Project

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Non-invasive and Regional 3D Measures of Coronary Vasomotor Function, Delayed Hyperenhancement and Vessel Wall Plaque Characteristics in Early Atherosclerosis Using Advanced High-Field Magnetic Resonance Imaging

English title Non-invasive and Regional 3D Measures of Coronary Vasomotor Function, Delayed Hyperenhancement and Vessel Wall Plaque Characteristics in Early Atherosclerosis Using Advanced High-Field Magnetic Resonance Imaging
Applicant Stuber Matthias
Number 143923
Funding scheme Project funding (Div. I-III)
Research institution Département de radiologie médicale Centre Hospitalier Universitaire Vaudois University of Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Clinical Cardiovascular Research
Start/End 01.03.2013 - 31.10.2016
Approved amount 474'301.00
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All Disciplines (2)

Discipline
Clinical Cardiovascular Research
Physiology : other topics

Keywords (1)

Vessel wall

Lay Summary (English)

Lead
Coronary endothelial dysfunction is a very early indicator of atherosclerosis. Using novel MRI methods, it can be measured non-invasively and safely. This project will help advance human atherosclerosis research and may lead to new methods to better monitor and guide therapy.
Lay summary
Cardiovascular disease is the leading cause of death in industrialized nations and about half of these deaths are attributed to coronary heart diseases according to the most recent statistics of the American Heart Association. The statistics for Switzerland are quite similar. Coronary heart disease or atherosclerosis can lead to heart attack and myocardial infarct, and is caused by a blood clot or thrombus that blocks the heart vessels (coronary arteries) and blood-supply to the heart muscle. To date, medicine has made great progress in prevention of the disease and in restoring blood-flow to the heart after an infarct. However, early detection of the disease before symptoms occur is currently not easily possible with non-invasive tests that operate without ionizing radiation. At the CHUV, a team of closely linked engineers, physicists and medical doctors have therefore developed novel non-invasive magnetic resonance imaging (MRI) technology that operates without radiation to study the coronary anatomy and function. Supported by strong preliminary results, we will test the hypothesis that our novel MRI methods have the sensitivity to successfully identify, characterize and quantify atherosclerotic changes of the heart vessels much before blockage of blood flow occurs. This will not only lead to new biological insights into atherosclerosis progression but will also help to better guide and monitor therapy in patients with risk factors and suspected coronary heart disease.
Direct link to Lay Summary Last update: 25.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
In vitro optimization and comparison of CT angiography versus radial cardiovascular magnetic resonance for the quantification of cross-sectional areas and coronary endothelial function
Yerly Jérôme, Becce Fabio, van Heeswijk Ruud B., Verdun Francis R., Gubian Danilo, Meuli Reto, Stuber Matthias (2019), In vitro optimization and comparison of CT angiography versus radial cardiovascular magnetic resonance for the quantification of cross-sectional areas and coronary endothelial function, in Journal of Cardiovascular Magnetic Resonance, 21(1), 11-11.
A black‐blood ultra‐short echo time (UTE) sequence for 3D isotropic resolution imaging of the lungs
