Project

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Training-induced behavioral and brain plasticity in inhibitory control

English title Training-induced behavioral and brain plasticity in inhibitory control
Applicant Spierer Lucas
Number 143348
Funding scheme Project funding (Div. I-III)
Research institution Département de Médecine Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Neurophysiology and Brain Research
Start/End 01.01.2013 - 31.12.2014
Approved amount 115'806.00
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Keywords (5)

executive functions; inhibitory control; plasticity; training; EEG

Lay Summary (French)

Lead
Neuroplasticité des fonctions d'inhibition.
Lay summary

Le contrôle de l’inhibition, un aspect clef des fonctions exécutives, se réfère à la capacité d’annuler des processus cognitifs ou moteurs déjà engagés afin de permettre un fonctionnement optimale dans des environnements en perpétuel changement. Des déficits au niveau du contrôle de l’inhibition ont été avancés comme caractérisant, ou même comme favorisant l’émergence de nombreuses pathologies psychiatriques ou neurologiques incluant par exemple l’addiction ou les troubles de l’attention. La réhabilitation de ces pathologies pourrait donc bénéficier d’un renforcement du contrôle de l’inhibition par des entrainements. Le développement de stratégies de réhabilitation efficaces demande en premier lieu de déterminer si et comment la performance de contrôle de l’inhibition peut être améliorée chez des sujets sains et les mécanismes neurophysiologiques sous-tendant ces amélioration comportementales. Une des principale difficultés dans ce sens et d’identifier les protocoles d’entrainement qui peuvent modifier les mécanismes neurophysiologiques déficitaires chez les patients pour améliorer au mieux le contrôle de l’inhibition et favoriser la généralisation des effets de l’entrainement à des conditions et des tâches non-entrainées. En utilisant des méthodes psychophysiques et de neuroimagerie électrique, ce projet vise à identifier les mécanismes spatio-temporaux de la neuroplasticité du contrôle de l’inhibition induite par des entrainements.

Direct link to Lay Summary Last update: 13.12.2012

Lay Summary (English)

Lead
Training-induced neuroplasticity of inhibitory control
Lay summary

Inhibitory control, a key aspect of executive functions, refers to the ability to cancel ongoing cognitive or motor processes and allows adapting to changing environments. Inhibitory control deficits have been advanced to characterize or even constitute a causal factor in the emergence of several prominent brain-related disorders including e.g. addiction or ADHD. The rehabilitation of these pathologies might thus benefit from training-induced reinforcement of inhibitory control functions. The development of efficient inhibitory control training regimens first requires determining whether and how inhibitory control proficiency could be improved in healthy individuals and the underlying neurophysiological mechanisms. A major challenge in this regard is to identify training procedures that will impact on the impaired neurophysiological mechanisms and structures, optimally improve inhibitory control performance and promote the generalization of the effects of the inhibitory control training to untrained conditions and tasks. Although the anatomo-functional organization of inhibitory control has been extensively studied, the behavioral and neural plasticity of this function remains largely unknown. Using psychophysics and state-of-the–art electrical neuroimaging approaches, the present project addresses the behavioral and spatio-temporal brain mechanisms of training-induced plasticity of inhibitory control. 

Direct link to Lay Summary Last update: 13.12.2012

Responsible applicant and co-applicants

Employees

Name Institute

Publications

Publication
Experience-based Auditory Predictions Modulate Brain Activity to Silence as Do Real Sounds.
Chouiter Leila, Tzovara Athina, Dieguez Sebastian, Annoni Jean-Marie, Magezi David, De Lucia Marzia, Spierer Lucas (2015), Experience-based Auditory Predictions Modulate Brain Activity to Silence as Do Real Sounds., in Journal of cognitive neuroscience, 1-13.
Age-related changes in the bimanual advantage and in brain oscillatory activity during tapping movements suggest a decline in processing sensory reafference.
Sallard Etienne, Spierer Lucas, Ludwig Catherine, Deiber Marie-Pierre, Barral Jérôme (2013), Age-related changes in the bimanual advantage and in brain oscillatory activity during tapping movements suggest a decline in processing sensory reafference., in Experimental brain research, 232(2), 469-479.
Early attentional processes distinguish selective from global motor inhibitory control: An electrical neuroimaging study.
Sallard Etienne, Barral Jérôme, Chavan Camille, Spierer Lucas (2013), Early attentional processes distinguish selective from global motor inhibitory control: An electrical neuroimaging study., in NeuroImage, 87:, 183-189.
High and Low Stimulus-Driven Conflict Engage Segregated Brain Networks, Not Quantitatively Different Resources.
Chouiter Leila, Dieguez Sebastian, Annoni Jean-Marie, Spierer Lucas (2013), High and Low Stimulus-Driven Conflict Engage Segregated Brain Networks, Not Quantitatively Different Resources., in Brain topography, 27(2), 279-292.
Plastic modifications within inhibitory control networks induced by practicing a stop-signal task: an electrical neuroimaging study.
Manuel Aurelie, Bernasconi Fosco, Spierer Lucas (2013), Plastic modifications within inhibitory control networks induced by practicing a stop-signal task: an electrical neuroimaging study., in Cortex, 49(4), 1141-7.
Training-induced behavioral and brain plasticity in inhibitory control.
Spierer Lucas, Chavan Camille, Manuel Aurelie (2013), Training-induced behavioral and brain plasticity in inhibitory control., in Frontiers in human neuroscience, 7, 427-427.

