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The evolution of sex chromosomes: a perspective from amphibians

Titel Englisch The evolution of sex chromosomes: a perspective from amphibians
Gesuchsteller/in Perrin Nicolas
Nummer 147091
Förderungsinstrument Projektförderung (Abt. I-III)
Forschungseinrichtung Département d'Ecologie et d'Evolution Faculté de Biologie et de Médecine Université de Lausanne
Hochschule Universität Lausanne - LA
Hauptdisziplin Zoologie
Beginn/Ende 01.06.2013 - 31.05.2016
Bewilligter Betrag 925'260.00
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Keywords (3)

sex chromosome evolution; X-Y recombination; amphibians

Lay Summary (Französisch)

Lead
Evolution des chromosomes sexuels: la perspective des amphibiens
Lay summary

Le sexe chez les mammifères est déterminé par une paire de chromosomes sexuels, homomorphique chez les femelles (XX), mais fortement hétéromorphique chez les mâles (XY). Le chromosome Y est petit, pauvre en gènes, et résulte d’un processus de dégradation progressive commencé il y a 170 millions d’années, lorsque cette paire cessé de recombiner chez les mammifères mâles. Les oiseaux présentent un système similaire, à ceci près que le chromosome dégénéré (W) se trouve chez les femelles (ZW) alors que les mâles ont une paire homomorphique (ZZ). Les théories actuelles de l’évolution des chromosomes sexuels expliquent bien le processus de dégénération progressive ayant conduit à cette situation.

            Mais si on se tourne vers les vertébrés à sang froid, comme les poissons ou les amphibiens, on s’aperçoit que la plupart des espèces ne montrent aucun hétéromorphisme ni dégénérescence de chromosomes. Les raisons en sont potentiellement multiples : détermination du sexe par l’environnement ou multigénique; remplacement régulier des chromosomes sexuels, avant qu’ils aient le temps de dégénérer; ou encore recombinaison occasionnelle entre le X et le Y.

            Dans ce projet je m’intéresse à documenter la dynamique de l’évolution des chromosomes sexuels chez diverses espèces d’amphibiens, en combinant des méthodes de biologie moléculaire, de génétique des populations, de phylogéographie, et de simulations basées individus, pour comprendre les principales forces à l’œuvre dans l’évolution des mécanismes de déterminisme du sexe.

Direktlink auf Lay Summary Letzte Aktualisierung: 27.03.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Publikationen

