sensory perception; plasticity; olfaction; neuromodulatio
Vincis Roberto, Lagier Samuel, Van de Ville Dimitri, Rodriguez Ivan, Carleton Alan (2015), Sensory-Evoked Intrinsic Imaging Signals in the Olfactory Bulb Are Independent of Neurovascular Coupling, in Cell reports
Tatti Roberta, Bhaukaurally Khaleel, Gschwend Olivier, Seal Rebecca, Edwards Robert, Rodriguez Ivan, Carleton Alan (2014), A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb, in Nature Communications
, 5:3791, 1-16.
Abraham Nixon, Vincis Roberto, Lagier Samuel, Rodriguez Ivan, Carleton Alan (2014), Long term functional plasticity of sensory inputs mediated by olfactory learning, in eLife
, 3:e02109, 1-14.
Dietschi Quentin, Assens Alexis, Challet Ludivine, Carleton Alan, Rodriguez Ivan (2013), Convergence of FPR-rs3-expressing neurons in the mouse accessory olfactory bulb, in Molecular and Cellular Neuroscience
, 56, 140-147.
Verbeni M, Sanchey O, Mollica E, Siegl-Cachedenier Irene, Carleton Alan, Guerrero Isabel, Ruiz I Altaba Ariel, Soler Juan (2013), Morphogenetic action through flux-limited spreading, in Physics of Life Reviews
, 10, 457-475.
Patterson Michael, Lagier Samuel, Carleton Alan (2013), Odor representations in the olfactory bulb evolve after the first breath and persist as an odor afterimage, in Proceedings of the National Academy of Sciences of the United States of America PNAS
, 110(35), E3340-E3349.
Abraham Nixon, Guerin Delphine, Bhaukaurally Khaleel, Carleton Alan (2012), Similar Odor Discrimination Behavior in Head-Restrained and Freely Moving Mice, in plos one
, e51789, 1-9.
How sensory processing is occurring into the brain and how to relate behavior to neuronal activities are key questions in modern neuroscience. Understanding the neural codes underlying brain function will be of great importance for future implementation of brain-machine interfaces. This research project proposes to study the cellular and network mechanisms controlling sensory perception. In particular, we would like to precise how sensory stimuli are coded by brain networks and how these representations may be influenced by experience or modulatory brain centers. In order to address these general questions, we propose to study olfaction as model sensory system. The olfactory system is central to the behavior of rodents (animal models that we study), is highly plastic and largely modulated by the neuromodulatory brain centers. This system has a relatively simple organization (only two synapses from sensory neurons to the cortex…), integrates cues and drive specific behavior. We propose to use a combination of genetic, electrophysiological, imaging and behavioral methods to study how odor information is processed in the central nervous system as it moves from the periphery to higher areas of the brain.