quantitative EEG analysis; infants; global functional coupling; REM sleep to non-REM sleep transition; preschool children; adolescents; wakefulness to sleep transition; sleep onset; maturation; spectrogram; heart-rate variability; muscle tone
Achermann Peter, Rusterholz Thomas, Stucky Benjamin, Olbrich Eckehard (2019), Oscillatory patterns in the electroencephalogram at sleep onset, in Sleep
, 42(8), 1-12.
Fernandez Guerrero Antonio, Achermann Peter (2019), Brain dynamics during the sleep onset transition: An EEG source localization study, in Neurobiology of Sleep and Circadian Rhythms
, 6, 24-34.
Fernandez Guerrero Antonio, Achermann Peter (2018), Intracortical Causal Information Flow of Oscillatory Activity (Effective Connectivity) at the Sleep Onset Transition, in Frontiers in Neuroscience
, 12, 912.
Malafeev Alexander, Laptev Dmitry, Bauer Stefan, Omlin Ximena, Wierzbicka Aleksandra, Wichniak Adam, Jernajczyk Wojciech, Riener Robert, Buhmann Joachim, Achermann Peter (2018), Automatic Human Sleep Stage Scoring Using Deep Neural Networks, in Frontiers in Neuroscience
, 12, 781.
Olbrich E., Rusterholz Thomas, LeBourgeois M., Achermann Peter (2017), Developmental Changes in Sleep Oscillations during Early Childhood, in Neural Plasticity
, 2017, 6160959.
Rusterholz Thomas, Achermann Peter, Dürr Roland, Koenig T., Tarokh Leila (2017), Global field synchronization in gamma range of the sleep EEG tracks sleep depth: Artifact introduced by a rectangular analysis window., in J. Neurosci. Meth.
, 284, 21-26.
Herzig David, Testorelli Moreno, Olstad Daniela Schäfer, Erlacher Daniel, Achermann Peter, Eser Prisca, Wilhelm Matthias (2017), Heart Rate Variability During Deep Sleep Offers a Time-Efficient Alternative to Morning Supine Measurements - A Study in World Class Alpine Skiers., in International journal of sports physiology and performance
Herzig D., Eser P., Radtke T., Wenger A., Rusterholz Thomas, Wilhelm M., Achermann Peter, Arhab A., Jenni O. G., Kakebeeke T.H., Leeger-Aschmann C.X., Messerli-Bürgy N., Meyer A.H., Munsch S., Puder J.J., Schmutz E.A., Stülb K., Zysset A.E., Kriemler S. (2017), Relation of Heart Rate and its Variability during Sleep with Age, Physical Activity, and Body Composition in Young Children., in Front. Physiol.
, 8, 109.
Achermann Peter, Borbély A. A. (2017), Sleep homeostasis and models of sleep regulation, in Kryger M., Dement W., Roth T. (ed.), Elsevier, Philadelphia, P.A., 377-387.
Borbély Alexander A., Rusterholz Thomas, Achermann Peter (2017), Three decades of continuous wrist-activity recording: analysis of sleep duration., in J. Sleep Res.
, 26(2), 188-194.
Rusterholz Thomas, Tarokh Leila, Van Dongen H.P.A., Achermann Peter (2016), Interindividual differences in the dynamics of the homeostatic process are trait-like and distinct for sleep versus wakefulness., in J. Sleep Res.
, 26(2), 171-178.
Kurth Salome, Lassonde Jonathan M, Pierpoint Lauren A, Rusterholz Thomas, Jenni Oskar G, McClain Ian J, Achermann Peter, LeBourgeois Monique K (2016), Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood., in Journal of sleep research
, 25(6), 646-654.
McClain Ian J, Lustenberger Caroline, Achermann Peter, Lassonde Jonathan M, Kurth Salome, LeBourgeois Monique K (2016), Developmental Changes in Sleep Spindle Characteristics and Sigma Power across Early Childhood., in Neural plasticity
, 2016, 3670951-3670951.
Achermann Peter, Rusterholz Thomas, Dürr Roland, Koenig Thomas, Tarokh Leila (2016), Global field synchronization reveals rapid eye movement sleep as most synchronized brain state in the human EEG, in Royal Society Open Science
, 3, 160201.
Kurth Salome, Dean Douglas C, Achermann Peter, O'Muircheartaigh Jonathan, Huber Reto, Deoni Sean C L, LeBourgeois Monique K (2016), Increased Sleep Depth in Developing Neural Networks: New Insights from Sleep Restriction in Children., in Frontiers in human neuroscience
, 10, 456-456.
