, in Molecular Imaging of Small Animals: Instrumentation and Applications, 467-494.
The effect of metal artefact reduction on CT-based attenuation correction for PET imaging in the vicinity of metallic hip implants: a phantom study.
Harnish Roy, Prevrhal Sven, Alavi Abass, Zaidi Habib, Lang Thomas F (2014), The effect of metal artefact reduction on CT-based attenuation correction for PET imaging in the vicinity of metallic hip implants: a phantom study., in Annals of nuclear medicine, 28(6), 540-50.
Unwrapping highly wrapped phase using nonlinear multi echo phase unwrapping
Fatnassi C., Fatnassi C., Boucenna R., Zaidi H. (2014), Unwrapping highly wrapped phase using nonlinear multi echo phase unwrapping, in IFMBE Proceedings, 51, 115-118.
3D Prior Image Constrained Projection Completion for X-ray CT Metal Artifact Reduction
Mehranian A, Ay MR, Rahmim A, Zaidi H (2013), 3D Prior Image Constrained Projection Completion for X-ray CT Metal Artifact Reduction, in IEEE Trans Nucl Sci Vol. 60, No. 5, pp , 60(5), 3318-3332.
A pivotal time for hybrid PET/MR imaging technology.
Zaidi Habib (2013), A pivotal time for hybrid PET/MR imaging technology., in J Am Coll Radiol, 10(11), 878-881.
Age-dependent small-animal internal radiation dosimetry.
Xie Tianwu, Zaidi Habib (2013), Age-dependent small-animal internal radiation dosimetry., in Mol Imaging, 12(6), 364-375.
Amyloid-β positron emission tomography imaging probes: a critical review.
Kepe V, Moghbel M, Långström B, Zaidi H, Vinters H, Huang S-C, Satyamurthy N, Doudet D, Mishani E, Cohen R, Høilund-Carlsen P, Alavi A, Barrio J (2013), Amyloid-β positron emission tomography imaging probes: a critical review., in J Alzheimers Dis, 36(4), 613-631.
An ordered-subsets proximal preconditioned gradient algorithm for edge-preserving PET image reconstruction.
Mehranian A, Rahmim A, Ay MR, Kotasidis F, Zaidi H (2013), An ordered-subsets proximal preconditioned gradient algorithm for edge-preserving PET image reconstruction., in Med Phys, 40(5), 052503-1-052503-14.
Assessment of S values in stylized and voxel-based rat models for positron-emitting radionuclides.
Xie Tianwu, Zaidi Habib (2013), Assessment of S values in stylized and voxel-based rat models for positron-emitting radionuclides., in Mol Imaging Biol Vol. 15, No. 5, 15(5), 542-551.
Attenuation Correction Strategies for Positron Emission Tomography/Computed Tomography and 4-Dimensional Positron Emission Tomography/Computed Tomography.
Pan Tinsu, Zaidi Habib (2013), Attenuation Correction Strategies for Positron Emission Tomography/Computed Tomography and 4-Dimensional Positron Emission Tomography/Computed Tomography., in PET Clinics Vol. 8, No. 1, pp , 8(1), 37-50.
Combined Modalities of Compton Scattering Tomography
Rigaud G, Régnier R, Nguyen MK, Zaidi H (2013), Combined Modalities of Compton Scattering Tomography, in IEEE Trans Nucl Sci Vol. 60, No. 1, pp , 60(1), 1570-1577.
Computed tomography calcium score scan for attenuation correction of N-13 ammonia cardiac positron emission tomography: effect of respiratory phase and registration method.
Zaidi H, Nkoulou R, Bond S, Baskin A, Schindler TH, Ratib O, Declerck J (2013), Computed tomography calcium score scan for attenuation correction of N-13 ammonia cardiac positron emission tomography: effect of respiratory phase and registration method., in Cardiovasc Imaging, 29(6), 1351-1360.
Contourlet-based active contour model for PET image segmentation.
Abdoli Mehrsima, Dierckx Rudi, Zaidi Habib (2013), Contourlet-based active contour model for PET image segmentation., in Med Phys, 40(8), 082507-1-082507-12.
Effect of emaciation and obesity on small-animal internal radiation dosimetry for positron-emitting radionuclides.
Xie Tianwu, Zaidi Habib (2013), Effect of emaciation and obesity on small-animal internal radiation dosimetry for positron-emitting radionuclides., in Eur J Nucl Med Mol Imaging, 40(11), 174-1759.
Evolving Medical Imaging Techniques.
Kwee A, Zaidi Habib (2013), Evolving Medical Imaging Techniques., in PET Clinics, 8(3), xi-xii.
Experimental assessment of the influence of beam hardening filters on image quality and patient dose in volumetric 64-slice X-ray CT scanners
Ay MR, Mehranian A, Maleki A, Ghadiri H, Ghafarian P, Zaidi H (2013), Experimental assessment of the influence of beam hardening filters on image quality and patient dose in volumetric 64-slice X-ray CT scanners, in Phys Med, 29(3), 249-260.
FDG PET/CT methodology for evaluation of treatment response in lymphoma: from “graded visual analysis” and “semiquantitative SUVmax” to global disease burden assessment
