Structural studies; cytotoxicity; mechanisms of action; Ruthenium complexes; NMR
Giannini Federico, Bartoloni Marco, Paul Lydia EH, Süss-Fink Georg, Reymond Jean-Louis, Furrer Julien (2015), Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes, in MedChemComm
, 6(2), 347-350.
Giannini Federico, Geiser Lennart, Paul Lydia EH, Roder Thomas, Therrien Bruno, Süss-Fink Georg, Furrer Julien (2015), Tuning the in vitro cell cytotoxicity of dinuclear arene ruthenium trithiolato complexes: Influence of the arene ligand, in Journal of Organometallic Chemistry
, 783, 40-45.
Stibal David, Therrien Bruno, Giannini Federico, Paul Lydia E. H., Furrer Julien, Suess-Fink Georg (2014), Monothiolato-Bridged Dinuclear Arene Ruthenium Complexes: The Missing Link in the Reaction of Arene Ruthenium Dichloride Dimers with Thiols, in EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
, (34), 5925-5931.
Giannini F., Furrer J., Suess-Fink G. (2014), Trithiolato-Bridged Dinuclear p-Cymene Ruthenium Complexes: A Study of their High in vitro Anticancer Activity, in JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
, 19, 439-439.
Giannini Federico, Geiser Lennart, Paul Lydia E. H., Roder Thomas, Suess-Fink Georg, Furrer Julien (2014), Tuning the in vitro cell cytotoxicity of dinuclear arene ruthenium trithiolato complexes: influence of the arene ligand, in JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
, 19, 788-788.
Giannini Federico, Paul Lydia E. H., Furrer Julien, Therrien Bruno, Suess-Fink Georg (2013), Highly cytotoxic diruthenium trithiolato complexes of the type [(eta(6)-p-MeC6H4Pri)(2)Ru-2(mu(2)-SR)(3)](+): synthesis, characterization, molecular structure and in vitro anticancer activity, in NEW JOURNAL OF CHEMISTRY
, 37(11), 3503-3511.
Giannini Federico, Furrer Julien, Suess-Fink Georg, Clavel Catherine M., Dyson Paul J. (2013), Synthesis, characterization and in vitro anticancer activity of highly cytotoxic trithiolato diruthenium complexes of the type [(eta(6)-p-(MeC6H4Pr)-Pr-i)(2)Ru-2(mu(2)-SR1)(2)(mu(2)-SR2)](+) containing different thiolato bridges, in JOURNAL OF ORGANOMETALLIC CHEMISTRY
, 744, 41-48.
Gupta Gajendra, Garci Amine, Murray Benjamin S., Dyson Paul J., Fabre Gabin, Trouillas Patrick, Giannini Federico, Furrer Julien, Suess-Fink Georg, Therrien Bruno (2013), Synthesis, molecular structure, computational study and in vitro anticancer activity of dinuclear thiolato-bridged pentamethylcyclopentadienyl Rh(III) and Ir(III) complexes, in DALTON TRANSACTIONS
, 42(43), 15457-15463.
The main part of the present research project focuses on the investigation of the cellular targets and mechanistic profiles of water-soluble arene ruthenium complexes using NMR Spectroscopy as a main tool. Another part will be devoted to the synthesis, characterization and biological evaluation of new ruthenium complexes containing modified arene ligands and of new ruthenium complexes containing selenium atoms. Ruthenium complexes and especially water-soluble arene ruthenium complexes, a domain pioneered in Switzerland, has undoubtedly opened new perspectives as potential anticancer drugs. In these systems, however, the mode of action, uptake and the biological processes are not yet fully understood. As such, our aims in this follow-up project remain to define cellular targets of the compounds and elucidate some of their mechanistic profiles by various analytical techniques, but especially by NMR Spectroscopy. This research proposal is a follow-up of the ongoing project No 200021-131867, which has proven to be successful and promising, and has in addition raised a lot of questions that shall be answered in this project. It is laid out for two years (01.01.2013 - 31.12.2014). Within this project, we propose to work on the topics presented subsequently involving Federico Giannini, who started his Ph.D. (01.01.2011), in close collaboration with the group of Prof. Georg Süss-Fink. Prof. Süss-Fink will continue his support as co-Ph.D. supervisor of Federico Giannini, and most of the complexes that will be studied will be provided by his group. This project will also occasionally involve the group of Prof. Dr. Oliver Mühlemann, and the group of PD Dr. Stefan Schürch, both from the Department of Chemistry and Biochemistry, University Bern, which host respectively the facilities required for cell lines cultures and cytotoxicity assessments, and dedicated mass spectrometers.