sexually antagonistic selection; sex determination; sex chromosomes; recombination
MaWen-Juan, VeltsosParis, ToupsMelissa, RodriguesNicolas, SermierRoberto, JeffriesDan, PerrinNicolas (2018), Tissue Specificity and Dynamics of Sex-Biased Gene Expression in a Common Frog Population with Differentiated, Yet Homomorphic, Sex Chromosomes, in Genes
, 9, 294.
VeltsosParis, CossardGuillaume, BeaudoingEmmanuel, BeydonGenséric, Savova BianchiDessislava, RouxCamille, Gonzalez-MartinezSantiago, PannellJohn (2018), Size and Content of the Sex-Determining Region of the Y Chromosome in Dioecious Mercurialis annua, a Plant with Homomorphic Sex Chromosomes, in Genes
, 9, 277.
Pannell John (2017), Plant sex determination, in Current Biology
, 27, R191-R197.
Kirkpatrick Mark (2017), The evolution of genome structure by natural and sexual selection, in Journal of Heredity
, 108, 3-11.
Perrin N (2016), Random sex determination: when developmental noise tips the sex balance., in BioEssays
, 38(12), 1218-1226.
Ma Wen-Juan, Pannell John (2016), Sex Determination: Separate Sexes Are a Double Turnoff in Melons., in Current Biology
, 26, R171-R174.
Cheng Changde, Kirkpatrick Mark (2016), Sex-specific selection and sex-biased gene expression in humans and flies., in PLOS Genetics
, 12, e1006170-e1006170.
Toups Melissa, Veltsos Paris, Pannell John (2015), Plant sex chromosomes: lost genes with little compensation., in Current Biology
, 25, R427-R430.
Rodrigues Nicolas, Studer Tania, Dufresnes Christophe, Ma Wen-Juan, Veltsos Paris, Perrin Nicolas, Dmrt1 polymorphism and sex chromosome differentiation in Rana temporaria, in Molecular Ecology
Ma WenJuan, Rodrigues Nicolas, Sermier Roberto, Brelsford Alan, Perrin Nicolas, Dmrt1 polymorphism covaries with sex-determination patterns in Rana temporaria, in Ecology and Evolution
Brelsford Alan, Lavanchy Guillaume, Sermier Roberto, Rausch Anna, Perrin Nicolas, Identifying homomorphic sex chromosomes from wild-caught adults with limited genomic resources, in Molecular Ecology Resources
Our project aims at integrating innovative theoretical and conceptual approaches with genetic/genomic investigations of nascent sex chromosomes. On one hand, we will develop evolutionary models and statistical procedures aimed at formalizing the dynamic view of sex-chromosome evolution that emerges from recent studies of non-model organisms. On the other hand, these models and procedures will be calibrated and tested with genetic/genomic data gathered from two highly divergent lineages (angiosperms and amphibians).Our evolutionary models will focus on two main questions: i) Why do some chromosomes evolve suppressed recombination and others not? And ii) What drives turnovers in sex determination systems? To do so, we will examine the interplay between sex-determination genes, sexually antagonistic genes, deleterious mutations and recombination on the dynamics and evolution of sex chromosomes. We will build on the conceptual frameworks, analytical methods and individual-based simulations already developed in our labs.Statistical procedures will characterize processes of molecular evolution in recombining sex chromosomes. We aim to predict patterns of neutral genetic variation expected on sex chromosomes experiencing deleterious/beneficial mutations and recombination. One of the goals is to identify signatures of sexually antagonistic selection in recombining sex chromosomes. We will also build on conceptual and analytical frameworks (such as Approximate Bayesian computations) already developed in our labs.Empirical calibration and tests of predictions stemming from the above models and procedures will focus on a group of plants (Mercurialis spp.) and amphibians (Rana spp.) identified for their labile sex determination systems and recombining sex chromosomes. For both group of species we will combine RAD-tag sequencing and transcriptome analyses with family pedigrees to measure X-Y differentiation and identify signatures of selective pressures along the recombining chromosomes. This will be done for several species from each radiation that differ in sex determination systems.