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Sleep onset and other state transitions: insights from quantitative EEG analysis

English title Sleep onset and other state transitions: insights from quantitative EEG analysis
Applicant Achermann Peter
Number 146643
Funding scheme Project funding (Div. I-III)
Research institution Institut für Pharmakologie und Toxikologie Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurophysiology and Brain Research
Start/End 01.04.2014 - 31.08.2017
Approved amount 400'920.00
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Keywords (12)

quantitative EEG analysis; infants; global functional coupling; REM sleep to non-REM sleep transition; preschool children; adolescents; wakefulness to sleep transition; sleep onset; maturation; spectrogram; heart-rate variability; muscle tone

Lay Summary (German)

Lead
Schlaf ist für unser tägliches Funktionieren und Wohlbefinden wichtig. Trotzdem ist seine biologische Funktion immer noch schlecht verstanden. Das Elektroenzephalogramm (EEG) reflektiert die neuronale Aktivität des Gehirns und ist ein zuverlässiger Zustandsindikator (z.B. Wach-Zustand, Schlaf). Mit Hilfe neuer quantitativer EEG-Analysemethoden sollen neue Einsichten gewonnen werden, welche Prozesse diesen Zuständen und ihren Übergängen zugrunde liegen.
Lay summary

Das Projekt befasst sich mit dem Einschlafprozess (Übergang Wach-Zustand/Schlaf) und dessen „trait“ Aspekten. Auch soll untersucht werden, ob der Übergang vom Wach-Zustand zu Non-REM-Schlaf Gemeinsamkeiten mit dem Übergang von REM- zu Non-REM-Schlaf hat (Stadienübergänge). Besonders ist, dass das Projekt auf einen grossen Pool existierender Daten von jungen Erwachsenen und longitudinalen Daten von Babys, Vorschulkindern und Jugendlichen zurückgreift. Dies ermöglicht, entwicklungsbedingte Veränderungen des Einschlafprozesses zu untersuchen. Auch eine translationale Erweiterung auf eine klinische Population ist vorgesehen.

Frühe Anzeichen von Schlaf sollen mit Hilfe verschiedener physiologischer Variablen erfasst und deren Abhängigkeit von erhöhtem Schlafdruck (z.B. durch Schlafentzug) erforscht werden. Auch interessiert, ob sich Einschlafen nach spontanem oder erzwungenem Aufwachen unterscheidet. Dies könnte neue Erkenntnisse über die Pathophysiologie von gestörtem Schlaf liefern.

Der Verlust des Bewusstseins beim Einschlafen beruht vermutlich auf dem Zusammenbruch funktioneller kortikaler Konnektivität. Dies soll durch die Analyse der Veränderung der globalen Feldsynchronisation im EEG, sowie des Einflusses von erhöhtem Schlafdruck erfasst werden. Räumliche EEG-Muster (Karten, Quellenlokalisation) beim Einschlafen werden ebenfalls untersucht.

Im translationalen Teil werden die Erkenntnisse aus der Grundlagenforschung auf eine klinische Population angewendet. Wir zielen darauf ab, neue quantitative analytische Werkzeuge zur Erfassung des Einschlafens anzuwenden. Diese sollen die gängigen Untersuchungen wie den multiplen Schlaflatenztest oder den „Wachbleibetest“ ergänzen.

Das Grundlagenforschungsprojekt soll helfen zu erklären, wie Stadienübergänge (im Speziellen das Einschlafen) bei Erwachsenen erfolgen und wie sich diese während der Entwicklung (von Babys zu Jugendlichen) verändern. Daraus sollen neue Erkenntnisse gewonnen werden, warum und wie wir einschlafen.

