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OMNY (tOMography, Nano, crYo stage)

English title OMNY (tOMography, Nano, crYo stage)
Applicant Holler Mirko
Number 145056
Funding scheme R'EQUIP
Research institution Paul Scherrer Institut
Institution of higher education Paul Scherrer Institute - PSI
Main discipline Other disciplines of Physics
Start/End 01.01.2013 - 31.12.2013
Approved amount 481'089.00
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All Disciplines (2)

Discipline
Other disciplines of Physics
Cellular Biology, Cytology

Keywords (8)

ptychography; cryogenic samples; nano tomography; X-ray microscopy; nano materials; materials science; bio materials; coherent diffractive imaging

Lay Summary (German)

Lead
Das Paul Scherrer Institut hat eine führende Stellung im Bereich der Röntenmikroskopie, speziell im Verfahren "tomographische Ptychographie". Hierbei können mittels harter Röntgenstrahlung dicke Proben 3-dimensional abgebildet werden. Die erreichbare Aufloesung wird derzeit durch den bestehenden Mess-Aufbau auf etwa 150 nm begrenzt und strahlungsempfindliche Proben können in der bestehenden Apparatur während der Messung beschädigt werden. Beides schränkt die wissenschaftliche Nutzung stark ein.
Lay summary

Inhalt und Ziel des Forschungsprojekts

Innerhalb des “OMNY” (tOMography, Nano, crYo stage) Projekts wird ein neuartiges Instrument für tomographische Ptychographie entwickelt. Die räumliche Auflösung in den tomographischen Messungen soll auf 10 nm verbessert werden. Zudem wird OMNY im Ultrahochvakuum installiert und wird eine gekühlte Probenumgebung mit Temperaturen unter 50 Kelvin zur Verfügung stellen um Strahlenschäden an Proben zu verhindern. Um das Instrument auch für biologische Proben einsetzen zu können wird ein Probentransfersystem für gefrorene Proben implementiert.

Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojekts

Das OMNY Instrument wird als neue Nutzerstation an der Swiss Light Source am Paul Scherrer Institut (PSI) für wissenschaftliche Anwendungen Forschungsgruppen innerhalb des PSI sowie externen Nutzern (national und international) zur Verfügung stehen. Das Instrument sichert die führende Stellung des PSI im Bereich Ptychographie. OMNY wird neuartige höchstauflösende (10 nm) Messungen in den Bereichen Materialwissenschaften (Zement, Elektronische Bauteile, magnetische Systeme, etc), sowie Biowissenschaften (Knochen, Gewebe, Zellen, etc.) erlauben.

