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Kovalente Tag Chemie - Intrazelluläre Kontrolle von Receptoren und Signalen

English title Covalent tag-chemistry targeting receptor dynamics and signaling
Applicant Wymann Matthias
Number 143699
Funding scheme Project funding (Div. I-III)
Research institution Institut für Biochemie und Genetik Universität Basel
Institution of higher education University of Basel - BS
Main discipline Organic Chemistry
Start/End 01.01.2013 - 30.04.2014
Approved amount 91'639.00
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All Disciplines (3)

Discipline
Organic Chemistry
Biochemistry
Cellular Biology, Cytology

Keywords (9)

Chemistry; Protein-reactive probes; Protein/protein interactions; Protein/membrane interactions; Phosphoinositide kinases; Molecular tools; Chemical Biology; Signal transduction; Cancer

Responsible applicant and co-applicants

Employees

Name Institute

Publications

Publication
Cell-permeant and photocleavable chemical inducer of dimerization.
Zimmermann Mirjam, Cal Ruben, Janett Elia, Hoffmann Viktor, Bochet Christian G, Constable Edwin, Beaufils Florent, Wymann Matthias P (2014), Cell-permeant and photocleavable chemical inducer of dimerization., in Angewandte Chemie (International ed. in English), 53(18), 4717-20.
Chemical development of intracellular protein heterodimerizers.
Erhart Dominik, Zimmermann Mirjam, Jacques Olivier, Wittwer Matthias B, Ernst Beat, Constable Edwin, Zvelebil Marketa, Beaufils Florent, Wymann Matthias P (2013), Chemical development of intracellular protein heterodimerizers., in Chemistry & biology, 20(4), 549-57.
Membrane dynamics in physiology and disease.
Wymann Matthias P, Simons Kai (2013), Membrane dynamics in physiology and disease., in The FEBS journal, 280(12), 2729-2729.

Collaboration

Group / person Country
Types of collaboration
Marketa Zvelebil, ICR, London Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Christian G. Bochet Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Carsten Schultz, EMBL, Heidelberg Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Berndt Giese, Dept. Chemistry, Fribourg Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
E.C. Constable & C. Housecroft, Dept. Chemistry, Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Peter Spiess, Fachhochschule Nordwestschweiz Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Workshop on “Membrane Biology” at Lago di Como, April 12-16, 2014; Mirjam Zimmermann Talk given at a conference Novel photocleavable cell permeant chemical inducer of dimerization to control protein dynamics in time and space 12.04.2014 Como, Italy Constable-Housecroft Catherine Elizabeth;
MIPTEC & BioValley Life Sciences Week Talk given at a conference Synthesis and Applications of Novel Protein Cross-Linkers 24.09.2013 Basel, Switzerland Constable-Housecroft Catherine Elizabeth; Constable Edwin Charles; Beaufils Florent; Wymann Matthias;
RICT, Drug Discovery and Selection Talk given at a conference Synthesis and Applications of Novel Protein Cross-Linkers 03.07.2013 Nice, France Constable Edwin Charles; Constable-Housecroft Catherine Elizabeth; Beaufils Florent; Wymann Matthias;


Communication with the public

Communication Title Media Place Year
Media relations: print media, online media verschiedene Pressemeldungen, UniBas UniBas, Chemische Zeitschriften German-speaking Switzerland International 2013

Awards

Title Year
Dora Seif Prize for cancer research 2014

Associated projects

Number Title Start Funding scheme
138302 Chemische Induktion der intrazellulären Signalübertragung 01.01.2012 Project funding (Div. I-III)
189065 Distinct PI3Kg Complexes in Inflammation, Allergy and Metabolic Control 01.11.2019 Project funding (Div. I-III)
126508 Dynamische Protein-Dimerisierung und Membran-Translokation 01.01.2010 Project funding (Div. I-III)
126143 Tracking of Phosphoinositide Pools - A Key Signalling Component in Cancer and Inflammation (EMRC/ECORES/08-EUROMEMBRANE) 01.07.2009 Project funding (special)

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