cardio-metabolic disorders; biological mechanisms; lifestyle factors; lifecourse; socioeconomic status; epigenetics; cohort studies
Castagne Raphaele, Delpierre Cyrille, Kelly-Irving Michelle, Campanella Gianluca, Guida Florence, Krogh Vittorio, Palli Domenico, Panico Salvatore, Sacerdote Carlotta, Tumino Rosario, Kyrtopoulos Soterios, Hosnijeh Fatemeh Saberi, Lang Thierry, Vermeulen Roel, Vineis Paolo, Stringhini Silvia, Chadeau-Hyam Marc (2016), A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers, in SCIENTIFIC REPORTS
, 6, 25170.
de Mestral Carlos, Stringhini Silvia, Marques-Vidal Pedro (2016), Barriers to healthy eating in Switzerland: A nationwide study., in Clinical nutrition (Edinburgh, Scotland)
Mayén Ana Chacon, Guessous Idris, Paccaud Fred, Stringhini Silvia, Marques-VIdal Pedro (2016), Educational differences in dietary intake and compliance with dietary recommendations in a Swiss adult population., in International Journal of Public Health
Mayén Ana-Lucia, Guessous Idris, Paccaud Fred, Stringhini Silvia, Marques-Vidal Pedro (2016), Educational differences in dietary intake and compliance with dietary recommendations in a Swiss adult population., in International journal of public health
Yepes Maryam, Maurer Jürgen, Stringhini Silvia, Viswanathan Barathi, Gedeon Jude, Bovet Pascal (2016), Ideal Body Size as a Mediator for the Gender-Specific Association Between Socioeconomic Status and Body Mass Index: Evidence From an Upper-Middle-Income Country in the African Region., in Health education & behavior : the official publication of the Society for Public Health Education
, 43(1 Suppl), 56-63.
Stringhini Silvia, Zaninotto Paola, Kumari Meena, Kivimaki Mika, Batty G David (2016), Lifecourse socioeconomic status and type 2 diabetes: the role of chronic inflammation in the English Longitudinal Study of Ageing., in Scientific Reports
Joost Stéphane, Duruz Solange, Marques-Vidal Pedro, Bochud Murielle, Stringhini Silvia, Paccaud Fred, Gaspoz Jean-Michel, Theler Jean-Marc, Chételat Joël, Waeber Gérard, Vollenweider Peter, Guessous Idris (2016), Persistent spatial clusters of high body mass index in a Swiss urban population as revealed by the 5-year GeoCoLaus longitudinal study., in BMJ open
, 6(1), 010145-010145.
Petrovic Dusan, Pivin Edward, Ponte Belen, Dhayat Nasser, Pruijm Menno, Ehret Georg, Ackermann Daniel, Guessous Idris, Younes Sandrine Estoppey, Pechère-Bertschi Antoinette, Vogt Bruno, Mohaupt Markus, Martin Pierre-Yves, Paccaud Fred, Burnier Michel, Bochud Murielle, Stringhini Silvia (2016), Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study., in Psychoneuroendocrinology
, 67, 76-85.
Mayén Ana-Lucia, Bovet Pascal, Marti-Soler Helena, Viswanathan Bharathi, Gedeon Jude, Paccaud Fred, Marques-Vidal Pedro, Stringhini Silvia (2016), Socioeconomic Differences in Dietary Patterns in an East African Country: Evidence from the Republic of Seychelles., in PloS one
, 11(5), 0155617-0155617.
Mayén Ana-Lucia, Stringhini Silvia, Ford Nicole D, Martorell Reynaldo, Stein Aryeh D, Paccaud Fred, Marques-Vidal Pedro (2016), Socioeconomic predictors of dietary patterns among Guatemalan adults., in International journal of public health
Vineis Paolo, Kelly-Irving Michelle, Rappaport Stephen, Stringhini Silvia (2016), The biological embedding of social differences in ageing trajectories., in Journal of epidemiology and community health
, 70(2), 111-3.
Stringhini Silvia, Forrester Terrence E, Plange-Rhule Jacob, Lambert Estelle V, Viswanathan Bharathi, Riesen Walter, Korte Wolfgang, Levitt Naomi, Tong Liping, Dugas Lara R, Shoham David, Durazo-Arvizu Ramon A, Luke Amy, Bovet Pascal (2016), The social patterning of risk factors for noncommunicable diseases in five countries: evidence from the modeling the epidemiologic transition study (METS)., in BMC public health
, 16, 956-956.
