Flammen Aerosol Technik; Biomedizinische Materialien; Nanopartikel
Spyrogianni Anastasia, Herrmann Inge K, Lucas Miriam S, Leroux Jean-Christophe, Sotiriou Georgios A (2016), Quantitative analysis of the deposited nanoparticle dose on cell cultures by optical absorption spectroscopy, in Nanomedicine
, 11(19), 2483-2496.
Fusco Stefano, Huang Hen-Wei, Peyer Kathrin E., Peters Christian, Haeberli Moritz, Ulbers Andre, Spyrogianni Anastasia, Pellicer Eva, Sort Jordi, Pratsinis Sotiris E., Nelson Bradley J., Sakar Mahmut Selman, Pane Salvador (2015), Shape-Switching Microrobots for Medical Applications: The Influence of Shape in Drug Delivery and Locomotion, in ACS APPLIED MATERIALS & INTERFACES
, 7(12), 6803-6811.
Sotiriou Georgios A., Etterlin Gion Diego, Spyrogianni Anastasia, Krumeich Frank, Leroux Jean-Christophe, Pratsinis Sotiris E. (2014), Plasmonic biocompatible silver-gold alloyed nanoparticles, in CHEMICAL COMMUNICATIONS
, 50(88), 13559-13562.
Multifunctional nanomaterials with application-tailored characteristics will be made flexibly by scalable flame spray pyrolysis (FSP). The focus is on synthesis of superparamagnetic, plasmonic and phosphorescent nanoparticles with controlled extent of aggregation or agglomeration and proven biomedical applications. More specifically, nanoparticles of different functionalities will be combined into multifunctional probes which can be detected and guided by multiple imaging and control techniques. Such materials have the potential to be used also for synergistic therapeutic action (e.g. theranostics). The surface of these nanoparticles would be modified to further control their bio-interactions. With FSP, liquid precursors are spray combusted resulting in multicomponent nanoparticles by single or multi-nozzle FSP configurations. Hermetically-coated, core-shell nanoparticles with an inorganic (e.g. SiO2) shell (e.g. 2-4 nm thin) can be synthesized also in situ in a single step using swirling vapor jets, downstream of the formation zone of FSP-made core nanoparticles. Such nanoparticles can exhibit the core properties (magnetic, coloristic, etc.) without any adverse (toxic) effects (e.g. nanosilver). Furthermore, multifunctional superparamagnetic nanoparticles can be embedded in polymers resulting in nanocomposites that have the polymer matrix flexibility. That way, such nanocomposites can be actuated by an external magnetic field having potential applications in biosensing (lab-on-a-chip) and controlled drug release. So, nanoparticles with the desired functionalities will be made by innovative reactor designs and systematic experimentation. All nanomaterials will be characterized by an array of techniques, such as X-ray diffraction, nitrogen adsorption, TEM/STEM imaging, spectroscopy analysis (FTIR, Raman, UV/vis, fluorescence) and other methods that are readily available in our and other ETH laboratories. That way, the particle properties will be investigated as a function of synthesis conditions (i.e. precursor composition, flame temperature, residence time, nozzle configuration etc.) and correlated to the final particle performance for the application of interest. The bio-interactions of such multifunctional nanoparticles will be evaluated with various cell lines in order to guide also the process design for synthesis of the so-called “safe” nanoparticles (e.g. SiO2-coated plasmonic nanosilver) for routine bio-applications in collaboration with Harvard University. A distinct target is the development of a scalable process and, eventually, technology for synthesis of multifunctional nanoparticles for bio-applications with closely-controlled characteristics. This project will assist the education of one doctoral student in nanomaterial process engineering and will allow BSc and MSc students to participate in such research. Results will be presented in international conferences and will be submitted for publication in refereed journals.