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Stochastische Polaritätserzeugung in Kristallen und natürlichem Gewebe

English title Stochastic Polarity Generation in Crystals and Natural Tissues
Applicant Hulliger Jürg
Number 146413
Funding scheme Project funding (Div. I-III)
Research institution Departement für Chemie und Biochemie Universität Bern
Institution of higher education University of Berne - BE
Main discipline Condensed Matter Physics
Start/End 01.04.2013 - 31.03.2016
Approved amount 423'185.00
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All Disciplines (2)

Discipline
Condensed Matter Physics
Physical Chemistry

Keywords (10)

polarity; stochastic mechanism; Morkov chains; crystals; natural tissues; orientational disorder; pyroelectricity; second harmonic generation; biomimetic materials; Monte Carlo simulations

Lay Summary (German)

Lead
Polarität von Molekülen stellt eine Grundeigenschaft von Materie dar. Wenn dipolare Moleküle Kristalle bilden, stellt sich die Frage, wie die Gesamtpolarität zustande kommt. Da dipolare Moleküle an Oberflächen wachsender Kristalle Orientierungsunordnung eingehen, beeinflusst dies die inhomogene Verteilung von Polarität in Kristallen. Im Projekt werden verschiedenste Arten von Kristallen sowie natürliches Gewebe daraufhin untersucht, wie das Wachstum die Polarität im festen Zustand beeinflusst.
Lay summary

Durch Anwendung zweier vom Gesuchsteller entwickelter Messmethoden wird die absolute Orientierung von Polarität in diversen Kristallen und natürlichem Gewebe bestimmt. Diese Resultate werden mit den Vorhersagen eigener theoretischer Modelle verglichen. Im Bereich biomimetischer Stoffe werden z. B. Gelatine Moleküle in anorganische Gitter miteingeschlossen. Da diese Peptidketten polar sind, stellt sich auch hier die Frage, ob dieser Einschluss zu makroskopisch polaren Kompositen führt. In diesem Fall konnte gezeigt werden, dass Kristallisationsaggregate von Apatit und Gelatine einen sog. bi-polaren Zustand bilden.

Polarität in Lebewesen ist von grosser Bedeutung, da etliche Rezeptoren für äussere Reize auf polarer Ordnung von Molekülen beruhen. Auch spielt die Polarität von Gewebe beim Wachstum und der Heilung eine wichtige Rolle. Noch wenig untersucht ist die Bedeutung fehlerhafter polarer Ordnung als Indikator für pathogene Veränderungen in Geweben. Unsere Arbeiten, welche sich grundlegend mit der Entstehung und dem Nachweis von Polarität beschäftigen, können hier aufzeigen, wie in der Medizin diese diagnostische Problemstellung berücksichtigt werden könnte.

Direct link to Lay Summary Last update: 28.03.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Peculiar orientational disorder in 4-bromo-4'-nitrobiphenyl (BNBP) and 4-bromo-4'cyanobiphenyl (BCNBP) leading to bipolar crystals
Burgener Matthias, Aboulfadl Hanane, Labat Gaël Charles, Bonin Michel, Sommer Martin, Sankolli Ravish, Wübbenhorst Michael, Hulliger Jürg (2016), Peculiar orientational disorder in 4-bromo-4'-nitrobiphenyl (BNBP) and 4-bromo-4'cyanobiphenyl (BCNBP) leading to bipolar crystals, in IUCr Journals, 3(2016), 219-225.
Absolute polarity determination of teeth cementum by phase sensitive second harmonic generation microscopy
Aboulfadl Hanane, Hulliger Jürg (2015), Absolute polarity determination of teeth cementum by phase sensitive second harmonic generation microscopy, in Journal of Structural Biology, 192(2015), 67-75.
Polar Nature of Biomimetic Fluorapatite/Gelatin Composites: A Comparison of Bipolar Objects and the Polar State of Natural Tissue
Burgener Matthias, Putzeys Tristan, Parvinzadeh Gashti Mazeyar, Busch Susanne, Aboulfadl Hanane, Wübbenhorst Michael, Kniep Rüdiger, Hulliger Jürg (2015), Polar Nature of Biomimetic Fluorapatite/Gelatin Composites: A Comparison of Bipolar Objects and the Polar State of Natural Tissue, in Biomacromolecules, 16(2015), 2814-2819.
Pyroelectric and piezoelectric scanning microscopy applied to reveal the bipolar state of 4-iodo-4'-nitrobiphenyl (INBP)
Burgener Matthias, Labat Gaël, Bonin Michel, Morelli Alessio, Hulliger Jürg (2013), Pyroelectric and piezoelectric scanning microscopy applied to reveal the bipolar state of 4-iodo-4'-nitrobiphenyl (INBP), in CrystEngComm, 15(2013), 7652-7656.