Flatz Aline, Casillas Alejandra, Stringhini Silvia, Zuercher Emilie, Burnand Bernard, Peytremann-Bridevaux Isabelle (2015), Association between education and quality of diabetes care in Switzerland., in International journal of general medicine
, 8, 87-92.
Fraga Silvia, Marques-Vidal Pedro, Vollenweider Peter, Waeber Gerard, Guessous Idris, Paccaud Fred, Barros Henrique, Stringhini Silvia (2015), Association of socioeconomic status with inflammatory markers: A two cohort comparison, in PREVENTIVE MEDICINE
, 71, 12-19.
Stringhini Silvia, Haba-Rubio José, Marques-Vidal Pedro, Waeber Gérard, Preisig Martin, Guessous Idris, Bovet Pascal, Vollenweider Peter, Tafti Mehdi, Heinzer Raphael (2015), Association of socioeconomic status with sleep disturbances in the Swiss population-based CoLaus study., in Sleep medicine
, 16(4), 469-76.
Demetriou Christiana A, van Veldhoven Karin, Relton Caroline, Stringhini Silvia, Kyriacou Kyriacos, Vineis Paolo (2015), Biological embedding of early-life exposures and disease risk in humans: a role for DNA methylation., in European journal of clinical investigation
, 45(3), 303-32.
Marques-Vidal Pedro, Waeber Gerard, Vollenweider Peter, Bochud Murielle, Stringhini Silvia, Guessous Idris (2015), Sociodemographic and Behavioural Determinants of a Healthy Diet in Switzerland, in ANNALS OF NUTRITION AND METABOLISM
, 67(2), 87-95.
Guerra Filipa, Stringhini Silvia, Vollenweider Peter, Waeber Gerard, Marques-Vidal Pedro (2015), Socio-demographic and behavioural determinants of weight gain in the Swiss population, in BMC PUBLIC HEALTH
, 15, 1.
Guerra Filipa, Stringhini Silvia, Vollenweider Peter, Waeber Gérard, Marques-Vidal Pedro (2015), Socio-demographic and behavioural determinants of weight gain in the Swiss population., in BMC public health
, 15, 73-73.
Nicod Edouard, Stringhini Silvia, Marques-Vidal Pedro, Paccaud Fred, Waeber Gérard, Lamiraud Karine, Vollenweider Peter, Bochud Murielle (2014), Association of education and receiving social transfers with allostatic load in the Swiss population-based CoLaus study., in Preventive medicine
, 63, 63-71.
Stringhini Silvia, Rousson Valentin, Viswanathan Bharathi, Gedeon Jude, Paccaud Fred, Bovet Pascal (2014), Association of socioeconomic status with overall and cause specific mortality in the republic of seychelles: results from a cohort study in the african region., in PloS one
, 9(7), 102858-102858.
Guessous Idris, Theler Jean-Marc, Izart Claire Durosier, Stringhini Silvia, Bodenmann Patrick, Gaspoz Jean-Michel, Wolff Hans (2014), Forgoing dental care for economic reasons in Switzerland: a six-year cross-sectional population-based study., in BMC oral health
, 14, 121-121.
Marti-Soler Helena, Gonseth Semira, Gubelmann Cédric, Stringhini Silvia, Bovet Pascal, Chen Pau-Chung, Wojtyniak Bogdan, Paccaud Fred, Tsai Dai-Hua, Zdrojewski Tomasz, Marques-Vidal Pedro (2014), Seasonal variation of overall and cardiovascular mortality: a study in 19 countries from different geographic locations., in PloS one
, 9(11), 113500-113500.
Mayén Ana-Lucia, Marques-Vidal Pedro, Paccaud Fred, Bovet Pascal, Stringhini Silvia (2014), Socioeconomic determinants of dietary patterns in low- and middle-income countries: a systematic review., in The American journal of clinical nutrition
, 100(6), 1520-31.
Vineis Paolo, Stringhini Silvia, Porta Miquel (2014), The environmental roots of non-communicable diseases (NCDs) and the epigenetic impacts of globalization., in Environmental research
, 133, 424-30.
Vu Francis, Bischoff Thomas, Wolff Hans, Guessous Idris, Dory Elodie, Dubois-Arber Françoise, Stringhini Silvia, Bodenmann Patrick (2013), [Social medicine: does it still make sense in 2013?]., in Revue médicale suisse
, 9(408), 1-7.
Stringhini Silvia, Spadea Teresa, Stroscia Morena, Onorati Roberta, Demaria Moreno, Zengarini Nicolás, Costa Giuseppe, Decreasing educational differences in mortality over 40 years: evidence from the Turin Longitudinal Study (Italy)., in Journal of epidemiology and community health
, Epub ahead of print.
