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Non-invasive analysis of language network connectivity by EEG, fMRI, and DTI for the planning of brain surgery

English title Non-invasive analysis of language network connectivity by EEG, fMRI, and DTI for the planning of brain surgery
Applicant Schaller Karl
Number 146633
Funding scheme Project funding (Div. I-III)
Research institution Service de Neurochirurgie Département des Neurosciences Cliniques Hôpitaux Universitaires de Genève
Institution of higher education University of Geneva - GE
Main discipline Neurology, Psychiatry
Start/End 01.10.2013 - 30.09.2016
Approved amount 440'920.00
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All Disciplines (3)

Discipline
Neurology, Psychiatry
Biomedical Engineering
Surgery

Keywords (5)

Neuroimaging; Eloquent Cortex; Neurosurgery; Language; Brain Connectivity

Lay Summary (German)

Lead
Nicht-invasive Lokalisation von Sprachnetzwerken vor Hirnoperationen
Lay summary

Die Chirurgie von Hirntumoren und epileptischen Foci bedingt eine gute Kenntnis über die funktionelle Rolle der Hirnregionen die sich in der Nähe der Läsion befinden, um neurologische Defizite nach der Operation möglichst zu verhindern. Sprachfunktionen sind dabei besonders wichtig, da sie verschiedene Hirngebiete betreffen und individuell sehr variieren können.  Elektrische Stimulation von Elektroden die direkt auf dem Gehirn liegen ist der Goldstandard für funktionelle Lokalisation. Für Sprachfunktionen ist diese Methode während der Operation aber höchst aufwendig und vor der Operation nur bei wenigen epileptischen Patienten möglich. Nicht-invasive Methoden basierend auf funktioneller Bildgebung mit Hilfe von Computer-Tomographie (MRT) oder Elektro- oder Magneto- Enzephalography (EEG/MEG) sind oft nicht spezifisch genug und zeigen Hirnregionen auf die zwar in Sprachfunktionen beteiligt sind aber nicht unbedingt unentbehrlich sind.

Unser Projekt schlägt vor, funktionelle Daten vom MRT und EEG zu kombinieren und sie mit Methoden zu analysieren die die funktionelle Bedeutung einzelner Module der komplexen Sprach-Netzwerke identifizieren.  Wir hoffen, dass solche multimodale Netzwerkanalysen die zentralen Schnittstellen isolieren können, die bei Hirnoperationen nicht angerührt werden sollten.

Direct link to Lay Summary Last update: 22.08.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Altered directed functional connectivity in temporal lobe epilepsy in the absence of interictal spikes: A high density EEG study
Coito Ana, Genetti Melanie, Pittau Francesca, Iannotti Giannina, Thomschewski Aljoscha, Höller Yvonne, Trinka Eugen, Wiest Roland, Seeck Margitta, Michel Christoph, Plomp Gijs, Vulliemoz Serge (2016), Altered directed functional connectivity in temporal lobe epilepsy in the absence of interictal spikes: A high density EEG study, in Epilepsia, 57(3), 402-411.
Comparison of high gamma electrocorticography and fMRI with electrocortical stimulation for localization of somatosensory and language cortex
Genetti Melanie, Tyrand Remi, Grouiller Frederic, Lascano Agustina, Vulliemoz Serge, Spinelli Laurent, Seeck Margitta, Schaller Karl, Michel Christoph (2015), Comparison of high gamma electrocorticography and fMRI with electrocortical stimulation for localization of somatosensory and language cortex, in Clinical Neurophysiology, 126(1), 121-130.
Directed Functional Brain Connectivity Based on EEG Source Imaging: Methodology and Application to Temporal Lobe Epilepsy
Coito Ana, Michel Christoph, Mierlo Peter, Vulliemoz Serge, Plomp Gijs, Directed Functional Brain Connectivity Based on EEG Source Imaging: Methodology and Application to Temporal Lobe Epilepsy, in IEEE Trans Biomed Eng..

Collaboration

Group / person Country
Types of collaboration
University of Rome Sapienza, Dr. Laura Astolfi Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
CIBM, Dr. Lazeyras, Dr. Grouiller Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
15 European Congress on clinical neurophysiolgy Talk given at a conference EEG Language Mapping 01.10.2015 Brno, Czech Republic Michel Christoph; Genetti Melanie; Seeck Margitta;
22th Annual Meeting of the Cognitive Neuroscience Society Talk given at a conference Electrical Neuroimaging 30.03.2015 San Francisco, United States of America Michel Christoph;
30th International Congress of Clinical Neurophysiology Poster Can high density EEG contribute to language localization? 20.03.2014 Berlin, Germany Michel Christoph; Genetti Melanie; Seeck Margitta;


Associated projects

Number Title Start Funding scheme
140332 Imaging large scale neuronal networks in epilepsy 01.05.2012 SPUM
182497 Mapping the brain networks of the bodily and cognitive self for the prediction of personality deficits following brain surgery 01.01.2019 Project funding (Div. I-III)
122073 Localization of functionally vital cortex in the individual patient: correlation between invasive and non-invasive methods 01.12.2008 Project funding (Div. I-III)

Abstract

The present project refers to the continuation of a pluri-disciplinary collaboration between neurosurgeons, epileptologists, neurophysiologists, neuropsychologists, and neuroradiologists, and it aims at a better understanding of the spatial allocation of language function in humans. The project is based on a contemporary dynamic-network-concept for functional allocation in the brain, which postulates the existence of interdependent neural circuits throughout the cerebral white matter for cognitive functions such as language. According to this concept a particular region may hold multiple functions, or multiple regions may hold the same one, respectively. This is opposed to the traditional modular localizational concept, according to which particular functions are localized in rather fixed cortical regions. A cohort of patients suffering from pharmacoresistant epilepsy, as well as patients with intrinsic tumors of the brain, who will undergo resective surgery shall be studied prospectively: Non-invasive structural and functional imaging (3D morphological MRI, DTI, and fMRI) and electrical source imaging (ESI) based on 256-channel EEG shall be performed together with neuropsychological tests - prior to surgery, and postoperatively at determined intervals. Particular focus will be put on a new method to analyze the ESI data that will take full advantage of the high temporal resolution of the EEG: It is based on time-varying partial directed coherence (PDC). Rigorous validation in animal models have shown that this method allows to determine information flow in the network and to identify the most active drivers, i.e. the most important “hubs” of the network. This analysis method will be applied to data already recorded during the previous grant period. In addition, the future patients and a new set of healthy volunteers shall undergo additional language tasks. Due to more precise allocation and hierarchization of language function, this project should prepare the avenue towards safer resection of tumors or epileptogenic zones in the neighborhood of, or, within eloquent brain regions.
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