Delacoste Jean, Feliciano Helene, Yerly Jérôme, Dunet Vincent, Beigelman‐Aubry Catherine, Ginami Giulia, van Heeswijk Ruud B., Piccini Davide, Stuber Matthias, Sauty Alain (2019), A black‐blood ultra‐short echo time (UTE) sequence for 3D isotropic resolution imaging of the lungs, in Magnetic Resonance in Medicine, 81(6), 3808-3818.
A double echo ultra short echo time (UTE) acquisition for respiratory motion-suppressed high resolution imaging of the lungMotion-Suppressed UTE
Delacoste Jean, Chaptinel Jerome, Beigelman-Aubry Catherine, Piccini Davide, Sauty Alain, Stuber Matthias (2018), A double echo ultra short echo time (UTE) acquisition for respiratory motion-suppressed high resolution imaging of the lungMotion-Suppressed UTE, in Magnetic Resonance in Medicine, 79(4), 2297-2305.
Improved respiratory self-navigation for 3D radial acquisitions through the use of a pencil-beam 2D-T 2 -prep for free-breathing, whole-heart coronary MRA Improved Self-Navigation With 2D-T 2 -Prep
Coristine Andrew J., Chaptinel Jerome, Ginami Giulia, Bonanno Gabriele, Coppo Simone, van Heeswijk Ruud B., Piccini Davide, Stuber Matthias (2018), Improved respiratory self-navigation for 3D radial acquisitions through the use of a pencil-beam 2D-T 2 -prep for free-breathing, whole-heart coronary MRA Improved Self-Navigation With 2D-T 2 -Prep, in Magnetic Resonance in Medicine, 79(3), 1293-1303.
A phantom study to determine the theoretical accuracy and precision of radial MRI to measure cross-sectional area differences for the application of coronary endothelial function assessmentPrecision of In vitro Coronary Area Measurements
Yerly Jérôme, Gubian Danilo, Knebel Jean-Francois, Schenk Ali, Chaptinel Jerome, Ginami Giulia, Stuber Matthias (2018), A phantom study to determine the theoretical accuracy and precision of radial MRI to measure cross-sectional area differences for the application of coronary endothelial function assessmentPrecision of In vitro Coronary Area Measurements, in Magnetic Resonance in Medicine, 79(1), 108-120.
Local coronary wall eccentricity and endothelial function are closely related in patients with atherosclerotic coronary artery disease
Hays Allison G., Iantorno Micaela, Schär Michael, Mukherjee Monica, Stuber Matthias, Gerstenblith Gary, Weiss Robert G. (2017), Local coronary wall eccentricity and endothelial function are closely related in patients with atherosclerotic coronary artery disease, in Journal of Cardiovascular Magnetic Resonance, 19(1), 51-51.
Respiratory optimized data selection for more resilient self-navigated whole-heart coronary MR angiography
Chaptinel Jerome, Piccini Davide, Bonanno Gabriele, Coppo Simone, Monney Pierre, Stuber Matthias, Schwitter Juerg (2017), Respiratory optimized data selection for more resilient self-navigated whole-heart coronary MR angiography, in Magnetic Resonance Materials in Physics, Biology and Medicine, 30(3), 215-225.
Respiratory optimized data selection for more resilient self-navigated whole-heart coronary MR angiography.
Chaptinel Jerome, Piccini Davide, Bonanno Gabriele, Coppo Simone, Monney Pierre, Stuber Matthias, Schwitter Juerg (2017), Respiratory optimized data selection for more resilient self-navigated whole-heart coronary MR angiography., in Magma (New York, N.Y.), xx(xx), xx-xx.
Four-dimensional respiratory motion-resolved whole heart coronary MR angiography.
Piccini Davide, Feng Li, Bonanno Gabriele, Coppo Simone, Yerly Jérôme, Lim Ruth P, Schwitter Juerg, Sodickson Daniel K, Otazo Ricardo, Stuber Matthias (2017), Four-dimensional respiratory motion-resolved whole heart coronary MR angiography., in Magnetic resonance in medicine, xx(xx), xx-xx.
Golden angle dual-inversion recovery acquisition coupled with a flexible time-resolved sparse reconstruction facilitates sequence timing in high-resolution coronary vessel wall MRI at 3 T.