 

Direct link to Lay Summary Last update: 21.02.2014

Responsible applicant and co-applicants

Employees

Publications

Publication
Developmental Changes in Sleep Oscillations during Early Childhood
Olbrich E., Rusterholz Thomas, LeBourgeois M., Achermann Peter (2017), Developmental Changes in Sleep Oscillations during Early Childhood, in Neural Plasticity, 2017, 6160959.
Global field synchronization in gamma range of the sleep EEG tracks sleep depth: Artifact introduced by a rectangular analysis window.
Rusterholz Thomas, Achermann Peter, Dürr Roland, Koenig T., Tarokh Leila (2017), Global field synchronization in gamma range of the sleep EEG tracks sleep depth: Artifact introduced by a rectangular analysis window., in J. Neurosci. Meth., 284, 21-26.
Heart Rate Variability During Deep Sleep Offers a Time-Efficient Alternative to Morning Supine Measurements - A Study in World Class Alpine Skiers.
Herzig David, Testorelli Moreno, Olstad Daniela Schäfer, Erlacher Daniel, Achermann Peter, Eser Prisca, Wilhelm Matthias (2017), Heart Rate Variability During Deep Sleep Offers a Time-Efficient Alternative to Morning Supine Measurements - A Study in World Class Alpine Skiers., in International journal of sports physiology and performance, 1-22.
Relation of Heart Rate and its Variability during Sleep with Age, Physical Activity, and Body Composition in Young Children.
Herzig D., Eser P., Radtke T., Wenger A., Rusterholz Thomas, Wilhelm M., Achermann Peter, Arhab A., Jenni O. G., Kakebeeke T.H., Leeger-Aschmann C.X., Messerli-Bürgy N., Meyer A.H., Munsch S., Puder J.J., Schmutz E.A., Stülb K., Zysset A.E., Kriemler S. (2017), Relation of Heart Rate and its Variability during Sleep with Age, Physical Activity, and Body Composition in Young Children., in Front. Physiol., 8, 109.
Sleep homeostasis and models of sleep regulation
Achermann Peter, Borbély A. A. (2017), Sleep homeostasis and models of sleep regulation, in Kryger M., Dement W., Roth T. (ed.), Elsevier, Philadelphia, P.A., 377-387.
Three decades of continuous wrist-activity recording: analysis of sleep duration.
Borbély Alexander A., Rusterholz Thomas, Achermann Peter (2017), Three decades of continuous wrist-activity recording: analysis of sleep duration., in J. Sleep Res., 26(2), 188-194.
Interindividual differences in the dynamics of the homeostatic process are trait-like and distinct for sleep versus wakefulness.
Rusterholz Thomas, Tarokh Leila, Van Dongen H.P.A., Achermann Peter (2016), Interindividual differences in the dynamics of the homeostatic process are trait-like and distinct for sleep versus wakefulness., in J. Sleep Res., 26(2), 171-178.
Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood.
Kurth Salome, Lassonde Jonathan M, Pierpoint Lauren A, Rusterholz Thomas, Jenni Oskar G, McClain Ian J, Achermann Peter, LeBourgeois Monique K (2016), Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood., in Journal of sleep research, 25(6), 646-654.
Developmental Changes in Sleep Spindle Characteristics and Sigma Power across Early Childhood.
McClain Ian J, Lustenberger Caroline, Achermann Peter, Lassonde Jonathan M, Kurth Salome, LeBourgeois Monique K (2016), Developmental Changes in Sleep Spindle Characteristics and Sigma Power across Early Childhood., in Neural plasticity, 2016, 3670951-3670951.
Global field synchronization reveals rapid eye movement sleep as most synchronized brain state in the human EEG