Basu Sandip, Zaidi Habib, Zaidi Habib, Salavati Ali, Hess Søren, Carlsen Poul Flemming Høilund, Alavi Abass (2013), FDG PET/CT methodology for evaluation of treatment response in lymphoma: from “graded visual analysis” and “semiquantitative SUVmax” to global disease burden assessment, in European Journal of Nuclear Medicine and Molecular Imaging, 41(11), 2158-2160.
Four-Dimensional Image Reconstruction Strategies in Cardiac-Gated and Respiratory-Gated PET Imaging.
Rahmim A, Tang J, Zaidi H (2013), Four-Dimensional Image Reconstruction Strategies in Cardiac-Gated and Respiratory-Gated PET Imaging., in PET Clinics, 8(1), 51-67.
Generalized 3D and 4D motion compensated whole-body PET image reconstruction employing nested em deconvolution
Karakatsanis Nicolas A., Zaidi Habib, Zaidi Habib, Tsoumpas Charalampos (2013), Generalized 3D and 4D motion compensated whole-body PET image reconstruction employing nested em deconvolution, in IST 2014 - 2014 IEEE International Conference on Imaging Systems and Techniques, Proceedings, 263-268.
Hybrid PET/MRI in neuro-imaging.
Garibotto V, Tabouret-Viaud. C, Rager O, Vulliemoz S, Delattre B, Haller S, Wissmeyer M, Seeck M, Lovblad KO, Zaidi H, Gold G, Ratib O, Zekry D, Vargas MI (2013), Hybrid PET/MRI in neuro-imaging., in Med Nucl, 37(10-11), 561-566.
K-edge ratio method for identification of multiple nanoparticulate contrast agents by spectral CT imaging.
Ghadiri Hossein, Ay MR, Shiran MB, Soltanian-Zadeh HR, Zaidi Habib (2013), K-edge ratio method for identification of multiple nanoparticulate contrast agents by spectral CT imaging., in Br J Radiol, 86(1029), 20130308.
Novel multimodality segmentation using level sets and Jensen-Renyi divergence.
Markel D, Zaidi H, El Naqa I (2013), Novel multimodality segmentation using level sets and Jensen-Renyi divergence., in Med Phys, 40(12), 121908-121915.
Novel Quantitative Techniques in Hybrid (PET-MR) Imaging of Brain Tumors.
Senthamizhchelvan S, Zaidi H (2013), Novel Quantitative Techniques in Hybrid (PET-MR) Imaging of Brain Tumors., in PET Clinics Vol. 8, No. 2, pp , 8(2), 219-232.
PET/MR imaging: technical aspects and potential clinical applications.
Torigian DA, Zaidi H, Kwee TC, Saboury B, Udupa J, Cho Z-H, Alavi A (2013), PET/MR imaging: technical aspects and potential clinical applications., in Radiology Vol. 267, No. 1, pp , 267(1), 26-44.
Regions of interest-based discriminant analysis of DaTSCAN SPECT and FDG-PET for the classification of dementia.
Garibotto V, Montandon ML, Tabouret-Viaud C, Allaoua M, Assal F, Burkhard PR, Ratib O, Zaidi H (2013), Regions of interest-based discriminant analysis of DaTSCAN SPECT and FDG-PET for the classification of dementia., in Clin Nucl Med, 38(3), e112-e117.
Scatter characterization and correction for simultaneous multiple small-animal PET imaging
Prasad Rameshwar, Zaidi Habib, Zaidi Habib, Zaidi Habib (2013), Scatter characterization and correction for simultaneous multiple small-animal PET imaging, in Molecular Imaging and Biology, 16(2), 199-209.
Smoothly clipped absolute deviation (SCAD) regularization for compressed sensing MRI using an augmented Lagrangian scheme.
Mehranian A, Saligheh Rad H, Rahmim A, Ay MR, Zaidi Habib (2013), Smoothly clipped absolute deviation (SCAD) regularization for compressed sensing MRI using an augmented Lagrangian scheme., in Magn Reson Imaging, 31(8), 1399-1411.
X-ray CT metal artifact reduction using wavelet domain L0 sparse regularization.
Mehranian A, Ay MR, Rahmim A, Zaidi Habib (2013), X-ray CT metal artifact reduction using wavelet domain L0 sparse regularization., in IEEE Trans Med Imaging, 32(9), 1707-1722.
Development of computational pregnant female and fetus models and assessment of radiation dose from positron-emitting tracers.
Xie Tianwu, Zaidi Habib, Development of computational pregnant female and fetus models and assessment of radiation dose from positron-emitting tracers., in European journal of nuclear medicine and molecular imaging.
One registration multi-atlas-based pseudo-CT generation for attenuation correction in PET/MRI.
Arabi Hossein, Zaidi Habib, One registration multi-atlas-based pseudo-CT generation for attenuation correction in PET/MRI., in European journal of nuclear medicine and molecular imaging, -in press.
One registration multi-atlas-based pseudo-CT generation for attenuation correction in PET/MRI.
Arabi H, Zaidi H, One registration multi-atlas-based pseudo-CT generation for attenuation correction in PET/MRI., in Eur J Nucl Med Mol Imaging.
Strategies for magnetic resonance imaging-guided attenuation correction in whole-body PET/MRI
Arabi Hossein, Strategies for magnetic resonance imaging-guided attenuation correction in whole-body PET/MRI, Université de Genève, Genève.