Direct link to Lay Summary Last update: 09.11.2012

Responsible applicant and co-applicants

Publications

Publication
Resonant Ptychographic Tomography Facilitates Three-Dimensional Quantitative Colocalization of Catalyst Components and Chemical Elements
Ihli Johannes, Diaz Ana, Shu Yuying, Guizar-Sicairos Manuel, Holler Mirko, Wakonig Klaus, Odstrcil Michal, Li Teng, Krumeich Frank, Müller Elisabeth, Cheng Wu-Cheng, Anton van Bokhoven Jeroen, Menzel Andreas (2018), Resonant Ptychographic Tomography Facilitates Three-Dimensional Quantitative Colocalization of Catalyst Components and Chemical Elements, in The Journal of Physical Chemistry C, 122(40), 22920-22929.
Quantitative region-of-interest tomography using variable field of view
da Silva J. C., Guizar-Sicairos M., Holler M., Diaz A., van Bokhoven J. A., Bunk O., Menzel A. (2018), Quantitative region-of-interest tomography using variable field of view, in Optics Express, 26(13), 16752-16752.
Evolutionary-Optimized Photonic Network Structure in White Beetle Wing Scales
Wilts Bodo D., Sheng Xiaoyuan, Holler Mirko, Diaz Ana, Guizar-Sicairos Manuel, Raabe Jörg, Hoppe Robert, Liu Shu-Hao, Langford Richard, Onelli Olimpia D., Chen Duyu, Torquato Salvatore, Steiner Ullrich, Schroer Christian G., Vignolini Silvia, Sepe Alessandro (2018), Evolutionary-Optimized Photonic Network Structure in White Beetle Wing Scales, in Advanced Materials, 30(19), 1702057-1702057.
OMNY—A tOMography Nano crYo stage
Holler M., Raabe J., Diaz A., Guizar-Sicairos M., Wepf R., Odstrcil M., Shaik F. R., Panneels V., Menzel A., Sarafimov B., Maag S., Wang X., Thominet V., Walther H., Lachat T., Vitins M., Bunk O. (2018), OMNY—A tOMography Nano crYo stage, in Review of Scientific Instruments, 89(4), 043706-043706.
Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography
Shahmoradian S. H., Tsai E. H. R., Diaz A., Guizar-Sicairos M., Raabe J., Spycher L., Britschgi M., Ruf A., Stahlberg H., Holler M. (2017), Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography, in Scientific Reports, 7(1), 6291-6291.
OMNY PIN—A versatile sample holder for tomographic measurements at room and cryogenic temperatures
Holler M., Raabe J., Wepf R., Shahmoradian S. H., Diaz A., Sarafimov B., Lachat T., Walther H., Vitins M. (2017), OMNY PIN—A versatile sample holder for tomographic measurements at room and cryogenic temperatures, in Review of Scientific Instruments, 88(11), 113701-113701.
High-resolution non-destructive three-dimensional imaging of integrated circuits
Holler Mirko, Guizar-Sicairos Manuel, Tsai Esther H. R., Dinapoli Roberto, Müller Elisabeth, Bunk Oliver, Raabe Jörg, Aeppli Gabriel (2017), High-resolution non-destructive three-dimensional imaging of integrated circuits, in Nature, 543(7645), 402-406.
Three-Dimensional Nanometer Features of Direct Current Electrical Trees in Low-Density Polyethylene
Pallon Love K. H., Nilsson Fritjof, Yu Shun, Liu Dongming, Diaz Ana, Holler Mirko, Chen Xiangrong R., Gubanski Stanislaw, Hedenqvist Mikael S., Olsson Richard T., Gedde Ulf W. (2017), Three-Dimensional Nanometer Features of Direct Current Electrical Trees in Low-Density Polyethylene, in Nano Letters, 17(3), 1402-1408.
Chemistry and Mass Density of Aluminum Hydroxide Gel in Eco-Cements by Ptychographic X-ray Computed Tomography
Cuesta Ana, De la Torre Angeles G., Santacruz Isabel, Trtik Pavel, da Silva Julio C., Diaz Ana, Holler Mirko, Aranda Miguel A. G. (2017), Chemistry and Mass Density of Aluminum Hydroxide Gel in Eco-Cements by Ptychographic X-ray Computed Tomography, in The Journal of Physical Chemistry C, 121(5), 3044-3054.
Error motion compensating tracking interferometer for the position measurement of objects with rotational degree of freedom
Holler Mirko, Raabe Jörg (2015), Error motion compensating tracking interferometer for the position measurement of objects with rotational degree of freedom, in Optical Engineering, 54(5), 054101-054101.
Mass Density and Water Content of Saturated Never-Dried Calcium Silicate Hydrates
da Silva Julio C., Trtik Pavel, Diaz Ana, Holler Mirko, Guizar-Sicairos Manuel, Raabe Jörg, Bunk Oliver, Menzel Andreas (2015), Mass Density and Water Content of Saturated Never-Dried Calcium Silicate Hydrates, in Langmuir, 31(13), 3779-3783.
Element-Specific X-Ray Phase Tomography of 3D Structures at the Nanoscale
Donnelly Claire, Guizar-Sicairos Manuel, Scagnoli Valerio, Holler Mirko, Huthwelker Thomas, Menzel Andreas, Vartiainen Ismo, Müller Elisabeth, Kirk Eugenie, Gliga Sebastian, Raabe Jörg, Heyderman Laura J. (2015), Element-Specific X-Ray Phase Tomography of 3D Structures at the Nanoscale, in Physical Review Letters, 114(11), 115501-115501.
Assessment of the 3 D Pore Structure and Individual Components of Preshaped Catalyst Bodies by X-Ray Imaging
da Silva Julio C., Mader Kevin, Holler Mirko, Haberthür David, Diaz Ana, Guizar-Sicairos Manuel, Cheng Wu-Cheng, Shu Yuying, Raabe Jörg, Menzel Andreas, van Bokhoven Jeroen A. (2015), Assessment of the 3 D Pore Structure and Individual Components of Preshaped Catalyst Bodies by X-Ray Imaging, in ChemCatChem, 7(3), 413-416.
X-ray ptychographic computed tomography at 16 nm isotropic 3D resolution
Holler Mirko, Diaz Ana, Guizar-Sicairos Manuel, Karvinen Petri, Färm Elina, Härkönen Emma, Ritala Mikko, Menzel Andreas, Raabe Jörg, Bunk Oliver (2014), X-ray ptychographic computed tomography at 16 nm isotropic 3D resolution, in Scientific Reports, 4, 3857.

