Project

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Blood pressure and renal function genetics

English title Blood pressure and renal function genetics
Applicant Bochud Murielle
Number 140331
Funding scheme SPUM
Research institution DMC IUMSP Université de Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Cardiovascular Diseases
Start/End 01.04.2012 - 31.03.2016
Approved amount 3'695'176.00
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All Disciplines (2)

Discipline
Cardiovascular Diseases
Internal Medicine

Keywords (5)

epidemiology; hypertension; genetics; renal function; ultrasound

Lay Summary (English)

Lead
Lay summary
High blood pressure (hypertension) and chronic kidney disease represent major health burdens worldwide, mainly by increasing cardiovascular mortality. In Switzerland, one in three adults suffers from high blood pressure and, one in ten from chronic kidney disease. So far the determinants, both genetic and non-genetic, of high blood pressure and chronic kidney disease are incompletely understood. However, we know that numerous genes, each with a small effect, play a role in both conditions because of the observed familial aggregations. We also know that environmental factors (including diet, drug treatment and physical activity) interact with the genetic background of people for their effects on blood pressure and kidney function. The aim of this family-based project, which is part of a wider European project, is to better understand the interface between genes and the environment on the risk of developing high blood pressure and chronic kidney disease. So far, we have provided new knowledge on how the CYP1A2 gene may influence blood pressure via chronic caffeine intake. This will be further explored in the coming years. The data gathered in this project, in collaboration with other Swiss projects, will also provide a better description of kidney morphology and function in the Swiss adult population.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
124087 Blood pressure and the kidney: interface between genes and environment 01.04.2009 SPUM
124087 Blood pressure and the kidney: interface between genes and environment 01.04.2009 SPUM
171352 Age-related renal function decline: a comprehensive study using metabolomic analysis 01.05.2017 Marie Heim-Voegtlin grants
157759 Steroid Analysis by GCxGC MS TOF (Mass Spectrometry Time-of-flight) 01.12.2014 R'EQUIP
143914 Deciphering the missing heritability 01.06.2013 Project funding (Div. I-III)
186203 Age-related renal function decline: a comprehensive study using metabolomic analysis 01.05.2019 Marie Heim-Voegtlin grants
169929 Systems level understanding of the genetic architecture of complex human traits 01.01.2017 Project funding (Div. I-III)

Abstract

This funding request lies within a SPUM project on blood pressure and renal function genetics recently financed by the FNS (33CM30-124087). Hypertension is a major public health burden worldwide. This project focuses on unraveling the genetic determinants of blood pressure (BP) and renal function in the general population in Switzerland and in the Seychelles (East Africa). The advantage of identifying genetic determinants early in the continuum from health to disease is to be able to target preventive measures to those who will benefit most and therapeutic measures at an early stage in the disease process. The backbone of the project is the ongoing European Project on Genes in Hypertension (EPOGH), a large ongoing multi-center family-based study (so far more than 5'000 participants have been phenotyped). This Swiss project will reinforce an ambitious international consortium and allow promising young Swiss clinicians and epidemiologists to closely interact with each other and to get cutting-edge training opportunities in the field of cardiovascular and renal diseases using clinical, epidemiological and public health perspectives. This prolongation request is for a 3-year follow-up examination of Swiss participants to the baseline project, which has been entitled Swiss Kidney Project on Genes in Hypertension (SKIPOGH). This follow-up examination includes new phenotypes and biomarkers, chosen based on the latest research findings on BP and renal function genetics.This SPUM project is based on a central main project (i.e. recruiting families from the general populations in Lausanne, Geneva and Bern) focusing on blood pressure genetics. Eight subprojects are proposed that are tightly related to the main project, both biologically and logistically. SKIPOGH includes the collection of numerous biological samples (serum, plasma, urine, DNA) from 1200 participants in three Swiss centers. All samples are stored at -80°C in secured biobanks located within University Hospitals. The project will lead to the creation of a unique and extremely valuable biobank and database in Switzerland. These can serve for additional research projects and for international collaborative projects.
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