Stefanelli Thomas, Bertollini Cristina, Lüscher Christian, Muller Dominique, Mendez Pablo (2016), Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles., in Neuron
, 89(5), 1074-85.
Flores Carmen E, Nikonenko Irina, Mendez Pablo, Fritschy Jean-Marc, Tyagarajan Shiva K, Muller Dominique (2015), Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation., in Proceedings of the National Academy of Sciences of the United States of America
, 112(1), 65-72.
Janett Elia, Bernardinelli Yann, Müller Dominique, Bochet Christian G (2015), Synthesis of FMRFaNV, a Photoreleasable Caged Transmitter Designed to Study Neuron-Glia Interactions in the Central Nervous System., in Bioconjugate chemistry
, 26(12), 2408-18.
Bernardinelli Yann, Randall Jerome, Janett Elia, Nikonenko Irina, König Stéphane, Jones Emma Victoria, Flores Carmen E, Murai Keith K, Bochet Christian G, Holtmaat Anthony, Muller Dominique (2014), Activity-dependent structural plasticity of perisynaptic astrocytic domains promotes excitatory synapse stability., in Current biology : CB
, 24(15), 1679-88.
Kehoe Laura A, Bellone Camilla, De Roo Mathias, Zandueta Aitor, Dey Partha Narayan, Pérez-Otaño Isabel, Muller Dominique (2014), GluN3A promotes dendritic spine pruning and destabilization during postnatal development., in The Journal of neuroscience : the official journal of the Society for Neuroscience
, 34(28), 9213-21.
Boda Bernadett, Mendez Pablo, Boury-Jamot Benjamin, Magara Fulvio, Muller Dominique (2014), Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome., in The European journal of neuroscience
, 39(7), 1130-7.
Nikonenko Irina, Nikonenko Alexander, Mendez Pablo, Michurina Tatyana V, Enikolopov Grigori, Muller Dominique (2013), Nitric oxide mediates local activity-dependent excitatory synapse development., in Proceedings of the National Academy of Sciences of the United States of America
, 110(44), E4142-E4151.
Brown Matthew T C, Tan Kelly R, O'Connor Eoin C, Nikonenko Irina, Muller Dominique, Lüscher Christian (2012), Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning., in Nature
, 492(7429), 452-6.
Adaptation of synaptic networks during development and in response to learning behaviours occurs through a continuous process of synapse formation and elimination. At least two distinct mechanisms play a central role in these processes: one involves a selective stabilization of synapses through activity-dependent mechanisms and a second involves modifications of synapse turnover and dynamics to allow network rewiring. The molecular mechanisms underlying these two aspects of synaptic structural plasticity are still mainly unknown. The objectives of this project are to characterize the role of several candidate molecules for which we have preliminary evidence that they contribute to synapse turnover and stabilization during development. The work will focus on a model of organotypic slice cultures using repetitive imaging approaches, molecular tools and electrophysiological recordings to determine i) the specific function of nitric oxide in controlling clustered spine growth, ii) the role of the GluN3A subunit of NMDA receptors in spine elimination during development and iii) the alterations of spine dynamics present in a mouse model of Fragile X syndrome.