Collaboration

Group / person Country
Types of collaboration
Dectris Ltd. Switzerland (Europe)
- Industry/business/other use-inspired collaboration
Electron Microscopy ETH Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media A Glimpse of a Microchip’s Delicate Architecture Discover magazine International 2017
Media relations: print media, online media eek Inside Computer Chips with 3D X-Rays R&D Magazine International 2017
Media relations: print media, online media Ein Chip in seiner ganzen Schönheit Spektrum.de International 2017
Media relations: print media, online media X-rays Map the 3D Interior of Integrated Circuits IEEE Spectrum International 2017

Awards

Title Year
Innovationspreis Synchrotronstrahlung https://www.helmholtz-berlin.de/zentrum/locations/freundeskreis/forschungspreise/innovationspreis/ehem-preise/2014_de.html 2017

Associated projects

Number Title Start Funding scheme
152554 Ptychography with extended depth of field for tomography applications 01.01.2015 Project funding (Div. I-III)
150632 Ion Miller for Magnetic Nanostructures Research with Large Facilities 01.03.2014 R'EQUIP
137772 High-resolution quantitative local X-ray phase tomography 01.04.2013 Project funding (Div. I-III)

Abstract

The Paul Scherrer Institut (PSI) has a leading position in X-ray microscopy and has pioneered a new lensless imaging technique called "scanning X-ray diffraction microscopy" or "Ptychograpy". We have recently extended this 2D imaging technique to 3D. Ptychographic computed tomography delivers quantitative 3D images of both amplitude and phase at a resolution of currently 150 nm in user operation. The large penetration depth of hard X-rays is ideal for imaging thick (tens of microns) specimens. This allowed starting several research projects in the field of bone research and bio-nanoporous materials in general, but also in the field of materials science, like cement and polymer research. However, the scientific application is currently limited by the available instrumentation: the resolution needs to be improved and cryogenic sample preparation and protection against radiation damage is required for imaging in life science. “OMNY” (tOMography, Nano, crYo stage) is a pioneering project to design and fabricate a new endstation for the Swiss Light Source (SLS) at PSI to overcome current limitations. OMNY will enable non-destructive, quantitative nano-tomography based on scanning X-ray microscopy in a cryogenic sample environment. An instrument like OMNY is beyond state of the art. OMNY will permit to address sample systems like soft tissue that can be imaged element specific and non-destructive in their native state. OMNY will become a unique 3D analytical tool available to a broad user community. OMNY is not limited to biological samples: it will also permit nanotomography on solid samples like cement, integrated circuits and magnetic structures, inter alia. OMNY will be implemented at the cSAXS beamline at SLS. The experimental environment that will be created by this new type of endstation also satisfies well the requirements of future SwissFEL applications. This renders the development and use of OMNY an important step towards future use of SwissFEL.
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