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Körperliche Aktivität als Komponente des Lebensstils zur aggressiven Minderung atherosklerotischer Modifikatoren (ADAM) bei älteren Individuen: die SAPALDIA Kohorten Studie

English title Physical activity as a life style component of aggressive decrease of atherosclerotic modifiers (ADAM) in elderly subjects: the SAPALDIA Cohort Study
Applicant Schmidt-Trucksäss Arno
Number 147022
Funding scheme Project funding (special)
Research institution Institut für Sport und Sportwissenschaft Medizinische Fakultät Universität Basel
Institution of higher education University of Basel - BS
Main discipline Cardiovascular Diseases
Start/End 01.05.2013 - 31.12.2015
Approved amount 165'187.00
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Keywords (11)

arteriosclerosis; cardiovascular disease; ADAM; ultrasound; carotid intima-media thickness; physical activity; cardio-ankle vascular index; arterial stiffness; pulse wave velocity; large nested project; SAPALDIA Cohort on Healthy Aging

Lay Summary (German)

Lead
Herz-Kreislauf-Erkrankungen stellen eines der grössten Gesundheitsprobleme weltweit dar. Zu den neuen Verfahren der frühzeitigen Erkennung eines Herz-Kreislaufrisikos zählt die Messung der arteriellen Gefässsteifigkeit mittels Cardio-Ankle-Vascular-Index (CAVI). Ziel der Studie ist es, die körperliche Aktivität als Komponente eines gesunden Lebensstils bei Individuen zwischen 50 - 80 Jahren aus der SAPALDIA Kohorten Studie in Bezug auf die arterielle Gefässsteifigkeit zu untersu-chen.
Lay summary

Ist regelmässige körperliche Aktivität als Komponente des gesunden Lebensstils zur aggressiven Minderung atherosklerotischer Modifikatoren (ADAM) bei älteren Menschen geeignet oder ist es in diesem Alter nicht mehr wirksam zur Erhaltung einer guten Gefässgesundheit? Diese Teilstudie der Schweiz weiten SAPALDIA Kohorten Studie soll eine Antwort auf die Frage geben. Sie zielt vorrangig darauf ab, einen Beitrag zur Prävention von Herz-Kreislauf-Erkrankungen bei älteren europäischen Personen zu leisten. Zu diesem Zweck wird die Verbindung zwischen arterieller Gefässsteifigkeit und körperlichen Aktivität bzw. deren Änderung bei 3024 Personen untersucht. Sie wurden 2010 und 2011 im Rahmen der SAPALDIA3 Kohorten-Studie nicht-invasiv mit einem neuen Messverfahren (Cardio-Ankle-Vascular-Index) untersucht, das auf der Blutdruckmessung mit Manschetten basiert. Dabei wurde gemessen, wie lange die durch den Herzschlag ausgelöste Pulswelle vom Herz bis zum Knöchel benötigt. Je schneller die Pulswelle ist, umso steifer sind die Arterien und die Belastung für das Herz. Körperliche Aktivität kann der Zunahme der arteriellen Gefässsteifigkeit entgegenwirken. Ob und inwieweit ein körperlich inaktiver Lebensstil zum Zeitpunkt der Untersuchung und mit Blick auf das Risikofaktorenprofil vor 10 Jahren mit einer erhöhten arteriellen Gefässsteifigkeit als Biomarker für ein grösseres Herz-Kreislauf-Risiko einhergeht, soll jetzt genau analysiert werden. Auch wird ermittelt, welches Mass an Bewegung dauerhaft für den Erhalt gesunder Arterien notwendig ist.

Dieses Projekt soll zur besseren Früherkennung, Prävention und gezielten Therapie von Herz-Kreislauf-Erkrankungen und damit zur Verbesserung der Gesundheit der Bevölkerung beitragen. Die Ergebnisse werden detailliertere Empfehlungen bezüglich eines körperlich aktiven Lebensstils ermöglichen.

