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The substrate of post-stroke cognitive impairment

English title The substrate of post-stroke cognitive impairment
Applicant Wegener Susanne
Number 145470
Funding scheme Marie Heim-Voegtlin grants
Research institution Neurologische Klinik Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurophysiology and Brain Research
Start/End 01.07.2013 - 31.10.2015
Approved amount 155'448.00
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Keywords (6)

neurorehabilitation; stroke; Magnetic Resonance Imaging; sensorimotor function; episodic memory; hippocampal neurogenesis

Lay Summary (German)

Lead
Titel des Projektes:Das Substrat kognitiver Störungen nach SchlaganfallNach einem Schlaganfall kommt es bei einem grossen Anteil der Patienten zu kognitiven Defiziten. Diese beeinflussen die Lebensqualität der Betroffenen und deren Fähigkeit, sich wieder in den Alltag zu integrieren. Aufmerksamkeit, exekutive Funktionen und Gedächtnis können hierbei betroffen sein. Nicht alle diese kognitiven Störungen lassen sich aber durch eine direkte Läsion des Hirngewebes erklären.
Lay summary

Inhalt und Ziel des Forschungsprojekts
Wir möchten mit unserem Projekt die Ursache von Störungen des episodischen Gedächtnisses nach einem Schlaganfall herausfinden. Mittels Magnetresonanztomographie (MRT) werden sowohl Ausmass des Hirninfarktes, als auch  mögliche, funktionell bedeutsame Verbindungen zwischen dem im Schlaganfall betroffenen sensomotorischen System und dem für Gedächtnisfunktionen bedeutsamen Netzwerk im Hippocampus und temporalen Regionen in einem Schlaganfall-Tiermodell (Ratte) untersucht. Sensomotorische und  kognitive Defizite werden  wiederholt mit speziellen Funktionstests beurteilt.
Des Weiteren wollen wir den Einfluss kognitiver Störungen nach einem Schlaganfall auf die motorische Erholung und umgekehrt, den Einfluss eines motorischen Rehabilitationsansatzes auf kognitive Defizite eruieren. Die histologische Aufarbeitung der Hirne soll Aufschluss über Zellschaden  und zelluläre Reparaturmechanismen geben.

Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojektes
Unsere Arbeit wird neue und wichtige Informationen über ein klinisch relevantes Problem: kognitive Störungen nach Schlaganfall, liefern. Diese Informationen sollen helfen zu verstehen, warum es zu solchen Störungen kommt und neue Wege zu finden, diese zu rehabilitieren. Ein neuartiger, in das klinische Setting einfach zu übertragener Ansatz wäre hier ein motorischer Rehabilitationsalgorithmus zur Verbesserung kognitiver Fähigkeiten.

Direct link to Lay Summary Last update: 22.01.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
A Generative Probabilistic Model and Discriminative Extensions for Brain Lesion Segmentation— With Application to Tumor and Stroke
Menze Bjoern H., Van Leemput Koen, Lashkari Danial, Riklin-Raviv Tammy, Geremia Ezequiel, Alberts Esther, Gruber Philipp, Wegener Susanne, Weber Marc-Andre, Szekely Gabor, Ayache Nicholas, Golland Polina (2016), A Generative Probabilistic Model and Discriminative Extensions for Brain Lesion Segmentation— With Application to Tumor and Stroke, in IEEE Transactions on Medical Imaging, 35(4), 933-946.
No Impact of Body Mass Index on Outcome in Stroke Patients Treated with IV Thrombolysis BMI and IV Thrombolysis Outcome.
Branscheidt Meret, Schneider Juliane, Michel Patrik, Eskioglou Elissavet, Kaegi Georg, Stark Robert, Fischer Urs, Jung Simon, Arnold Marcel, Wertli Maria, Held Ulrike, Wegener Susanne, Luft Andreas, Sarikaya Hakan (2016), No Impact of Body Mass Index on Outcome in Stroke Patients Treated with IV Thrombolysis BMI and IV Thrombolysis Outcome., in PloS one, 11(10), 0164413-0164413.
Ultrasound and Clinical Predictors of Recurrent Ischemia in Symptomatic Internal Carotid Artery Occlusion.
Schneider Juliane, Sick Beate, Luft Andreas R, Wegener Susanne (2015), Ultrasound and Clinical Predictors of Recurrent Ischemia in Symptomatic Internal Carotid Artery Occlusion., in Stroke, 46(11), 3274-6.
3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow.
Wegener Susanne (2014), 3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow., in JCBFM, 1-9.