Collaboration

Group / person Country
Types of collaboration
University of Groningen Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
- Industry/business/other use-inspired collaboration
EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
University of Pennsylvania United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Industry/business/other use-inspired collaboration
Johns Hopkins University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Odense spring meeting Talk given at a conference delivered 2 invited talks: Hybrid imaging and Advances in MRI-guided attenuation correction in PET/MRI 11.04.2016 Odense, Denmark Zaidi Habib;
• International Conference on Clinical PET-CT and Molecular Imaging: PET-CT in the Era of Multimodality Imaging and Image Guided Therapy (IPET-2015) Talk given at a conference Image-derived PET metrics in monitoring response to therapy 05.10.2015 Vienna, Austria Zaidi Habib;


Awards

Title Year
2015 Sir Godfrey Hounsfield Award given by the British Institute of Radiology. The prize was awarded at the BIR annual congress, November 4-5, 2015, held in London (UK). 2015
Best of British Journal of Radiology (BJR) 2014 ‒ Becker M and Zaidi H "Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI" Br J Radiol Vol. 87, No. 1036, pp 20130677 (2014) 2015
Frequently cited paper 2014 ‒ Akbarzadeh A, Ay MR, A. Ahmadian A, Riahi Alam N, and Zaidi H Ann Nucl Med Vol. 27, No. 2, pp 152-162 (2013) 2014
2013 John S. Laughlin Young Scientist Award given by the American Association of Physicists in Medicine (AAPM) to recognize outstanding scientific achievements in medical physics for a young scientist. 2013
2013 Vikram Sarabhai Distinguished Oration Award given by the Society of Nuclear Medicine (India). The prize was awarded at the SNMI annual meeting, December 12-15, 2013, held in Mumbai (India) 2013
Appreciation Award given by the Middle East Federation of Organizations of Medical Physics (MEFOMP) for contribution and dedicated support of Medical Physics in the Middle East region. 2013