Direct link to Lay Summary Last update: 06.05.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Associations of Novel and Traditional Vascular Biomarkers of Arterial Stiffness: Results of the SAPALDIA 3 Cohort Study.
Endes Simon, Caviezel Seraina, Schaffner Emmanuel, Dratva Julia, Schindler Christian, Künzli Nino, Bachler Martin, Wassertheurer Siegfried, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2016), Associations of Novel and Traditional Vascular Biomarkers of Arterial Stiffness: Results of the SAPALDIA 3 Cohort Study., in PloS one, 11(9), 0163844-0163844.
Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study.
Endes Simon, Schaffner Emmanuel, Caviezel Seraina, Dratva Julia, Autenrieth Christine S, Wanner Miriam, Martin Brian, Stolz Daiana, Pons Marco, Turk Alexander, Bettschart Robert, Schindler Christian, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2016), Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study., in Age and ageing, 45(1), 110-5.
Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study.
Endes Simon, Schaffner Emmanuel, Caviezel Seraina, Dratva Julia, Autenrieth Christine Sonja, Wanner Miriam, Martin Brian, Stolz Daiana, Pons Marco, Turk Alexander, Bettschart Robert, Schindler Christian, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2016), Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study., in European journal of epidemiology, 31(3), 275-85.
Carotid Stiffness and Physical Activity in Elderly-A Short Report of the SAPALDIA 3 Cohort Study
Caviezel Seraina, Dratva Julia, Schaffner Emmanuel, Schindler Christian, Endes Simon, Autenrieth Christine S., Wanner Miriam, Martin Brian, de Groot Eric, Gaspoz Jean-Michel, Kuenzil Nino, Probst-Hensch Nicole, Schmidt-Trucksass Arno (2015), Carotid Stiffness and Physical Activity in Elderly-A Short Report of the SAPALDIA 3 Cohort Study, in PLOS ONE, 10(6), 1-9.
Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study.
Endes Simon, Schaffner Emmanuel, Caviezel Seraina, Dratva Julia, Autenrieth Christine S, Wanner Miriam, Martin Brian, Stolz Daiana, Pons Marco, Turk Alexander, Bettschart Robert, Schindler Christian, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2015), Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study., in European Journal of Epidemiology, July(29), 0-10.
Reproducibility of oscillometrically measured arterial stiffness indices: Results of the SAPALDIA 3 cohort study
Endes Simon, Caviezel Seraina, Dratva Julia, Schaffner Emmanuel, Schindler Christian, Rothe Thomas, Rochat Thierry, Kuenzli Nino, Probst-Hensch Nicole, Schmidt-Trucksaess Arno (2015), Reproducibility of oscillometrically measured arterial stiffness indices: Results of the SAPALDIA 3 cohort study, in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 75(2), 170-176.
Reproducibility of oscillometrically measured arterial stiffness indices: Results of the SAPALDIA 3 cohort study.
Endes Simon, Caviezel Seraina, Dratva Julia, Schaffner Emmanuel, Schindler Christian, Rothe Thomas, Rochat Thierry, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno (2015), Reproducibility of oscillometrically measured arterial stiffness indices: Results of the SAPALDIA 3 cohort study., in Scandinavian journal of clinical and laboratory investigation, 75(2), 170-6.

Collaboration

Group / person Country
Types of collaboration
SwissTPH Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Austrian Institute of Technology Austria (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Kongress der Deutschsprachigen Gesellschaft für arterielle Gefässsteifigkeit (DeGAG) Talk given at a conference Associations of Novel and Traditional Vascular Biomarkers of Arterial Stiffness: Results of the SAPALDIA 3 Cohort Study 24.09.2016 Berlin, Germany Künzli Nino; Schmidt-Trucksäss Arno; Probst-Hensch Nicole; Endes Simon;
European Society of Cardiology (ESC) Congress Poster Long-term change of physical activity towards a physically active lifestyle is associated with reduced arterial stiffness in elderly males: results of the SAPALDIA 3 cohort study 29.08.2015 London, Great Britain and Northern Ireland Künzli Nino; Endes Simon; Schmidt-Trucksäss Arno; Probst-Hensch Nicole;
Akutgeriatrischen Universitätsklinik (AGUK) Seminare 2015 Individual talk Steife Arterien im Alter: vermeidbar oder Schicksal? 19.05.2015 Basel, Switzerland Schmidt-Trucksäss Arno;
Healthy Aging Research Council Talk given at a conference Age-related changes in cardiovascular system – prevention and treatment with exercise prescription. 16.04.2015 Lodz, Poland Schmidt-Trucksäss Arno;
The 22nd International Puijo Symposium Talk given at a conference PHYSICAL ACTIVITY AND ARTERIAL STIFFNESS IN AN ELDERLY POPULATION: RESULTS OF THE SAPALDIA3 COHORT STUDY 24.06.2014 Kuopio, Finland Künzli Nino; Endes Simon; Schmidt-Trucksäss Arno; Probst-Hensch Nicole;
Kongress der Deutschsprachigen Gesellschaft für arterielle Gefässsteifigkeit (DeGAG) Talk given at a conference Long-term effect of a physical active lifestyle on arterial stiffness in SAPALDIA 3 13.09.2013 Basel, Switzerland Künzli Nino; Schmidt-Trucksäss Arno; Probst-Hensch Nicole; Endes Simon;
European Society of Cardiology (ESC) Congress Talk given at a conference Reproducibility of the cardio-ankle vascular index (CAVI) in Caucasians (SAPALDIA 3) 31.08.2013 Amsterdam, Netherlands Schmidt-Trucksäss Arno; Probst-Hensch Nicole; Endes Simon; Künzli Nino;
Swiss Public Health Conference Talk given at a conference Reproducibility of the cardio-ankle vascular index (CAVI) in Caucasians (SAPALDIA 3) 15.07.2013 Zürich, Switzerland Probst-Hensch Nicole; Schmidt-Trucksäss Arno; Künzli Nino; Endes Simon;
Congress of the European College of Sport Science (ECSS) Talk given at a conference Long-term effect of a physical active lifestyle on arterial stiffness in SAPALDIA 3 26.06.2013 Barcelona, Spain Schmidt-Trucksäss Arno; Probst-Hensch Nicole; Endes Simon; Künzli Nino;