Publikation
High-density sex-specific linkage maps of a European tree frog (Hyla arborea) identify the sex chromosome without information on offspring sex.
Brelsford Alan, Dufresnes Christophe, Perrin Nicolas (2016), High-density sex-specific linkage maps of a European tree frog (Hyla arborea) identify the sex chromosome without information on offspring sex., in Heredity, 116(2), 177-181.
Trans-species variation in Dmrt1 is associated with sex determination in four European tree-frog species.
Brelsford A, Dufresnes C, Perrin N (2016), Trans-species variation in Dmrt1 is associated with sex determination in four European tree-frog species., in Evolution, 70(4), 840-847.
Empirical evidence for large X-effects in animals with undifferentiated sex chromosomes
Dufresnes Christophe, Majtyka Tomasz, Baird Stuart, Gerchen Jörn, Borzée Amaël, Ogielska Maria, Perrin Nicolas, Stöck Mathias (2016), Empirical evidence for large X-effects in animals with undifferentiated sex chromosomes, in Scientific Reports, 6, 21029.
High-density linkage maps fail to detect any genetic component to sex determination in a Rana temporaria family.
Brelsford Alan, Rodrigues Nicolas, Perrin Nicolas (2016), High-density linkage maps fail to detect any genetic component to sex determination in a Rana temporaria family., in Journal of Evolutionary Biology, 29(1), 220-225.
Massive genetic introgression in threatened northern crested newts (Triturus cristatus) by an invasive congener (T. carnifex) in Western Switzerland
Dufresnes Christophe, Pellet Jérôme, Bettinelli-Riccardi Sandra, Thiébaud Jacques, Perrin Nicolas, Fumagalli Luca (2016), Massive genetic introgression in threatened northern crested newts (Triturus cristatus) by an invasive congener (T. carnifex) in Western Switzerland, in Conservation Genetics, 17, 839-846.
The genetic contribution to sex determination and number of sex chromosomes vary among populations of common frogs (Rana temporaria).
Rodrigues Nicolas, Vuille Yvan, Brelsford Alan, Merilä Juha, Perrin Nicolas (2016), The genetic contribution to sex determination and number of sex chromosomes vary among populations of common frogs (Rana temporaria)., in Heredity, 117(1), 25-32.
Effect of biogeographic history on population vulnerability in European amphibians.
Dufresnes Christophe, Perrin Nicolas (2015), Effect of biogeographic history on population vulnerability in European amphibians., in Conservation Biology, 29(4), 1235-1241.
Introgressive hybridization of threatened European tree frogs (Hyla arborea) by introduced H. intermedia in Western Switzerland
Dufresnes Christophe, Dubey Sylvain, Ghali Karim, Canestrelli Daniele, Perrin Nicolas (2015), Introgressive hybridization of threatened European tree frogs (Hyla arborea) by introduced H. intermedia in Western Switzerland, in Conservation Genetics, 16(6), 1507-1513.
Origin and genome evolution of polyploid green toads in Central Asia: evidence from microsatellite markers.
Betto-Colliard Caroline, Sermier Roberto, Litvintchuk Spartak, Perrin Nicolas, Stöck Mathias (2015), Origin and genome evolution of polyploid green toads in Central Asia: evidence from microsatellite markers., in Heredity, 114(3), 300-308.
Sex-chromosome differentiation and 'sex races' in the common frog (Rana temporaria).
Rodrigues Nicolas, Vuille Yvan, Loman Jon, Perrin Nicolas (2015), Sex-chromosome differentiation and 'sex races' in the common frog (Rana temporaria)., in Proceedings of the Royal Society B / Biological Sciences, 282(1806), 20142726.
Sex-Chromosome Homomorphy in Palearctic Tree Frogs Results from Both Turnovers and X-Y Recombination.
Dufresnes Christophe, Borzée Amaël, Horn Agnès, Stöck Mathias, Ostini Massimo, Sermier Roberto, Wassef Jérôme, Litvintchuk Spartak, Kosch Tiffany, Waldman Bruce, Jang Yikweon, Brelsford Alan, Perrin Nicolas (2015), Sex-Chromosome Homomorphy in Palearctic Tree Frogs Results from Both Turnovers and X-Y Recombination., in Molecular Biology and Evolution, 32(9), 2328-2337.
Timeframe of speciation inferred from secondary contact zones in the European tree frog radiation (Hyla arborea group).
Dufresnes Christophe, Brelsford Alan, Crnobrnja-Isailović Jelka, Tzankov Nikolay, Lymberakis Petros, Perrin Nicolas (2015), Timeframe of speciation inferred from secondary contact zones in the European tree frog radiation (Hyla arborea group)., in BMC Evolutionary Biology, 15, 155.
Sex determination: why so many ways of doing it?
Bachtrog Doris, Mank Judith, Peichel Cathy, Kirkpatrick Mark, Otto Sarah, Ashman Tia-Lynn, Hahn Mathew, Kitano Jun, Mayrose Ite, Ming Ray, Perrin Nicolas, Ross Laura, Valenzuela Nicole, Vamosi Jana (2014), Sex determination: why so many ways of doing it?, in PLoS Biology, 12(7), e1001899.
The evolution of sex determination
Beukeboom Leo, Perrin Nicolas (2014), The evolution of sex determination, Oxford University Press, Oxford.
Evolutionary melting pots: a biodiversity hotspot shaped by ring diversifications around the Black Sea in the Eastern tree frog (Hyla orientalis).
Dufresnes Christophe, Litvinchuk Spartak, Leuenberger Julien, Gahli Karim, Zinenko Oleksandr, Stöck Mathias, Perrin Nicolas, Evolutionary melting pots: a biodiversity hotspot shaped by ring diversifications around the Black Sea in the Eastern tree frog (Hyla orientalis)., in Molecular Ecology.

Verbundene Projekte

Nummer Titel Start Förderungsinstrument
129894 Evolution of sex chromosomes: a perspective from amphibians 01.06.2010 Projektförderung (Abt. I-III)
147625 The evolutionary genomics of recombining sex chromosomes 01.04.2014 Sinergia
166323 The evolution of sex chromosomes: a perspective from amphibians 01.06.2016 Projektförderung (Abt. I-III)

Abstract

Non-recombining sex chromosomes are expected to accumulate deleterious mutations under the combined effects of Muller’s ratchet and Hill-Robertson effects, and for this reason to progressively degenerate. Such decay has been largely documented in birds and mammals, most of which have strongly heteromorphic sex chromosomes with degenerated W and Y, respectively. In sharp contrast, however, cold-blooded vertebrates rarely show such a differentiation, even when sex determination is purely genetic. The present project aims at investigating the evolutionary dynamics of non-degenerating sex chromosomes, using amphibians as model organisms.
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