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Daily Symptoms in Major Depressive Disorder and Social Phobia: Factors that Influence Fluctuations and the Memory-Experience Gap

English title Daily Symptoms in Major Depressive Disorder and Social Phobia: Factors that Influence Fluctuations and the Memory-Experience Gap
Applicant Gloster Andrew
Number 149524
Funding scheme Project funding (Div. I-III)
Research institution Klinische Psychologie und Psychotherapie Fakultät für Psychologie Universität Basel
Institution of higher education University of Basel - BS
Main discipline Psychology
Start/End 01.02.2014 - 30.09.2017
Approved amount 396'554.00
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Keywords (7)

Ecological Momentary Assessment; Social Phobia; Experience Memory Gap; Major Depression; Daily Symptoms; Well-being; Technology

Lay Summary (German)

Lead
Depressionen und Soziale Phobien gehören zu den am häufigsten vorkommenden psychischen Störungen. Beide Störungsbilder führen zu hohen individuellen und gesamt gesellschaftlichen Kosten. Um die alltägliche Befindlichkeit der Betroffenen wie auch bestehende Behandlungsmöglichkeiten weiter verbessern zu können, ist ein besseres Verständnis von Faktoren, die den Störungsbildern zugrunde liegen, notwendig.
Lay summary
Inhalt und Ziel des Forschungsprojekts:
Diese Studie erforscht die tagesübergreifende Ausprägung und Schwankungen störungsbezogener Symptome bei Patienten mit einer Depression und Patienten mit einer Sozialen Phobie. Zudem wird die zirkadiane Ausprägung der Emotionalität und des Wohlbefindens (letzteres auch bei gesunden Personen) untersucht. Ziel ist es, die Verbindung zwischen tagesabhängigen Schwankungen in der Emotionaltät/Wohlbefinden und der Ausprägung der psychopathologischen Symptomatik zu verstehen. Um dies zu untersuchen, halten die Patienten und Patientinnen über eine Woche hinweg täglich ihre Beobachtungen über Emotionen, dem Erleben spezifischer Situationen und Symptome mittels eines Smartphones fest. Auf dieser Basis können Zusammenhänge zwischen Emotionserleben, spezifischen Situationen und den Schwankungen in der täglichen Symptomausprägung untersucht werden. Zusätzlich untersucht das Projekt, wie gut sich Patienten und Patientinnen an die alltäglichen Schwankungen ihrer Symptomatik erinnern, indem die tägliche mit der wöchentlichen Selbstbeobachtung verglichen wird.

Wissenschaftlicher und gesellschaftlicher Kontext:
Dies ist eine der ersten Studien, welche alltägliche Symptomschwankungen bei Personen mit einer Depression und Personen mit einer Sozialen Phobie untersucht. Die Studienergebnisse führen zu einem besseren Verständnis darüber, welche Faktoren im Alltag bei den Betroffenen zu einer Verschlechterung oder Besserung ihrer Beschwerden führen. Dieses Wissen kann in die Therapie eingebaut werden und den Betroffenen ermöglichen, ihre Beschwerden im Alltag besser zu meistern.
Direct link to Lay Summary Last update: 20.01.2014

Responsible applicant and co-applicants

Employees

Publications

Publication
Changes of valued behaviors and functioning during an Acceptance and Commitment Therapy Intervention
Wersebe Hanna, Lieb Roselind, Meyer Andrea H., Hoyer Jürgen, Wittchen Hans-Ulrich, Gloster Andrew T. (2017), Changes of valued behaviors and functioning during an Acceptance and Commitment Therapy Intervention, in Journal of Contextual Behavioral Science, 6, 63-70.
Daily Fluctuation of Emotions & Memories Thereof: Design and Methods of an Event Sampling Study of Major Depression, Social Phobia, and Controls
Gloster Andrew T., Miche Marcel, Wersebe Hanna, Mikoteit Thorsten, Hoyer Jürgen, Imboden Christian, Bader Klaus, Meyer Andrea, Hatzinger Martin, Lieb Roselind (2017), Daily Fluctuation of Emotions & Memories Thereof: Design and Methods of an Event Sampling Study of Major Depression, Social Phobia, and Controls, in International Journal of Methods in Psychaitric Research, 26(3), e1578.
Mental disorders and the risk for the subsequent first suicide attempt: results of a community study on adolescents and young adults
Miche Marcel, Hofer Patrizia, Voss Catharina, Meyer Andrea, Gloster Andrew T., Beesdo-Baum Katja, Lieb Roselind, Mental disorders and the risk for the subsequent first suicide attempt: results of a community study on adolescents and young adults, in European Child Adolescent Psychiatry.