Self-organised

Title Date Place
Kongress der Deutschsprachigen Gesellschaft für arterielle Gefässsteifigkeit (DeGAG) 13.09.2013 Basel, Switzerland

Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Sport als Anti-Aging-Methode: kann ich meinem Alter davonlaufen? German-speaking Switzerland 2014

Awards

Title Year
Young Investigator Award der Gesellschaft für arterielle Gefässsteifigkeit (DeGAG), 2. Preis 2016
Young Investigator Award der Gesellschaft für arterielle Gefässsteifigkeit (DeGAG), 2. Preis 2013

Associated projects

Number Title Start Funding scheme
134276 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) 01.04.2011 Cohort Studies Large
108796 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) 01.04.2006 Cohort Studies Large
177506 SAPALDIA 5 - Cohort on Healthy Aging 01.04.2018 Cohort Studies Large

Abstract

This proposal outlines a research program of a large nested study of the third part of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA 3) including 3026 subjects. The research program seeks (i) to evaluate the measuring characteristics of the new cardio-ankle vascular index (CAVI) as a measurement tool of arterial stiffness for the first time in a Caucasian cohort and (ii) to analyse the association between physical activity (PA) as a preventive life style component of aggressive decrease of atherosclerotic modifiers (ADAM) and cardiovascular disease (CVD) in this Caucasian clientele. Cardiovascular diseases constitute a major worldwide health problem, upon which the bigger part of death causes are attributed to. Cardiovascular health issues are closely related to long-term asymptomatic changes of the vasculature in terms of arteriosclerosis and, especially, atherosclerosis as its major condition. Starting point of these alterations are vessel stiffening processes, for which reason arterial stiffness is an early, subclinical marker of potentially grave cardiovascular modifications. CAVI’s beneficial characteristic is the lower correlation with blood pressure (BP) fluctuations during investigations compared to other arterial stiffness measurements. Therefore, CAVI as a non-invasive, easy-to-apply technique may present a highly useful clinical tool for cardiovascular risk stratification and evidence-based treatment procedures at an early stage. In order to evaluate the potential usefulness of CAVI in Caucasians this research project targets three specific aims. At first this study aims at determining CAVI’s measuring characteristics so as to lay the basis for serial clinical application of CAVI in Caucasian populations. This will be performed by scrutinizing CAVI’s reproducibility, its dependency on blood pressure (BP) and the correlation with carotid intima-media thickness (CIMT), a traditional ultrasonographic marker of atherosclerosis measured in the SAPALDIA 3 cohort. All the named has not been shown for Caucasian people before, which is a prerequisite for the clinical application in these subjects. Within the second and third aim of the research project CAVI will be implemented for stratifying the cardiovascular risk based on physical inactivity. During the data collection of SAPALDIA 3 the International Physical Activity Questionnaire (IPAQ) has been consulted to classify the subjects’ physical activity (PA), which is regarded as an important health promotion measure with protective impact on the cardiovascular system and, thus, as one component of ADAM. Therefore, CAVI will be analysed across groups of different physical activity patterns in the SAPALDIA 3 cohort. In this context the question, whether a sedentary lifestyle is associated with increased CAVI values is of particular relevance. Up-to-date there exists no comparable cohort in which a measure of arterial stiffness may be analysed in association with a detailed questionnaire of PA like the IPAQ. Furthermore, this project implies the unique and worldwide first chance to study changes of PA in association with CAVI measurement over a time period of several years like between SAPALDIA 2 and SAPALDIA 3. Differences of arterial stiffness in association with changes in PA ranking from SAPALDIA 2 to SAPALDIA 3 over a reasonable time span of nine years may strengthen PA recommendations in middle-aged and elderly with respect to the prevention of manifest cardiovascular disease. Consequently, a systematic study is proposed, which tends to establish CAVI for cardiovascular risk group evaluations like physically inactive people. Because of CAVI having specific significance for examinations of asymptomatic subjects the herewith obtained cohort study results may lead to improvements of early stage diagnosis and treatment of cardiovascular disease including guidelines for appropriate PA.
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