Collaboration

Group / person Country
Types of collaboration
Prof. Micah Murray and Marzia DeLucia, Center for Biomedical Imaging / University of Lausanne Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Jean-Marie Annoni/ University of Fribourg Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Swiss Society For Neuroscience Annual Meeting Poster Plasticity of inhibitory control 01.01.2014 Berne, Switzerland Spierer Lucas; Chavan Camille;
Society for Neuroscience Annual Meeting Poster Plasticity of inhibitory control 01.11.2013 San-Diego, United States of America Chavan Camille;
Lemanic Neuroscience Annual Meeting Poster Plasticity of inhibitory control 01.09.2013 Les Diablerets, Switzerland Spierer Lucas; Chavan Camille;
3rd Research Day in Medicine Poster Plasticity of inhibitory control 01.05.2013 Fribourg, Switzerland Spierer Lucas; Chavan Camille;


Self-organised

Title Date Place
Swiss Society for Neuroscience Annual Meeting 01.01.2015 Fribourg, Switzerland

Associated projects

Number Title Start Funding scheme
156854 Structural and functional brain plasticity in inhibitory control: towards expertise 01.01.2015 Project funding (Div. I-III)
156854 Structural and functional brain plasticity in inhibitory control: towards expertise 01.01.2015 Project funding (Div. I-III)
175469 State-dependency of inhibitory control plasticity 01.01.2018 Project funding (Div. I-III)

Abstract

‘Training-induced behavioral and brain plasticity in inhibitory control’ Inhibitory control, a key aspect of executive functions, refers to the ability to cancel ongoing cognitive or motor processes and allows adapting to changing environments. Inhibitory control deficits have been advanced to characterize or even constitute a causal factor in the emergence of several prominent brain-related disorders including e.g. addiction or ADHD. The rehabilitation of these pathologies might thus benefit from training-induced reinforcement of inhibitory control functions. The development of efficient inhibitory control training regimens first requires determining whether and how inhibitory control proficiency could be improved in healthy individuals and the underlying neurophysiological mechanisms. A major challenge in this regard is to identify training procedures that will impact on the impaired neurophysiological mechanisms and structures, optimally improve inhibitory control performance and promote the generalization of the effects of the inhibitory control training to untrained conditions and tasks. Although the anatomo-functional organization of inhibitory control has been extensively studied, the behavioral and neural plasticity of this function remains largely unknown. Using psychophysics and state-of-the-art electrical neuroimaging approaches, the present project addresses the behavioral and spatio-temporal brain mechanisms of training-induced plasticity of inhibitory control. Recent evidence from our group show that inhibitory control training with basic Go and Stop stimuli and unvarying associations between these stimuli and the Go and Stop goals develops automatic, stimulus-driven forms of inhibition instead of reinforcing top-down frontal inhibitory mechanisms. Although such training regimens do improve inhibitory proficiency, their effects are specific to the trained stimulus and do not impact the frontal structures mainly impaired in inhibition-related pathologies, which is suboptimal in a rehabilitation perspective. Here, we will investigate the effects of various inhibitory control training regimen to eventually enable impacting on frontal areas and inducing a transfer of the effects of training to untrained stimuli, conditions and tasks All projects involve active inhibitory control training sessions to induce behavioral and neurophysiological plasticity as well as pre- and post- training sessions to assess the transfer of the effects of training to other conditions and tasks. Psychophysics and electrical neuroimaging analyses of event-related potentials (ERPs) are respectively utilized to identify the behavioral improvements, the generalization patterns and the spatio-temporal brain mechanisms of training-induced changes in inhibitory control. Electrical neuroimaging analyses notably include the time-wise, multifactorial statistical assessment of (1) the dynamic changes of scalp-recorded electric field configuration and their temporal segmentation into quasi-stable functional micro-states indexing modulations of the configuration of intracranial generators with training, (2) global electric field power indexing modulation of response strength of the intracranial generators, (3) intracranial distributed linear electrical source estimations. The primary importance of these projects is conceptual: to answer several fundamental questions on the anatomo-functional organization of executive functions and their plasticity. The planned studies are designed to have an immediate clinical applicability, including the development of targeted rehabilitation strategies for neurological and psychiatric conditions with inhibitory control deficits.
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