Achermann Peter, Rusterholz Thomas, Dürr Roland, Koenig Thomas, Tarokh Leila (2016), Global field synchronization reveals rapid eye movement sleep as most synchronized brain state in the human EEG, in Royal Society Open Science, 3, 160201.
Increased Sleep Depth in Developing Neural Networks: New Insights from Sleep Restriction in Children.
Kurth Salome, Dean Douglas C, Achermann Peter, O'Muircheartaigh Jonathan, Huber Reto, Deoni Sean C L, LeBourgeois Monique K (2016), Increased Sleep Depth in Developing Neural Networks: New Insights from Sleep Restriction in Children., in Frontiers in human neuroscience, 10, 456-456.
Sleep Physiology in Toddlers: Effects of Missing a Nap on Subsequent Night Sleep.
Lassonde Jonathan M, Rusterholz Thomas, Kurth Salome, Schumacher Allyson M, Achermann Peter, LeBourgeois Monique K (2016), Sleep Physiology in Toddlers: Effects of Missing a Nap on Subsequent Night Sleep., in Neurobiology of sleep and circadian rhythms, 1(1), 19-26.
Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine.
Garrido Maria, Skorucak Jelena, Raduazzo Daniela, Turco Matteo, Spinelli Giuseppe, Angeli Paolo, Amodio Piero, Achermann Peter, Montagnese Sara (2016), Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine., in Metabolic brain disease, 31(4), 965-74.
Automated sleep analysis
Achermann Peter, Malafeev Alexander, Skorucak Jelena, Tarokh Leila (2015), Automated sleep analysis, Proceedings 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Soc, New York, NY.
Sleep spindles are related to schizotypal personality traits and thalamic glutamine/glutamate in healthy subjects.
Lustenberger Caroline, O'Gorman Ruth L, Pugin Fiona, Tüshaus Laura, Wehrle Flavia, Achermann Peter, Huber Reto (2015), Sleep spindles are related to schizotypal personality traits and thalamic glutamine/glutamate in healthy subjects., in Schizophrenia bulletin, 41(2), 522-31.
The Multidimensional Aspects of Sleep Spindles and Their Relationship to Word-Pair Memory Consolidation.
Lustenberger Caroline, Wehrle Flavia, Tüshaus Laura, Achermann Peter, Huber Reto (2015), The Multidimensional Aspects of Sleep Spindles and Their Relationship to Word-Pair Memory Consolidation., in Sleep, 38(7), 1093-103.
The spectrum of the non-rapid eye movement sleep electroencephalogram following total sleep deprivation is trait-like.
Tarokh Leila, Rusterholz Thomas, Achermann Peter, Van Dongen Hans P A (2015), The spectrum of the non-rapid eye movement sleep electroencephalogram following total sleep deprivation is trait-like., in Journal of Sleep Research, 24(4), 360-3.
Research design and quantitative methods
Achermann Peter, Tarokh Leila, Peigneux Philippe (2014), Research design and quantitative methods, in European Sleep Research Society (ed.), European Sleep Research Society, Regensburg, 517-527.
Developmental Changes in Ultradian Sleep Cycles across Early Childhood: Preliminary Insights
Lopp S., Navidi W., Achermann Peter, LeBourgeois M.K., Diniz Behn C., Developmental Changes in Ultradian Sleep Cycles across Early Childhood: Preliminary Insights, in J. Biol. Rhythms, 32, 64-74.
Mapping slow waves by EEG topography and source localization: effects of sleep deprivation.
Bersagliere A., Pascual-Marqui R.D., Tarokh Leila, Achermann Peter, Mapping slow waves by EEG topography and source localization: effects of sleep deprivation., in Brain Topogr..