Ginami Giulia, Yerly Jérôme, Masci Pier Giorgio, Stuber Matthias (2017), Golden angle dual-inversion recovery acquisition coupled with a flexible time-resolved sparse reconstruction facilitates sequence timing in high-resolution coronary vessel wall MRI at 3 T., in Magnetic resonance in medicine, xx(xx), xx-xx.
Improved border sharpness of post-infarct scar by a novel self-navigated free-breathing high-resolution 3D whole-heart inversion recovery magnetic resonance approach.
Rutz Tobias, Piccini Davide, Coppo Simone, Chaptinel Jerome, Ginami Giulia, Vincenti Gabriella, Stuber Matthias, Schwitter Juerg (2016), Improved border sharpness of post-infarct scar by a novel self-navigated free-breathing high-resolution 3D whole-heart inversion recovery magnetic resonance approach., in The international journal of cardiovascular imaging, 32(12), 1735-1744.
A Cylindrical, Inner Volume Selecting 2D-T2-Prep Improves GRAPPA-Accelerated Image Quality in MRA of the Right Coronary Artery
Coristine Andrew J., Yerly Jerome, Stuber Matthias (2016), A Cylindrical, Inner Volume Selecting 2D-T2-Prep Improves GRAPPA-Accelerated Image Quality in MRA of the Right Coronary Artery, in PLOS ONE, 11(10), e0163618-e0163618.
A Cylindrical, Inner Volume Selecting 2D-T2-Prep Improves GRAPPA-Accelerated Image Quality in MRA of the Right Coronary Artery.
Coristine Andrew J, Yerly Jerome, Stuber Matthias (2016), A Cylindrical, Inner Volume Selecting 2D-T2-Prep Improves GRAPPA-Accelerated Image Quality in MRA of the Right Coronary Artery., in PloS one, 11(10), 0163618-0163618.
An iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improves image quality in a preliminary patient studyIterative Approach to Respiratory Self-Navigation
Ginami Giulia, Bonanno Gabriele, Schwitter Juerg, Stuber Matthias, Piccini Davide (2016), An iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improves image quality in a preliminary patient studyIterative Approach to Respiratory Self-Navigation, in Magnetic Resonance in Medicine, 75(4), 1594-1604.
Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function.
Iantorno Micaela, Hays Allison G, Schär Michael, Krishnaswamy Rupa, Soleimanifard Sahar, Steinberg Angela, Stuber Matthias, Gerstenblith Gary, Weiss Robert G (2016), Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function., in Circulation. Cardiovascular imaging, 9(3), 003954-003954.
How accurately and Precisely Are we Measuring Coronary Endothelial Function with Radial MRI?
Yerly Jerome (2016), How accurately and Precisely Are we Measuring Coronary Endothelial Function with Radial MRI?, in ISMRM Book of abstracts, ISMRM, Singapore.
How Accurately and Precisely Are we Measuring Coronary Endothelial Function with Radial MRI?
Yerly Jerome (2016), How Accurately and Precisely Are we Measuring Coronary Endothelial Function with Radial MRI?, in Book of Abstracts, ISMRM, Singapore.
Free-running 4D whole-heart self-navigated golden angle MRI: Initial resultsFree-Running 4D Whole-Heart MRI
Coppo Simone, Piccini Davide, Bonanno Gabriele, Chaptinel Jérôme, Vincenti Gabriella, Feliciano Hélène, van Heeswijk Ruud B., Schwitter Juerg, Stuber Matthias (2015), Free-running 4D whole-heart self-navigated golden angle MRI: Initial resultsFree-Running 4D Whole-Heart MRI, in Magnetic Resonance in Medicine, 74(5), 1306-1316.
An iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improves image quality in a preliminary patient study.
Ginami Giulia, Bonanno Gabriele, Schwitter Juerg, Stuber Matthias, Piccini Davide (2015), An iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improves image quality in a preliminary patient study., in Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine /, 000-000.
