Brain mechanics; Computational fluid dynamics; Homogenization theory; Mechanobiology; Fluid structure interaction; Finite volume method; Porous media; Microfabrication; Brain Mechanics; Intracranial dynamics
Stefopoulos Georgios, Robotti Francesco, Falk Volkmar, Poulikakos Dimos, Ferrai Aldo (2016), Endothelialization of rationally microtextured surfaces with minimal cell seeding under flow, in Small
, 12, 4113.
Asgari Mahdi, de Zélicourt Diane, Kurtcuoglu Vartan (2016), Glymphatic solute transport does not require bulk flow, in Scientific Reports
, 6, 38635.
Asgari Mahdi, de Zelicourt Diane, Kurtcuoglu Vartan (2015), How astrocyte networks may contribute to cerebral metabolite clearance, in Scientific Reports
, 5, 15024.
Siyahhan Bercan, Knobloch Verena, de Zelicourt Diane, Asgari Mahdi, Daners Marianne Schmid, Poulikakos Dimos, Kurtcuoglu Vartan (2014), Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles, in Journal of the Royal Society Interface
, 11(94), 20131189.
Robotti Francesco, Franco Davide, Bänninger Livia, Wyler Jair, Starck Christoph, Falk Volkmar, Poulikakos Dimos, Ferrari Aldo (2014), The influence of surface micro-structure on endothelialization under supraphysiological wall shear stress, in Biomaterials
, 35, 8479.
Asgari Mahdi, de Zélicourt Diane, Kurtcuoglu Vartan, Barrier dysfunction or drainage reduction: Differentiating causes of CSF protein increase, in Fluids and Barriers of the CNS
Impaired dynamics of intracranial fluid flow and pressure due to injury or disease is one of the main causes of brain damage and therewith associated death in young children and the elderly. Due to the limited understanding of the body’s control of intracranial dynamics, only symptomatic treatment is possible.The proposed research aims to elucidate a mechanism of intracranial dynamics control that could pave the way to specific (rather than symptomatic) treatment of traumatic brain injury, hydrocephalus and other intracranial disorders. Control of intracranial dynamics requires mechanosensing within the intracranial space. However, no cerebral flow or shear sensing areas are known to date. In contrast, arteries, kidneys and other organs have been shown to have well defined mechanotransduction pathways. We postulate that similar sensing mechanisms must be at work in the brain. This hypothesis will be tested using a hybrid approach: A novel computational model that takes into account the cerebral micro-structure will yield an estimate of local shear stresses. These data will be used to design a microfluidic flow chamber capable of reproducing frequencies and amplitudes of in vivo shear stress on cell cultures. If the hypothesis of shear stress sensing proves correct, it will fundamentally change the view of the brain as a mechanically passive organ. With this rectified understanding of brain mechanics, new opportunities for the treatment of intracranial pathologies are bound to emerge.