Collaboration

Group / person Country
Types of collaboration
Sleep Research Laboratory, Brown Medical School, Providence, RI United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Sleep and Performance Research Center, Washington State University, Spokane, WA United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
The Key Institute for Brain Mind Research, University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
University of Colorado at Boulder, CO United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw Poland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Dipartimento di Medicina Clinica e Sperimentale, Padova Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Epidemiology, Biostatistics and Prevention Institute, University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Department of Neurology, Bern University Hospital, Bern Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Max Planck Institute for Mathematics in the Sciences, Leipzig Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Retreat of the Clinical Research Priority Program “Sleep and Health” Talk given at a conference Connectivity measures to track sleep 15.09.2017 Zurich, Switzerland Achermann Peter;
Seminar, University of Surrey Individual talk Global field synchronization: measuring functional connectivity of brain processes during sleep and prolonged wakefulness 18.05.2017 Guildford, Great Britain and Northern Ireland Achermann Peter;
Annual Symposium Swiss Society for Sleep Research, Sleep Medicine and Chonobioloy Talk given at a conference Classifying sleep stages by using machine learning algorithms 11.05.2017 Lugano, Switzerland Achermann Peter;
Retirement Symposium Domien Beersma Talk given at a conference EEG slow-wave energy and homeostatic sleep regulation 22.03.2017 Groningen, Netherlands Achermann Peter;
Seminar, University of Groningen Individual talk Sleep regulation and related quantitative EEG measures 21.03.2017 Groningen, Netherlands Achermann Peter;
24. Jahrestagung der DGSM Talk given at a conference Quantitative EEG Analyse in der Grundlagenforschung und klinischen Anwendung 03.12.2016 Dresden, Germany Achermann Peter;
Scientific Symposium of the CRPP Sleep and Health Talk given at a conference Quantitative EEG analysis 07.10.2016 Zurich, Switzerland Achermann Peter;
»Dreiländertagung« Swiss, Austrian and German Societies for Biomedical Engineering Talk given at a conference EEG analysis of 24-h recordings 05.10.2016 Basel, Switzerland Achermann Peter;
23rd Congress of the European Sleep Research Society Talk given at a conference Trait-like aspects in the sleep EEG and sleep regulation 14.09.2016 Bologna, Italy Achermann Peter;
23rd Congress of the European Sleep Research Society Talk given at a conference The two process model of sleep regulation revisited 13.09.2016 Bologna, Italy Achermann Peter;
Department of Integrative Physiology, University of Colorado Boulder Individual talk Introduction to spectral analysis 22.03.2016 Boulder, United States of America Achermann Peter;
Department of Integrative Physiology, University of Colorado Boulder Individual talk The dynamics of sleep EEG oscillatory activities and sleep homeostasis 22.03.2016 Boulder, C.O., United States of America Achermann Peter;
Retreat of the Clinical Research Priority Program “Sleep and Health” Individual talk Key questions in analyzing sleep 05.02.2016 Zurich, Switzerland Achermann Peter;
Oxford-Zurich Meeting Talk given at a conference The dynamics of sleep EEG oscillatory activities and sleep homeostasis 20.11.2015 Oxford, Great Britain and Northern Ireland Achermann Peter;
CRPP Seminar “Sleep and Health”, USZ Individual talk Sleep regulation and related quantitative EEG measures 06.11.2015 Zurich, Switzerland Achermann Peter;
Worldsleep 2015 Talk given at a conference Quantitative EEG measures and cognition in children and adolescents 03.11.2015 Istanbul, Turkey Tarokh Leila; Achermann Peter;
Worldsleep 2015 Talk given at a conference How can mathematical models help sleep research? 03.11.2015 Istanbul, Turkey Achermann Peter;
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Talk given at a conference Automated sleep analysis 27.08.2015 Milano, Italy Achermann Peter;
Neurologie-Schlaf-Fortbildung, USZ Individual talk Quantitative analysis of sleep based on EEG, EMG and EOG recordings 14.07.2015 Zurich, Switzerland Achermann Peter;
3rd Alpine Sleep Summer School Talk given at a conference Mechanisms of sleep homeostasis 01.07.2015 Lugano, Switzerland Achermann Peter;
Centre for Cognitive Neuroscience, School of Psychology Individual talk Mobile phones – Do they affect the brain? 03.03.2015 Adelaide, Australia Achermann Peter;
Centre for Cognitive Neuroscience, School of Psychology Individual talk Cognition, sleep and circadian rhythms 02.03.2015 Adelaide, Australia Achermann Peter;
Centre for Sleep Research, School of Psychology, Social Work and Social Po Individual talk Quantitative analysis: Could it be of help in scoring sleep in healthy individuals and patients 24.02.2015 Adelaide, Australia Achermann Peter;
Centre for Sleep Research, School of Psychology, Social Work and Social Policy Individual talk Introduction to the EEG 23.02.2015 Adelaide, Australia Achermann Peter;
Centre for Sleep Research, School of Psychology, Social Work and Social Policy Individual talk Principles and application of spectral analysis 23.02.2015 Adelaide, Australia Achermann Peter;
Workshop at Symposium of the Clinical Research Priority Program “Sleep and Helath” Talk given at a conference Analysis of the sleep EEG: basics and pitfalls 15.01.2015 Zürich, Switzerland Achermann Peter;
Symposium of the Clinical Research Priority Program “Sleep and Health” Talk given at a conference Workshop: Analysis of the sleep EEG: basics and pitfalls 15.01.2015 Zurich, Switzerland Achermann Peter;
22nd Congress of the European Sleep Research Society Talk given at a conference Regional differences in the impact of sleep deprivation on sleep EEG power in early to mid adolescence 19.09.2014 Tallinn, Estonia Achermann Peter;
22nd Congress of the European Sleep Research Society Talk given at a conference Regional differences in the impact of sleep deprivation on sleep EEG power in early to mid adolescence 19.09.2014 Tallin, Estonia Tarokh Leila; Achermann Peter;


