neurorehabilitation; cognitive neuroscience; neuropsychology; auditory processing; neural plasticity
De Meo R., Bourquin N. M. P., Knebel J. F., Murray M. M., Clarke S. (2015), From bird to sparrow: Learning-induced modulations in fine-grained semantic discrimination, in Neuroimage
, 118, 163-173.
Clarke Stephanie, Bindschaedler Claire, Crottaz-Herbette Sonia (2015), Impact of Cognitive Neuroscience on Stroke Rehabilitation, in Stroke
, 46(5), 1408-1413.
Cammoun L., Thiran J. P., Griffa A., Meuli R., Hagmann P., Clarke S. (2015), Intrahemispheric cortico-cortical connections of the human auditory cortex, in Brain Structure & Function
, 220(6), 3537-3553.
Da Costa S., Bourquin N. M. P., Knebel J. F., Saenz M., Van der Zwaag W., Clarke S. (2015), Representation of Sound Objects within Early-Stage Auditory Areas: A Repetition Effect Study Using 7T fMRI, in Plos One
, 10(5), 19-19.
Clarke Stephanie, Geiser Eveline (2015), Roaring lions and chirruping lemurs: How the brain encodes sound objects in space, in Neuropsychologia
, 75, 304-313.
Da Costa Sandra, Saenz Melissa, Clarke Stephanie, van der Zwaag Wietske (2015), Tonotopic Gradients in Human Primary Auditory Cortex: Concurring Evidence From High-Resolution 7 T and 3 T fMRI, in Brain Topography
, 28(1), 66-69.
De Meo Rosanna, Murray Micah M., Clarke Stephanie, Matusz Pawel J. (2015), Top-down control and early multisensory processes: chicken vs. egg, in Frontiers in Integrative Neuroscience
, 9, 17.
Crottaz-Herbette Sonia, Fornari Eleonora, Clarke Stephanie (2014), Prismatic Adaptation Changes Visuospatial Representation in the Inferior Parietal Lobule, in Journal of Neuroscience
, 34(35), 11803-11811.
Carmeli Cristian, Donati Alessia, Antille Valerie, Viceic Dragana, Ghika Joseph, von Gunten Armin, Clarke Stephanie, Meuli Reto, Frackowiak Richard S., Knyazeva Maria G. (2013), Demyelination in Mild Cognitive Impairment Suggests Progression Path to Alzheimer's Disease, in Plos One
, 8(8), 8.
Manuel Aurelie L., Radman Narges, Mesot Delphine, Chouiter Leila, Clarke Stephanie, Annoni Jean-Marie, Spierer Lucas (2013), Inter- and Intrahemispheric Dissociations in Ideomotor Apraxia: A Large-Scale LesionSymptom Mapping Study in Subacute Brain-Damaged Patients, in Cerebral Cortex
, 23(12), 2781-2789.
Bourquin Nathalie M. -P., Murray Micah M., Clarke Stephanie (2013), Location-independent and location-linked representations of sound objects, in Neuroimage
, 73, 40-49.
Bourquin Nathalie M. -P., Simonin Alexandre, Clarke Stephanie (2013), Repetition-Induced Plasticity of Motor Representations of Action Sounds, in Brain Topography
, 26(1), 152-156.
Da Costa Sandra, van der Zwaag Wietske, Miller Lee M., Clarke Stephanie, Saenz Melissa (2013), Tuning In to Sound: Frequency-Selective Attentional Filter in Human Primary Auditory Cortex, in Journal of Neuroscience
, 33(5), 1858-1863.
Duffour-Nikolov Catherine, Tardif Eric, Maeder Philippe, Thiran Anne Bellmann, Bloch Jocelyne, Frischknecht Rolf, Clarke Stephanie (2012), Auditory spatial deficits following hemispheric lesions: Dissociation of explicit and implicit processing, in Neuropsychological Rehabilitation
, 22(5), 674-696.
Urben Sebastien, Baumann Pierre, Barcellona Sandra, Hafil Muriel, Preuss Ulrich, Peter-Favre Claire, Clarke Stephanie, Halfon Olivier, Holzer Laurent (2012), Cognitive Efficacy of Quetiapine in Early-Onset First-Episode Psychosis: A 12-Week Open Label Trial, in Psychiatric Quarterly
, 83(3), 311-324.
Bourquin Nathalie M. -P., Spierer Lucas, Murray Micah M., Clarke Stephanie (2012), Neural plasticity associated with recently versus often heard objects, in Neuroimage
, 62(3), 1800-1806.
Clarke P G H, Clarke S (2012), Nineteenth century research on cell death., in Experimental oncology
, 34(3), 139-45.
Established during the last decade on the basis of electrophysiological and anatomical studies in non-human primates and activation and lesion studies in humans, the dual-pathway model of auditory processing gives an understanding to the highly efficient way auditory stimuli are processed at cortical level. In this context several issues are currently of high interest: i) the way new semantic representations are created; ii) the nature of the link between semantic and spatial aspects of a specific sound object; iii) the influence of spatial cues on the processing of non-verbal, non-musical auditory emotional information through the ventral and dorsal pathway; and iv) the contribution of early-stage auditory areas to coding objects and their role in learning-induced plasticity. We will address them in EEG and fMRI (including 7T) paradigms in normal subjects.The finely tuned networks which underlie auditory processing in normal subjects are most likely subject to major changes following brain lesions, as suggested by previous human and non-human studies (including our own). This is most likely even more true for learning-induced plasticity, which may recruit different networks in brain-damaged patients than in normal subjects. During the grant period we will use comparable short- and long-term paradigms in both groups and assess plasticity related to recognition or spatial discrimination training.Our specific aims are:i)Determine how learning-induced plasticity influences coding within auditory semantic and auditory spatial representations; compare effects of short (half-day) and long training (4 consecutive days).ii)Determine whether spatial characteristics of sound objects impact on emotional processing, i. e., whether position-independent and position-linked representations play a role in emotional auditory processing.iii)Assess the role of early-stage auditory areas in semantic, spatial and emotional representations and their contribution to training induced plasticity.iv)Compare functional organisation and learning-induced plasticity of the auditory semantic and spatial representations in normal subjects and in brain-damaged patients. The primary importance of this project is conceptual, in that will help to understand sound object representation and its break-down in brain damage. The analysis of processing within early-stage auditory areas will allow comparison with non-human primate models and hence most likely a better grasp of the underlying neural mechanisms. As a whole this project is, however, also likely to give new understanding of training-induced plasticity following brain lesions, which is at heart of cognitive rehabilitation.