Repositioning precision of coronary arteries measured on X-ray angiography and its implications for coronary MR angiography.
Coppo Simone, Firsova Maria, Locca Didier, Knebel Jean-François, van Heeswijk Ruud B, Stuber Matthias (2015), Repositioning precision of coronary arteries measured on X-ray angiography and its implications for coronary MR angiography., in Journal of magnetic resonance imaging : JMRI, 41(5), 1251-8.
Fat signal suppression for coronary MRA at 3T using a water-selective adiabatic T2 -preparation technique.
Coristine Andrew J, van Heeswijk Ruud B, Stuber Matthias (2014), Fat signal suppression for coronary MRA at 3T using a water-selective adiabatic T2 -preparation technique., in Magnetic resonance in medicine, 72(3), 763-9.
Free-running 4D whole-heart self-navigated golden angle MRI: Initial results.
Coppo Simone, Piccini Davide, Bonanno Gabriele, Chaptinel Jérôme, Vincenti Gabriella, Feliciano Hélène, van Heeswijk Ruud B, Schwitter Juerg, Stuber Matthias (2014), Free-running 4D whole-heart self-navigated golden angle MRI: Initial results., in Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine /, 000-000.
Free-running 4D whole-heart self-navigated golden angle MRI: Initial results.
Coppo Simone, Piccini Davide, Bonanno Gabriele, Chaptinel Jérôme, Vincenti Gabriella, Feliciano Hélène, van Heeswijk Ruud B, Schwitter Juerg, Stuber Matthias (2014), Free-running 4D whole-heart self-navigated golden angle MRI: Initial results., in Magnetic resonance in medicine, 74(5), 1306-16.
Robust volume-targeted balanced steady-state free-precession coronary magnetic resonance angiography in a breathhold at 3.0 Tesla: a reproducibility study.
Soleimanifard Sahar, Stuber Matthias, Hays Allison G, Weiss Robert G, Schär Michael (2014), Robust volume-targeted balanced steady-state free-precession coronary magnetic resonance angiography in a breathhold at 3.0 Tesla: a reproducibility study., in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Ma, 16, 27-27.
Self-navigation with compressed sensing for 2D translational motion correction in free-breathing coronary MRI: a feasibility study.
Bonanno Gabriele, Puy Gilles, Wiaux Yves, van Heeswijk Ruud B, Piccini Davide, Stuber Matthias (2014), Self-navigation with compressed sensing for 2D translational motion correction in free-breathing coronary MRI: a feasibility study., in PloS one, 9(8), 105523-105523.
An Improved Set-up for Coronary Endothelial Function Assessment with MR-Compatible Digital Isometric Handgrip and Real-Time Visual Feedback
Nordio Giovanna, An Improved Set-up for Coronary Endothelial Function Assessment with MR-Compatible Digital Isometric Handgrip and Real-Time Visual Feedback, in Book of Abstracts SMRA, Society for Magnetic Resonance Angiography, Rome.
Coronary Endothelial Function Assessment Using Self-Gated Cardiac Cine MRI and k-t Sparse SENSE
Yerly Jerome, Coronary Endothelial Function Assessment Using Self-Gated Cardiac Cine MRI and k-t Sparse SENSE, in Book of Abstracts SMRA, Society for Msgnetic Resonance Angiography, Rome.
Coronary endothelial function assessment using self-gated cardiac cine MRI and k-t sparse SENSE
Yerly J., Ginami G., Nordio G., Coristine A. J., Coppo S., Monney P., Stuber M., Coronary endothelial function assessment using self-gated cardiac cine MRI and k-t sparse SENSE, in Magn Reson Med.
Coronary Endothelial Function Assessment Using Self-Gated Cardiac Cine MRI with Golden Angle Acquisition and K-T Sparse SENSE
Ginami Giulia, Coronary Endothelial Function Assessment Using Self-Gated Cardiac Cine MRI with Golden Angle Acquisition and K-T Sparse SENSE, in ISMRM Book of Abstracts, ISMRM, Toronto.

