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SAPALDIA Off-spring study

Applicant Dratva Julia
Number 141671
Funding scheme Marie Heim-Voegtlin grants
Research institution Department of Epidemiology and Public Health Swiss Tropical and Public Health Institute Universität Basel
Institution of higher education University of Basel - BS
Main discipline Methods of Epidemiology and Preventive Medicine
Start/End 01.06.2012 - 30.11.2012
Approved amount 63'756.00
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All Disciplines (2)

Discipline
Methods of Epidemiology and Preventive Medicine
Cardiovascular Diseases

Keywords (6)

epidemiology; adolescence; carotid intima media thickness; environmental tabacco smoke; early life factors; childhood

Lay Summary (English)

Lead
Lay summary

Early life is considered a period of amplified susceptibility to adverse effects of exogenous and endogenous causes of diseases. Many chronic diseases, such as cardiovascular and respiratory diseases, occurring in later life may in part be explained by priming factors experienced in early life and tracking of risk factors into older age.

Within the frame of the Swiss Study on Air Pollution and Health In Adults cohort (SAPALDIA) the  SAPALDIA Youth Study, a retrospective cohort, recruited 360 offspring or of SAPALDIA participants.

The SAPALDIA Youth Study  can bridge time periods, early life and adolescence, by using the parental data as proxies for the early life environment of the offspring. The study aims at investigating the impact of early life and cumulative life-time ETS exposure on vascular health in childhood, measured by intima media thickness. The intima media thickness is considered an early marker of atherosclerosis in all ages. An increasing body of evidence documents the importance of childhood risk factors on the development of atherosclerosis in adults. Most studies in children have focused on metabolic and hemodynamic factors of early arterial injury. Early exposure to tobacco smoke, a major predictor of adult atherosclerosis, has only scarcely been studied, although ETS is known to be associated with adverse birth outcomes, respiratory disease in childhood and cardio-metabolic risk factors.

The SAPALDIA Youth Study is based on the hypothesis that ETS exposure in pregnancy and childhood is associated with an increased intima media thickness, and further that the effect is amplified by recurrent childhood infectious diseases and chronic subclinical inflammation. These hypotheses will be tested in the collected data in offspring, aged 10-20 years. Parental smoking status and home ETS exposure, collected prospectively in 1991 and 2001, will serve as proxy for the youth's ETS exposure in childhood.

The SAPALDIA Youth Study aims at a better understanding of the complex exogenous and endogenous risk factors of chronic diseases. ETS exposure in children continues to be highly prevalent and a major public health concern. Hence, the main aim of the proposed study is to investigate the role of early life ETS exposure in atherogenesis and thereby to contribute to the knowledge of adverse ETS effects on children's health and essentially to the prevention of cardiovascular disease.

Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Birth Weight and Carotid Artery Intima-Media Thickness.
Dratva Julia, Breton Carrie V, Hodis Howard N, Mack Wendy J, Salam Muhammad T, Zemp Elisabeth, Gilliland Frank, Kuenzli Nino, Avol Ed (2012), Birth Weight and Carotid Artery Intima-Media Thickness., in The Journal of pediatrics, 0.

Collaboration

Group / person Country
Types of collaboration
Institut for Sport und Sportwissenschaften, Universität Basel, Pof. Dr. med. Arno Schmidt-Trucksäss Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
University of Southern California, Preventive Medicine (Division of Environmental & Occupational Hea United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
FHNW Wädenswil, Prof. Christine Brombach Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
IUF Leibniz-Institut für umwelt- medizinische Forschung gGmbH, Prof. Dr. med. Barabara Hoffmann Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Universität Bergen; Prof. Dr. med. Cecilie Svanes Norway (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Academisch Medisch Centrum, Department of Vascular Medicine, University Amsterda, Dr. Eric de Groot Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
SAPALIDA Team Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
ESC Europäische Gesellschaft für Cardiologie, internationaler Kongress mit Vortrag 25.08.2012 München, BRD
Jahreskongress der Gesellschaft für Kardiologie, Poster Präsentation 14.06.2012 Lausanne, CH
Europrevent, internationaler Kongress Poster Präsentation 03.05.2012 Dublin, Irland


Self-organised

Title Date Place

Knowledge transfer events



Self-organised

Title Date Place
Early life factors of health throughout the life course 14.12.2012 Basel, CH

Communication with the public

Communication Title Media Place Year
New media (web, blogs, podcasts, news feeds etc.) Unibasel Newsletter Unibasel Newsletter German-speaking Switzerland 07.12.2012

Awards

Title Year
"Frau & Herz" Herzstiftung Olten, CH 2012

Associated projects

Number Title Start Funding scheme
129021 SAPALDIA Off-spring study 01.06.2010 Marie Heim-Voegtlin grants
148470 SAPALDIA Cohort on Healthy Aging 01.04.2014 Cohort Studies Large
108796 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) 01.04.2006 Cohort Studies Large

Abstract

Chronic diseases can partially be explained by early life priming factors and tracking of risk factors into older age. Intima media thickness (IMT) is considered an early marker of atherogenesis in child- and adulthood. Environmental tobacco exposure (ETS) in children is highly prevalent. ETS has been associated with childhood illnesses and cardio-metabolic risk factors. Little is known on the role of early life ETS exposure for atherogenesis. 200 off-spring of the Swiss Cohort Study on Air Pollution And Lung Diseases In Adults (SAPALDIA), born 1991-2001, to equal parts ETS exposed and non-exposed in childhood, will be recruited in 2010 to investigate the hypothesis that early life ETS exposure is associated with an increased IMT, potentially amplified by childhood infections. The prospectively collected parental data from SAPALDIA 1 and 2 offer the unique possibility to estimate unbiased early life environmental exposures, such as ETS, and to study their effect on atherogenesis.
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