Collaboration

Group / person Country
Types of collaboration
Prof. R. Kniep, MPI Dresden Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Dr. Michael Wübbenhorst / University of Leuven Belgium (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Prof. B. Müller, Biomaterial Science Center Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. D. Hesse, MPI für Mikrostrukturphysik Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
9th Annual World Protein & Peptide Conference (PepCon-2016) Talk given at a conference Absolute Polarity of Teeth Cementum by Phase Sensitive Second Harmonic Generation Microscopy 25.04.2016 Dalian, China Oulevey Hanane;
2nd International Conference on Advances in Biophysics (ICAB 2016) Talk given at a conference Polar ordering of macromulecular chains in biomimetic composite materials and natural tissue 18.03.2016 Los Angeles, United States of America Burgener Matthias;


Awards

Title Year
Fakultätspreis für die beste Dissertation im Fach Chemie 2014 2015

Associated projects

Number Title Start Funding scheme
129472 Stochastische Polaritätserzeugung in Kristallen und natürlichem Gewebe 01.04.2010 Project funding (Div. I-III)
101658 Unordnung von Molekülen an Kristallflächen und im Kristallvolumen: Kraftfeldrechnungen 01.10.2003 Project funding (Div. I-III)
37166 Chemie und Kristallzüchtung: funktionelle Molekularkristalle 01.10.1993 Project funding (Div. I-III)
159231 Polaritätsbildung in molekularen Kristallen, natürlichem Gewebe und biomimetischen Materialien 01.04.2015 Project funding (Div. I-III)
103587 Experimental investigation of stochastically grown-in polarity in molecular crystals 01.04.2004 Project funding (Div. I-III)
64564 R'EQUIP 2001: High Sensitivity Phase Sensitive Second Harmonic Microscopy 01.07.2001 R'EQUIP
57476 Property directed crystallisation of organic host-guest materials 01.04.2000 NRP 47 Supramolecular Functional Materials
129472 Stochastische Polaritätserzeugung in Kristallen und natürlichem Gewebe 01.04.2010 Project funding (Div. I-III)

Abstract

Polar symmetry of real objects, molecules and crystals is a fundamental property for establishing complex functions.In the world of crystals, there are two essentially different ways to generate a polar structure:(i) by nucleation and replication, or(ii) by a Markov-type process involving polarity by growth - irrespective of the symmetry crated by nucleation.This completely new concept (ii) for developing/understanding materials by a Markov chain mechanism was independently discovered by Harris et al. and Hulliger et al. in 1997.Since then the group in Berne has elaborated basic theoretical and experimental means to investigate this phenomenon covering all kind of materials: macroscopic heap formation, crystals of low molecular weight and long chain proteins forming tissues. In 2003, the applicant presented a first theoretical model explaining experimentally known pyroelectric effects in collagenous tissues. Nowadays, new scanning probe techniques (e.g. scanning piezoelectric microscopy) reveal more and more of the fine structure of growth induced polarity in tissues.In view of basic features associated with stochastic polarity formation being elaborated in detail, there are still basic issues which merit full understanding and experimental demonstration. In particular the world of biomimetic and real biological materials are fascinating objects to study the generation and function of polar order.The present proposal will thus focus on the following main issues:1) The outcome of our previous SNF proposal (200021_129472) leads us to a new understanding of polarity in condensed molecular matter: Following basic principles, polarity can only exist in antiparallel domains (E=0), yielding zero average polarity for the entire object. This brings us to investigate selected molecular crystals to study their surface near polarization achieved by thermal treatment.2) Biomimetic materials are of great interest for thooth and bone repair. Here we will study apatite and brushite formation in different organic gels and investigate that polar state of the composite.3) Scanning pyroelectric (1), scanning piezoelectric (2) and phase sensitive second harmonic (3) microscopy are the essential techniques to study polar effects in molecular based materials. All these methods (1, 2: Berne; 3: collaboration with MPI Halle) will thus be applied to investigate materials.In essence, a continuation of the former proposal attempts to concentrate research on (i) an essential state of polar molecular matter and (ii) bio- and biomimetic materials.
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