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Integration of medical oncology and palliative care procedures in various institutional and economical settings: Development of tailored interventions based on patient needs and testing of its preliminary efficacy on patient reported outcomes, tumour

Gesuchsteller/in Strasser Florian
Nummer 142226
Förderungsinstrument Romanian-Swiss Research Programme (RSRP)
Forschungseinrichtung Onkologische Palliativmedizin Palliativzentrum Kantonsspital St. Gallen
Hochschule Kantonsspital St.Gallen - KSPSG
Hauptdisziplin Klinische Krebsforschung
Beginn/Ende 01.01.2013 - 31.12.2015
Bewilligter Betrag 373'320.00
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Keywords (1)

Chemotherapy

Lay Summary (Deutsch)

Lead
Integration von onkologischen und palliativmedizinischen Massnahmen in verschiedenen institutionellen und wirtschaftlichen Rahmenbedingungen: Entwicklung von massgeschneiderten, auf Patientenbedürfnissen basierenden klinischen Praxis-Instrumenten und Abschätzung ihrer möglichen Wirksamkeit für die Lebensqualität von Patienten, die Tumorkontrolle und Kosten.
Lay summary
Für die Betreuung von Patienten mit unheilbarer Krebskrankheit spielen Krebsspezialisten-Teams eine zentrale Rolle. Allerdings ist die Integration von palliativmedizinischen Massnahmen in die klinische Routine eine Herausforderung, insbesondere bei limitierten ökonomischen Ressourcen. Klinische Praxis- Instrumente können sowohl die Patientenbedürfnisse sichtbarer machen wie auch spezifische palliativmedizinische Massnahmen in die onkologische Praxis integrieren. Für diese Massnahmen ist eine Abschätzung ihrer Wirksamkeit auf patientenbezogene Endpunkte, Tumorkontrolle, chemotherapiebezogene Nebenwirkungen sowie Gesundheitskosten wichtig.

Das gemeinschaftliche Forschungsprogramm zwischen Rumänien und der Schweiz fokussiert sich auf 5 onkologische Einrichtungen in Rumänien und eine in der Schweiz. Die Forschungshypothese ist, dass die Bereitstellung von massgeschneiderter Hilfestellung in der klinischen Praxis, basierend auf vorher erhobenen epidemiologischen Daten in jedem Institut, die Ergebnisse verbessern kann. Zuerst werden Patientendaten mit validierten Instrumenten zu Symptomen sog. palliativen Schlüsselinterventionen gesammelt. Daraufhin werden die Daten gemeinsam an einem Workshop, und unter Beizug von intl. Experten, analysiert. Anschliessend werden spezifische Interventionen (Schulungen von Krebsspezialistenteams, Einsatz von Patienten-Erfassungsinstrumenten in die Routine, Monitoring von palliativen Interventionen) in jeder der 5 Institutionen eingesetzt und ihre mögliche Wirksamkeit in einer Pilotstudie abgeschätzt. Ein abschliessender Workshop fasst die Resultate zusammen für die Weiterentwicklung in Rumänien.

Unsere Arbeit hat einerseits zum Ziel, die onkologisch palliativmedizinische Versorgung in Rumänien zu optimieren. Andererseits werden die erhobenen Daten für die Planung zukünftiger Studien im Bereich der onkologischen Palliativmedizin in Ländern mit limitierten ökonomischen Ressourcen hilfreich sein.

Direktlink auf Lay Summary Letzte Aktualisierung: 15.01.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Zusammenarbeit

Gruppe / Person Land
Formen der Zusammenarbeit
Institute of Oncology Bucharest Rumänien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
End of Life Research Group Belgien (Europa)
- Austausch von Mitarbeitern
Institutul Oncologic Cluj Rumänien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
SAKK Statistic Group Schweiz (Europa)
- Austausch von Mitarbeitern
Regional Oncologic Institute Iasi Rumänien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
Spitalul Judetean de Urgenta Alba Iulia Rumänien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
Hospice Casa Sperantei Rumänien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen

Wissenschaftliche Veranstaltungen

Aktiver Beitrag

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The 14th World Congress of the EAPC Poster Exploring of factors affecting recruitment in a longitudinal, multicentre, observational study of key interventions palliative cancer care (KIPCC) 08.05.2015 Copenhagen, Dänemark Strasser Florian;
The Conferences of the Regional Institute of Oncology Iasi, Romania (CONFER 2014) Vortrag im Rahmen einer Tagung Impact of palliative care interventions on cancer outcomes 29.11.2014 Iasi, Rumänien Strasser Florian;
Palliative Care Congress Biel (Switzerland) Poster Key Interventions of Palliative Cancer Care- Gaps between need and delivery:A longitudinal multicenter study 26.11.2014 Biel, Schweiz Strasser Florian; Magaya-Kalbermatten Natalie;
SAKK Semi-Annual Meeting Vortrag im Rahmen einer Tagung Invited presentation in the working group the network of outcome research on Mapping patient perceived need for palliative care interventions and perceived delivery of them by health care professionals. 20.11.2014 Bern, Schweiz Strasser Florian;
ESMO Congress Poster Key Interventions of Palliative Cancer Care (KI-PCC) - patient perceived need and remembered delivery by health-care professionales (HCP): A prospective, longitudinal, multicenter study 26.09.2014 Madrid, Spanien Strasser Florian;
Oncology Days-Oncology Institute “Prof Dr I. Chiricuta" Poster Integration of medical oncology and palliative care procedures in various institutional and economical settings 12.06.2014 Cluj, Rumänien Achimas Patrick;
National Research Conference on Palliative Care (SAMW) Poster Romanian-Swiss Research Program IZERZO: Protocol development of the “Reality Map of Integrated Oncology and Palliative Care (PC) in Romanian Cancer Centres” 26.11.2013 Bern, Schweiz Strasser Florian; Magaya-Kalbermatten Natalie;
SAKK Semi-Annual Meeting Vortrag im Rahmen einer Tagung Invited presentation in the working group the ntework of outcome research on quality indicators exemplifying this project. 20.11.2013 Basel, Schweiz Strasser Florian;
Palliative Care National Conference Vortrag im Rahmen einer Tagung Early integration of oncology and palliative care on the example of cancer cachexia 24.10.2013 Sibiu, Rumänien Strasser Florian;