Lassonde Jonathan M, Rusterholz Thomas, Kurth Salome, Schumacher Allyson M, Achermann Peter, LeBourgeois Monique K (2016), Sleep Physiology in Toddlers: Effects of Missing a Nap on Subsequent Night Sleep., in Neurobiology of sleep and circadian rhythms
, 1(1), 19-26.
Garrido Maria, Skorucak Jelena, Raduazzo Daniela, Turco Matteo, Spinelli Giuseppe, Angeli Paolo, Amodio Piero, Achermann Peter, Montagnese Sara (2016), Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine., in Metabolic brain disease
, 31(4), 965-74.
Achermann Peter, Malafeev Alexander, Skorucak Jelena, Tarokh Leila (2015), Automated sleep analysis
, Proceedings 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Soc, New York, NY.
Lustenberger Caroline, O'Gorman Ruth L, Pugin Fiona, Tüshaus Laura, Wehrle Flavia, Achermann Peter, Huber Reto (2015), Sleep spindles are related to schizotypal personality traits and thalamic glutamine/glutamate in healthy subjects., in Schizophrenia bulletin
, 41(2), 522-31.
Lustenberger Caroline, Wehrle Flavia, Tüshaus Laura, Achermann Peter, Huber Reto (2015), The Multidimensional Aspects of Sleep Spindles and Their Relationship to Word-Pair Memory Consolidation., in Sleep
, 38(7), 1093-103.
Tarokh Leila, Rusterholz Thomas, Achermann Peter, Van Dongen Hans P A (2015), The spectrum of the non-rapid eye movement sleep electroencephalogram following total sleep deprivation is trait-like., in Journal of Sleep Research
, 24(4), 360-3.
Achermann Peter, Tarokh Leila, Peigneux Philippe (2014), Research design and quantitative methods, in European Sleep Research Society (ed.), European Sleep Research Society, Regensburg, 517-527.
Lopp S., Navidi W., Achermann Peter, LeBourgeois M.K., Diniz Behn C., Developmental Changes in Ultradian Sleep Cycles across Early Childhood: Preliminary Insights, in J. Biol. Rhythms
, 32, 64-74.
Bersagliere A., Pascual-Marqui R.D., Tarokh Leila, Achermann Peter, Mapping slow waves by EEG topography and source localization: effects of sleep deprivation., in Brain Topogr.
Sleep is crucial for day-time functioning and well-being. Nevertheless, its purpose and biological function are not yet well understood. The EEG, a measure of synchronous synaptic activity of large neuronal populations, is a widely used, reliable state indicator. Applying novel methods of quantitative EEG analysis provides new insights into processes underlying sleep states and its transitions. The present research program will make use of this approach. The efforts will center in particular on transitions from wakefulness to sleep (sleep onset) and on trait-like aspects of state transitions. We also aim to answer the question whether wake to non-REM sleep transitions and REM to non-REM sleep transitions share common neurophysiological correlates. The uniqueness and strength of the project derives from the large data base that includes longitudinal data recorded from infants, preschool children and adolescents. Thus state transitions can be investigated from a developmental perspective. Moreover, we envisage a translational expansion to a clinical population. I aim to identify early signs of sleep based on different physiological measures and the impact of increased sleep pressure on such signs. The approach will be initiated by the analysis of records from young healthy adults, verified in independent datasets, and then extended to longitudinal data from infants, preschool children and adolescents, as well as to data from a clinical population. Comparing the sleep onset process after spontaneous and forced awakenings should help to gain a better understanding of the pathophysiology of disturbed sleep. The fading of consciousness during sleep onset may be associated with a breakdown in cortical connectivity. By monitoring global field synchronization, functional connectivity between brain areas will be assessed during sleep onset. Moreover, the impact of increased sleep pressure will be evaluated. Also brain imaging techniques (mapping, source localization) will be applied to analyze frequency and state-specific spatial patterns. An important aspect of the project concerns translational research. Identifying early signs of sleep in healthy young adults and characterizing developmental aspects in the process of sleep onset is also of clinical relevance. In particular, the new procedures may be useful as quantitative analytic tools in assessing sleep onset in patients and supplementing the routinely used multiple sleep latency test and maintenance of wakefulness test. In summary, the projects should contribute to a better functional understanding of state transitions in adult sleep and during development, thereby providing insights into one of the basic questions in sleep research, why and how we fall asleep.