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Neuronal markers of grapheme-phoneme training response for prediction of successful reading acquisition in children at familial risk for developmental dyslexia

English title Neuronal markers of grapheme-phoneme training response for prediction of successful reading acquisition in children at familial risk for developmental dyslexia
Applicant Brem Silvia
Number 141201
Funding scheme Project funding (Div. I-III)
Research institution Kinder- und Jugendpsychiatrischer Dienst Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurophysiology and Brain Research
Start/End 01.07.2013 - 30.06.2016
Approved amount 514'274.00
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All Disciplines (2)

Discipline
Neurophysiology and Brain Research
Psychology

Keywords (7)

reading acquisition; developmental dyslexia; letter-speech sound training; functional magnetic resonance imaging (fMRI); event-related potential (ERP); neuroimaging; children

Lay Summary (German)

Lead
Gute Lesefertigkeiten sind wichtig für eine erfolgreiche schulische und berufliche Karriere. Zwischen 5-10% der Kinder zeigen jedoch unerwartet grosse Schwierigkeiten beim Lesenlernen. Bei einem Grossteil dieser Kinder sind Familienangehörige von einer Lese-Rechtschreibstörung (LRS) betroffen. Eine Früherkennung ist zentral für eine möglichst effektive und frühzeitige Unterstützung und Förderung. Noch ist die Möglichkeit einer Vorhersage mit reinen Verhaltensmassen im Vorschulalter beschränkt.
Lay summary

Inhalt und Ziele:

In dieser Langzeitstudie begleiten wir eine Gruppe von Kindern mit einem familiären Risiko für LRS ab dem Kindergartenalter bis in die zweite Klasse und untersuchen den Leselernprozess. Verschiedene Masse aus Verhaltenstests und Bildgebung (Magnetresonanztomographie und Elektroenzephalographie), welche das Erlernen von Buchstaben-Sprachlautverknüpfungen im Kindergartenalter widerspiegeln, werden für eine verbesserte Vorhersage der Lesefertigkeiten der Kinder erhoben. Kinder die beim Lesenlernen Probleme zeigen, werden mit einem neu entwickelten Computerspiel unterstützt.

Diese Studie verfolgt hauptsächlich drei Ziele: 1). Verbessertes Verständnis der Leseentwicklung im Hirn, insbesondere der Integration von Schrift und Sprachlaut. 2). Verbesserte Vorhersage der Leseentwicklung im Vorschulalter bei Risikokindern. 3). Weiterentwicklung eines computerisierten  Buchstaben-Sprachlaut Trainings zur Unterstützung des Lesenlernens in der 1./2. Klasse.

Wissenschaftlicher und gesellschaftlicher Kontext:

Diese Studie verfolgt einen neuen Ansatz, um die Früherkennung von Kindern mit Lese-Rechtschreibschwäche massgeblich zu verbessern. Dadurch könnten Risikokinder möglichst früh und gezielt durch geeignete Trainings unterstützt werden, um die Probleme beim Lesenlernen sowie auch negative Schulerfahrungen von Beginn an zu vermindern.

 

 

 

Direct link to Lay Summary Last update: 24.04.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Emerging neural specialization of the ventral occipitotemporal cortex to characters through phonological association learning in preschool children
Pleisch Georgette, Karipidis Iliana I., Brauchli Christian, Röthlisberger Martina, Hofstetter Christoph, Stämpfli Philipp, Walitza Susanne, Brem Silvia (2019), Emerging neural specialization of the ventral occipitotemporal cortex to characters through phonological association learning in preschool children, in NeuroImage.
Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
Karipidis Iliana I., Pleisch Georgette, Brandeis Daniel, Roth Alexander, Röthlisberger Martina, Schneebeli Maya, Walitza Susanne, Brem Silvia (2018), Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders, in Scientific Reports, 8(1), 7121-7121.
Neural initialization of audiovisual integration in prereaders at varying risk for developmental dyslexiaAudiovisual Integration in Prereaders
I. Karipidis Iliana, Pleisch Georgette, Röthlisberger Martina, Hofstetter Christoph, Dornbierer Dario, Stämpfli Philipp, Brem Silvia (2017), Neural initialization of audiovisual integration in prereaders at varying risk for developmental dyslexiaAudiovisual Integration in Prereaders, in Human Brain Mapping, 38(2), 1038-1055.
Automated detection and labelling of high-density EEG electrodes from structural MR images
Marino Marco, Quanyiung Li, Brem Silvia, Wenderoth Nicole, Mantini Dante (2016), Automated detection and labelling of high-density EEG electrodes from structural MR images, in Journal of Neural Engineering, 13, 1-11.