Collaboration

Group / person Country
Types of collaboration
Prof. Dr. Rolf-Dieter Stieglitz, Clinical Psychology and Psychiatry, University of Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Dr. Andrea Meyer, Clinical Psychology and Epidemiology, University of Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Dr. Jens Gaab, Clinical Psychology and Psychotherapy, University of Basel Switzerland (Europe)
- Publication
- Research Infrastructure
Dr. Jens Klotsche, German Rheumatism Research Center Berlin, Epidemiology Unit, A Leibnitz Institute Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Jürgen Hoyer, Director Institute of Applied Psychotherapy, Technische University Dresden Germany (Europe)
- Publication
- Research Infrastructure
- Exchange of personnel
Dr.med.Thorsten Mikoteit, Oberarzt ZASS-UPKBasel, Clinic for Affective, Stress, & Sleep Disorders Switzerland (Europe)
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
30. Symposium der Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) Poster Impact of irregular sleep patterns on emotion regulation and cognitive flexibility in patients with major depression and in healthy controls 04.10.2017 Munich, Germany Miché Marcel; Gloster Andrew; Lieb Roselind; Wersebe Hanna;
15th Swiss Psychological Society Conference Talk given at a conference Stress and Social Interaction: The Impact of Daily Flexible vs. Rigid Response Styles in Participants with Depression, Social Phobia, & Controls 04.09.2017 Lausanne, Switzerland Gloster Andrew;
15th World Congress of the Association of Contextual Behavioral Science Talk given at a conference Remember, remember: Evaluating the Memory-Experience Gap for Psychological Flexibility using Ecological Momentary Assessment — Preliminary Results 22.06.2017 Seville, Spain Gloster Andrew; Lieb Roselind;
15th World Congress of the Association of Contextual Behavioral Science Talk given at a conference “I’d like to see you – except when I don’t”: Types of Social Interaction and Psychological Flexibility – Preliminary Results 22.06.2017 Seville, Spain Lieb Roselind; Gloster Andrew;
46th European Association of Behavioural and Cognitive Therapies Talk given at a conference The role of psychological flexibility in reducing psychological suffering 31.08.2016 Stockholm, Sweden Gloster Andrew;
14th World Congress of the Association of Contextual Behavioral Science Talk given at a conference The Ups and Downs of a Flexible Life: Using ESM to Capture Daily Fluctuations of Emotions and Behaviors in Participants with Depression, Social Anxiety, & Controls 16.06.2016 Seattle, United States of America Gloster Andrew;


Associated projects

Number Title Start Funding scheme
150427 Psychological Flexibility and Well-Being 01.07.2013 International short research visits
163716 Effects of Psychological Flexibility in Social Context: A Multi-Level Approach 01.06.2016 SNSF Professorships

Abstract

Background: The temporal properties of symptom fluctuations and the understanding of the dynamic contexts that give rise to these fluctuations are poorly understood. As a result, much remains to be learned about the factors that influence symptomatology and well-being as well as patients’ general inability to precisely reflect and report about their experiences. This research study will use ecological momentary assessment/ event sampling methodology (EMA/ESM), an assessment method that captures data close to the time of occurrence in participants’ own environment, as a means of capturing data that inform about maintaining factors of symptoms and well-being. The relative neglect of these issues to date and the failure to fully explore rich variability of dynamic expression of patient symptomatology has led to obfuscation about the factors that maintain psychopathology and incomplete theories of psychopathology.Method: In this study we will obtain EMA/ESM data to test current theory about factors that exacerbate and ameliorate psychopathological symptoms and mental states such as well-being. In order to examine the gap between people’s experiences and memory of these experiences, participants will retrospectively recall aspects of the data they recorded via EMA/ESM. Participants will include patients with mental disorders and healthy controls (n=117). The patient groups will consist of people diagnosed with social phobia (n = 48) and major depressive disorder (MDD) (n=117), both of which are prevalent and associated with high levels of disability, suffering, and lost opportunity. Factors to be examined include affect, daily events, social interactions, health behaviors, experiential avoidance, and psychological flexibility. Importantly, the inclusion of an anxiety disorder, a mood disorder, and healthy controls allows for critical testing of the generalizability and specificity of our findings. Expected Outcomes: In gathering rich multi-level data, we will be able to critically examine various aspects about the psychopathology of MDD and social phobia. First, the EMA/ESM data will provide information on the factors that exacerbate symptomatology and promote well-being. This information will be further used to help determine factors that promote stability/ instability of daily symptom fluctuations. Second, these data will be used to determine the degree of accuracy in recalling EMA/ESM assessed symptomatology/ well-being and explore which heuristics (e.g., recency and saliency bias) and characteristics are associated with the memory-experience gap. Participants’ retrospectively recalled data will be examined to determine whether participant characteristics (e.g., severity and type of symptomatology, degree of emotional suppression, symptom stability, etc.) potentiate the inaccuracies. By examining these factors across a mood disorder, an anxiety disorder, and a control group with neither disorder, the implication of our findings will have transdiagnostic relevance. As such, the proposed project has the potential to be of high scientific and societal value by helping to better understand and assess two prevalent and debilitating mental disorders.
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