Stringhini Silvia, Polidoro Silvia, Sacerdote Carlotta, Kelly Rachel S, van Veldhoven Karin, Agnoli Claudia, Grioni Sara, Tumino Rosario, Giurdanella Maria Concetta, Panico Salvatore, Mattiello Amalia, Palli Domenico, Masala Giovanna, Gallo Valentina, Castagné Raphaële, Paccaud Fred, Campanella Gianluca, Chadeau-Hyam Marc, Vineis Paolo, Life-course socioeconomic status and DNA methylation of genes regulating inflammation., in International journal of epidemiology
, Epub ahead of print.
Social inequalities in health are a ubiquitous phenomenon. Conversely, research still has to provide a comprehensive understanding of the mechanisms underlying them. Several processes of social causation have been postulated, including patterns of unhealthy behaviors, psychosocial factors, and living and working conditions. Recent studies suggested that differences in lifestyle may contribute to a large proportion of social inequalities in health. In the last years, research started addressing the issue of how socioeconomic status eventually “gets under the skin”. Human and animal studies have identified several interrelated processes through which the social environment could be embedded, including dysregulation of the hypothalamic-pituitary-adrenal axis, inflammatory processes, neural function and structure, and, ultimately, epigenetic mechanisms. These studies cover a promising new field of research, and several questions remain to be addressed: 1.Studies examining the biology of social adversity have generally described socioeconomic differences in biological markers, but the actual contribution of these intermediate steps to social inequalities in chronic diseases has rarely been evaluated. Further, few studies have evaluated the interactions between lifestyle-related risk factors and biological markers. 2.Some new lifestyle factors potentially implicated in the etiology of socioeconomic differences in health, such as inadequate sleep, have been under-researched. 3.The influence of early life vs. adult socioeconomic status on the biological pathways leading to diseases remains unknown, as well as the extent to which the impact of early life exposure to social adversity can be modified later in life. This research project will focus on cardio-metabolic disorders, which show a strong gradient in their social distribution and whose burden on the most disadvantaged sections of society is rapidly increasing worldwide. The overarching aim is to extend the study of social inequalities in health and their determinants by incorporating an analysis of the biological mechanisms linking lifetime social adversity to cardio-metabolic disease. Specific aims of this research are: 1.To assess the contribution of lifestyle factors (unhealthy behaviors, chronic stress and inadequate sleep) to the association between lifecourse socioeconomic status and cardio-metabolic disorders. 2.To establish the extent to which the contribution of lifestyle factors to social inequalities in cardio-metabolic disorders is mediated by socioeconomic differences in inflammatory markers.3.To understand if social adversity in early life has an impact on gene expression and DNA methylation, and if this can partly explain socioeconomic differences in inflammatory markers. This research project will provide a better understanding of the social, behavioural and biological pathways leading from lifetime socioeconomic adversity to adult life cardio-metabolic disease risk. This will not only add further observations on the role of exposure in early life in shaping health through adulthood, but will also clarify to what extent exposure to early life social adversity has an impact on adult health through behavioural vs. biological pathways. Moreover, this research will establish the extent to which the undesirable health consequences of adverse social exposure in early life are potentially reversible. Last but not least, an epigenome-wide analysis of socioeconomic differences in gene regulation will allow new insight to be gained into the mechanisms through which the social environment has an impact on health. Analyses will be conducted using data from 3 Swiss population-based studies (the CoLaus study, N=6000; the Bus Santé study, N=15,000; the SKIPOGH study, N=1100), the British Whitehall II study (N=10,308), and the multi-country METS study (N=2500). All studies have a longitudinal design allowing the assessment of incident health outcomes. Several indicators of socioeconomic status across the lifecourse (educational level, income, father’s occupation, among others) will be used in this research project. Lifestyle factors considered are health behaviors (smoking, alcohol consumption, diet and physical activity), inadequate sleep and chronic stress. Information on epigenome-wide gene expression and DNA methylation will be collected in a subsample of 250 participants of the SKIPOGH study. The multidisciplinarity (social epidemiology, cardiovascular, cardio-metabolic and genetic epidemiology, public health, sleep medicine, internal medicine, and molecular biology) characterizing this research project offers potential to produce novel and innovative answers to the question of how socioeconomic status over the lifecourse leads to disease decades later. Further, the use of five datasets offering a vast number of phenotypes measured repeatedly over time, along with precise indicators of socioeconomic status over the lifecourse, will allow the replication of results to ensure their consistency and the examination of between-country variations.