Associated projects

Number Title Start Funding scheme
124114 Impact of qualitative MR perfusion imaging on the management of patients with carotid artery disease 01.10.2009 SPUM
135576 Development of quantitative procedures for dual-modality PET/MR imaging 01.09.2011 Project funding (Div. I-III)

Abstract

Early diagnosis and therapy increasingly operate at the cellular, molecular or even at the genetic level. As diagnostic techniques transition from the systems to the molecular level, the role of multi-modal imaging becomes increasingly important. Whole body hybrid (PET/CT and PET/MR) imaging, making use of the standardized uptake value (SUV), is well established in clinical setting for diagnosis and staging, treatment response monitoring and radiation therapy treatment planning of a wide range of oncologic malignancies. However, the SUV metric derived from static PET data does not capture the dynamics of the PET probe biodistribution in the body. Alternatively, dynamic PET imaging, presently employed mostly in research setting, is capable of tracing tracer kinetics thus allowing for more accurate quantification of tracer uptake. This acquisition mode enables to enhance, in certain situations, normal and abnormal (tumor) tissue characterization, assessment of treatment response or radiation therapy planning. However, given the long acquisition times, complexity of data analysis and the need to handle large data sets, dynamic data acquisition protocols have been confined to limited axial field-of-view (single-bed) coverage. As such, parametric imaging based on full kinetic analysis using spatiotemporal image reconstruction is rarely used due to noise induced bias and variance in kinetic parameters and analysis is usually restricted to semi-quantitative (SUV) indices.We request funding to develop and validate in clinical setting a methodology to translate dynamic PET acquisition for 4D parametric imaging with motion compensation to routine clinical practice of whole-body PET-CT and PET-MR imaging for the assessment and characterization of disease spread and recurrence. This work will push forward the development and widespread adoption of dynamic whole body PET-CT and PET-MRI, the latter being an embryonic technology that has excellent potential to become a powerful tool for clinical research and diagnosis. This research involves medical physicists, physicians, radiologists, radiochemists and scientists working at the Department of Radiology and Medical Informatics of Geneva University Hospital (HUG), and image processing and analysis researchers from the University of Geneva (UniGe) and the Swiss Federal Institute of Technology (EPFL) in collaboration with international academic partners to achieve our goals.The division of nuclear medicine together with national and international partners foresees to develop innovative approaches for motion compensated direct 4D parametric whole-body PET imaging. We submit this funding request to boost our research in this area with the goals to:A.Perform Monte Carlo simulation studies to optimize the study design and the data acquisition and processing protocol by studying the effects of various parameters on imaging performance, and generation of dynamic PET data sets corresponding to the geometry of our PET-CT and PET-MRI systems;B.Develop new, more accurate and robust 4D image reconstruction algorithm along with a 2-tissue compartment model to directly estimate parametric images of microparameters on dynamic whole-body [18F]-FDG PET data and compare the generated parametric maps with those obtained from traditional post-reconstructed kinetic analysis;C.Implement and evaluate a new approach to direct parameter estimation by incorporating a recently proposed kinetic modeling strategy within a direct 4D image reconstruction to reduce error propagation from erroneous model fits, thus improving kinetic parameter precision and accuracy;D.Develop and validate novel 4D MR-derived motion correction schemes to eliminate artefacts seen in PET-CT by developing MR-based motion-compensated PET attenuation correction strategies;E.Develop new and robust multivariate and multiparametric PET image analysis tools and validate the developed quantitative PET imaging methodology using simulated and experimental dynamic phantom studies and clinical data and apply it in a clinical environment in various oncologic applications.
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