Collaboration

Group / person Country
Types of collaboration
New York University, New York, NY United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Johns Hopkins University, Baltimore, MD United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events



Self-organised

Title Date Place
5th Annual Retreat of the Cardiovascular Magnetic Resonance Center @ CIBM-CHUV-MR 30.08.2017 Sévrier, France
4th Annual Retreat of the Cardiovascular Magnetic Resonance Center @ CIBM-CHUV-MR 07.09.2016 Sévrier, France
3rd Annual Retreat of the Cardiovascular Magnetic Resonance Center @ CIBM-CHUV 09.09.2015 Sévrier, France
2ndAnnual Retreat of the Cardiovascular Magnetic Resonance Center @ CIBM-CHUV 04.06.2014 Gex, France
1st Annual Retreat of the Cardiovascular Magnetic Resonance Center @ CIBM 30.05.2013 Gex, Jura, France

Awards

Title Year
Editor's Pick Magn Reson Med. Of her article entitled "An iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improves image quality in a preliminary patient study". The related interview can be found here: https://www.youtube.com/watch?v=6DyPhlz4NmI 2016
Highlights in Magn Reson Med. In addition to the Editor's pick, her article "An iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improves image quality in a preliminary patient study" was also featured as a "Highlight" just before the annual conference of the Society in Singapore in 2016. 2016
Magna Cum Laude (best 15% trainee submissions) For her abstract: An Iterative Approach to Respiratory Self-Navigation Allows for Improved Image Quality and 100% Scan Efficiency in Contrast-Enhanced Inversion-Recovery Whole-Heart Coronary MRA at 3T; a First Patient Study. 24th Proc Int Soc Magn Reson Med (ISMRM), Singapore. 2016
SCMR Regional Scholarship Award for her abstract: Whole Heart Free Breathing Phase Sensitive Inversion Recovery MRI Integrated with Iterative Self Navigation for 100% Scan Efficiency; a First Patient Study. Proc Soc Cardiov Magn Reson (SCMR), Los Angeles (CA), USA (2016) 2016
Summa Cum Laude (best 5% trainee submissions) For her abstract: Flexible Time-Resolved Golden Angle Dual-Inversion Recovery Acquisition to Facilitate Sequence Timing in High-Resolution Coronary Vessel Wall MRI at 3T; 23rd Proc Int Soc Magn Reson Med (ISMRM), Toronto, Canada (2015) 2015
Magna Cum Laude (best 15% trainee submissions) For her abstract: An Iterative Self-Navigation Approach to Improve Image Quality in Subjects with Irregular Breathing in Whole Heart Coronary MRA; Joint annual meeting ISMRM and ESMRMB, Milano, (Italy) 2014

Associated projects

Number Title Start Funding scheme
173129 A Paradigm Shift in Magnetic Resonance Imaging of the Heart: 5D Imaging - Sample Now and Ask Questions Later 01.06.2017 Project funding (Div. I-III)
150828 Development of Advanced Translational High-Field MRI 12.05.2014 R'EQUIP

Abstract

Acute myocardial infarction is a consequence of atherosclerotic plaque rupture. Despite recent advances in systemic risk factor modification, diagnosis and therapy, coronary atherosclerotic progression remains a process whose heterogeneous spatial, and staccato temporal progression are impossible to predict with current clinical tools but which result in clinical events affecting millions of people worldwide each year. Current “anatomic” based imaging approaches do not identify specific, clinically useful predictors of coronary plaque progression or stability. For these reasons, a clinical measurement that may ultimately be able to predict impending plaque rupture is desperately needed. Abnormal coronary endothelial function (CEF) plays a crucial role in the development, progression, and clinical manifestations of coronary artery disease (CAD) and is an independent predictor of adverse cardiovascular events. CEF could previously only be quantified with catheterization-based invasive testing that precluded assessment in low-risk populations. However, CEF can now be measured non-invasively using magnetic resonance imaging (MRI). This critically enables research and discovery in the domain of early atherosclerosis progression. In fact, in vivo human results from the principal investigator (PI) of this proposal were the first to show that physiologic coronary artery vasodilation in healthy subjects and its pathologic absence in patients with CAD can be measured using MRI combined with isometric handgrip exercise. Simultaneously, a greater degree of endothelial dysfunction in severely diseased coronary arteries than in the contralateral, minimally diseased arteries exposed to identical systemic and genetic risk factors was measured. These findings advance the hypothesis that regional heterogeneity of CEF in a given coronary artery exists, reflecting local differences in the vascular microenvironment that correlates with early local anatomic manifestations of atherosclerosis. While our original MRI methods provided a novel, reproducible, non-invasive means to assess CEF at one or two locations in each vessel, they do not permit easy assessment of intra-arterial heterogeneity. Therefore, and in preparation for this grant submission, we have exploited recent MRI hardware and software advances to implement three-dimensional (3D) MRI techniques, which now permit a larger interrogation of the coronary arterial tree for CEF studies. The Specific Aims that follow logically and mechanistically include: 1.)Optimize and refine the existing 3D CEF MRI protocol through the use of new hardware and software.2.)In patients with established early CAD, test the hypothesis that segmental differences in CEF are related to the extent of local anatomical atherosclerosis (luminal stenosis by x-ray coronary angiography, coronary vessel wall thickness & plaque eccentricity by MRI).3.) In patients with established early CAD, test the hypothesis that regional delayed hyperenhancement of the coronary vessel wall is associated with local abnormal CEF..In particular we will focus on early-moderate (non-stenotic disease) because such lesions may result in most acute coronary events and because, unlike stenotic lesions, there is no lesion specific treatment at this time. We believe the results and insights obtained from these sophisticated non-invasive MRI approaches will lay the foundation for a new line of clinical investigation using local CEF to ultimately predict plaque stability and thereby advance the field of primary and secondary cardiovascular prevention.
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