Collaboration

Group / person Country
Types of collaboration
Dr. Dante Mantini, Neural Control of Movement Lab Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Dr. Urs Maurer, Psychologisches Institut, Universität Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Dr. Dr. Elise Klein, Leibnitz-Institut für Wissensmedien Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Dr. Daniel Brandeis, Zentralinstitut für seelische Gesundheit Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof. Dr. Volker Dellwo, Phonetisches Laboratorium, UZH Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Ulla Richardson, Agora Center, University of Jyväskylä Finland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Nicole Wenderoth, Neural Control of Movement Lab Switzerland (Europe)
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Annual Meeting of the Organisation for Human Brain Mapping OHBM 2016 Poster Word reading in novice readers: a simultaneous EEG/fMRI study 26.06.2016 Genf, Switzerland Brem Alexandra; Pleisch Georgette; Brem Silvia; Hofstetter Christoph; Karipidis Iliana; Röthlisberger Martina;
Annual Meeting of the Organisation for Human Brain Mapping OHBM 2016 Poster Development of speech sound and letter processing in children at risk for developmental dyslexia 26.06.2016 Genf, Switzerland Röthlisberger Martina; Karipidis Iliana; Pleisch Georgette; Hofstetter Christoph; Brem Silvia;
Annual Meeting of the Organisation for Human Brain Mapping OHBM 2016 Poster Structural changes in the brain when children with a risk for dyslexia learn to read 26.06.2016 Genf, Switzerland Karipidis Iliana; Pleisch Georgette; Hofstetter Christoph; Röthlisberger Martina; Brem Silvia;
11th Bernstein Conference 2015, Satellite Workshop Talk given at a conference The development of print processing in normal reading and dyslexic children 14.09.2015 Heidelberg, Germany Brem Silvia;
ISBET Conference Poster Print-sensitivity and lexicality effects in the visual N1 ERP of children in first grade 09.09.2015 München, Germany Karipidis Iliana; Röthlisberger Martina; Brem Silvia; Pleisch Georgette; Brem Alexandra;
Interspeech 2015 Poster Swiss GraphoGame: Concept and design of a computerised reading intervention in children with high risk for poor reading outcomes 06.09.2015 Dresden, Germany Röthlisberger Martina; Brem Silvia; Karipidis Iliana; Pleisch Georgette;
Schweizerischer Heilpädagogik-Kongress Talk given at a conference Graphogame - Eine Lernsoftware zum Lesenlernen: Unterstützung von schwachen Lesern 03.09.2015 Bern, Switzerland Röthlisberger Martina; Brem Silvia;
Annual Meeting of the Organisation for Human Brain Mapping OHBM 2015 Poster Grapheme-phoneme integration in the temporal cortex of the prereading brain 14.06.2015 Honolulu, United States of America Röthlisberger Martina; Brem Silvia; Karipidis Iliana; Pleisch Georgette;
Annual Meeting of the Organisation for Human Brain Mapping OHBM 2015 Poster Neural basis of grapheme-phoneme training in children: An EEG-fMRI study on visual print processing 14.06.2015 Honolulu, United States of America Röthlisberger Martina; Karipidis Iliana; Brem Silvia; Pleisch Georgette;
DGKJP-Kongress 2015 Poster Initial grapheme-phoneme integration in prereading children with a fmilial risk for developmental dyslexia 04.03.2015 München, Germany Röthlisberger Martina; Brem Silvia; Pleisch Georgette; Karipidis Iliana;
Resting States and State Dependent Processing in Health and Disease Talk given at a conference Stages of learning and reading development: Visual specialisation and audiovisual integration of letter-speech sound information 28.09.2014 Monte Verità, Ascona, Switzerland Brem Silvia;
Resting States and State Dependent Processing in Health and Disease Poster Neural basis of visual processing in prereaders 28.09.2014 Monte Verità, Ascona, Switzerland Pleisch Georgette; Röthlisberger Martina; Karipidis Iliana; Brem Silvia;
Resting States and State Dependent Processing in Health and Disease Poster Audiovisual integration in the prereading brain 28.09.2014 Monte Verità, Ascona, Switzerland Pleisch Georgette; Röthlisberger Martina; Karipidis Iliana; Brem Silvia;
Annual Meeting of the Organisation for Human Brain Mapping OHBM 2014 Poster Impact of short character-sound training on the visual N1 ERP in healthy adults 08.06.2014 Hamburg, Germany Brem Silvia;
Forschungskolloquium "Brain and Development", Kinderspital Zürich Individual talk Print processing in typical and atypical rading development: Insights from multimodal neuroimaging 13.05.2014 Zürich, Switzerland Brem Silvia;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Öffentliche Vorträge im Rahmen des Kinder- und Jugendpsychiatrischen Kolloquiums am KJPD Zürich Talk 07.05.2015 Zürich, Switzerland Brem Silvia;