Selber organisiert

Titel Datum Ort
3. Implementation IZERZO Project at St Luke Hospital 16.01.2016 Bukarest, Rumänien
2. Presentation IZERZO Project Results at St Luke Hospital 16.11.2015 St Luke Hospital, Bucharest, Rumänien
1. Presentation IZERZO Project at St Luke Hospital 16.09.2015 St Luke Hospital, Bucharest, Rumänien
Research Seminar Palliative Care, Kantonsspital St. Gallen (Switzerland) 28.05.2014 Kantonsspital St Gallen, Schweiz

Veranstaltungen zum Wissenstransfer



Selber organisiert

Titel Datum Ort
Implementation of Checklists in clinical practice of medical oncologists 20.11.2015 Bucharest, Rumänien

Kommunikation mit der Öffentlichkeit

Kommunikation Titel Medien Ort Jahr
Referate/Veranstaltungen/Ausstellungen Communicating the diagnosis and the prognosis- an actual problem International 2015
Referate/Veranstaltungen/Ausstellungen Practical Guidelines Elaborated During the Romanian Swiss Partnership IZERZO- Integration of medica International 2015
Referate/Veranstaltungen/Ausstellungen Research in Medical Oncology and Palliative Care International 2015
Referate/Veranstaltungen/Ausstellungen Ïllness and Prognosis Understanding in Routine Care International 2014
Referate/Veranstaltungen/Ausstellungen Integration of medical oncology and palliative care procedures in various institutional and economic International 2014
Referate/Veranstaltungen/Ausstellungen Mid-term meeting International 2014
Referate/Veranstaltungen/Ausstellungen National Congress of Romanian Society of Anaesthesia and Critical Care International 2014

Auszeichnungen

Titel Jahr
Second Prize for Poster "Key Interventions of Palliative Cancer Care- Gaps between need and delivery:A longitudinal multicenter study" at Palliative Care Congress Biel (Switzerland), palliative.ch, 26th November 2014. 2014

Abstract

Background: In the care of advanced incurable cancer patients medical oncologists play a sentinel role in not only providing tumour directed treatment, but also in identifying and treating palliative care needs. In busy oncological clinics and more pronounced in resource restricted settings, the integration of palliative care procedures in daily practise however is challenging. Models of integrated oncology and palliative care are developing, one important is the ESMO designated centers incentive program providing 13 criteria’s. However this is linked to substantial institutional commitments, which might not be rapidly feasible on the necessary time. Therefore the provision of clinical practise tools to integrate specific palliative care procedures into daily practise of medical oncologists and testing their effects on patient reported outcomes, tumour control including anticancer treatment toxicities and also health services costs seems timely and appropriate. These interventions can be summarized under promoting of illness understanding, multidimensional symptom assessment and management, indication criteria of chemotherapy in palliative intention, care plans to promote continuity of care in support networks and proactive end of life preparation including family members. Aim: The joint research program between Romania and Switzerland focuses on 4 institutions in Romania and one institution in Switzerland. The research hypothesis is that the provision of tailored clinic practice tools, based on prior epidemiological data in each institution, can improve outcomes. Methods: The research plan includes collection of real-practice patient-based data, development of tailored educational & clinical practice tools interventions based on these results, and testing for feasibility and collection of information about preliminary efficacy on the levels patient reported outcomes, tumor control, and costs.First a workshop for protocol finalization will be conducted in Romania including the 4 institutions and the principle investigators, this to ensure development of research capacities. The second phase will include for 6 months in all 4 institutions collection of patient needs with validated tools for symptoms, but also the other for key interventions, collected by a research nurse locally spending 30 minutes per patient, who are selected randomly. Parallel the palliative outcome scale will be validated according to standard procedures and formal translation. In the third phase, data will be analyzed and a second workshop of two days conducted in Romania, including all participant research personal and selected European leaders of medical oncology in palliative care. Decisions will be made about which tailored interventions are provided in each institution. In the fourth phase these interventions will be implemented as pilot projects, mainly focusing on feasibility, led by the local institutions, supported by experts in palliative care education and in medical oncology, utilizing also the international network of educators in oncological palliative medicine (ESMO palliative care working group and international association of hospice and palliative care). Examples of interventions are the use of pain intensity, presence of depression, and weight loss (%) in every patient seen by medical oncologists. Another example includes the documentation of the goals of anticancer treatment including pre-chemotherapy evaluation of cancer-related symptoms and patient-rated importance of expected toxicities. Another example may encompass the provision of a care plan coordinating also home care services and continuity of care with the oncologist. The educational effects will be tested by knowledge tests to assure effectivity. In a fifth phase information about preliminary efficacy will be collected based on patient reported outcomes, tumour control and chemotherapy toxicities and also health services used to extrapolate costs. In the final phase this data will be also analyzed and discussed in a third workshop, where it will be decided on potential intervention trials for exploring effectiveness of new clinical practice tools and palliative care procedures webbed in medical oncology care. Expected impact: It is foreseen to publish several manuscripts based on this research, guided by investigators from Romania. The results will provide the basis for further implementation research of tailored interventions of palliative care procedures provided by medical oncologists.
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