neurorehabilitation; stroke; Magnetic Resonance Imaging; sensorimotor function; episodic memory; hippocampal neurogenesis
Menze Bjoern H., Van Leemput Koen, Lashkari Danial, Riklin-Raviv Tammy, Geremia Ezequiel, Alberts Esther, Gruber Philipp, Wegener Susanne, Weber Marc-Andre, Szekely Gabor, Ayache Nicholas, Golland Polina (2016), A Generative Probabilistic Model and Discriminative Extensions for Brain Lesion Segmentation— With Application to Tumor and Stroke, in IEEE Transactions on Medical Imaging
, 35(4), 933-946.
Branscheidt Meret, Schneider Juliane, Michel Patrik, Eskioglou Elissavet, Kaegi Georg, Stark Robert, Fischer Urs, Jung Simon, Arnold Marcel, Wertli Maria, Held Ulrike, Wegener Susanne, Luft Andreas, Sarikaya Hakan (2016), No Impact of Body Mass Index on Outcome in Stroke Patients Treated with IV Thrombolysis BMI and IV Thrombolysis Outcome., in PloS one
, 11(10), 0164413-0164413.
Schneider Juliane, Sick Beate, Luft Andreas R, Wegener Susanne (2015), Ultrasound and Clinical Predictors of Recurrent Ischemia in Symptomatic Internal Carotid Artery Occlusion., in Stroke
, 46(11), 3274-6.
Wegener Susanne (2014), 3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow., in JCBFM
Post-stroke cognitive impairment is a frequently encountered problem after stroke that interferes with a good clinical recovery. The reason for this cognitive impairment remains largely unknown, especially with respect to episodic memory, since most ischemic stroke lesions do not encompass the brain structures involved in episodic memory functions such as the medial temporal lobe (MTL). In a rat stroke model, we wish to characterize how MCA territory stroke causes deficits in cognitive impairment, specifically deficits in episodic memory. We are planning to use MRI including assessment of cerebral blood flow (CBF) and Manganese-enhanced MRI. Through activity-dependent anterograde transport, the paramagnetic Mn2+ can be tracked by MRI in brain structures that are functionally connected. We plan MRI assessment with Mn2+ labeling of the hippocampal system before and after experimental ischemia together with behavioral assessment including sensorimotor and episodic memory functions. Furthermore, we wish to determine if a motor training task can improve post-stroke cognitive impairment in our rat model.