Communication with the public

Communication Title Media Place Year
Other activities BrainFair 2015: diverse Vorträge an Schulen German-speaking Switzerland 2015
Other activities Tagung Verband Dyslexie Schweiz, 2014 German-speaking Switzerland 2014
Other activities Tagung Verband Dyslexie Schweiz, 2013 German-speaking Switzerland 2013

Awards

Title Year
Norbert & Elinore Herschkowitz Preis der Schweizerischen Hirnliga 2017
"Best poster Award" für Frau I. I. Karipidis (Erstautorin) am 11th ZIHP Symposium 2015 Zürich, für das Poster "Initial grapheme-phoneme integration in prereading children with a familial risk for developmental dyslexia" 2015

Associated projects

Number Title Start Funding scheme
125407 Neural print tuning and persistence of dyslexia 01.04.2009 Project funding (Div. I-III)
130237 Neuroimaging of cognitive flexibility and action monitoring in paediatric obsessive-compulsive disorder (OCD) and attention deficit-hyperactivity disorder (ADHD) 01.11.2010 Project funding (Div. I-III)

Abstract

Background: Poor reading skills are responsible for many troublesome school careers and considerable social costs. It has long been known that developmental dyslexia, a specific reading disorder, runs in families and occurs in 30-65% of the children in affected families. Predicting at preschool age whether a given child will struggle with reading is important because these children could be supported with targeted trainings to alleviate and/or prevent reading problems and emerging frustration. Current approaches to predict poor reading outcome with purely behavioural measures have only limited success. New approaches combining behavioural and neuroimaging measures to improve prediction, are imperative. Specific Aims and working hypotheses: The major aim of this project is to examine whether behavioural and neural markers of letter-speech sound mapping in familial “high-risk” (HR) children may advance prediction of reading outcome. Furthermore we aim to determine differences in the development of reading networks of HR children with normal and poor reading outcome and examine whether improvements in reading and normalization of brain activation of poor readers can be achieved with a supportive letter-speech sound correspondence training during the first school year.Experimental Design and Methods: In a longitudinal study, we will follow a group kindergarteners (5-7yrs) at risk for developmental dyslexia with behavioural measures and combined electroencephalography (EEG)-functional magnetic resonance imaging ((f)MRI) until second grade. Behavioural data and neural correlates of letter-speech sound correspondence learning in kindergarten will be used to predict their reading outcome at school. Children exhibiting deficits in reading in first grade are supported by a novel computerized intervention game and their reading development is compared to peers without supportive training.Expected value: This project is expected to critically advance prediction of developmental dyslexia in HR children before school enrolment through the combination of behavioural and neuroimaging measures. The identification of children at high risk for developing reading problems in kindergarten is a prerequisite to provide early and adequate support. Finally, our computerized reading training is intended to be used with high risk children to help them with reading acquisition.
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