Collaboration

Group / person Country
Types of collaboration
Prof. Jan Klohs/ETH Institute for Biomedical Technology Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Dr. Di Pietro/ Institute of Biochemistry Catholic University of Rome, Rome, Italy Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Björn Menze TU München Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. B. Sick/ UZH, Institute of Epidemiology, Biostatistics and Prevention Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Dr. M. Hoehn, MPI Cologne Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Dr. Winklhofer/Prof. Valavanis, Dept. of Neuroradiology USZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
PD Dr. Andreas Boss Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
17. Unionstagung Bern Talk given at a conference Carotid-Duplex sonography: what does really determine treatment? 17.10.2016 Bern, Switzerland Wegener Susanne;
8th European-Japanese Cerebrovascular Conference Individual talk Collateral flow and penumbra: revival of an old concept for acute decision making in stroke 24.06.2016 Zurich, Switzerland Wegener Susanne;
SFCNS meeting Individual talk Association of Metformin treatment with stroke severity and outcome 10.05.2016 Basel, Switzerland Wegener Susanne;
14th Zurich Course on Vascular Ultrasound Talk given at a conference Carotisstenose – Abklärung und Indikation zur Therapie 17.03.2016 Zurich, Switzerland Wegener Susanne;
ZNZ annual meeting Poster Manganese-enhanced MRI for the study of post-stroke cognitive impairment in a rodent stroke model 11.09.2015 Zürich, Switzerland Wegener Susanne;
The 56th scientific meeting of the Anglo-German Medical Society Talk given at a conference Stroke: Outcomes 05.09.2015 Zurich, Switzerland Wegener Susanne;
Research Retreat Neurokopf Talk given at a conference Imaging in experimental stroke models 02.07.2015 Zürich, Switzerland Wegener Susanne;
European Stroke Conference Poster Transcranial ultrasound predictors of recurrent ischemic stroke in symptomatic internal carotid artery occlusion 19.05.2015 Glasgow, Great Britain and Northern Ireland Wegener Susanne;
European Stroke Conference Talk given at a conference Analysis of Collateral Circulation in Proximal Cerebral Vessel Occlusions based on Digital Subtraction Angiography (DSA) 19.05.2015 Glasgow, Great Britain and Northern Ireland Wegener Susanne;
Clinical Research Day Poster Transcranial ultrasound predictors of recurrent ischemic stroke in symptomatic internal carotid artery occlusion 09.04.2015 Zurich, Switzerland Wegener Susanne;
Highlights in Neurology 2014 Talk given at a conference Neues zur Antikoagulation beim Schlaganfall 08.01.2015 Zurich, Switzerland Wegener Susanne;
Jahrestagung Society for Neurosciences Poster Reduced COX expression and metabolic adjustments in 3- nitropropionic acid-induced ischemia tolerance in the rat brain 18.11.2014 Washington, United States of America Wegener Susanne;
Euroean Stroke Conference Talk given at a conference 3-nitropropionic acid (NPA) induced ischemia tolerance is mediated by reduced metabolic activity and cerebral blood flow 07.05.2014 Nizza, France Wegener Susanne;


Self-organised

Title Date Place
Symposium "Schlaganfall-Akuttherapie off-label" 10.03.2016 Zurich, Switzerland
Symposium Mismatch und Thrombolyse 26.02.2015 Zurich, Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Weiterbildung Stroke Network Talk 25.08.2016 Zurich, Switzerland Wegener Susanne;
NOACs zur Antikoagulation beim Schlaganfall Talk 22.06.2016 Wald, Switzerland Wegener Susanne;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Brain FAIR German-speaking Switzerland 2015
Talks/events/exhibitions World Stroke Day German-speaking Switzerland 2015
Talks/events/exhibitions im Fokus: Hirnschlag German-speaking Switzerland 2014
Talks/events/exhibitions Tag der offenen ¨Tür Klinik für Neurologie German-speaking Switzerland 2014

Awards

Title Year
SIWF-Award for dedication in continuing medical education 2015

Abstract

Post-stroke cognitive impairment is a frequently encountered problem after stroke that interferes with a good clinical recovery. The reason for this cognitive impairment remains largely unknown, especially with respect to episodic memory, since most ischemic stroke lesions do not encompass the brain structures involved in episodic memory functions such as the medial temporal lobe (MTL). In a rat stroke model, we wish to characterize how MCA territory stroke causes deficits in cognitive impairment, specifically deficits in episodic memory. We are planning to use MRI including assessment of cerebral blood flow (CBF) and Manganese-enhanced MRI. Through activity-dependent anterograde transport, the paramagnetic Mn2+ can be tracked by MRI in brain structures that are functionally connected. We plan MRI assessment with Mn2+ labeling of the hippocampal system before and after experimental ischemia together with behavioral assessment including sensorimotor and episodic memory functions. Furthermore, we wish to determine if a motor training task can improve post-stroke cognitive impairment in our rat model.
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