Self-organised

Title Date Place

Knowledge transfer events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Brain Fair Performances, exhibitions (e.g. for education institutions) 18.03.2017 Zürich, Switzerland
Brain Fair Talk 18.03.2017 Zurich, Switzerland
Chronobiologie Talk 12.05.2015 Regensdorf, Switzerland
Distinguished Researcher Workshop 06.04.2015 Adelaide, Australia
Why do we sleep? Hypothesis and controversies Talk 26.02.2015 Adelaide, Australia


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Brain Fair German-speaking Switzerland 2017
Media relations: radio, television Handystrahlung TeleZ German-speaking Switzerland 2017
Talks/events/exhibitions Chronobiologie (Public lecture for Lions Club) German-speaking Switzerland 2015
Talks/events/exhibitions Why do we sleep? Hypothesis and controversies (Public lecture Adelaide) International 2015
Talks/events/exhibitions Insomnia - Alive. Sound from 40 sleepless hours Western Switzerland 2014
Media relations: print media, online media Interview zu Mobilfunkstrahlung Schaffhauser Nachrichten German-speaking Switzerland 2014
Media relations: radio, television Somnomat 3SAT German-speaking Switzerland 2014

Awards

Title Year
Distinguished Researcher at the University of South Australia, Adelaide, Australia 2015

Associated projects

Number Title Start Funding scheme
136249 Resting states of the brain and state dependent information processing in health and disease 01.01.2012 Sinergia
162809 Rocking Movements-A Key Technology to Better Sleep? 01.02.2016 Interdisciplinary projects
176323 EEG based microsleep episode detection in the maintenance of wakefulness test and the driving simulator using a machine learning approach 01.11.2017 Project funding (Div. I-III)
130766 Human sleep regulation: Insights from inter-individual differences 01.05.2010 Project funding (Div. I-III)

Abstract

Sleep is crucial for day-time functioning and well-being. Nevertheless, its purpose and biological function are not yet well understood. The EEG, a measure of synchronous synaptic activity of large neuronal populations, is a widely used, reliable state indicator. Applying novel methods of quantitative EEG analysis provides new insights into processes underlying sleep states and its transitions. The present research program will make use of this approach. The efforts will center in particular on transitions from wakefulness to sleep (sleep onset) and on trait-like aspects of state transitions. We also aim to answer the question whether wake to non-REM sleep transitions and REM to non-REM sleep transitions share common neurophysiological correlates. The uniqueness and strength of the project derives from the large data base that includes longitudinal data recorded from infants, preschool children and adolescents. Thus state transitions can be investigated from a developmental perspective. Moreover, we envisage a translational expansion to a clinical population. I aim to identify early signs of sleep based on different physiological measures and the impact of increased sleep pressure on such signs. The approach will be initiated by the analysis of records from young healthy adults, verified in independent datasets, and then extended to longitudinal data from infants, preschool children and adolescents, as well as to data from a clinical population. Comparing the sleep onset process after spontaneous and forced awakenings should help to gain a better understanding of the pathophysiology of disturbed sleep. The fading of consciousness during sleep onset may be associated with a breakdown in cortical connectivity. By monitoring global field synchronization, functional connectivity between brain areas will be assessed during sleep onset. Moreover, the impact of increased sleep pressure will be evaluated. Also brain imaging techniques (mapping, source localization) will be applied to analyze frequency and state-specific spatial patterns. An important aspect of the project concerns translational research. Identifying early signs of sleep in healthy young adults and characterizing developmental aspects in the process of sleep onset is also of clinical relevance. In particular, the new procedures may be useful as quantitative analytic tools in assessing sleep onset in patients and supplementing the routinely used multiple sleep latency test and maintenance of wakefulness test. In summary, the projects should contribute to a better functional understanding of state transitions in adult sleep and during development, thereby providing insights into one of the basic questions in sleep research, why and how we fall asleep.
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